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VGVPPLAGASRTDMEGTFARPMTELVTGKAFPYVVVTGIAMTTALATDAETTWKLLLDRQSGIRTLDDPF VEEFDLPVRIGGHLLEEFDHQLTRIELRRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTGLGSAE ELVFSYDDMRARGMKAVSPLTVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEAIARAWQQIVLGEA DAAICGGVETRIEAVPIAGFAQMRIVMSTNNDDPAGACRPFDRDRDGFVFGEGGALLLIETEEHAKARGA NILARIMGASITSDGFHMVAPDPNGERAGHAITRAIQLAGLAPGDIDHVNAHATGTQVGDLAEGRAINNA LGGNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLVNLDPEIDLDVVAGEPRPGNYRYAI NNSFGFGGHNVAIAFGRY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2246 | kasB | - | 100% (438) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. tuberculosis H37Rv | Rv2245 | kasA | e-155 | 66.42% (408) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. tuberculosis H37Rv | Rv3800c | pks13 | 4e-39 | 27.77% (461) | polyketide synthase PKS13 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2270 | kasB | 0.0 | 100.00% (438) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. gilvum PYR-GCK | Mflv_2776 | - | 0.0 | 81.29% (417) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. leprae Br4923 | MLBr_01656 | kasB | 0.0 | 90.78% (423) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. abscessus ATCC 19977 | MAB_4608 | - | 1e-160 | 65.64% (422) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. marinum M | MMAR_3339 | kasB | 0.0 | 91.61% (417) | 3-oxoacyl- |
| M. avium 104 | MAV_2191 | - | 0.0 | 88.26% (426) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. smegmatis MC2 155 | MSMEG_4328 | - | 0.0 | 79.62% (417) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. thermoresistible (build 8) | TH_2837 | - | 0.0 | 82.22% (405) | PUTATIVE beta-ketoacyl synthase |
| M. ulcerans Agy99 | MUL_1303 | kasB | 0.0 | 91.61% (417) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. vanbaalenii PYR-1 | Mvan_3757 | - | 0.0 | 81.29% (417) | 3-oxoacyl-(acyl carrier protein) synthase II |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2776|M.gilvum_PYR-GCK ---------------------MASPTTGN-GLPDVVVTGIAMTTALATDA
Mvan_3757|M.vanbaalenii_PYR-1 ---------------------MASPTTGN-GLPDVVVTGIAMTTSLATDA
Rv2246|M.tuberculosis_H37Rv MGVPPLAGASRTDMEGTFARPMTELVTGK-AFPYVVVTGIAMTTALATDA
Mb2270|M.bovis_AF2122/97 MGVPPLAGASRTDMEGTFARPMTELVTGK-AFPYVVVTGIAMTTALATDA
MLBr_01656|M.leprae_Br4923 -------------MIARLMTTSPELVTGK-AFPNVVVTGIAMTTALATDA
MMAR_3339|M.marinum_M ---------------------MTELVTGK-AFPHVVVTGIAMTTALATDA
MUL_1303|M.ulcerans_Agy99 ---------------------MTELVTGK-AFPHVVVTGIAMTTALATDA
MAV_2191|M.avium_104 MRAATARKVAGQVREGIFARPMTELVTGK-TLPNVVVTGIAMTTALATDA
MSMEG_4328|M.smegmatis_MC2_155 ---------------------MAALSTGN-GLPNVVVTGVAMTTALATDA
TH_2837|M.thermoresistible__bu ----------------------------------VVVTGVAMTTALATDA
MAB_4608|M.abscessus_ATCC_1997 ---------------------MAKPSTANGGFPNIVVTGMAMTTSIAPDV
:****:****::*.*.
