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DDTDDELASLSEFIFLQENARQAGVSGPLPTVARLDAGPVSGLKFGDDDPQVVFLHGGGQNAHTWDTVIL GLGAPALALDLPGHGRSAWCEDGDYGPVLNAVAVEPVIREHAPSARLVVGMSLGGLTALRLAVTAPKLVP QLVMVDVTPSAPERHTQMTDAQKGTVALVQGERTFPTFDAMLDVTVAAAPHRDRESLRRGVFHNAKRLED GTWTWRYDSIRKGEGFEGLWEDVPRLTTPTTLIRGANSFFVNDDDASEFARTAPGFQGVHVVENSGHSVQ SDQPRVLVDLLRKVLAN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0865 | - | - | 100% (298) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_4622 | - | 3e-23 | 32.81% (256) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_3026 | - | 2e-22 | 30.86% (256) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0046c | - | 1e-111 | 64.16% (293) | hydrolase |
| M. tuberculosis H37Rv | Rv0045c | - | 1e-111 | 64.16% (293) | hydrolase |
| M. leprae Br4923 | MLBr_02297 | - | 2e-05 | 30.83% (120) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 1e-23 | 32.03% (256) | putative hydrolase (alpha/beta fold) |
| M. marinum M | MMAR_0064 | - | 1e-105 | 61.87% (299) | hydrolase |
| M. avium 104 | MAV_0062 | - | 1e-110 | 63.55% (299) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6906 | - | 1e-126 | 73.38% (293) | putative hydrolase |
| M. thermoresistible (build 8) | TH_1312 | - | 1e-122 | 72.26% (292) | POSSIBLE HYDROLASE |
| M. ulcerans Agy99 | MUL_0063 | - | 1e-103 | 61.54% (299) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_6042 | - | 1e-137 | 79.12% (297) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0046c|M.bovis_AF2122/97 --MLSD---DELTGLDEFALLAENAEQAGVNGPLPEVERVQAGA----IS
Rv0045c|M.tuberculosis_H37Rv --MLSD---DELTGLDEFALLAENAEQAGVNGPLPEVERVQAGA----IS
MMAR_0064|M.marinum_M ---MTDSFPDDLTGLTEFDLLAENAEQAGVTGPLPEVERIEVGAAETRIS
MUL_0063|M.ulcerans_Agy99 ---MTDSFPDDLTRLTEFDLLAENAEQAGVTGPLPEVERIEVGAAETRIS
MAV_0062|M.avium_104 ---MTDVSEDELAGLSEFALLHENAEQAGVSGPLPEVARVESGSGDAKVS
Mflv_0865|M.gilvum_PYR-GCK ----MDDTDDELASLSEFIFLQENARQAGVSGPLPTVARLDAGP----VS
Mvan_6042|M.vanbaalenii_PYR-1 ---MADISDDELPHLDEFALLHENAEQVGVT-EVPRAERIDAGP----VS
MSMEG_6906|M.smegmatis_MC2_155 MSTTHEISDDELPTLDEFALLHENAAQIGRTEPLPPVERITHGP----VS
TH_1312|M.thermoresistible__bu ----MPMGSD------EFRYLPENAEQAGVD-TIPPARRVGHGP----IS
MAB_2045|M.abscessus_ATCC_1997 -----------------MSAKRTGDSSAPVVERVPTADGLALAV-----D
MLBr_02297|M.leprae_Br4923 -MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAG--------QD
. :* .
