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TSPFTPPDNPFERRGFGFGFGPVDRRALHERRRHARREFRDHVREHRGDAAFGPGFGGFGPGGFGPGGGG FGPGSFGPGFGFGPGSRRGGGPRGRSRRGDVRAAILTLLTDRPMHGYEMIQEINERSRQMWKPSPGSVYP TLQLLVDEGLIVSTEAEGSKKLFELTDDGRAAAEKIDTAPWDAMAEQADPGAVNLRNAAGQLMGAVAQSA HAATPEQQQRILDIVNNARREIYSVLGED*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1330 | - | - | 100% (240) | PadR-like family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0868 | - | 7e-06 | 34.88% (86) | PadR-like family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4805 | - | 8e-05 | 55.32% (47) | hypothetical protein Mflv_4805 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3518 | - | 1e-06 | 37.97% (79) | hypothetical protein Mb3518 |
| M. tuberculosis H37Rv | Rv3488 | - | 2e-06 | 37.97% (79) | hypothetical protein Rv3488 |
| M. leprae Br4923 | MLBr_02313 | - | 2e-60 | 63.54% (181) | hypothetical protein MLBr_02313 |
| M. abscessus ATCC 19977 | MAB_0383c | - | 3e-73 | 61.18% (237) | putative transcriptional regulator, PadR-like |
| M. marinum M | MMAR_5206 | - | 3e-85 | 64.75% (244) | PadR-like transcriptional regulatory protein |
| M. avium 104 | MAV_0407 | - | 9e-96 | 72.18% (248) | transcriptional regulator, PadR family protein |
| M. smegmatis MC2 155 | MSMEG_6227 | - | 5e-80 | 63.64% (253) | transcriptional regulator, PadR family protein |
| M. thermoresistible (build 8) | TH_1310 | - | 2e-05 | 32.56% (86) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4279 | - | 1e-84 | 64.34% (244) | PadR-like transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5462 | - | 1e-113 | 79.12% (249) | PadR-like family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3518|M.bovis_AF2122/97 --------------------------------------------------
Rv3488|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1330|M.gilvum_PYR-GCK ---------------------MTSPFTPPDNPFERRG----FGFGFGPVD
Mvan_5462|M.vanbaalenii_PYR-1 ---------------------MNTPFTPPENPFDRRG----FGFGFGPEG
MMAR_5206|M.marinum_M ---------------------MNNLFTPPGGPFGPRP---GFGFGPGPAQ
MUL_4279|M.ulcerans_Agy99 MYSIYQSSIVATFQKTRKEHNMNNLFTPPGGPFGPRP---GFGFGPGPAQ
MLBr_02313|M.leprae_Br4923 ---------MASASQTQRITNMNDPFLPPNGPFAAEP---SLGFG-----
MAV_0407|M.avium_104 ---MFRSARPVRKPTNVRTKTMSNPFTPPDGPFGARPG-FGFGFGPGRVD
MSMEG_6227|M.smegmatis_MC2_155 ---------------------MSTPFAFPTGDFGFGPAGRRAMLHHRRAA
MAB_0383c|M.abscessus_ATCC_199 ---------------MTSHEERAEQFR-PDTPFG-------FGFGFDPTG