Mflv_2776|M.gilvum_PYR-GCK EQTWTSLLDGRSGIRKLDDPFVEQFDLPVRIGGHL-LEEFDAQLTKVENR
Mvan_3757|M.vanbaalenii_PYR-1 EATWKSLLDGHSGIRKLQDPFVEEFDLPVQIGGHL-LEEFDSQLTKVENR
Rv2246|M.tuberculosis_H37Rv ETTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHL-LEEFDHQLTRIELR
Mb2270|M.bovis_AF2122/97 ETTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHL-LEEFDHQLTRIELR
MLBr_01656|M.leprae_Br4923 ETTWKLLLDNQSGIRMLDDPFIEEFNLPVRIGGHL-LEEFDHQLTRVELR
MMAR_3339|M.marinum_M ETTWKLLLDSQSGIRTLDDPFVEEFNLPVRIGGHL-LEEFDHQLTRVELR
MUL_1303|M.ulcerans_Agy99 ETTWKLLLDSQSGIRTLDDPFVEEFNLPVRIGGHL-LEEFDHQLTRVELR
MAV_2191|M.avium_104 ETTWKLLLDSQSGIRTLDDPFVEEFDLPVRIGGHL-LEEFDSQLTRVELR
MSMEG_4328|M.smegmatis_MC2_155 ESTWKKLLDGQSGIRTLTDPFVEEYNLPVRIGGHL-LEEFDSELTRVELR
TH_2837|M.thermoresistible__bu EGTWKKLLDGQSGIRLLEDDFIEKYDLPVRIGGHL-LEDFDSELTRVELR
MAB_4608|M.abscessus_ATCC_1997 EGTWKGLLNGESGIRVLDDDFVAQYDLPVKIGGHLKVRDFDKDMTKIELR
* **. **: .**** * * *: :::***:***** :.:** ::*::* *
Mflv_2776|M.gilvum_PYR-GCK RMSYIQKMATVLGRRVWENAGAPE-VDTERLLVSIGTGLGGAEALVFAYD
Mvan_3757|M.vanbaalenii_PYR-1 RMSYVQKMATVLGRRVWENAGSPE-VDTERLLVSIGTGLGGAEALVFAYD
Rv2246|M.tuberculosis_H37Rv RMGYLQRMSTVLSRRLWENAGSPE-VDTNRLMVSIGTGLGSAEELVFSYD
Mb2270|M.bovis_AF2122/97 RMGYLQRMSTVLSRRLWENAGSPE-VDTNRLMVSIGTGLGSAEELVFSYD
MLBr_01656|M.leprae_Br4923 RMGYLQRMSTVLSRRLWENAGSPE-VDTNRLMVSIGTGLGSAEELVFSYD
MMAR_3339|M.marinum_M RTAYLQRMSTVIGRRVWENAGSPE-VDTNRLAVSIGTGLGSAEELVFGYD
MUL_1303|M.ulcerans_Agy99 RTAYLQRMSTVIGRRVWENAGSPE-VDTNRLAVSIGTGLGSAEELVFGYD
MAV_2191|M.avium_104 RTGYLQRMSTILGRRVWENAGSPE-VDSNRLMVSIGTGLGSSEEMVFSYD
MSMEG_4328|M.smegmatis_MC2_155 RLSYLQKMATVLGRRVWANAGSPE-VDARRLMVSMGTGLGSTEELVFAYD
TH_2837|M.thermoresistible__bu RLSYLQKMSTVLSRRVWENAGSPE-VDPRRLMVSIGTGMGSTEELVFSYD
MAB_4608|M.abscessus_ATCC_1997 RLSYVQRLAAILGRQVWEDAGAPEDIDLERLTVSVGTGLGGGEKLVEAYD
* .*:*::::::.*::* :**:** :* .** **:***:*. * :* .**
Mflv_2776|M.gilvum_PYR-GCK GLRERGLRSVSPLSVQMYMPNGPSAVVGLERHAKAGVVTPVSACASGSEG
Mvan_3757|M.vanbaalenii_PYR-1 GLRERGLRSVSPLSVQMYMPNGPSAVVGLERHAKAGVVTPVSACASGSEG
Rv2246|M.tuberculosis_H37Rv DMRARGMKAVSPLTVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEA
Mb2270|M.bovis_AF2122/97 DMRARGMKAVSPLTVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEA
MLBr_01656|M.leprae_Br4923 DMRARGMKAVSPLAVQKYMPNGAAAAVGLEHHAKAGVMTPVSACASGSEA
MMAR_3339|M.marinum_M EMRVRGFRAISPLAVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGSEA
MUL_1303|M.ulcerans_Agy99 EMRVRGFRAISPLAVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGSEA
MAV_2191|M.avium_104 DMRARGMKAVSPLGVQKYMPNGAAAAVGLEHHAKAGVITPVSACASGSEG
MSMEG_4328|M.smegmatis_MC2_155 GMRSKGLRAVSPLVVQMYMPNGAAAAIGLERQAKAGVCTSISACASGSEA
TH_2837|M.thermoresistible__bu DMRAKGLKAVSPLAVQKYMPNAAAAAVGLERKARAGVITPVSACASGSEG
MAB_4608|M.abscessus_ATCC_1997 EMRARGTKAVSPLTVQMFMPNGPAAVIGLERKARGGVITPVSACASGNEG
:* :* :::*** ** :***..:*.:***::*:.** *.:****** *.
