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MCRLFGLHAGRPVAATFWLLDAPNSLAQQSRRNPDGTGLGVFGADGKPTVLKQPIPAWRDTSFATEARQM TGTTFVAHVRYATTGATEEENTHPFLQDDRIFAHNGVVEGLDILDARLSELGVTDLVHGDTDSERVFAVI TASIRRRDGDVDAGLADALHWLSTHVPIYALNILLATATDLWALRYPDTHELYLRDRAAGESGRFSLRSN RIRTGSAHLENSPSVVFASEAMDDGAWQLLEAGEVIHVGPDLTIHRRMVLPEPPAHRMERSDLTAAAASA QHPMG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2003 | - | - | 100% (285) | glutamine amidotransferase, class-II |
| M. gilvum PYR-GCK | Mflv_1317 | - | 1e-10 | 27.82% (266) | hypothetical protein Mflv_1317 |
| M. gilvum PYR-GCK | Mflv_4939 | - | 2e-06 | 27.49% (171) | D-fructose-6-phosphate amidotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1090 | - | 1e-103 | 64.44% (284) | hypothetical protein Mb1090 |
| M. tuberculosis H37Rv | Rv1061 | - | 1e-103 | 64.44% (284) | hypothetical protein Rv1061 |
| M. leprae Br4923 | MLBr_00371 | glmS | 2e-05 | 27.66% (141) | glucosamine--fructose-6-phosphate aminotransferase |
| M. abscessus ATCC 19977 | MAB_0371 | - | 1e-09 | 29.65% (199) | hypothetical protein MAB_0371 |
| M. marinum M | MMAR_4405 | - | 2e-98 | 61.11% (288) | hypothetical protein MMAR_4405 |
| M. avium 104 | MAV_1188 | - | 1e-100 | 61.46% (288) | glutamine amidotransferase, class-II |
| M. smegmatis MC2 155 | MSMEG_6248 | - | 3e-08 | 30.53% (190) | hypothetical protein MSMEG_6248 |
| M. thermoresistible (build 8) | TH_0065 | - | 6e-11 | 31.66% (199) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0220 | - | 3e-96 | 60.34% (290) | hypothetical protein MUL_0220 |
| M. vanbaalenii PYR-1 | Mvan_2921 | - | 3e-14 | 34.27% (178) | glutamine amidotransferase, class-II |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1090|M.bovis_AF2122/97 MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRR---------NPDGTGLG
Rv1061|M.tuberculosis_H37Rv MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRR---------NPDGTGLG
MMAR_4405|M.marinum_M MCRLFGLHAGRDCVTATFWLLNAPDSLAAQSKR---------NPDGTGLG
MUL_0220|M.ulcerans_Agy99 MCRLFGLHAGRDCVTATFWLLNAPDSLAAQSKR---------NPDGTGLG
MAV_1188|M.avium_104 MCRLFGLHAGTRACTATFWLLDAPDSLAEQSRR---------NPDGTGLA
Mflv_2003|M.gilvum_PYR-GCK MCRLFGLHAG-RPVAATFWLLDAPNSLAQQSRR---------NPDGTGLG
MSMEG_6248|M.smegmatis_MC2_155 MCRHVAWLGAPRSLAD--LVLDPPQGLLVQSYAPRRQKHGLMNADGWGAG
TH_0065|M.thermoresistible__bu MCRHLGWLGRPRSIAE--LMLEPPYGLLVQSYAPRRQKYGLLNADGWGVG
MAB_0371|M.abscessus_ATCC_1997 MCRHLGWLGAPRSLSS--LMLEPPHGLVVQSYSPRRQKHGLVNADGWGAG
Mvan_2921|M.vanbaalenii_PYR-1 MCRLLGVASTLPVSVADAVGETVLTDFLALTKI---------HGDGWGVA
MLBr_00371|M.leprae_Br4923 MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSG-----------IALING
