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MSSREPHPDDDDTGPLNVDRVGPPTDDPRSRYDAPMSVNPRPVHRNRTPIVPIAAAAAAVVGIGALAWIF WPDAEGGQDTSADSAPVRQTESQQATDARLQGLLPEGYAPGACQPLEPSKGTLAQIDCVENDDVGGPLTA TYTLVENDTARKAFFDDVTARLSVVDCPGNIQSPGPWRRNAAPDQPVGTLVCGFQESRPTVAWTTDADLL ISEVQSGPQGPNMVQLYTWWASHS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1514 | - | - | 100% (234) | hypothetical protein Mflv_1514 |
| M. gilvum PYR-GCK | Mflv_2026 | - | 5e-23 | 28.64% (206) | protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1025 | - | 4e-45 | 47.18% (195) | hypothetical protein MAB_1025 |
| M. marinum M | MMAR_1982 | pknH_2 | 1e-34 | 35.34% (232) | transmembrane serine/threonine-protein kinase H PknH_2 |
| M. avium 104 | MAV_4742 | - | 3e-15 | 30.97% (155) | hypothetical protein MAV_4742 |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_1441 | - | 3e-49 | 42.57% (249) | PROBABLE ATP-DEPENDENT DNA HELICASE |
| M. ulcerans Agy99 | MUL_3375 | pknH_2 | 3e-33 | 36.65% (191) | transmembrane serine/threonine-protein kinase H PknH_2 |
| M. vanbaalenii PYR-1 | Mvan_5242 | - | 4e-87 | 62.18% (238) | hypothetical protein Mvan_5242 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu LSGAGRAGRIGAAVTARHSPADLAEALGLFPPTEEQAAVIAAPPGPLVVI
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu AGAGAGKTETMAARVVWLVANGYARPDQVLGLTFTRKAAGQLLRRVRSRL
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu ARLAGTGLVPANSAPDWTTESVTVSTYHAFAGTLLREHGLLLPVEPDTRL
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu IGETELWQLAYRVVCEHPGPLDTDKTPAAITAMVLRLAGQLAEHLVDTDQ
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu LRDTHVELERLVHTLPAGPYQRDRGPSQWLLNMLATQTERAALVPLIDAV
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M ------------MSASARRSRVGTRFGPYYLKRQLGTGGMGEVYEAVDTV
MUL_3375|M.ulcerans_Agy99 ------------MSASARRSRVGTRFGPYYLKRQLGTGGMGEVYEAVDTV
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu HRRMRAEKVMDFGMQMAAAARLASEHPQVGAALRQRFRVVLLDEYQDTGH
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M RQRVVALKLMSESLSHDPVFRMRMQREARNAGRLQEPHVVPIHDYGEIDG
MUL_3375|M.ulcerans_Agy99 RQRVVALKLMSESLSHDPVFRMRMQREARNAGRLQEPHVVPIHDYGEIDG
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu AQRIALSALFGGGVDDDLALTAVGDPIQSIYGWRGASATNLPRFATDFPH
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M QLYLDMRLIEGTHLALLLERFGPVTPPWAVALVHQVASALDAAHAAGVMH
MUL_3375|M.ulcerans_Agy99 QLYLDMRLIERTHLALLLERFGPVTPPWAVALVHQVASALDAAHAAGVMH
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu SDGSPAPTLELRTSWRNPPRTLHLANAISAEARRRSVAVRALRPRPDAEP
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M RDVKPENILVTQDDFVYLVDFGIASAATDEKLTQIGSAVGTWRYMAPERF
MUL_3375|M.ulcerans_Agy99 RDVKPENILVTQDDFVYLVDFGIASAATDEKLTQIGSAVGTWRYMAPERF
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu GTIRCALLDDVQSEREWVAEQLAALYRHARDAGDTPPTAAVLVRRNADAA
