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MKFVGKLRAAARRSTVVALAAIVLPGLISAVGGSATAGAFSRPGLPVEYLMVPSAGMGRDIKVQFQSGGP NAPGVYLLDGLRAQDDFNGWDINTPAFEWYLDSGLAVVMPVGGQSSFYSDWYSPACGKAGCSTYKWETFL TQELPAYLAANKGVDPNRNAAIGLSMAGSAALTLAIYYPQQFQYAGSMSGFLNLSEGWWPALVNISMGDA GGYDANDMWGRTEDPNSAWKRNDPMVNIGKLVANNTRIWVYCGDGKPAEVNGNVAGNNLPAKFLEGLTIR TNRTFQEEYIAAGGKNGVFNFPANGTHDWPYWGQQLQQMKPDIQRVLGAVPQPSAPAAPVAAEAPGAGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1164 | - | - | 100% (349) | putative esterase |
| M. gilvum PYR-GCK | Mflv_4459 | - | e-142 | 72.70% (326) | putative esterase |
| M. gilvum PYR-GCK | Mflv_3335 | - | e-133 | 68.40% (326) | putative esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0134c | fbpC | 1e-136 | 66.96% (342) | secreted antigen 85-C FBPC (85C) (antigen 85 complex C) |
| M. tuberculosis H37Rv | Rv0129c | fbpC | 1e-136 | 66.96% (342) | secreted antigen 85-C FBPC (85C) (antigen 85 complex C) |
| M. leprae Br4923 | MLBr_00097 | fbpA | 1e-130 | 66.57% (335) | antigen 85A, mycolytransferase |
| M. abscessus ATCC 19977 | MAB_0176 | - | 1e-110 | 59.94% (332) | antigen 85-A precursor |
| M. marinum M | MMAR_0328 | fbpC | 1e-141 | 68.66% (351) | secreted antigen 85-C FbpC |
| M. avium 104 | MAV_0214 | - | 1e-136 | 67.05% (352) | antigen 85-A |
| M. smegmatis MC2 155 | MSMEG_2078 | - | 1e-149 | 76.60% (329) | antigen 85-C |
| M. thermoresistible (build 8) | TH_2078 | fbpA | 1e-163 | 81.38% (333) | SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) |
| M. ulcerans Agy99 | MUL_4793 | fbpC | 1e-141 | 68.66% (351) | secreted antigen 85-C FbpC |
| M. vanbaalenii PYR-1 | Mvan_5645 | - | 0.0 | 90.65% (353) | putative esterase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00097|M.leprae_Br4923 MKFVDRFR---GAVAGMLRRLVVEAMGVALLSALIGVVG----SAPAEAF
MAV_0214|M.avium_104 MTLVDRLR---GAVAGMPRRLVVGAAGAALLSGLIGAVGG---SATAGAF
Mb0134c|M.bovis_AF2122/97 MTFFEQVRRLRSAATTLPRRLAIAAMGAVLVYGLVGTFGG---PATAGAF
Rv0129c|M.tuberculosis_H37Rv MTFFEQVRRLRSAATTLPRRLAIAAMGAVLVYGLVGTFGG---PATAGAF
MMAR_0328|M.marinum_M MKFVEKLR---GAAAGAPRRLTIAAIGAALLSGLVGAVGG---AATAGAF
MUL_4793|M.ulcerans_Agy99 MKFVEKLR---GAAAGAPRRLTIAAIGAALLSGLVGAVGG---AATAGAF
