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TGSASRVAVITGAARGQGRSHAVALAGQGIDIIAVDRCADIDSIPYPLATPADLDETAEQVREAGGRIHT AVADVRDLAELRAGIDSGIERFGDVDIVVANAGVVAIGCPDPDDDQLYRDIVDVNLIGVWHTIAATAPSM IRRGTGGSMVLISSMQGLVGRGGDGSAATFAYAASKHGVVGLMRSAANACAPHNIRVNSIHPTGVATPMI FNEHMARVFEADPEGSAMSGNLLPVPFVEPADVTAAVMYLVSDSARYITGTALPVDAGFAVM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1256 | - | - | 100% (273) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1904 | - | 6e-73 | 51.69% (267) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3996 | - | 2e-70 | 51.46% (274) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 9e-72 | 53.58% (265) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2750 | - | 9e-72 | 53.58% (265) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01740 | - | 3e-18 | 31.19% (218) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3081 | - | 5e-75 | 55.47% (265) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_1965 | fabG | 3e-69 | 52.24% (268) | short chain dehydrogenase |
| M. avium 104 | MAV_3823 | - | 4e-89 | 61.80% (267) | carveol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2687 | - | 2e-74 | 55.76% (269) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_0236 | - | 3e-77 | 54.68% (267) | PROBABLE DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_3392 | fabG | 3e-68 | 51.49% (268) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_3394 | - | 2e-74 | 53.18% (267) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1256|M.gilvum_PYR-GCK -----MTGSASRVAVITGAARGQGRSHAVALAGQGIDIIAVDRCADIDSI
MAV_3823|M.avium_104 -----MGEFDNTVAVVTGAARGQGRSHAVALAQQGADVIVVDICADLPAI
TH_0236|M.thermoresistible__bu -----MGNLEGKVAFITGAARGQGRAHAVRLASEGADIIALDICADIDSM
Mvan_3394|M.vanbaalenii_PYR-1 -----MGSLDGRVAFITGVARGQGRSHAVRLAADGADIIGVDICSDIASN
Mb2771|M.bovis_AF2122/97 MIDR---PLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASV
Rv2750|M.tuberculosis_H37Rv MIDR---PLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASV
MSMEG_2687|M.smegmatis_MC2_155 MSDTA--PLSGKVAFITGAARGQGRAEAVRLAADGADIIAVDLCAQIASV
MMAR_1965|M.marinum_M MSRPLDGPLSGRVAFITGAARGQGRAHALRLARDGADVIAVDLCDQIASV
MUL_3392|M.ulcerans_Agy99 MSRPLDGPLSGRVAFITGAARGQGRAHALRLARDGADVIAVDLCDQIASV
MAB_3081|M.abscessus_ATCC_1997 -----MGKLDGKVAFITGAARGQGRAHAIKLASEGASIIAVDICAQIPSV
MLBr_01740|M.leprae_Br4923 -MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCDG---
. ..:**.* * **: *: ** * .: * :
Mflv_1256|M.gilvum_PYR-GCK PYPLATPADLDETAEQVREAGGRIHTA-VADVRDLAELRAGIDSGIERFG
MAV_3823|M.avium_104 PYALGTDAELAETVRLVESAGRAAVPV-IADVRDLQALRVGVQAGIDRLG