Mflv_2776|M.gilvum_PYR-GCK IAQAWRNIVMGEADIAICGGVEQRIEAVPIAAFAQMRIVMSTNNDDPAGA
Mvan_3757|M.vanbaalenii_PYR-1 IAQAWRNIVLGEADIAICGGVEQRIEAVPIAGFAQMRIVMSANNDDPAGA
Rv2246|M.tuberculosis_H37Rv IARAWQQIVLGEADAAICGGVETRIEAVPIAGFAQMRIVMSTNNDDPAGA
Mb2270|M.bovis_AF2122/97 IARAWQQIVLGEADAAICGGVETRIEAVPIAGFAQMRIVMSTNNDDPAGA
MLBr_01656|M.leprae_Br4923 IAHAWQQIVLGEADSAICGGVETKIEAVPIAGFSQMRIVMSTKNDNPAGA
MMAR_3339|M.marinum_M IARAWQQVVLGEADIAICGGVETRIEAVPIAGFANMRIVMSTNNDDPAGA
MUL_1303|M.ulcerans_Agy99 IARAWQQVVLGEADIAICGGVETRIEAVPIAGFANMRIVMSTNNDDPAGA
MAV_2191|M.avium_104 IAQAWRNIVFGEADIAICGGVETKIEAVPIAAFAQMRIVMSTKNDDPVGA
MSMEG_4328|M.smegmatis_MC2_155 IANAWRNIVLGEADIAICGGVETKIEAVPIAGFAQMRIVLSNSNDDPEGA
TH_2837|M.thermoresistible__bu IAHAWRNIVLGEADIAICGGVETKIEAVPIAGFAQMRIVLSTTNDDPPGA
MAB_4608|M.abscessus_ATCC_1997 IAHAWRQIAYGDADIAICGGIEAAIEAAPIAAFANMRIVMSTDNDNPAGA
**.**:::. *:** *****:* ***.***.*::****:* **:* **
Mflv_2776|M.gilvum_PYR-GCK CRPFDKDRDGFVFGEAGALLVIETEEHAKARGATPLARLMGASITSDGFH
Mvan_3757|M.vanbaalenii_PYR-1 CRPFDKDRDGFVFGEAGALMVIETEEHARARGATPLARVMGASITSDGYH
Rv2246|M.tuberculosis_H37Rv CRPFDRDRDGFVFGEGGALLLIETEEHAKARGANILARIMGASITSDGFH
Mb2270|M.bovis_AF2122/97 CRPFDRDRDGFVFGEGGALLLIETEEHAKARGANILARIMGASITSDGFH
MLBr_01656|M.leprae_Br4923 CRPFDRDRDGFVFGEAGALMLIETEDSAKARSANILARIMGASITSDGFH
MMAR_3339|M.marinum_M CRPFDKDRDGFVFGEGGALMVIETEEHAKARGANILARIMGASITSDGFH
MUL_1303|M.ulcerans_Agy99 CRPFDKDRDGFVFGEGGALMVIETEEHAKARGANILARIMGASITSDGFH
MAV_2191|M.avium_104 CRPFDRDRTGFVFGEAGALMVIETEEHAKARGANILARIMGASITSDGYH
MSMEG_4328|M.smegmatis_MC2_155 CKPFDKDRNGFVFGEAGALMVIETEEHAKARGANILGRLMGASVTSDGYH
TH_2837|M.thermoresistible__bu CKPFDKDRNGFVFGEAGALMVIETEEHAKARGANILGRLMGASITSDGYH
MAB_4608|M.abscessus_ATCC_1997 SRPFDKNRTGFVFGEGGALMVIETEEHAKARGARIYARLLGAGITSDGFH
.:***::* ******.***::****: *:**.* .*::**.:****:*
Mflv_2776|M.gilvum_PYR-GCK MVAPDPDGERAGYAMTRAIELAGLTPTDIDHVNAHATGTSVGDVAEGRAI
Mvan_3757|M.vanbaalenii_PYR-1 MVAPDPNGERAGYAITRAIELAGLKPTDIDHVNAHATGTSVGDLAEGHAI
Rv2246|M.tuberculosis_H37Rv MVAPDPNGERAGHAITRAIQLAGLAPGDIDHVNAHATGTQVGDLAEGRAI
Mb2270|M.bovis_AF2122/97 MVAPDPNGERAGHAITRAIQLAGLAPGDIDHVNAHATGTQVGDLAEGRAI
MLBr_01656|M.leprae_Br4923 MVAPDPNGERAGHAIARAVHLAGLSPSDIDHVNAHATGTQVGDLAEAKAI
MMAR_3339|M.marinum_M MVAPDPNGERAGHAITRAVQLAGLQPSDIDHVNAHATGTQVGDVAEGRAI
