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MSYRNTALRLVSAAAFTGSLALAGSAPALAEPNTGSASDMNTLAASLSKGYGLNNCKPQELTESGELAEL LCGQSPDPSGPGSGVYALFSNGTNLASAFSSTIKDVSLANCGDAGQSPGTWKQNGQTGGQIACGTYKNYA TLTWTTDAKNVLGHLTAANSDVNALYQWWRTNG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4742 | - | - | 100% (173) | hypothetical protein MAV_4742 |
| M. avium 104 | MAV_4741 | - | 6e-52 | 55.68% (176) | hypothetical protein MAV_4741 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2026 | - | 1e-15 | 34.48% (145) | protein kinase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1025 | - | 5e-16 | 30.82% (159) | hypothetical protein MAB_1025 |
| M. marinum M | MMAR_0722 | - | 2e-41 | 48.30% (176) | hypothetical protein MMAR_0722 |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_1441 | - | 3e-17 | 29.28% (181) | PROBABLE ATP-DEPENDENT DNA HELICASE |
| M. ulcerans Agy99 | MUL_3375 | pknH_2 | 5e-15 | 27.74% (155) | transmembrane serine/threonine-protein kinase H PknH_2 |
| M. vanbaalenii PYR-1 | Mvan_5242 | - | 4e-15 | 26.88% (186) | hypothetical protein Mvan_5242 |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1441|M.thermoresistible__bu LSGAGRAGRIGAAVTARHSPADLAEALGLFPPTEEQAAVIAAPPGPLVVI
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu AGAGAGKTETMAARVVWLVANGYARPDQVLGLTFTRKAAGQLLRRVRSRL
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu ARLAGTGLVPANSAPDWTTESVTVSTYHAFAGTLLREHGLLLPVEPDTRL
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu IGETELWQLAYRVVCEHPGPLDTDKTPAAITAMVLRLAGQLAEHLVDTDQ
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu LRDTHVELERLVHTLPAGPYQRDRGPSQWLLNMLATQTERAALVPLIDAV
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu HRRMRAEKVMDFGMQMAAAARLASEHPQVGAALRQRFRVVLLDEYQDTGH
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu AQRIALSALFGGGVDDDLALTAVGDPIQSIYGWRGASATNLPRFATDFPH
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu SDGSPAPTLELRTSWRNPPRTLHLANAISAEARRRSVAVRALRPRPDAEP
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu GTIRCALLDDVQSEREWVAEQLAALYRHARDAGDTPPTAAVLVRRNADAA
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu PMAQALTARGVPVEVVGLAGLLAVPEVADVVAMLRLAADPTAGSAAVRIL
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu TGPRWRLGARDLTALWRRAVELGTVEPPGARPDTDGVEQILAGIGPDADE
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu PCLADAICDPGDAAAYSEEGYRRITALAQELTALRAHLHHPLPDLIAEIR
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
TH_1441|M.thermoresistible__bu RILGVDAEARAGQPVAAGWAGTENLDAFADVVAEFAVRPNATVPALLGYL
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK --MTDPQHGSRVGSQVGPYRLQRLLGKGGMGEVYEAYDTVKDRVVALKLL