** .. . : . .
Mb1090|M.bovis_AF2122/97 -VFDEHHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGS-LD
Rv1061|M.tuberculosis_H37Rv -VFDEHHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGS-LD
MMAR_4405|M.marinum_M -VFDDRGRPELHKQPIAAWQDADFAAEAHEMTGTTFIAHVRYATAGS-HS
MUL_0220|M.ulcerans_Agy99 -VFDDRGRPELHKQPIAAWQDADFAAEAHEMTGTTFIAHVRYATAGS-HS
MAV_1188|M.avium_104 -VFDEHARPQLHKEPIAAWRDAAFAREAHQLTGTTVIAHVRYATTGS-LD
Mflv_2003|M.gilvum_PYR-GCK -VFGADGKPTVLKQPIPAWRDTSFATEARQMTGTTFVAHVRYATTGA-TE
MSMEG_6248|M.smegmatis_MC2_155 -FFDDEGVARRWRSDKPLWGDASFASVAPALRSRCVLAAVRSATIGMPIE
TH_0065|M.thermoresistible__bu -FFDDDGVARRWRSATPLWGDASFASIAPVLRSGCVVAAVRSATVGMPIE
MAB_0371|M.abscessus_ATCC_1997 -FFA-EGASRRWRSARPLWGDASFASVAPVLRSGCVVAAVRSASVGMPIE
Mvan_2921|M.vanbaalenii_PYR-1 SAVGADDTPRVDVSADSALDDTRFGTAVKEPARG-SVVHLRWATNGLAVQ
MLBr_00371|M.leprae_Br4923 SAKSGNLTVRRRAGRLSNLESVLAEMVPASLAGNVGLGHIRWATHGR-PT
. .. : :* *: *
Mb1090|M.bovis_AF2122/97 IRNTHPFLQDG--RIFAHNGVVEGLDVLDERLREVGADDLVLGQTDSERV
Rv1061|M.tuberculosis_H37Rv IRNTHPFLQDG--RIFAHNGVVEGLDVLDERLREVGADDLVLGQTDSERV
MMAR_4405|M.marinum_M VVNTHPFLQDG--RIFAHNGTLGDLELLDTRLREVGTAGLVQGQTDSERV
MUL_0220|M.ulcerans_Agy99 VVNTHPFLQDG--RIFAHNGTLGDLELLDTRLREVGTAGLVQGQTDSERV
MAV_1188|M.avium_104 VRNTHPFLQDG--RIFAHNGVLEGLDVIDARLREVGVDGLVLGDTDSERV
Mflv_2003|M.gilvum_PYR-GCK EENTHPFLQDD--RIFAHNGVVEGLDILDARLSELGVTDLVHGDTDSERV
MSMEG_6248|M.smegmatis_MC2_155 PSASAPFSDGQ--WLLSHNGLVD-----------RGVLPLTGA-AESTVD
TH_0065|M.thermoresistible__bu PSASAPFTDGH--WLLSHNGRVD-----------RAVLDTAAARAESTVD
MAB_0371|M.abscessus_ATCC_1997 ETAAAPFTDGT--WLLSHNGIVD-----------RGAVGEAFG-AESVVD
Mvan_2921|M.vanbaalenii_PYR-1 PENSHPFAADG--VAMAHNGSIKPMAALD-ALLEPRVVSTLRGTTDSERY
MLBr_00371|M.leprae_Br4923 DRNAHPHRDATGKIAVVHNGIIENFPSLRHELEIAGVEFVSDTDTEVAVH
: *. . *** : . ::
Mb1090|M.bovis_AF2122/97 FALITASIRARDGNESAGLIDALRWLA---------ANVPIYAVNVLLST
Rv1061|M.tuberculosis_H37Rv FALITASIRARDGNESAGLIDALRWLA---------ANVPIYAVNVLLST
MMAR_4405|M.marinum_M FALITAAIRTHDGDVSAGLLDAMGWLA---------ANVPIYAVNVLLST
MUL_0220|M.ulcerans_Agy99 FALITAAIRTHDGGVSAGLLDAMGWLA---------ANVPIYAVNVLLST
MAV_1188|M.avium_104 FALITAAIRARDGDITAGLVDAVRWLA---------EQVPIYAVNLLLST
Mflv_2003|M.gilvum_PYR-GCK FAVITASIRRRDGDVDAGLADALHWLS---------THVPIYALNILLAT
MSMEG_6248|M.smegmatis_MC2_155 SAIVAALIFSRG---LDALGATIAEVG---------ELDPNARLNILAAN
TH_0065|M.thermoresistible__bu SALLAATIFERG---LDRLGETLRDVA---------AADPDARLNILAGN
MAB_0371|M.abscessus_ATCC_1997 SAILAARIFASG---VQNLGETVRQIG---------AADPGARLNILAAN
Mvan_2921|M.vanbaalenii_PYR-1 FALIRQHRRSAP-DLVESVRRAVAELR---------QMYPEASLNALILG
MLBr_00371|M.leprae_Br4923 LVAQAYCAGETAGDFVGSVLAVLRRLQGHFTLVFANADEPGTIVAARRST
. : .: : * :
Mb1090|M.bovis_AF2122/97 AT--DVWALRYPESHELYILDRRGDGAP----EFHLRSKRIRAHSTHLRE
Rv1061|M.tuberculosis_H37Rv AT--DVWALRYPESHELYILDRRGDGAP----EFHLRSKRIRAHSTHLRE
MMAR_4405|M.marinum_M AT--GMWALRYPESHNLYILDRR-NGAPAPRREFHLRTKRIRARSEHLRT
MUL_0220|M.ulcerans_Agy99 ATGIGMWALRYPESHNLYILDRR-NGAPASRREFHLRTKRIRARSEHLRT
MAV_1188|M.avium_104 AT--EMWALRYPHTHQLYVLDRSADAARQP--EFDLHTIRIHARSQQLRT
Mflv_2003|M.gilvum_PYR-GCK AT--DLWALRYPDTHELYLRDRAAGESG----RFSLRSNRIRTGSAHLEN
MSMEG_6248|M.smegmatis_MC2_155 GS--------------------------------RLLATTWGDTLSVLHR
TH_0065|M.thermoresistible__bu GT--------------------------------RLLATTWGDTLSVLAG
