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SVVSALLLAAIVALLALAIGVAIGVRAVPRLRERRQRRSAEQSGITVSQMLERIVSFSPIGIAVVDNFRD VVYKNDRAQELGLLGDRLLDDRAWVAAQRTLTTGEPHGFDLSPRKGSRTGRSGLSVRGYCRLLAEEDRRF AVVYVDDQSEHARMEATRRDFVANVSHELKTPVGALGVLAEAVLASVEDPDTVRHFAEKMVTEADRLANM VGELIELSRLQGGEPLPDLEAVDVDVVVSEALSRHKVAADNADIAITTDAPTGFQVLGDQTLLVAAVANL VSNAIAYSPNGSAVSISRRRNGDNIQIAVTDRGIGIAPADQERVFERFFRVDKARSRATGGTGLGLAIVK HVAANHNGSIRLWSQPGTGSTFTLSIPAAPPGEQRSGDAAGGAADLAQRED*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0083 | - | - | 100% (402) | histidine kinase |
| M. gilvum PYR-GCK | Mflv_0036 | - | 2e-32 | 33.07% (254) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_4711 | - | 4e-32 | 32.30% (257) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0500 | senX3 | 1e-150 | 72.30% (379) | putative two component sensor histidine kinase SENX3 |
| M. tuberculosis H37Rv | Rv0490 | senX3 | 1e-150 | 72.30% (379) | putative two component sensor histidine kinase SENX3 |
| M. leprae Br4923 | MLBr_02440 | - | 1e-145 | 68.21% (390) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_4048c | - | 1e-140 | 69.31% (378) | sensor-like histidine kinase senX3 |
| M. marinum M | MMAR_0815 | senX3 | 1e-144 | 67.73% (409) | two-component sensor histidine kinase SenX3 |
| M. avium 104 | MAV_4661 | - | 1e-148 | 71.39% (388) | hisitidine protein kinase SenX3 |
| M. smegmatis MC2 155 | MSMEG_0936 | senX3 | 1e-158 | 75.33% (377) | sensor histidine kinase SenX3 |
| M. thermoresistible (build 8) | TH_2898 | - | 1e-132 | 71.51% (337) | PUTATIVE sensor histidine kinase SenX3 |
| M. ulcerans Agy99 | MUL_4559 | senX3 | 1e-143 | 68.06% (407) | two component sensor histidine kinase SenX3 |
| M. vanbaalenii PYR-1 | Mvan_0830 | - | 0.0 | 84.83% (402) | histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0083|M.gilvum_PYR-GCK MSVVSALLLAAIVALLALAIGVAIGVRAVPRLRERRQRRSAEQSGITVSQ
Mvan_0830|M.vanbaalenii_PYR-1 MSVVSALLLAAVVALLALAVGVVFGARVVPRLREHRQRRSAEQAGITVSQ
Mb0500|M.bovis_AF2122/97 MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQ
Rv0490|M.tuberculosis_H37Rv MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQ
MLBr_02440|M.leprae_Br4923 --MFSALLLAGVLSGLAFVVGIVAGIRLSPRLIERRQRLANEWAGITVLQ
MMAR_0815|M.marinum_M MTVFSALLLAGVLSALALAAGVAVGARLSQRLVRRRQQASTEWTGITVAQ
MUL_4559|M.ulcerans_Agy99 --MFSALLLAGVLSALALAAGVAVGARLSQRLVRRRQQASTEWTGITVAQ
MAV_4661|M.avium_104 --MFSALLLAGVLSVLALAAGVAVGTRLSPRAAQRRQRISTEWTGITVAQ
MSMEG_0936|M.smegmatis_MC2_155 ------------MSLLTLIAGVAVGVTVVPRIVARRQRRAAYAAGMTVSQ
MAB_4048c|M.abscessus_ATCC_199 -MTAASALLVATAALAALAVGAALGVWYSRRASTHRNASEVAQTGLTVSQ
TH_2898|M.thermoresistible__bu --------------------------------------------------
Mflv_0083|M.gilvum_PYR-GCK MLERIVSFSPIGIAVVDNFRDVVYKNDRAQELGLLGDRLLDDRAWVAAQR