Mb0046c|M.bovis_AF2122/97 ALRWGGSAPRVIFLHGGGQNAHTWDTVIVGLGEP---ALAVDLPGHGHSA
Rv0045c|M.tuberculosis_H37Rv ALRWGGSAPRVIFLHGGGQNAHTWDTVIVGLGEP---ALAVDLPGHGHSA
MMAR_0064|M.marinum_M ALRWGGRAPRVIFLHGGGQNAHTWDTVIVGLGEP---ALAVDLPGHGHSA
MUL_0063|M.ulcerans_Agy99 ALRWGGRAPRVIFLHDGGQNAHTWDTVIVGLGEP---ALAVDLPGHGHSA
MAV_0062|M.avium_104 ALRWGSTDARIVFVHGGGQNAHTWDTVIVGVGEP---ALAVDLPGHGHSA
Mflv_0865|M.gilvum_PYR-GCK GLKFGDDDPQVVFLHGGGQNAHTWDTVILGLGAP---ALALDLPGHGRSA
Mvan_6042|M.vanbaalenii_PYR-1 AVKFGDDAPRVVFLHGGGQNAHTWDTVVVGLGLP---ALAVDLPGHGRSA
MSMEG_6906|M.smegmatis_MC2_155 ALKFGTEAPRVVFLHGGGQNAHTWDTVILGLGEP---ALAVDLPGHGRSQ
TH_1312|M.thermoresistible__bu ALQFGTAPPRLVFLHGGGQNAHTWDTVIVGLGEP---ALAVDLPGHGHSA
MAB_2045|M.abscessus_ATCC_1997 LYHCDAPRAVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSD
MLBr_02297|M.leprae_Br4923 CAPSATARPLVMLLHGFGSFWWSWRHQLRGLTEAR--LVAVDLRGYGGSD
. ::::*. *. :* : * * *:* *
Mb0046c|M.bovis_AF2122/97 WREDGNYSP-QLNSETLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAP-
Rv0045c|M.tuberculosis_H37Rv WREDGNYSP-QLNSETLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAP-
MMAR_0064|M.marinum_M WRQDGDYSP-QHNADALVPALRELASEAEFVVGMSLGGLTAIRLGALAP-
MUL_0063|M.ulcerans_Agy99 WRQDGDYSP-QHNADALVPALRELAPEAEFVVGMSLGGLTAIRLGALAP-
MAV_0062|M.avium_104 WRADGDYSP-QLNADALLPMLREHAAGADLVVGMSLGGLTAIRLGAVAP-
Mflv_0865|M.gilvum_PYR-GCK WCEDGDYGP-VLNAVAVEPVIREHAPSARLVVGMSLGGLTALRLAVTAP-
Mvan_6042|M.vanbaalenii_PYR-1 WREDGDYGP-KLNAVAVEPMVRDLASDADLVVGMSLGGLTALRLAVTAP-
MSMEG_6906|M.smegmatis_MC2_155 WREDGDYGP-KLNAETVKPVLRDLAPEPRLVVGMSLGGLTALRIAATEP-
TH_1312|M.thermoresistible__bu WREDGDYGP-KTNADTLAPVLRDFAPQPDLVVGMSLGGLTALRLAVTAP-
MAB_2045|M.abscessus_ATCC_1997 WDPDGRYDMDRLGSDLLAVRSYADSGRPVAAIGASLGGLTILGTHLLAPP
MLBr_02297|M.leprae_Br4923 KPPRG-YDGWTLAGDTAG-LIRALGHSSATLVGHAEGGLACWATALLHP-
* *. . . . :* : ***: *
Mb0046c|M.bovis_AF2122/97 DLVGELVLVDVTPSALQRHAELTAEQRGTVALMHGEREFPSFQAMLDLTI
Rv0045c|M.tuberculosis_H37Rv DLVGELVLVDVTPSALQRHAELTAEQRGTVALMHGEREFPSFQAMLDLTI
MMAR_0064|M.marinum_M ELVDELVLIDVTPSALQRHAEMTAEQRGTVALMHGEREFPSFQAMLDLTV
MUL_0063|M.ulcerans_Agy99 ELVDELVLIDVTPSALQRHAEMTAEQRGTVALMHGEREFPSFQAVLDLTV
MAV_0062|M.avium_104 DLVKELVLIDVTPSALQRHSEMTKEQQGTVALMHGEREFDSFQAMLDLTI
Mflv_0865|M.gilvum_PYR-GCK KLVPQLVMVDVTPSAPERHTQMTDAQKGTVALVQGERTFPTFDAMLDVTV
Mvan_6042|M.vanbaalenii_PYR-1 ELVRRLVLVDVTPSAPERHTEMTDAQKGTVALVQGERIFPSFEAMLEVTA
MSMEG_6906|M.smegmatis_MC2_155 ALVPELVLVDVTPSAPERHTEMTKAQMGTVALVRENRTFPSFAAMLDVTV
TH_1312|M.thermoresistible__bu ELVPRLVLVDVTPSAPRRHTEMTDEQKGTVALVEGPRTFDSFEAMVELTV
MAB_2045|M.abscessus_ATCC_1997 DLWQAVVLVDVTP-----RMEMDGARRVVAFMSAHPEGFDSLESAADVIA
MLBr_02297|M.leprae_Br4923 RLVRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTR
* :.::: . : : . . : . .: . :
Mb0046c|M.bovis_AF2122/97 AAAPHRDVKSLRRG-----------------------VFHNSRRLDNGNW
Rv0045c|M.tuberculosis_H37Rv AAAPHRDVKSLRRG-----------------------VFHNSRRLDNGNW
MMAR_0064|M.marinum_M AAAPHREVKALRRG-----------------------VFHNSRRLENGNW