MAB_0371|M.abscessus_ATCC_1997 GN--------------------------------ELVATTWGDTLSILEA
Mvan_2921|M.vanbaalenii_PYR-1 EG--------------------------------QLIAVHAHARSVLLDE
MLBr_00371|M.leprae_Br4923 PLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDG
: :
Mb1090|M.bovis_AF2122/97 RSSVVFAT------------EPMDDNPRWRLLD--AGELVHVDAALRVNR
Rv1061|M.tuberculosis_H37Rv RSSVVFAT------------EPMDDNPRWRLLD--AGELVHVDAALRVNR
MMAR_4405|M.marinum_M RPSVVFAS------------QPMDDDPRWRLLD--PGELVHVDVDLRITR
MUL_0220|M.ulcerans_Agy99 RPSVVFAS------------QPMDDDPRWRLLD--PGELVHVDVDLRITR
MAV_1188|M.avium_104 RPSVVFAT------------ERMDADPRWRLLE--PGELVHVDAGLRVTR
Mflv_2003|M.gilvum_PYR-GCK SPSVVFAS------------EAMDDG-AWQLLE--AGEVIHVGPDLTIHR
MSMEG_6248|M.smegmatis_MC2_155 PDGVVLAS------------EPYDDDPGWSDIP--DRHLVDVRDAHVVVT
TH_0065|M.thermoresistible__bu DDGVVLAS------------EPYDDDPRWRDVP--DRHLVEVTGAGVEMM
MAB_0371|M.abscessus_ATCC_1997 ADGVVVAS------------EPYDDDPSWVDIP--DRRLVRVRDGKVEIE
Mvan_2921|M.vanbaalenii_PYR-1 DIEEISATDLPV--------EHLEDYFSLRVARPDDATVVIGSTGFGDLD
MLBr_00371|M.leprae_Br4923 NDDAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGG
: * : ::
Mb1090|M.bovis_AF2122/97 SLVLPDPPRHPIRREDLSEPVLHAQHTSA---------------------
Rv1061|M.tuberculosis_H37Rv SLVLPDPPRHPIRREDLSEPVLHAQHTSA---------------------
MMAR_4405|M.marinum_M SLALPDPPRHRLRLADLGPEVQEALHPPA---------------------
MUL_0220|M.ulcerans_Agy99 SLALPDPPRHRLRLADLGPEVQEALHPPA---------------------
MAV_1188|M.avium_104 RLVLPDPPRQLLRRDELSTPVRDSQHALPDTRRAG---------------
Mflv_2003|M.gilvum_PYR-GCK RMVLPEPPAHRMERSDLTAAAASAQHPMG---------------------
MSMEG_6248|M.smegmatis_MC2_155 PL------------------------------------------------
TH_0065|M.thermoresistible__bu ALEGTA--------------------------------------------
MAB_0371|M.abscessus_ATCC_1997 GL------------------------------------------------
Mvan_2921|M.vanbaalenii_PYR-1 WSPLPPESVASVALDDLSMTVVPIMAD-----------------------
MLBr_00371|M.leprae_Br4923 RIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYTIEHWTRLPVEVE
Mb1090|M.bovis_AF2122/97 --------------------------------------------------
Rv1061|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4405|M.marinum_M --------------------------------------------------
MUL_0220|M.ulcerans_Agy99 --------------------------------------------------
MAV_1188|M.avium_104 --------------------------------------------------
Mflv_2003|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6248|M.smegmatis_MC2_155 --------------------------------------------------
TH_0065|M.thermoresistible__bu --------------------------------------------------
MAB_0371|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2921|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00371|M.leprae_Br4923 LASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNT
Mb1090|M.bovis_AF2122/97 --------------------------------------------------
Rv1061|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4405|M.marinum_M --------------------------------------------------
MUL_0220|M.ulcerans_Agy99 --------------------------------------------------
MAV_1188|M.avium_104 --------------------------------------------------
Mflv_2003|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6248|M.smegmatis_MC2_155 --------------------------------------------------