Mflv_1164|M.gilvum_PYR-GCK MKFVGKL-------RAAARRSTVVALAAIVLPGLISAVGG---SATAGAF
Mvan_5645|M.vanbaalenii_PYR-1 MKLVGALP---RVIRSMGRRLTVAALAAIVLPGLISAVGG---SATAGAF
TH_2078|M.thermoresistible__bu MKLVAKLR---GAARALPRRLTVAALAAALLPGLVGAFGG---SATAGAF
MSMEG_2078|M.smegmatis_MC2_155 MTFIDKIR---G---HWARRMTVAAVAALLLPGLVGVVGG---SATAGAF
MAB_0176|M.abscessus_ATCC_1997 MKLFSKMRG--ALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAF
*.:. . ** .: * .. :: .: . .* .. * **
MLBr_00097|M.leprae_Br4923 SRPGLPVEYLQVPSPSMGRDIKVQFQNGGANSPALYLLDGLRAQDDFSGW
MAV_0214|M.avium_104 SRPGLPVEYLQVPSAAMGRDIKVQFQSGGANSPALYLLDGMRAQDDFNGW
Mb0134c|M.bovis_AF2122/97 SRPGLPVEYLQVPSASMGRDIKVQFQGGGP--HAVYLLDGLRAQDDYNGW
Rv0129c|M.tuberculosis_H37Rv SRPGLPVEYLQVPSASMGRDIKVQFQGGGP--HAVYLLDGLRAQDDYNGW
MMAR_0328|M.marinum_M SRPGLPVEYLQIPSAAMGRDIKVQFQGGGA--HSVYLLDGLRAQDDYNGW
MUL_4793|M.ulcerans_Agy99 SRPGLPVEYLQIPSAAMGRDIKVQFQGGGA--HSVYLLDGLRAQDDYNGW
Mflv_1164|M.gilvum_PYR-GCK SRPGLPVEYLMVPSAGMGRDIKVQFQSGGPNAPGVYLLDGLRAQDDFNGW
Mvan_5645|M.vanbaalenii_PYR-1 SRPGLPVEYLMVPSAGMGRDIKVQFQSGGPNAPGVYLLDGLRAQDDFSGW
TH_2078|M.thermoresistible__bu SRPGLPVEYLMVPSAAMGRDIKVQFQSGGEGSPGVYLLDGLRARDDFNGW
MSMEG_2078|M.smegmatis_MC2_155 SRPGLPVEYLMVPSPSMGRDIKVQFQSGGPGSHAVYLLDGLRAQDDFNGW
MAB_0176|M.abscessus_ATCC_1997 SRPGLPVEYLQVPSASMGREIKVQFQPGGA--KAVYLLDGLRARDDFSGW
********** :**..***:****** ** .:*****:**:**:.**
MLBr_00097|M.leprae_Br4923 DINTTAFEWYYQSGISVVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFL
MAV_0214|M.avium_104 DINTPAFEWYNQSGISVAMPVGGQSSFYSDWYKPACGKAGCTTYKWETFL
Mb0134c|M.bovis_AF2122/97 DINTPAFEEYYQSGLSVIMPVGGQSSFYTDWYQPSQSNGQNYTYKWETFL
Rv0129c|M.tuberculosis_H37Rv DINTPAFEEYYQSGLSVIMPVGGQSSFYTDWYQPSQSNGQNYTYKWETFL
MMAR_0328|M.marinum_M DINTPAFEEYYNSGLSVVMPVGGQSSFYSDWYQPSQGNGQGYTYKWETFL
MUL_4793|M.ulcerans_Agy99 DINTPAFEEYYNSGLSVVMPVGGQSSFYSDWYQPSQGNGQGYTYKWETFL
Mflv_1164|M.gilvum_PYR-GCK DINTPAFEWYLDSGLAVVMPVGGQSSFYSDWYSPACGKAGCSTYKWETFL
Mvan_5645|M.vanbaalenii_PYR-1 DINTQAFEWYLDSGLAVVMPVGGQSSFYSDWYAPACGKAGCSTYKWETFL
TH_2078|M.thermoresistible__bu DIETAAFEWYYESGLSVIMPVGGQSSFYSDWYSPACGNNGCQTYKWETFL