TH_0236|M.thermoresistible__bu DYPNASPADLEETAKLVEGTGRSIVAR-QADVRDADAVDEVVREGVERFG
Mvan_3394|M.vanbaalenii_PYR-1 GYPMATPAELEETVALVEAQGAKMLGS-VADVRDFSAVKGALDAGVEHFG
Mb2771|M.bovis_AF2122/97 PYPLSTADDLAATVELVEDAGGGIVAR-QGDVRDRASLSVALQAGLDEFG
Rv2750|M.tuberculosis_H37Rv PYPLSTADDLAATVELVEDAGGGIVAR-QGDVRDRASLSVALQAGLDEFG
MSMEG_2687|M.smegmatis_MC2_155 PYPLATPDDLATTAELVEKAGGRIVTR-QADVRDEPELAAALAAGLDEFG
MMAR_1965|M.marinum_M PYPLGTAEELATTVKLVEDTGARIVAS-QADVRDREALAAALQAGIDELG
MUL_3392|M.ulcerans_Agy99 PYPLGTAEELATTVKLVEDTGARIVAS-QADVRDREALAAALQAGIDELG
MAB_3081|M.abscessus_ATCC_1997 EYPMATTEDLDLTVKEVDALGRAISAH-ETDVRDREALQAAFDAGVHDLG
MLBr_01740|M.leprae_Br4923 ---------LAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIHARHP
* *. . * *: * :
Mflv_1256|M.gilvum_PYR-GCK DVDIVVANAGVVAIG---CPDPDDDQLYRDIVDVNLIGVWHTIAATAPSM
MAV_3823|M.avium_104 DIDVVVANAGVVAIG---VTEAESEPVFNTIVDTNLKGVWHTMLATVPSI
TH_0236|M.thermoresistible__bu RLDIVVANAGIVRLSSDEPSQRR--QIFRDIIDVNLVGVWNTVEAAIPHV
Mvan_3394|M.vanbaalenii_PYR-1 RLDIVCANAGIATMSFRELTDAEDLEMWTDVLDVNLVGTFHTAKAAIPHL
Mb2771|M.bovis_AF2122/97 RLDIVVANAGIAMMQ----AGDDG---WRDVIDVNLTGVFHTVQVAIPTL
Rv2750|M.tuberculosis_H37Rv RLDIVVANAGIAMMQ----AGDDG---WRDVIDVNLTGVFHTVQVAIPTL
MSMEG_2687|M.smegmatis_MC2_155 RLDIVVANAGIAPML----SGPEG---WRDVIDVNLTGVHHTVEVAIPTL
MMAR_1965|M.marinum_M QVDIVVANAGIAPMQ----SGDDG---WRDVIDVNLSGAYYTVEVAIPTM
MUL_3392|M.ulcerans_Agy99 QVDIVVANAGIAPMQ----SGDDG---WRDVIDVNLSGAYYTVEVAIPTM
MAB_3081|M.abscessus_ATCC_1997 PVDIVVANAGIATLTPE--CGDDG---WRDVLDVNLTGVYHTIEVARPSM
MLBr_01740|M.leprae_Br4923 SMDIVMNIAGVSVWG---TVDRLTHDQWSNVVAINLMGPIHIIETFVPAI
:*:* **: : :: ** * . * :
Mflv_1256|M.gilvum_PYR-GCK IRRGTGGSMVLISSMQGLVGRGGDGSAATFAYAASKHGVVGLMRSAANAC
MAV_3823|M.avium_104 VRKGRGGSVVLVSSSQGLTGRGGDGSAAMFAYAASKHGVVGLMRSAANAY
TH_0236|M.thermoresistible__bu INGGQGGSIVITSSSAGLKGTGTD-RAGGQAYAAAKRGLVGLMQVWANQL
Mvan_3394|M.vanbaalenii_PYR-1 IAGGRGGSMVFTSSTAGLRGFGGM-QGGGLGYAASKHGIVGLMRALANAL
Mb2771|M.bovis_AF2122/97 IEQGTGGSIVLISSAAGLVGIGSS-DPGSLGYAAAKHGVVGLMRAYANHL
Rv2750|M.tuberculosis_H37Rv IEQGTGGSIVLISSAAGLVGIGSS-DPGSLGYAAAKHGVVGLMRAYANHL
MSMEG_2687|M.smegmatis_MC2_155 VEQGDGGAIVLISSVAGLVGIGGG-DRGSLGYTAAKHGIVGLMRAYANHL
MMAR_1965|M.marinum_M IEQGRGGSIVLISSAAGLVGISSA-DAGAIGYAASKHALVGLMRVYANLL
MUL_3392|M.ulcerans_Agy99 IEQGRGGSIVLISSAAGLVGISSA-DAGAIGYVASKHALVGLMRVYANLL
MAB_3081|M.abscessus_ATCC_1997 VQRGAGGSIVLTSSVAGLTGMVMD-NPGGLAYTAAKHGLVGLMRSYANML
MLBr_01740|M.leprae_Br4923 LAAGRGGHLVNVSSAAGLVALPWH-----AAYSASKYGLRGLSEVLRFDL
: * ** :* ** ** . .* *:* .: ** .