MUL_3375|M.ulcerans_Agy99 --MSASARRSRVGTRFGPYYLKRQLGTGGMGEVYEAVDTVRQRVVALKLM
TH_1441|M.thermoresistible__bu SAAMEVENGLAPADVTVATDRVQILTVHAAKGLEWEVVAVPHLSRRVFPS
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK PESASHDPVFRKRLQREAHAAGRLQEPHVVPIHDYGEIDGLLFVDMRMID
MUL_3375|M.ulcerans_Agy99 SESLSHDPVFRMRMQREARNAGRLQEPHVVPIHDYGEIDGQLYLDMRLIE
TH_1441|M.thermoresistible__bu TASPRTWLTDAGELPPLLRGDRATTSEHGVPVLDTADVNDRKALSDKIAE
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 ------MDTDTGAGSPASEGSADAADTAPLPVLN--------ALPGMLSD
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK GVDLRRILKEQGAMSPARATAIVRQIASALDAAHRAGIMHRDVKPENILV
MUL_3375|M.ulcerans_Agy99 RTHLALLLERFGPVTPPWAVALVHQVASALDAAHAAGVMHRDVKPENILV
TH_1441|M.thermoresistible__bu HKNRLAQRRTDEERRLLYVAVTRAEDTLLVSGHHWGATESKPRGPSEFLL
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 PG---------------------------------------PFAPSE---
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK TRDDFAYLVDFG--------------------IANAATDESLTELGTAVG
MUL_3375|M.ulcerans_Agy99 TQDDFVYLVDFG--------------------IASAATDEKLTQIGSAVG
TH_1441|M.thermoresistible__bu EIKDVIDRSAEAGDPCGTIDLWAPEPPDGTPNPLRDKAFEVLWPAPPXXX
Mvan_5242|M.vanbaalenii_PYR-1 ------------------MSSHEPEPDDADTGPLHVSRLRTPLGEGPGDR
MAB_1025|M.abscessus_ATCC_1997 ---------QDFGQPPFVEQPASPDPYWSAPAAPTPQFAGASTPQPIGEK
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK TYAYMAPERFAAGEVTHRADVYALTCVLHECLTGTQPFEGDSVSVVITAH
MUL_3375|M.ulcerans_Agy99 TWRYMAPERFSDAEVNQRADIYSLTCVLHECLTGTPPYRADSAGMLITAH
TH_1441|M.thermoresistible__bu PAGPPPPVSPRITTPSAG-GAQPNRRRLIAGVAGVAAVAVLGGLAFWLLS
Mvan_5242|M.vanbaalenii_PYR-1 EPRYDAPLS---VNPRP---VHRDRRPVVLVAAAAAALVGLGALAWVFWP
MAB_1025|M.abscessus_ATCC_1997 PWGSGASASTVDFASWADKGPERSKRPLIIGGAVLAAVVLVGGVIAIFAS
MAV_4742|M.avium_104 ---------------------MSYRNTALRLVSAAAFTGSLALAGS--AP
MMAR_0722|M.marinum_M ---------------------MTHLTTVLRAATAAALMGSFAYLGIGIGT
Mflv_2026|M.gilvum_PYR-GCK LNQPAPRPSSLRQGIPAGLDEVIARGMAKRPEDRFASAGELADAATDALT
MUL_3375|M.ulcerans_Agy99 LMAPIPRPSQLRPDIPATFDAVIARGMAKRPEDRFASAGELAAAAHQALS
* .. .
TH_1441|M.thermoresistible__bu PSGTDQ--------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 SSGGEG--------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 GGGDDA--------------------------------------------
MAV_4742|M.avium_104 ALAE----------------------------------------------
MMAR_0722|M.marinum_M ASAE----------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK RAEQDQAASILQRSQAA-------------TMMAPLPPPPPPPPP-----
MUL_3375|M.ulcerans_Agy99 APHQAQEFRILKRGEEAGGLHTDAAAEAGITFASPSTASPSAPTPVASTS