MSMEG_2078|M.smegmatis_MC2_155 DINTNAFEMFLDSGLSVVMPVGGQSSFYSDWYQPACGNNGCVTYKWETFL
MAB_0176|M.abscessus_ATCC_1997 DIETTAFEDYYQSGISMVMPVGGQSSFYTDWYNPAKGKDGVWTYKWETFT
**:* *** : :**::: **********:*** *: .: *******
MLBr_00097|M.leprae_Br4923 TSELPQYLQSNKQIKPTGSAAVGLSMAGLSALTLAIYHPDQFIYVGSMSG
MAV_0214|M.avium_104 TSELPQYLSAQKQVKPTGSGVVGLSMAGSSALILAAYHPDQFVYAGSLSA
Mb0134c|M.bovis_AF2122/97 TREMPAWLQANKGVSPTGNAAVGLSMSGGSALILAAYYPQQFPYAASLSG
Rv0129c|M.tuberculosis_H37Rv TREMPAWLQANKGVSPTGNAAVGLSMSGGSALILAAYYPQQFPYAASLSG
MMAR_0328|M.marinum_M TREMPAWLQANKGVSPTGNAAVGLSMSGGSALVLAAYYPQQFPYAASLSG
MUL_4793|M.ulcerans_Agy99 TREMPAWLQANKGVSPTGNAAVGLSMSGGSALVLAAYYPQQFPYAASLSG
Mflv_1164|M.gilvum_PYR-GCK TQELPAYLAANKGVDPNRNAAIGLSMAGSAALTLAIYYPQQFQYAGSMSG
Mvan_5645|M.vanbaalenii_PYR-1 TQELPAYLAANKGVDPNRNAAVGLSMAGSAALTLAIYHPQQFQYAGSLSG
TH_2078|M.thermoresistible__bu TQELPAYLASNYGVDRNRNAAVGLSMAGSAALVLAIYYPQQFQYAASLSG
MSMEG_2078|M.smegmatis_MC2_155 TSELPEWLAANRDVAATGNAAIGLSMAGSAALILAAYHPDRFIYAGSMSG
MAB_0176|M.abscessus_ATCC_1997 TQELPAYLAANKGISQTGNAVVGLSMGASAALTLSIYHPQLFVYAGALSG
* *:* :* :: : . ...:****.. :** *: *:*: * *..::*.
MLBr_00097|M.leprae_Br4923 LLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDP--AWKRNDPTVNVGT
MAV_0214|M.avium_104 LLDPSQGMGPSLIGLAMGDAGGYKAADMWGPKEDP--AWARNDPSLQVGK
Mb0134c|M.bovis_AF2122/97 FLNPSEGWWPTLIGLAMNDSGGYNANSMWGPSSDP--AWKRNDPMVQIPR
Rv0129c|M.tuberculosis_H37Rv FLNPSEGWWPTLIGLAMNDSGGYNANSMWGPSSDP--AWKRNDPMVQIPR
MMAR_0328|M.marinum_M FLNPSEGWWPTLIGLAMNDSGGYNANSMWGPSTDP--AWKRNDPMVQIPR
MUL_4793|M.ulcerans_Agy99 FLNPSEGWWPTLIGLAMNDSGGYNANSMWGPSTDP--AWKRNDPMVQIPR
Mflv_1164|M.gilvum_PYR-GCK FLNLSEGWWPALVNISMGDAGGYDANDMWGRTEDPNSAWKRNDPMVNIGK
Mvan_5645|M.vanbaalenii_PYR-1 YLNLSEGWWPMLVNISMGDAGGYDANDMWGRTEDPDSAWKRNDPMVNIAK
TH_2078|M.thermoresistible__bu FLNLSEGWWPMLVGLAMGDAGGYDPNDMWGRTEDPNSAWKRNDPMVNIDK
MSMEG_2078|M.smegmatis_MC2_155 FLNPSEGWWPFLINISMGDAGGYKANDMWGPTEDPNSAWKRNDPMVQIPR
MAB_0176|M.abscessus_ATCC_1997 FLNPSD--MKFQIGLAMGDAGGFSASDMWGPDSDP--AWQRNDPFLNIQK
*: *: :.::*.*:**:.. .*** ** ** **** :::
MLBr_00097|M.leprae_Br4923 LIANNTRIWMYCGNGKPTELG-----GNNLPAKLLEGLVRTSNIKFQDGY