TH_0065|M.thermoresistible__bu --------------------------------------------------
MAB_0371|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2921|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00371|M.leprae_Br4923 NGSQIPRECDAVLYTRAGPEIGVASTKTFLAQVAANYLLGLALAQARGTK
Mb1090|M.bovis_AF2122/97 --------------------------------------------------
Rv1061|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4405|M.marinum_M --------------------------------------------------
MUL_0220|M.ulcerans_Agy99 --------------------------------------------------
MAV_1188|M.avium_104 --------------------------------------------------
Mflv_2003|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6248|M.smegmatis_MC2_155 --------------------------------------------------
TH_0065|M.thermoresistible__bu --------------------------------------------------
MAB_0371|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2921|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00371|M.leprae_Br4923 YPDEVQREYRELEAMPDLVARVIAGMGPVADLAYRFAQSTTVLFLGRHVG
Mb1090|M.bovis_AF2122/97 --------------------------------------------------
Rv1061|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4405|M.marinum_M --------------------------------------------------
MUL_0220|M.ulcerans_Agy99 --------------------------------------------------
MAV_1188|M.avium_104 --------------------------------------------------
Mflv_2003|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6248|M.smegmatis_MC2_155 --------------------------------------------------
TH_0065|M.thermoresistible__bu --------------------------------------------------
MAB_0371|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2921|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00371|M.leprae_Br4923 YPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKG
Mb1090|M.bovis_AF2122/97 --------------------------------------------------
Rv1061|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4405|M.marinum_M --------------------------------------------------
MUL_0220|M.ulcerans_Agy99 --------------------------------------------------
MAV_1188|M.avium_104 --------------------------------------------------
Mflv_2003|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6248|M.smegmatis_MC2_155 --------------------------------------------------
TH_0065|M.thermoresistible__bu --------------------------------------------------
MAB_0371|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2921|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00371|M.leprae_Br4923 SAMLHAKLLSNIREIQTRGAVTIVIAEEGDDTVRLYADHLIELPAVSTLL
Mb1090|M.bovis_AF2122/97 -------------------------------------
Rv1061|M.tuberculosis_H37Rv -------------------------------------
MMAR_4405|M.marinum_M -------------------------------------
MUL_0220|M.ulcerans_Agy99 -------------------------------------
MAV_1188|M.avium_104 -------------------------------------
Mflv_2003|M.gilvum_PYR-GCK -------------------------------------
MSMEG_6248|M.smegmatis_MC2_155 -------------------------------------
TH_0065|M.thermoresistible__bu -------------------------------------
MAB_0371|M.abscessus_ATCC_1997 -------------------------------------
Mvan_2921|M.vanbaalenii_PYR-1 -------------------------------------
MLBr_00371|M.leprae_Br4923 QPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE