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MGKFPDVVVTGVAMTTALGTDAESTWQALLEGRSGIRVLQDSFIEEFDLPVRIGGHLLETFDEQLTPEEN YNLSYVQRMAVVLGRRVWEHAGSPDVDPNRLAVSIGTGMGGIEELLFAYENLRGARFDEVNPTAVQQYAP SGPSSAVALERHARAGVLAPVSACASGSEGVAQAWRQIIFGEADIAICGGVEARIEAVPIAGFAQMRIVM STNNDDPEGACRPFDRDRDGFVFGEGGALLVIETEAHAKARGAKILGRLMGASITSDGFHMVAPDPNGER AGYAMSHAVELAGLASADIDHVNAHATGTTVGDVAEGIAINKALGGHKPAVYAPKGALGHSVGAVGAVES ILTLFALRDGVIPPTRNLRNLDPEIDLDVVAGEPRRGRYEYAINNSFGFGGHNVSLVFGRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1799 | - | - | 100% (411) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. gilvum PYR-GCK | Mflv_2776 | - | 0.0 | 77.83% (406) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. gilvum PYR-GCK | Mflv_2777 | - | e-147 | 63.33% (409) | 3-oxoacyl-(acyl carrier protein) synthase II |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2270 | kasB | 0.0 | 75.68% (407) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. tuberculosis H37Rv | Rv2246 | kasB | 0.0 | 75.68% (407) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. leprae Br4923 | MLBr_01656 | kasB | 1e-174 | 72.66% (406) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. abscessus ATCC 19977 | MAB_4608 | - | 1e-153 | 63.50% (411) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. marinum M | MMAR_3339 | kasB | 0.0 | 75.68% (407) | 3-oxoacyl- |
| M. avium 104 | MAV_2191 | - | 1e-178 | 74.26% (408) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. smegmatis MC2 155 | MSMEG_4328 | - | 1e-180 | 74.63% (406) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. thermoresistible (build 8) | TH_2837 | - | 0.0 | 75.74% (404) | PUTATIVE beta-ketoacyl synthase |
| M. ulcerans Agy99 | MUL_1303 | kasB | 0.0 | 75.68% (407) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. vanbaalenii PYR-1 | Mvan_4950 | - | 0.0 | 90.24% (410) | 3-oxoacyl-(acyl carrier protein) synthase II |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1799|M.gilvum_PYR-GCK ---------------------------MGKFPDVVVTGVAMTTALGTDAE
Mvan_4950|M.vanbaalenii_PYR-1 ---------------------------MSRFPDVVVTGVAMTTALGTDVE
MMAR_3339|M.marinum_M ---------------------MTELVTGKAFPHVVVTGIAMTTALATDAE
MUL_1303|M.ulcerans_Agy99 ---------------------MTELVTGKAFPHVVVTGIAMTTALATDAE
Mb2270|M.bovis_AF2122/97 MGVPPLAGASRTDMEGTFARPMTELVTGKAFPYVVVTGIAMTTALATDAE
Rv2246|M.tuberculosis_H37Rv MGVPPLAGASRTDMEGTFARPMTELVTGKAFPYVVVTGIAMTTALATDAE
MLBr_01656|M.leprae_Br4923 -------------MIARLMTTSPELVTGKAFPNVVVTGIAMTTALATDAE
MAV_2191|M.avium_104 MRAATARKVAGQVREGIFARPMTELVTGKTLPNVVVTGIAMTTALATDAE
MSMEG_4328|M.smegmatis_MC2_155 ---------------------MAALSTGNGLPNVVVTGVAMTTALATDAE
TH_2837|M.thermoresistible__bu ---------------------------------VVVTGVAMTTALATDAE
MAB_4608|M.abscessus_ATCC_1997 --------------------MAKPSTANGGFPNIVVTGMAMTTSIAPDVE
:****:****::..*.*
Mflv_1799|M.gilvum_PYR-GCK STWQALLEGRSGIRVLQDSFIEEFDLPVRIGGHL-LETFDEQLTPEENYN
Mvan_4950|M.vanbaalenii_PYR-1 STWQALLEGRSGIRRLEDSFIEEFDLPVRIGGHL-LETFDEQLTPEENWE
MMAR_3339|M.marinum_M TTWKLLLDSQSGIRTLDDPFVEEFNLPVRIGGHL-LEEFDHQLTRVELRR
MUL_1303|M.ulcerans_Agy99 TTWKLLLDSQSGIRTLDDPFVEEFNLPVRIGGHL-LEEFDHQLTRVELRR
Mb2270|M.bovis_AF2122/97 TTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHL-LEEFDHQLTRIELRR
Rv2246|M.tuberculosis_H37Rv TTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHL-LEEFDHQLTRIELRR
MLBr_01656|M.leprae_Br4923 TTWKLLLDNQSGIRMLDDPFIEEFNLPVRIGGHL-LEEFDHQLTRVELRR
MAV_2191|M.avium_104 TTWKLLLDSQSGIRTLDDPFVEEFDLPVRIGGHL-LEEFDSQLTRVELRR
MSMEG_4328|M.smegmatis_MC2_155 STWKKLLDGQSGIRTLTDPFVEEYNLPVRIGGHL-LEEFDSELTRVELRR
TH_2837|M.thermoresistible__bu GTWKKLLDGQSGIRLLEDDFIEKYDLPVRIGGHL-LEDFDSELTRVELRR
MAB_4608|M.abscessus_ATCC_1997 GTWKGLLNGESGIRVLDDDFVAQYDLPVKIGGHLKVRDFDKDMTKIELRR
**: **: .**** * * *: :::***:***** :. ** ::* * .
Mflv_1799|M.gilvum_PYR-GCK LSYVQRMAVVLGRRVWEHAGSPD-VDPNRLAVSIGTGMGGIEELLFAYEN
Mvan_4950|M.vanbaalenii_PYR-1 LSYVQRMAVVLGRRVWENAGSPD-VDPNRLTVSIGTGMGGIEELAFAYDH
MMAR_3339|M.marinum_M TAYLQRMSTVIGRRVWENAGSPE-VDTNRLAVSIGTGLGSAEELVFGYDE
MUL_1303|M.ulcerans_Agy99 TAYLQRMSTVIGRRVWENAGSPE-VDTNRLAVSIGTGLGSAEELVFGYDE
Mb2270|M.bovis_AF2122/97 MGYLQRMSTVLSRRLWENAGSPE-VDTNRLMVSIGTGLGSAEELVFSYDD
Rv2246|M.tuberculosis_H37Rv MGYLQRMSTVLSRRLWENAGSPE-VDTNRLMVSIGTGLGSAEELVFSYDD
MLBr_01656|M.leprae_Br4923 MGYLQRMSTVLSRRLWENAGSPE-VDTNRLMVSIGTGLGSAEELVFSYDD
MAV_2191|M.avium_104 TGYLQRMSTILGRRVWENAGSPE-VDSNRLMVSIGTGLGSSEEMVFSYDD
MSMEG_4328|M.smegmatis_MC2_155 LSYLQKMATVLGRRVWANAGSPE-VDARRLMVSMGTGLGSTEELVFAYDG
TH_2837|M.thermoresistible__bu LSYLQKMSTVLSRRVWENAGSPE-VDPRRLMVSIGTGMGSTEELVFSYDD
MAB_4608|M.abscessus_ATCC_1997 LSYVQRLAAILGRQVWEDAGAPEDIDLERLTVSVGTGLGGGEKLVEAYDE
.*:*:::.::.*::* .**:*: :* .** **:***:*. *:: .*:
Mflv_1799|M.gilvum_PYR-GCK LRGARFDEVNPTAVQQYAPSGPSSAVALERHARAGVLAPVSACASGSEGV
Mvan_4950|M.vanbaalenii_PYR-1 LREHHLELVNPTVVQQYAPSGPSSAVALERHARAGILAPVSACASGSEGI
MMAR_3339|M.marinum_M MRVRGFRAISPLAVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGSEAI
MUL_1303|M.ulcerans_Agy99 MRVRGFRAISPLAVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGSEAI
Mb2270|M.bovis_AF2122/97 MRARGMKAVSPLTVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEAI
Rv2246|M.tuberculosis_H37Rv MRARGMKAVSPLTVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEAI
MLBr_01656|M.leprae_Br4923 MRARGMKAVSPLAVQKYMPNGAAAAVGLEHHAKAGVMTPVSACASGSEAI
MAV_2191|M.avium_104 MRARGMKAVSPLGVQKYMPNGAAAAVGLEHHAKAGVITPVSACASGSEGI
MSMEG_4328|M.smegmatis_MC2_155 MRSKGLRAVSPLVVQMYMPNGAAAAIGLERQAKAGVCTSISACASGSEAI
TH_2837|M.thermoresistible__bu MRAKGLKAVSPLAVQKYMPNAAAAAVGLERKARAGVITPVSACASGSEGI
MAB_4608|M.abscessus_ATCC_1997 MRARGTKAVSPLTVQMFMPNGPAAVIGLERKARGGVITPVSACASGNEGI
:* :.* ** : *...::.:.**::*:.*: :.:****** *.:
Mflv_1799|M.gilvum_PYR-GCK AQAWRQIIFGEADIAICGGVEARIEAVPIAGFAQMRIVMSTNNDDPEGAC
Mvan_4950|M.vanbaalenii_PYR-1 AQAWRHIIFGEADIAICGGVEARIEAVPIAGFAQMRIVMSTNNDDPPGAC
MMAR_3339|M.marinum_M ARAWQQVVLGEADIAICGGVETRIEAVPIAGFANMRIVMSTNNDDPAGAC
MUL_1303|M.ulcerans_Agy99 ARAWQQVVLGEADIAICGGVETRIEAVPIAGFANMRIVMSTNNDDPAGAC
Mb2270|M.bovis_AF2122/97 ARAWQQIVLGEADAAICGGVETRIEAVPIAGFAQMRIVMSTNNDDPAGAC
Rv2246|M.tuberculosis_H37Rv ARAWQQIVLGEADAAICGGVETRIEAVPIAGFAQMRIVMSTNNDDPAGAC
MLBr_01656|M.leprae_Br4923 AHAWQQIVLGEADSAICGGVETKIEAVPIAGFSQMRIVMSTKNDNPAGAC
MAV_2191|M.avium_104 AQAWRNIVFGEADIAICGGVETKIEAVPIAAFAQMRIVMSTKNDDPVGAC
MSMEG_4328|M.smegmatis_MC2_155 ANAWRNIVLGEADIAICGGVETKIEAVPIAGFAQMRIVLSNSNDDPEGAC
TH_2837|M.thermoresistible__bu AHAWRNIVLGEADIAICGGVETKIEAVPIAGFAQMRIVLSTTNDDPPGAC
MAB_4608|M.abscessus_ATCC_1997 AHAWRQIAYGDADIAICGGIEAAIEAAPIAAFANMRIVMSTDNDNPAGAS
*.**::: *:** *****:*: ***.***.*::****:*. **:* **.
Mflv_1799|M.gilvum_PYR-GCK RPFDRDRDGFVFGEGGALLVIETEAHAKARGAKILGRLMGASITSDGFHM
Mvan_4950|M.vanbaalenii_PYR-1 RPFDRDRDGFVFGEGGALLVIETAEHARARGAKVLGRLMGASITSDGFHM
MMAR_3339|M.marinum_M RPFDKDRDGFVFGEGGALMVIETEEHAKARGANILARIMGASITSDGFHM
MUL_1303|M.ulcerans_Agy99 RPFDKDRDGFVFGEGGALMVIETEEHAKARGANILARIMGASITSDGFHM
Mb2270|M.bovis_AF2122/97 RPFDRDRDGFVFGEGGALLLIETEEHAKARGANILARIMGASITSDGFHM
Rv2246|M.tuberculosis_H37Rv RPFDRDRDGFVFGEGGALLLIETEEHAKARGANILARIMGASITSDGFHM
MLBr_01656|M.leprae_Br4923 RPFDRDRDGFVFGEAGALMLIETEDSAKARSANILARIMGASITSDGFHM
MAV_2191|M.avium_104 RPFDRDRTGFVFGEAGALMVIETEEHAKARGANILARIMGASITSDGYHM
MSMEG_4328|M.smegmatis_MC2_155 KPFDKDRNGFVFGEAGALMVIETEEHAKARGANILGRLMGASVTSDGYHI
TH_2837|M.thermoresistible__bu KPFDKDRNGFVFGEAGALMVIETEEHAKARGANILGRLMGASITSDGYHI
MAB_4608|M.abscessus_ATCC_1997 RPFDKNRTGFVFGEGGALMVIETEEHAKARGARIYARLLGAGITSDGFHV
:***::* ******.***::*** *:**.*.: .*::**.:****:*:
Mflv_1799|M.gilvum_PYR-GCK VAPDPNGERAGYAMSHAVELAGLASADIDHVNAHATGTTVGDVAEGIAIN
Mvan_4950|M.vanbaalenii_PYR-1 VAPDPNGKRAGYAMSHAVELAGLSATDIDHVNAHATGTTVGDVAEGVAIN
MMAR_3339|M.marinum_M VAPDPNGERAGHAITRAVQLAGLQPSDIDHVNAHATGTQVGDVAEGRAIN
MUL_1303|M.ulcerans_Agy99 VAPDPNGERAGHAITRAVQLAGLQPSDIDHVNAHATGTQVGDVAEGRAIN
Mb2270|M.bovis_AF2122/97 VAPDPNGERAGHAITRAIQLAGLAPGDIDHVNAHATGTQVGDLAEGRAIN
Rv2246|M.tuberculosis_H37Rv VAPDPNGERAGHAITRAIQLAGLAPGDIDHVNAHATGTQVGDLAEGRAIN
MLBr_01656|M.leprae_Br4923 VAPDPNGERAGHAIARAVHLAGLSPSDIDHVNAHATGTQVGDLAEAKAIN