MAV_0214|M.avium_104 LVANNTRIWVYCGNGKPSDLG-----GDNLPAKFLEGFVRTSNLKFQDAY
Mb0134c|M.bovis_AF2122/97 LVANNTRIWVYCGNGTPSDLG-----GDNIPAKFLEGLTLRTNQTFRDTY
Rv0129c|M.tuberculosis_H37Rv LVANNTRIWVYCGNGTPSDLG-----GDNIPAKFLEGLTLRTNQTFRDTY
MMAR_0328|M.marinum_M LVANNTRIWVYCGNGTPSDLG-----GDNMPAKFLEGLTLRTNQTFRDTY
MUL_4793|M.ulcerans_Agy99 LVANNTRIWVYCGNGTPSDLG-----GDNMPAKFLEGLTLRTNQTFRDTY
Mflv_1164|M.gilvum_PYR-GCK LVANNTRIWVYCGDGKPAEVNGNVA-GNNLPAKFLEGLTIRTNRTFQEEY
Mvan_5645|M.vanbaalenii_PYR-1 LVANNTRIWVFCGNGKPAEVNGNVA-GNNLPAKFLEGFTLRTNKTFQEEY
TH_2078|M.thermoresistible__bu LVANNTRIWVFCGDGTPADIGAGVPEGDNFNAKFLESFTLRTNKTFQQEY
MSMEG_2078|M.smegmatis_MC2_155 LVANNTRIWVYCGNGQPNELG-----GGDLPATFLEGLTIRTNETFRDNY
MAB_0176|M.abscessus_ATCC_1997 IIDNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGMAIGSNKKFVEAY
:: *.**:*::** * . ::. :: . :**.:. :* .* : *
MLBr_00097|M.leprae_Br4923 NAGGGHNAVFNFPDSGTHSWEYWGEQLNDMKPDLQQYLGATPGA------
MAV_0214|M.avium_104 NGAGGHNAVWNFDANGTHDWPYWGAQLQAMKPDLQSVLGATPGAGPATAA
Mb0134c|M.bovis_AF2122/97 AADGGRNGVFNFPPNGTHSWPYWNEQLVAMKADIQHVLNGATPPAAPAAP
Rv0129c|M.tuberculosis_H37Rv AADGGRNGVFNFPPNGTHSWPYWNEQLVAMKADIQHVLNGATPPAAPAAP
MMAR_0328|M.marinum_M LASGGRNGVFNFPTNGTHSWPYWNQQLVAMKGDILKVLNGPAVPAAPAAP
MUL_4793|M.ulcerans_Agy99 LASGGRNGVFNFPTNGTHSWPYWNQQLVAMKGDILKVLNGPAVPAAPAAP
Mflv_1164|M.gilvum_PYR-GCK IAAGGKNGVFNFPANGTHDWPYWGQQLQQMKPDIQRVLGAVPQPSAPAAP
Mvan_5645|M.vanbaalenii_PYR-1 LAAGGKNGVFNFPSGGTHDWPYWGQQLQQMKPDIQRVLGAVPQPSAPAAP
TH_2078|M.thermoresistible__bu IAAGGKNGVFNFPDAGTHSWGYWGQQLQQMKPDIQRVLGVS------AA-
MSMEG_2078|M.smegmatis_MC2_155 IAAGGNNGVFNFPNNGTHNWAYWGRELQAMVPDLQRVLG-----------
MAB_0176|M.abscessus_ATCC_1997 TAAGGKNAHIEFPPGGIHNWTYWGQQLRAMKPDMVAYLQSH---------
. **.*. :* * *.* **. :* * *: *
MLBr_00097|M.leprae_Br4923 -----------
MAV_0214|M.avium_104 ATNAGNGQGT-
Mb0134c|M.bovis_AF2122/97 AA---------
Rv0129c|M.tuberculosis_H37Rv AA---------
MMAR_0328|M.marinum_M EAPAAPVAPAA
MUL_4793|M.ulcerans_Agy99 EAPAAPVAPAA
Mflv_1164|M.gilvum_PYR-GCK VAAEAPGAGG-
Mvan_5645|M.vanbaalenii_PYR-1 VDAVAPTSGG-
TH_2078|M.thermoresistible__bu -----------
MSMEG_2078|M.smegmatis_MC2_155 -----------
MAB_0176|M.abscessus_ATCC_1997 -----------