Mvan_0830|M.vanbaalenii_PYR-1 MLERIVSQSPVGMAVVDTYRDVVYTNGRAQELGLVRDRLLDDRAWVAAER
Mb0500|M.bovis_AF2122/97 MLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQ
Rv0490|M.tuberculosis_H37Rv MLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQ
MLBr_02440|M.leprae_Br4923 MLQRIIALMPLGAAVVDTYRDVVYLNEQAKELGLVRDRQLDDQAWRAAQQ
MMAR_0815|M.marinum_M MLQRIVALMPMGVAVVDSHRDVVYLNDRAKELGLVRDRQLDDQAWEAAQQ
MUL_4559|M.ulcerans_Agy99 MLQRIVALMPMGVAVVDSHRDVVYLNDRAKELGLVRDRQLDDQAWEAAQQ
MAV_4661|M.avium_104 MLERIVALMPLGAAVVDAHRDVVYLNDRAKELGLVRDRQLDDQAWEAAQQ
MSMEG_0936|M.smegmatis_MC2_155 MLQHITSLSPMGVAVVDTFNDVVYSNDRAVELNVVRDRILDDRAWQAAQR
MAB_4048c|M.abscessus_ATCC_199 MLERIVAISPTGIVVVDKHQDVVLVNARARELGLVRDRQLDGQAWNAAQR
TH_2898|M.thermoresistible__bu ----------VGIIVVDTFRDVVYSNEQARQLNLVRDGLIDDKTWEAVQQ
* *** ..*** * :* :*.:: * :*.::* *..:
Mflv_0083|M.gilvum_PYR-GCK TLTTGEPHGFDLSPRKG---SRTGRSG-----LSVRGYCRLLAEEDRRFA
Mvan_0830|M.vanbaalenii_PYR-1 ALATGEPVGFDLSPRKR---SQPGRSG-----LSIRGHVQLLTEQDRRFA
Mb0500|M.bovis_AF2122/97 ALG-GEDVEFDLSPRKR---SATGRSG-----LSVHGHARLLSEEDRRFA
Rv0490|M.tuberculosis_H37Rv ALG-GEDVEFDLSPRKR---SATGRSG-----LSVHGHARLLSEEDRRFA
MLBr_02440|M.leprae_Br4923 ALG-GDDVEFDLLPGKR---PAAGRSG-----LSVHGHARLLSEKDRRFA
MMAR_0815|M.marinum_M ALR-GSDVEFDLSPGKR---PG-GRSG-----LSVHGQARLLSEEDRRFT
MUL_4559|M.ulcerans_Agy99 ALR-GSDVEFDLSPGKR---PG-GRSG-----LSVHGQARLLSEEDRRFT
MAV_4661|M.avium_104 ALT-GVDVEFDLRPAKR---SG-GRSG-----LSVHGQARLLSEEDRRFA
MSMEG_0936|M.smegmatis_MC2_155 VFETGQDVEVDLSPLKV---ANPGRSG-----ISVRGKVRLLTDDDRRFA
MAB_4048c|M.abscessus_ATCC_199 TLATGEAVEVDLTTKPR----APGRAG-----FSLRGHVRRLSDADTRWV
TH_2898|M.thermoresistible__bu TLITGADGDVDLSEVRTPSWGWPGRSANRSTPRSIRGHVRLLTDEDRRFA
.: * .** **:. *::* : *:: * *:.
Mflv_0083|M.gilvum_PYR-GCK VVYVDDQSEHARMEATRRDFVANVSHELKTPVGALGVLAEAVLASVEDPD
Mvan_0830|M.vanbaalenii_PYR-1 VVYVDDQSEHARMEATRRDFVANVSHELKTPVGAMGVLAEAVLASADDPD
Mb0500|M.bovis_AF2122/97 VVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLASADDSE
Rv0490|M.tuberculosis_H37Rv VVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLASADDSE
MLBr_02440|M.leprae_Br4923 VVFVHDQSDYVRMEAARRDFVANVSHELKTPVGAMALLAEALLASADDAE
MMAR_0815|M.marinum_M VVFAYDQSDYARMEATRRDFVANVSHELKTPVGAMALLAEALLASADDSD
MUL_4559|M.ulcerans_Agy99 VVFAYDQSDYARMEATRRDFVANVSHELKTPVGAMALLAEALLASADDSD
MAV_4661|M.avium_104 VVFAHDQSDYARMEATRRDFVANVSHELKTPVGAMALLAEALLASADDSE
MSMEG_0936|M.smegmatis_MC2_155 VVYIDDQSEHARMEATRRDFVANVSHELKTPVGAMSVLAEALLASADDPD
MAB_4048c|M.abscessus_ATCC_199 VIYVDDDSEHVRMEATRRDFVANVSHELKTPVGAMGVLAEALLESSDDPE
TH_2898|M.thermoresistible__bu VVYINDESEHARMEATRRDFVANVSHELKTPVGALKVLAEALLASADDEE
*:: *:*::.****:******************: :****:* * :* :
Mflv_0083|M.gilvum_PYR-GCK TVRHFAEKMVTEADRLANMVGELIELSRLQGGEPLPDLEAVDVDVVVSEA