TH_1441|M.thermoresistible__bu --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK ------------PPPPQFAATPPPGGAATYQGGYQPPPPPGWGP-----P
MUL_3375|M.ulcerans_Agy99 QPDLRISGPLSIPSFPTSEANVPLFDASTSSWGDLTAAPPPQAPPAPLTP
TH_1441|M.thermoresistible__bu --------------------------------------------------
Mvan_5242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4742|M.avium_104 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK PVPPGRPGGSGGSKGPLIAVVAGAVVLLVLAAVG-IWLVTKSDDPGSTTA
MUL_3375|M.ulcerans_Agy99 PTPPVPPTPPQPPKQTSDTSPSGPGPHFLAASLRNPWMLLGAAALVALIV
TH_1441|M.thermoresistible__bu ---------------ADGARADDTAETTSPPRDTAAENRLLTMLPPGYSA
Mvan_5242|M.vanbaalenii_PYR-1 ---------------HAGA-PTTTTETES---REEAETRLLDMVPPGYAA
MAB_1025|M.abscessus_ATCC_1997 ---------------PTEPTAAPPTTTVSS-RDTDAETRLLSMLPAGYAA
MAV_4742|M.avium_104 ----------------------------PNTGSASDMNTLAASLSKGYGL
MMAR_0722|M.marinum_M ----------------------------PDNGNPADVDTLAESLSKGYDL
Mflv_2026|M.gilvum_PYR-GCK SPTS---SSAAPTTSREPTRRTRTTTSAP-PATGSYDQQLMAMLSGGHDG
MUL_3375|M.ulcerans_Agy99 FAAQGIWLSFRPKSESASTSPSTASPSAPSPASADALARLLSTLPLGYAP
. * :. *:
TH_1441|M.thermoresistible__bu GACGPVPA-PEGALAQVVCRENTDPGGPPTATYTLARDEAAMQRAFDEII
Mvan_5242|M.vanbaalenii_PYR-1 DACEAVVP-VNGALAQVSCDKNDDTGGPLTATYTLAKDGRALRELFDGVV
MAB_1025|M.abscessus_ATCC_1997 SACKAVEP-ANEAVAQVKCGRSDDPDGPIEASYSLVKDKSALAAGLSRLT
MAV_4742|M.avium_104 NNCKPQELTESGELAELLCGQSPDPSGPGSGVYALFSNGTNLASAFSSTI
MMAR_0722|M.marinum_M TNCAPQPIN-PGELAELVCDQSADSAGPAEARYILFANTDAMNGKFKAGL
Mflv_2026|M.gilvum_PYR-GCK SNCEPVSPPAQTAVATVDCTQNTNPGGPAFTRYSLFADRGALDAAFDEAI
MUL_3375|M.ulcerans_Agy99 GTCRAFLP-AKDSLARVTCDKNVDPGGPSRGVYTLFGETATLRQYFDGLL
* . :* : * .. :. ** * * : : :.
TH_1441|M.thermoresistible__bu AA--SATVNCPNFIQSPGPWRRNATPDRISGTLFCGIQQNEPLVAWTDDA
Mvan_5242|M.vanbaalenii_PYR-1 NA--SAVVNCPGNIQSPGPWRRNATPEQTAGTLVCGFQQSRPTVAWTTDT
MAB_1025|M.abscessus_ATCC_1997 KR--NAVVVCPGRIQSPGPWRRNATPDQVSGTVFCGTNQGHPVVAWTDEE
MAV_4742|M.avium_104 KD--VSLANCGDAGQSPGTWKQ---NGQTGGQIACGTYKNYATLTWTTDA
MMAR_0722|M.marinum_M ND--ETLTSCGES-QSPTTWHQG--TSGTAGQVACGTHDGAAEIIWTTDA
Mflv_2026|M.gilvum_PYR-GCK RVNSELLECPGSGVDSPTTWHYTETPDQVVGQVACGTYNENPDIVWTNDE
MUL_3375|M.ulcerans_Agy99 RT-DIMVDCPGE-KKSPTAWHHPDSP-QVGGMIFCAIQEGSPSVVWTNEA
.** .*: * : *. . . : ** :
TH_1441|M.thermoresistible__bu NLVVSAVHSGPQGPTLDELYAWWTTHS
Mvan_5242|M.vanbaalenii_PYR-1 DLMVSEVQSGPQGPNMVQLYTWWASHS
MAB_1025|M.abscessus_ATCC_1997 RLLLSETRSGATGPTLDQLYAWWSSHS
MAV_4742|M.avium_104 KNVLG--HLTAANSDVNALYQWWRTNG
MMAR_0722|M.marinum_M KNVLS--DIRGANTDVPSLYRWWQNNG
Mflv_2026|M.gilvum_PYR-GCK KLLL----ADAQSPNLEDLHDWWLEFG
MUL_3375|M.ulcerans_Agy99 QLMISVVPGDPRGPNLEELYSWWKKHS
:: .. : *: ** .