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M SDAEVNQRADIYSLTCVLHECLTGTPPYRADSAGMLITAHLMAP------
MUL_3375|M.ulcerans_Agy99 SDAEVNQRADIYSLTCVLHECLTGTPPYRADSAGMLITAHLMAP------
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu PMAQALTARGVPVEVVGLAGLLAVPEVADVVAMLRLAADPTAGSAAVRIL
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu TGPRWRLGARDLTALWRRAVELGTVEPPGARPDTDGVEQILAGIGPDADE
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu PCLADAICDPGDAAAYSEEGYRRITALAQELTALRAHLHHPLPDLIAEIR
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu RILGVDAEARAGQPVAAGWAGTENLDAFADVVAEFAVRPNATVPALLGYL
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M -----------------------------------IPRPSQLRPGIPATF
MUL_3375|M.ulcerans_Agy99 -----------------------------------IPRPSQLRPDIPATF
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu SAAMEVENGLAPADVTVATDRVQILTVHAAKGLEWEVVAVPHLSRRVFPS
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1982|M.marinum_M DAVIARGMAKRPEDRFASAG---------------ELAAAAHQALSAPHQ
MUL_3375|M.ulcerans_Agy99 DAVIARGMAKRPEDRFASAG---------------ELAAAAHQALSAPHQ
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu TASPRTWLTDAGELPPLLRGDRATTSEHGVPVLDTADVNDRKALSDKIAE
MAB_1025|M.abscessus_ATCC_1997 ------MDTDTGAGSPASEGSADAADTAPLPVLN--------ALPGMLSD
MMAR_1982|M.marinum_M AQEFRILKRSEEAGGLHTDAAAEAGITFASPSTASPSAPTPVASTSQP--
MUL_3375|M.ulcerans_Agy99 AQEFRILKRGEEAGGLHTDAAAEAGITFASPSTASPSAPTPVASTSQP--
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1441|M.thermoresistible__bu HKNRLAQRRTDEERRLLYVAVTRAEDTLLVSGHHWGATESKPRGPSEFLL
MAB_1025|M.abscessus_ATCC_1997 PG---------------------------------------PFAPSE---
MMAR_1982|M.marinum_M --------------------------------------DLRISGPLSIPS
MUL_3375|M.ulcerans_Agy99 --------------------------------------DLRISGPLSIPS
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK ------------------MSSREPHPDDDDTGPLN-----VDRVGPPTD-
Mvan_5242|M.vanbaalenii_PYR-1 ------------------MSSHEPEPDDADTGPLH-----VSRLRTPLGE
TH_1441|M.thermoresistible__bu EIKDVIDRSAEAGDPCGTIDLWAPEPPDGTPNPLRDKAFEVLWPAPPXXX
MAB_1025|M.abscessus_ATCC_1997 ---------QDFGQPPFVEQPASPDPYWSAPAAPTPQFAGASTPQPIGEK
MMAR_1982|M.marinum_M FPTSEANVPLFDASTSSWGDLTAAPPPQAPPAPPTP-----PTPPVPPTP
MUL_3375|M.ulcerans_Agy99 FPTSEANVPLFDASTSSWGDLTAAPPPQAPPAPLTP-----PTPPVPPTP
MAV_4742|M.avium_104 --------------------------------------------------
Mflv_1514|M.gilvum_PYR-GCK ---DPRSRYDAPMSVNP-RPVHRNRTPIVPIAAAAAAVVGIGALAWIFWP
Mvan_5242|M.vanbaalenii_PYR-1 GPGDREPRYDAPLSVNP-RPVHRDRRPVVLVAAAAAALVGLGALAWVFWP
TH_1441|M.thermoresistible__bu PAGPPPPVSPRITTPSA-GGAQPNRRRLIAGVAGVAAVAVLGGLAFWLLS
MAB_1025|M.abscessus_ATCC_1997 PWGSGASASTVDFASWADKGPERSKRPLIIGGAVLAAVVLVGGVIAIFAS
MMAR_1982|M.marinum_M PQPPKQTSDTSPSGPGPHSLAARLRNPWMLLGAAALVALIVFAAQGIWLS
MUL_3375|M.ulcerans_Agy99 PQPPKQTSDTSPSGPGPHFLAASLRNPWMLLGAAALVALIVFAAQGIWLS
MAV_4742|M.avium_104 -------------------MSYRNTALRLVSAAAFTGSLALAGSAPALAE
: * : .