MUL_1303|M.ulcerans_Agy99 MVAPDPNGERAGHAITRAVQLAGLQPSDIDHVNAHATGTQVGDVAEGRAI
MAV_2191|M.avium_104 MVAPDPNGERAGHAMSRAIQLAGLTPGDIDHVNAHATGTSVGDVAESKAI
MSMEG_4328|M.smegmatis_MC2_155 IVAPDPNGEQAGYAMTRAIELAGLKPTDIDHVNAHATGTNVGDVAESKAI
TH_2837|M.thermoresistible__bu IVAPDPNGEQAGWAMTRAIELAGLQPSDIDHVNAHATGTTVGDVAEGKAI
MAB_4608|M.abscessus_ATCC_1997 VVAPHPDGIGAAKAMNRALETAGLDAKDIDHVNAHATATSVGDVAEGRAI
:***.*:* *. *: **:. *** . **********.* ***:**.:**
Mflv_2776|M.gilvum_PYR-GCK NRALGGH--RPAVYAPKSALGHSVGAVGAVESILTVQALRDGVVPPTLNL
Mvan_3757|M.vanbaalenii_PYR-1 NLAMGGH--RPAVYAPKSALGHSVGAVGAVESILTVQSLRDGIIPPTLNL
Rv2246|M.tuberculosis_H37Rv NNALGGN--RPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNL
Mb2270|M.bovis_AF2122/97 NNALGGN--RPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNL
MLBr_01656|M.leprae_Br4923 NKALCNN--RPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNL
MMAR_3339|M.marinum_M NNALGSH--KPAVYAPKSALGHSVGAVGAVESILTVLALRDQVVPPTLNL
MUL_1303|M.ulcerans_Agy99 NNALGSH--KPAVYAPKSALGHSVGAVGAVESILTVLALRDQVVPPTLNL
MAV_2191|M.avium_104 NNALGPHGGNAAVYAPKAALGHSVGAVGAVESILTVLALRDQVVPPTLNL
MSMEG_4328|M.smegmatis_MC2_155 NNAMGGH--KPAVYAPKGALGHSVGAVGAVESILTVLALRDGIIPPTRNL
TH_2837|M.thermoresistible__bu NNAMKGH--RPAVYAPKAALGHSVGAVGAVESILTVFALRDGVIPPTLNL
MAB_4608|M.abscessus_ATCC_1997 HKSGLQH---AAVYAPKGALGHSVGAVGAVEAVITVKSLQEGIIPPTLNY
: : : .******.*************:::** :*:: ::*** *
Mflv_2776|M.gilvum_PYR-GCK KNQDPEIDLDVVAGSPRPGNYNYALNNSFGFGGHNVALAFGKY
Mvan_3757|M.vanbaalenii_PYR-1 KNLDPEIDLDVVAGGPRPGNYEYAINNSFGFGGHNVALAFGKY
Rv2246|M.tuberculosis_H37Rv VNLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAIAFGRY
Mb2270|M.bovis_AF2122/97 VNLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAIAFGRY
MLBr_01656|M.leprae_Br4923 VNLDPDIDLDVVAGKPRPGDYRYAVNNSFGFGGHNVAIAFGCY
MMAR_3339|M.marinum_M VNLDPEIDLDVVAGKPRPGNYRYAVNNSFGFGGHNVAITFGRY
MUL_1303|M.ulcerans_Agy99 VNLDPEIDLDVVAGKPRPGNYRYAVNNSFGFGGHNVAITFGRY
MAV_2191|M.avium_104 ENLDPEIDLDVVAGKPRPGNYQYAINNSFGFGGHNVAIAFGRY
MSMEG_4328|M.smegmatis_MC2_155 NNLDPEIDLDVVAGEPRQGDYKYAINNSFGFGGHNVALAFGKY
TH_2837|M.thermoresistible__bu KNQDPEIDLDVVAGEPRTGDFKYAINNSFGFGGHNVALAFGKY
MAB_4608|M.abscessus_ATCC_1997 ETPDPEIDLDIVSKEPRKGDYKYAVNNSFGFGGHNVAIALGKY
. **:****:*: ** *::.**:************:::* *