Mvan_0830|M.vanbaalenii_PYR-1 TVRHFAEKMVTESNRLANMVGELIELSRLQGAERLPDLGTVDVDTVVSEA
Mb0500|M.bovis_AF2122/97 TVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEA
Rv0490|M.tuberculosis_H37Rv TVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEA
MLBr_02440|M.leprae_Br4923 TVSRFAEKVLIEANRLGYMVAELIELSRLQGAERLPNVTDIDVDIIVSEA
MMAR_0815|M.marinum_M TVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLHNVTDVDVDTIVSEA
MUL_4559|M.ulcerans_Agy99 TVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLHNVTDVDVDTIVSEA
MAV_4661|M.avium_104 TVRRFAEKVLVEANRLGDMVAELIELSRLQGAERLTNVTEVDVDSVVNEA
MSMEG_0936|M.smegmatis_MC2_155 TVRRFAEKMVAESHRLADMIGELIELSRLQGAERLPDLDAVDVDSIVSEA
MAB_4048c|M.abscessus_ATCC_199 TVRHFGEQVLAESRRLGNMVTELIALSRLQGAEKLPDLEVVDVDFVVSEA
TH_2898|M.thermoresistible__bu TVRRFADRMVAESTRLADMIGELIDLSRLQGGEPLPDLTAVDVDTVVAEA
** :*.:::: *: **. *: *** ******.* * :: :*** :* **
Mflv_0083|M.gilvum_PYR-GCK LSRHKVAADNADIAITTDAPTGFQVLGDQTLLVAAVANLVSNAIAYSPNG
Mvan_0830|M.vanbaalenii_PYR-1 LSRHKVAADNADIVITTDAPTGYQVLGDQTLLVTAIANLVSNAIAYSPNG
Mb0500|M.bovis_AF2122/97 ISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRG
Rv0490|M.tuberculosis_H37Rv ISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRG
MLBr_02440|M.leprae_Br4923 IARHKVAADTAAIEVRTDPPSGLRVLGDQTLLVTALANLVSNAIAYSPGG
MMAR_0815|M.marinum_M ISRHKVAADNAEIEVRTDSSSGLHVLGDQTLLVTALANLVSNAIAYSSPG
MUL_4559|M.ulcerans_Agy99 ISRHKVAADNAEIEVRTDSSSGLHVLGDQTLLVTALANLVSNAIAYSSPG
MAV_4661|M.avium_104 ISRHKVAADNANIEVRTDAPSGLRVLGDETLLVTALANLVSNAIAYSPPG
MSMEG_0936|M.smegmatis_MC2_155 VSRHKVAADNSQISITTDAPTGYRVLGDEGLLVTAIANLVSNAIAYSPNG
MAB_4048c|M.abscessus_ATCC_199 LSRSKVAAENADIAVTTDAPSGFEVRGDPTLLITAISNLVANAIAYSPQG
TH_2898|M.thermoresistible__bu LSRHKVAADNADITIITDPPSGYRVRGDLGLLVTAVANLVSNAIAYSPNG
::* ****:.: * : **..:. .* ** **::*::***:******. *
Mflv_0083|M.gilvum_PYR-GCK SAVSISRRRNGDNIQIAVTDRGIGIAPADQERVFERFFRVDKARSRATGG
Mvan_0830|M.vanbaalenii_PYR-1 SAVSISRRRRGGNIEIAVTDRGIGIAPEDQERVFERFFRVDKARSRATGG
Mb0500|M.bovis_AF2122/97 SLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGG
Rv0490|M.tuberculosis_H37Rv SLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGG
MLBr_02440|M.leprae_Br4923 SLVSISRRRRGDNIEIAVTDRGIGIALEDQERVFERFFRGDKARSRATGG
MMAR_0815|M.marinum_M SPVSISRRKRGDNVEIAVTDRGIGIALEDQERVFERFFRGDKARSRATGG
MUL_4559|M.ulcerans_Agy99 SPVSISRRKRGDNVEIAVTDRGIGIALEDQERVFERFFRGDKARSRATGG
MAV_4661|M.avium_104 SPVSISRRRRGDNIEIAVTDRGIGIALEDQERVFERFFRGDKARSRATGG
MSMEG_0936|M.smegmatis_MC2_155 TDVSISRRKRGGNIEIAVTDRGIGIAKDDQERVFERFFRVDKARSRATGG
MAB_4048c|M.abscessus_ATCC_199 SPVSISRRRRGDKVEIAVTDRGIGIAKEHQERVFERFFRVDKARSRDTGG
TH_2898|M.thermoresistible__bu STVSISRQRRGGFVEISVTDRGIGIAPEDQERVFERFFRVDKARSRATGG