Mflv_1256|M.gilvum_PYR-GCK APHNIRVNSIHPTGVATPMIF----------NEHMARVFE---ADPEGSA
MAV_3823|M.avium_104 APQKIRVNSVHPSGVATPMIL----------NDFVVNRML---ENPN-PA
TH_0236|M.thermoresistible__bu GPHSIRVNTIHPTGVATGMVM----------NETMAKLFE---QGDEALS
Mvan_3394|M.vanbaalenii_PYR-1 APHNIRVNTVHPTAVNTMMAV----------NPAMTEFLE---HYPDGGP
Mb2771|M.bovis_AF2122/97 APQNIRVNSVHPCGVDTPMIN----------NEFFQQWLT--TADMDAPH
Rv2750|M.tuberculosis_H37Rv APQNIRVNSVHPCGVDTPMIN----------NEFFQQWLT--TADMDAPH
MSMEG_2687|M.smegmatis_MC2_155 APHSIRVNSVHPTGVDTPMID----------NEFTRGWLAHITEETGRPV
MMAR_1965|M.marinum_M APHSIRVNSLHPSGVDTPMIN----------NEFIRRWLADLVAETGSGP
MUL_3392|M.ulcerans_Agy99 APHSIRVNSLHPSGVDPPMIN----------NEFIRHWLADLVAETGSGP
MAB_3081|M.abscessus_ATCC_1997 APHNIRVNTIHPSGVATPMLI----------NPVTEKLFADGSPEGMS--
MLBr_01740|M.leprae_Br4923 ARYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAE
. * *. : * .* . : : .
Mflv_1256|M.gilvum_PYR-GCK MSGNLLP-------------------------------VPFVEPADVTAA
MAV_3823|M.avium_104 LSQTLLPE------------------------------VPLVESRDVTEA
TH_0236|M.thermoresistible__bu AMQNVLP-------------------------------IQILQPEDIAEA
Mvan_3394|M.vanbaalenii_PYR-1 HLQNPMP-------------------------------VDLLEPEDISAA
Mb2771|M.bovis_AF2122/97 NLGNALP-------------------------------VELVQPTDIANA
Rv2750|M.tuberculosis_H37Rv NLGNALP-------------------------------VELVQPTDIANA
MSMEG_2687|M.smegmatis_MC2_155 DMGNALP-------------------------------VQAIDADDVANA
MMAR_1965|M.marinum_M GAGNALP-------------------------------VQILQADDIAGA
MUL_3392|M.ulcerans_Agy99 GAGNALP-------------------------------VQILQADDIAGA
MAB_3081|M.abscessus_ATCC_1997 DTGNALP-------------------------------VVLMEPEDMANT
MLBr_01740|M.leprae_Br4923 RAAEKILAGVAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTR
: : : :
Mflv_1256|M.gilvum_PYR-GCK VMYLVSDSARYITGTALPVDAGFAVM-------
MAV_3823|M.avium_104 VLWLAGPRSRYVTGVAIPVDAGHVAM-------
TH_0236|M.thermoresistible__bu VAWLVSDAGRFITGTAWPLDAGFSVR-------
Mvan_3394|M.vanbaalenii_PYR-1 VAYLVSDAARYVTGVTFPVDAGFCNKL------
Mb2771|M.bovis_AF2122/97 VAWLASEEARYVTGVTLPVDAGFVNKR------
Rv2750|M.tuberculosis_H37Rv VAWLASEEARYVTGVTLPVDAGFVNKR------
MSMEG_2687|M.smegmatis_MC2_155 VAWLVSDQARYVTGVTLPVDAGIVNKR------
MMAR_1965|M.marinum_M LAWLVSDEARYITGVALPVDAGCVNKR------
MUL_3392|M.ulcerans_Agy99 LAWLVSDEARYITGVALPVDAGCVNKR------
MAB_3081|M.abscessus_ATCC_1997 VAWLVSEDARYITGVALPVDAGFTNRR------
MLBr_01740|M.leprae_Br4923 ALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN
* : : :