MUL_0063|M.ulcerans_Agy99 AAAPHREVKALRRG-----------------------VFHNSLRLENGNW
MAV_0062|M.avium_104 AAAPHREVKALRRG-----------------------VFHNSRKLDNGKW
Mflv_0865|M.gilvum_PYR-GCK AAAPHRDRESLRRG-----------------------VFHNAKRLEDGTW
Mvan_6042|M.vanbaalenii_PYR-1 AAAPHRDRKSLRRG-----------------------VFHNAKRLDDGTW
MSMEG_6906|M.smegmatis_MC2_155 QAAPHRDRNSLRRG-----------------------VFHNSKQLEDGTW
TH_1312|M.thermoresistible__bu AAAPHRDPAALRRG-----------------------VFHNSKQLDDGTW
MAB_2045|M.abscessus_ATCC_1997 AYNPHRPRPENLDG-----------------------LRKVLARREDGRW
MLBr_02297|M.leprae_Br4923 NNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRW
.. . : *
Mb0046c|M.bovis_AF2122/97 VWRYDAIRTFGDFAGLWDD------------------VDALSAPITLVRG
Rv0045c|M.tuberculosis_H37Rv VWRYDAIRTFGDFAGLWDD------------------VDALSAPITLVRG
MMAR_0064|M.marinum_M AWRYDAIRAFPDFAVLWDD------------------VDALAAPVTLVRG
MUL_0063|M.ulcerans_Agy99 AWRYDGIRAFPDFAVLWD-------------------VDALAAPVTLVRG
MAV_0062|M.avium_104 TWRYDAIRKFPDFDGLWAD------------------VDALSAPVTLVRG
Mflv_0865|M.gilvum_PYR-GCK TWRYDSIRKGEGFEGLWED------------------VPRLTTPTTLIRG
Mvan_6042|M.vanbaalenii_PYR-1 TWRYDSIRTGEGFENLWDD------------------VPRLTAPTTLIRG
MSMEG_6906|M.smegmatis_MC2_155 TWRYDSFRKGDGFEGLWDD------------------VESITMPTTLVRG
TH_1312|M.thermoresistible__bu TWRYDSIRKGDGFEGLWDD------------------VPRLTTPTTLIRG
MAB_2045|M.abscessus_ATCC_1997 SWRWDPAFVTSNFQFLQGDPDEGAEYFEMMSAFLLDGARQVSAPTLLVRG
MLBr_02297|M.leprae_Br4923 AVRSQLRNEGRKFMKSMSR--------------------PFSVPLLHVRG
* : * .: * :**
Mb0046c|M.bovis_AF2122/97 GSSGFVTDQ--------DTAELHRRATHFRGVHIVEKSGHSVQSDQPRAL
Rv0045c|M.tuberculosis_H37Rv GSSGFVTDQ--------DTAELHRRATHFRGVHIVEKSGHSVQSDQPRAL
MMAR_0064|M.marinum_M GKSGFVSDE--------DIAELRGRAKGFRGAQTVENSGHSVQSDQPRVL
MUL_0063|M.ulcerans_Agy99 GKSGFVSDE--------DIAELRGRAKGFRGAQTVENSGHSVQSDQPRVL
MAV_0062|M.avium_104 GSSGFVSDE--------DAAELSRRAKHFRTAHVVANSGHSVQSDQPRAL
Mflv_0865|M.gilvum_PYR-GCK ANSFFVNDD--------DASEFARTAPGFQGVHVVENSGHSVQSDQPRVL
Mvan_6042|M.vanbaalenii_PYR-1 AHSFFVNDD--------DADAFARTAPGFQRVHIVENSGHSVQSDQPLAL
MSMEG_6906|M.smegmatis_MC2_155 ANSFFVNDE--------DAEQFAHRAPGFKRTHVVADAGHSVQGDQPAKL
TH_1312|M.thermoresistible__bu ARSAFVNDEDAAEFAHEDAAEFARTAPGFQGVHVVPDAGHSVQSDQPRAL
MAB_2045|M.abscessus_ATCC_1997 LLSDIVSEET--------VRHFLTVVPHAQTVDVSG-AGHMIAGDNNDAF
MLBr_02297|M.leprae_Br4923 DADPYLLAD---------SVDRTRRYAPHGRYVSVSDAGHFSHEEAPEEI
. : : :** : :
Mb0046c|M.bovis_AF2122/97 IEIVRGVLDTR------
Rv0045c|M.tuberculosis_H37Rv IEIVRGVLDTR------
MMAR_0064|M.marinum_M VEILRGVLGGR------
MUL_0063|M.ulcerans_Agy99 VEILRGVLGGR------
MAV_0062|M.avium_104 IHILRGVLDAR------
Mflv_0865|M.gilvum_PYR-GCK VDLLRKVLAN-------
Mvan_6042|M.vanbaalenii_PYR-1 IELLRGVLAD-------
MSMEG_6906|M.smegmatis_MC2_155 VEILREVLGLPR-----
TH_1312|M.thermoresistible__bu IGLLRDILNT-------
MAB_2045|M.abscessus_ATCC_1997 STAVVEFLDRTI-----
MLBr_02297|M.leprae_Br4923 NRYLTRFLKQVHGPRLS
: .*