: *****::.* ::*:********* .********** ****** ***
Mflv_0083|M.gilvum_PYR-GCK TGLGLAIVKHVAANHNGSIRLWSQPGTGSTFTLSIPAAP------PGEQR
Mvan_0830|M.vanbaalenii_PYR-1 TGLGLAIVKHVAANHNGSIRLWSQPGTGSTFTLSIPAAL------PLDPH
Mb0500|M.bovis_AF2122/97 SGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHD-DERPE
Rv0490|M.tuberculosis_H37Rv SGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHD-DERPE
MLBr_02440|M.leprae_Br4923 SGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTLSIPAAMPLYQDNDEQSG
MMAR_0815|M.marinum_M SGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTLSIPASS-APDDSD-QPD
MUL_4559|M.ulcerans_Agy99 SGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTLSIPTSS-APDDSD-QPD
MAV_4661|M.avium_104 SGLGLAIVKHVAANHNGTIGVWSKPGTGSTFTLSIPAAV-ASHRGDGESE
MSMEG_0936|M.smegmatis_MC2_155 TGLGLAIVKHVAANHNGSIRLWSQPGTGSTFTLSIPEYP----------D
MAB_4048c|M.abscessus_ATCC_199 TGLGLAIVKHVAANHNGVIKLWSQPGTGSTFTLSLPVYED-DVDDDDAED
TH_2898|M.thermoresistible__bu TGLGLAIVKHVAANHNGTIRLWSQPGTGSTFTLSIPAYPDSDVASDERED
:**************:* * :**:*********::*
Mflv_0083|M.gilvum_PYR-GCK SGDAAGGAADLAQRED----------------------------------
Mvan_0830|M.vanbaalenii_PYR-1 GDDAVD-SDELAERED----------------------------------
Mb0500|M.bovis_AF2122/97 QAREPELRSNRSQREEE---------------LSR---------------
Rv0490|M.tuberculosis_H37Rv QAREPELRSNRSQREEE---------------LSR---------------
MLBr_02440|M.leprae_Br4923 QPRGCDMWLNRPQREEEEFKSMTPAQAMMQSEVTRGNVNDKCPDCGGRGI
MMAR_0815|M.marinum_M QPRARDARPNRSQREEE---------------LSR---------------
MUL_4559|M.ulcerans_Agy99 QPRGRDARPNRSQREEE---------------LSR---------------
MAV_4661|M.avium_104 QPQGREVRPNRSQREEE---------------LSR---------------
MSMEG_0936|M.smegmatis_MC2_155 PESHSDEREDQRER------------------------------------
MAB_4048c|M.abscessus_ATCC_199 TQADSPTGDTTPRKDATNHPPRPHGLPASGSSKADGLLTSTSPADGLRIG
TH_2898|M.thermoresistible__bu QKQS----------------------------------------------
Mflv_0083|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0830|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0500|M.bovis_AF2122/97 --------------------------------------------------
Rv0490|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02440|M.leprae_Br4923 AG------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 SSPADGLRIGSSPADGLRIGSSPADGLRIGSSQVPPSRLREEHKATTREE
TH_2898|M.thermoresistible__bu --------------------------------------------------
Mflv_0083|M.gilvum_PYR-GCK ----
Mvan_0830|M.vanbaalenii_PYR-1 ----
Mb0500|M.bovis_AF2122/97 ----
Rv0490|M.tuberculosis_H37Rv ----
MLBr_02440|M.leprae_Br4923 ----
MMAR_0815|M.marinum_M ----
MUL_4559|M.ulcerans_Agy99 ----
MAV_4661|M.avium_104 ----
MSMEG_0936|M.smegmatis_MC2_155 ----
MAB_4048c|M.abscessus_ATCC_199 HVRR
TH_2898|M.thermoresistible__bu ----