TH_1310|M.thermoresistible__bu --------------------------------------------------
Mb3518|M.bovis_AF2122/97 --------------------------------------------------
Rv3488|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1330|M.gilvum_PYR-GCK RRALHERRRHA--RREFRDHVREHRGDAAFGPGFGGFGPGGFGPGGGGFG
Mvan_5462|M.vanbaalenii_PYR-1 RRTVHERRRQA--RREFHDHIREHRGDAGFGPGPGGFGPGGFGPGFGGFG
MMAR_5206|M.marinum_M RRALHSARRHA--RREFFEHLRDHDADHDGPLGFG----GGFGPGFG---
MUL_4279|M.ulcerans_Agy99 RRALHSARRHA--RREFFEHLRDHDADHDGPLGFG----GGFGPGFG---
MLBr_02313|M.leprae_Br4923 -----------------------------------------FSPGPG---
MAV_0407|M.avium_104 RRALHEARRQA--RRDFREHLREHAGGHDGPLGFG----PGFGPGFG---
MSMEG_6227|M.smegmatis_MC2_155 RREFRDQMRAH--LHEAREQALDPRCEMGGPGGPGP--MGGPGRGFGGFG
MAB_0383c|M.abscessus_ATCC_199 RGPGLRGRRHGSRRHECDPRGEFHEQAWAGRRGPGAFMDRGFGPGFG---
TH_1310|M.thermoresistible__bu --------------------------------------------------
Mb3518|M.bovis_AF2122/97 ---------------------------MREFQRAAVRLHILHHAADNEVH
Rv3488|M.tuberculosis_H37Rv ---------------------------MREFQRAAVRLHILHHAADNEVH
Mflv_1330|M.gilvum_PYR-GCK PGS--FGPGFGFGPGSRRG--GGPRG---RSRRGDVRAAILTLLTDRPMH
Mvan_5462|M.vanbaalenii_PYR-1 PGGGKFGPGFGFGPGGRGGRRGGPRGG-GRSRRGDVRAAILKLLTDRPMH
MMAR_5206|M.marinum_M ---PGLG--FGFGPGGARG--GGRRGGPGRGRRGDVRAAILVLLSEQPMH
MUL_4279|M.ulcerans_Agy99 ---PGLG--FGFGPGGARG--GGRRGGPGRGRRGDVRAAILVLLSEQPMH
MLBr_02313|M.leprae_Br4923 ---PEFS--FSFGP--------RRRGDAGRGRRGDVRAAILMLLTERPMH
MAV_0407|M.avium_104 ---PAFGPGFGFGPGGPRG--AWRRGGPGRGKRGDVRAAVLALLAERPMH
MSMEG_6227|M.smegmatis_MC2_155 FG-FDPGAGFGFGPGGPRG--RRGHGRGRRGRRGDVRAAILKLLAERPMH
MAB_0383c|M.abscessus_ATCC_199 ---RGFGPGFGFGFGEQPR--GRGRG---RGQRGDVRAAILALLAERPMH
TH_1310|M.thermoresistible__bu -------------------------------VIRLLELAILGLLLESPMH
:. :* : :*
Mb3518|M.bovis_AF2122/97 GAWLTQELSRHG---YRVSPGTLYPTLHRLEADGLLVSEQR---------
Rv3488|M.tuberculosis_H37Rv GAWLTQELSRHG---YRVSPGTLYPTLHRLEADGLLVSEQR---------
Mflv_1330|M.gilvum_PYR-GCK GYEMIQEINERSRQMWKPSPGSVYPTLQLLVDEGLIVSTEAEG-------
Mvan_5462|M.vanbaalenii_PYR-1 GYEMIQEINDRSQQLWKPSPGSIYPTLQLLVDEGLLTAAETEG-------
MMAR_5206|M.marinum_M GYEMIQQIADRSNGLWRPSPGSVYPTLQLLDDEGLIAASASDG-------
MUL_4279|M.ulcerans_Agy99 GYEMIQQIADRSNGLWRPSPGSVYPTLQLLDDEGLIAASASDA-------
MLBr_02313|M.leprae_Br4923 GYQMIQQIAERSNGIWRPSPGSVYPTLQLLSDKNLITASATDG-------
MAV_0407|M.avium_104 GYEMIQLIAERSNGLWKPSPGSVYPTLQLLADEGLITATETDG-------
MSMEG_6227|M.smegmatis_MC2_155 GYEMIQEIGERTDNLWRPSPGSVYPTLQLLVDEGLISGTEAEG-------