Mflv_1514|M.gilvum_PYR-GCK DAEGGQDTSADSAPVRQTES---QQATDARLQGLLPEGYAPGACQPLEPS
Mvan_5242|M.vanbaalenii_PYR-1 SS-GGEGHAGAPTTTTETES---REEAETRLLDMVPPGYAADACEAVVPV
TH_1441|M.thermoresistible__bu PSGTDQADGARADDTAETTSPPRDTAAENRLLTMLPPGYSAGACGPVPAP
MAB_1025|M.abscessus_ATCC_1997 GGGDDAPTEPTAAPPTTTVSS-RDTDAETRLLSMLPAGYAASACKAVEPA
MMAR_1982|M.marinum_M FRPKSESASTSPSTASPSAPSPASADALARLLSTLPLGYAPGTCRAFLPA
MUL_3375|M.ulcerans_Agy99 FRPKSESASTSPSTASPSAPSPASADALARLLSTLPLGYAPGTCRAFLPA
MAV_4742|M.avium_104 PNTGSASDMN-------------------TLAASLSKGYGLNNCKPQELT
. * :. **. . * .
Mflv_1514|M.gilvum_PYR-GCK K-GTLAQIDCVENDDVGGPLTATYTLVENDTARKAFFDDVTARLSVVDCP
Mvan_5242|M.vanbaalenii_PYR-1 N-GALAQVSCDKNDDTGGPLTATYTLAKDGRALRELFDGVVNASAVVNCP
TH_1441|M.thermoresistible__bu E-GALAQVVCRENTDPGGPPTATYTLARDEAAMQRAFDEIIAASATVNCP
MAB_1025|M.abscessus_ATCC_1997 N-EAVAQVKCGRSDDPDGPIEASYSLVKDKSALAAGLSRLTKRNAVVVCP
MMAR_1982|M.marinum_M K-DSLARVTCDKNVDPGGPSRGVYTLFGETATLRQYFDGLLRTDIMVDCP
MUL_3375|M.ulcerans_Agy99 K-DSLARVTCDKNVDPGGPSRGVYTLFGETATLRQYFDGLLRTDIMVDCP
MAV_4742|M.avium_104 ESGELAELLCGQSPDPSGPGSGVYALFSNGTNLASAFSSTIKDVSLANCG
: :*.: * .. * .** . *:* : :. . *
Mflv_1514|M.gilvum_PYR-GCK GNIQSPGPWRRNAAPDQPVGTLVCGFQESRPTVAWTTDADLLISEVQSGP
Mvan_5242|M.vanbaalenii_PYR-1 GNIQSPGPWRRNATPEQTAGTLVCGFQQSRPTVAWTTDTDLMVSEVQSGP
TH_1441|M.thermoresistible__bu NFIQSPGPWRRNATPDRISGTLFCGIQQNEPLVAWTDDANLVVSAVHSGP
MAB_1025|M.abscessus_ATCC_1997 GRIQSPGPWRRNATPDQVSGTVFCGTNQGHPVVAWTDEERLLLSETRSGA
MMAR_1982|M.marinum_M GEKKSPTAWHHPDSP-QVGGMIFCAIQEGSPSVVWTNEAQLMISVVQGDP
MUL_3375|M.ulcerans_Agy99 GEKKSPTAWHHPDSP-QVGGMIFCAIQEGSPSVVWTNEAQLMISVVPGDP
MAV_4742|M.avium_104 DAGQSPGTWKQ---NGQTGGQIACGTYKNYATLTWTTDAKNVLGHLTAAN
. :** .*:: : * : *. :. . :.** : ::. .
Mflv_1514|M.gilvum_PYR-GCK QGPNMVQLYTWWASHS
Mvan_5242|M.vanbaalenii_PYR-1 QGPNMVQLYTWWASHS
TH_1441|M.thermoresistible__bu QGPTLDELYAWWTTHS
MAB_1025|M.abscessus_ATCC_1997 TGPTLDQLYAWWSSHS
MMAR_1982|M.marinum_M RGPNLEELYSWWKKHS
MUL_3375|M.ulcerans_Agy99 RGPNLEELYSWWKKHS
MAV_4742|M.avium_104 --SDVNALYQWWRTNG
. : ** ** .:.