MAV_2191|M.avium_104 VAPDPNGERAGHAMSRAIQLAGLTPGDIDHVNAHATGTSVGDVAESKAIN
MSMEG_4328|M.smegmatis_MC2_155 VAPDPNGEQAGYAMTRAIELAGLKPTDIDHVNAHATGTNVGDVAESKAIN
TH_2837|M.thermoresistible__bu VAPDPNGEQAGWAMTRAIELAGLQPSDIDHVNAHATGTTVGDVAEGKAIN
MAB_4608|M.abscessus_ATCC_1997 VAPHPDGIGAAKAMNRALETAGLDAKDIDHVNAHATATSVGDVAEGRAIH
***.*:* *. *: :*:. *** . **********.* ***:**. **:
Mflv_1799|M.gilvum_PYR-GCK KALGGH--KPAVYAPKGALGHSVGAVGAVESILTLFALRDGVIPPTRNLR
Mvan_4950|M.vanbaalenii_PYR-1 YALGGH--KPAVYAPKGALGHSVGAVGAVESILTLLALRDGVIPATRNLK
MMAR_3339|M.marinum_M NALGSH--KPAVYAPKSALGHSVGAVGAVESILTVLALRDQVVPPTLNLV
MUL_1303|M.ulcerans_Agy99 NALGSH--KPAVYAPKSALGHSVGAVGAVESILTVLALRDQVVPPTLNLV
Mb2270|M.bovis_AF2122/97 NALGGN--RPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLV
Rv2246|M.tuberculosis_H37Rv NALGGN--RPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLV
MLBr_01656|M.leprae_Br4923 KALCNN--RPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLV
MAV_2191|M.avium_104 NALGPHGGNAAVYAPKAALGHSVGAVGAVESILTVLALRDQVVPPTLNLE
MSMEG_4328|M.smegmatis_MC2_155 NAMGGH--KPAVYAPKGALGHSVGAVGAVESILTVLALRDGIIPPTRNLN
TH_2837|M.thermoresistible__bu NAMKGH--RPAVYAPKAALGHSVGAVGAVESILTVFALRDGVIPPTLNLK
MAB_4608|M.abscessus_ATCC_1997 KSGLQH---AAVYAPKGALGHSVGAVGAVEAVITVKSLQEGIIPPTLNYE
: : .******.*************:::*: :*:: ::*.* *
Mflv_1799|M.gilvum_PYR-GCK NLDPEIDLDVVAGEPRRGRYEYAINNSFGFGGHNVSLVFGRA
Mvan_4950|M.vanbaalenii_PYR-1 NLDPEIDLDVVAGEPRHGDFKYAINNSFGFGGHNVSLVFGRP
MMAR_3339|M.marinum_M NLDPEIDLDVVAGKPRPGNYRYAVNNSFGFGGHNVAITFGRY
MUL_1303|M.ulcerans_Agy99 NLDPEIDLDVVAGKPRPGNYRYAVNNSFGFGGHNVAITFGRY
Mb2270|M.bovis_AF2122/97 NLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAIAFGRY
Rv2246|M.tuberculosis_H37Rv NLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAIAFGRY
MLBr_01656|M.leprae_Br4923 NLDPDIDLDVVAGKPRPGDYRYAVNNSFGFGGHNVAIAFGCY
MAV_2191|M.avium_104 NLDPEIDLDVVAGKPRPGNYQYAINNSFGFGGHNVAIAFGRY
MSMEG_4328|M.smegmatis_MC2_155 NLDPEIDLDVVAGEPRQGDYKYAINNSFGFGGHNVALAFGKY
TH_2837|M.thermoresistible__bu NQDPEIDLDVVAGEPRTGDFKYAINNSFGFGGHNVALAFGKY
MAB_4608|M.abscessus_ATCC_1997 TPDPEIDLDIVSKEPRKGDYKYAVNNSFGFGGHNVAIALGKY
. **:****:*: :** * :.**:***********::.:*