MAB_0383c|M.abscessus_ATCC_199 GYEMIREIAERSNNIWRPSPGSVYPTLQLLVDEGLITETEGGS-------
TH_1310|M.thermoresistible__bu GYELRKRLTGLLGAFRAFSYGSLYPALRRMQADGLIVEDPAPDGTPKVRR
* : : : * *::**:*: : ..*:
Mb3518|M.bovis_AF2122/97 -------VVDGRARRVYRATPAG-----------------------RAAL
Rv3488|M.tuberculosis_H37Rv -------VVDGRARRVYRATPAG-----------------------RAAL
Mflv_1330|M.gilvum_PYR-GCK SKKLFELTDDGRAAAEKIDTAP------------------------WDAM
Mvan_5462|M.vanbaalenii_PYR-1 SKKLFELTEDGRAAAEKIETAP------------------------WDEI
MMAR_5206|M.marinum_M SKKLFELTEQGREAADKIETPP------------------------WDEI
MUL_4279|M.ulcerans_Agy99 SKKLFELTEQGREAADKIETPP------------------------WDEI
MLBr_02313|M.leprae_Br4923 SKKLFELTDDGRAAAAKVEMPP------------------------WDQI
MAV_0407|M.avium_104 SKKLFELTDDGRAAAEKIETPP------------------------WDEI
MSMEG_6227|M.smegmatis_MC2_155 SKKLFELTEAGRAAAEAIETPP------------------------WEQI
MAB_0383c|M.abscessus_ATCC_199 SRKQFELTEEGTAAAEKLDTPP------------------------WEKI
TH_1310|M.thermoresistible__bu ARRVYRLTEAGKQRFTELVADTGPQNYSDDGFGVHLAFFNRTPAEARMRI
. * . :
Mb3518|M.bovis_AF2122/97 TEDRR-------ALEELAREVLGRQSHTAGNGT-----------------
Rv3488|M.tuberculosis_H37Rv TEDRR-------ALEELAREVLGGQSHTAGNGT-----------------
Mflv_1330|M.gilvum_PYR-GCK AEQAD---PGAVNLRNAAGQLMGAVAQSAHAATPEQQQRILDIVNNARRE
Mvan_5462|M.vanbaalenii_PYR-1 TEAFKDEAPEAMGLRTAVGQLMGAVAQSAHAATPEQQQRIVDIVNNARRE
MMAR_5206|M.marinum_M AEGVD---PAHINLRTAMRQLIGAVMQTAHAASPEQQQRVIDIINNARRE
MUL_4279|M.ulcerans_Agy99 AEGVD---PAHINLRTAMRQLIGAVMQTAHAASPEQQQRVIDIINNARRE
MLBr_02313|M.leprae_Br4923 AQGIN---PGYINLRTAMNQLFGAVTQSAHTASADQQQRIIDTINNARRE
MAV_0407|M.avium_104 AEGAD---PGHMNLRAAIGQLFGAVGQSAHTASPEQQQRIVDILNNARRE
MSMEG_6227|M.smegmatis_MC2_155 AEDVD---PAAVNLRGAIAQLMGAVAQSAYTATEDQQQRILDVVNNARRE
MAB_0383c|M.abscessus_ATCC_199 NEDAD---PSVLDLRSALGQLMGAVAQSAHAASPEQQQRIIEIVNSARKQ
TH_1310|M.thermoresistible__bu LEGRR---RQVEERREGLREAIARASNSFDRYTRQLHQLGLESSEREVNW
: . : :. :: :
Mb3518|M.bovis_AF2122/97 ------------------
Rv3488|M.tuberculosis_H37Rv ------------------
Mflv_1330|M.gilvum_PYR-GCK IYSVLGED----------
Mvan_5462|M.vanbaalenii_PYR-1 IYQILGED----------
MMAR_5206|M.marinum_M IYGILGEE----------
MUL_4279|M.ulcerans_Agy99 IYGILGEE----------
MLBr_02313|M.leprae_Br4923 IYGILGEN----------
MAV_0407|M.avium_104 IYGILGED----------
MSMEG_6227|M.smegmatis_MC2_155 IYQILGEE----------
MAB_0383c|M.abscessus_ATCC_199 IYGILGETD---------
TH_1310|M.thermoresistible__bu LNDLIAAERMAQGRAEQP