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RSGRVPPATIIAGVSDGEQAKPRRRRGRRRGRRAAGPPEAGTDQAPGARQQNSGARQQSSGAGTADQAGQ PPKPQRTRTRRPQERLRTVHETSAGGLVIDGLDGPKDSQVAALIGRVDRRGRMLWSLPKGHIEMGETAEQ TAIREVAEETGIEGSVLAALGSIDYWFVTEGRRVHKTVHHYLMRFLGGELSDEDVEVTEVAWVPLKDLPS RLAYADERKLAEVADELIDKLHTEGPGALPPLPHSAPRRRGQTHSHTRKHRSDPSAQQQPGRRTNGCGQG P*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0844 | - | - | 100% (282) | NUDIX hydrolase |
| M. gilvum PYR-GCK | Mflv_4224 | - | 2e-10 | 33.62% (116) | NUDIX hydrolase |
| M. gilvum PYR-GCK | Mflv_3031 | - | 2e-09 | 35.71% (98) | NUDIX hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3938 | - | 1e-100 | 71.38% (269) | hypothetical protein Mb3938 |
| M. tuberculosis H37Rv | Rv3908 | - | 1e-100 | 71.38% (269) | hypothetical protein Rv3908 |
| M. leprae Br4923 | MLBr_02698 | - | 6e-95 | 67.40% (273) | hypothetical protein MLBr_02698 |
| M. abscessus ATCC 19977 | MAB_4935 | - | 3e-90 | 68.13% (273) | MutT/NUDIX family protein |
| M. marinum M | MMAR_5472 | - | 1e-101 | 72.01% (268) | hypothetical protein MMAR_5472 |
| M. avium 104 | MAV_5296 | - | 1e-101 | 69.78% (268) | MutT/nudix family protein |
| M. smegmatis MC2 155 | MSMEG_6927 | - | 1e-117 | 73.15% (298) | MutT/nudix family protein |
| M. thermoresistible (build 8) | TH_0513 | - | 2e-91 | 78.95% (209) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_5061 | - | 1e-102 | 70.55% (275) | hypothetical protein MUL_5061 |
| M. vanbaalenii PYR-1 | Mvan_6062 | - | 1e-136 | 86.91% (275) | NUDIX hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0844|M.gilvum_PYR-GCK MRSGRVPPATIIAGVSD--GEQAKPRRRRGRRRGRR--------AAGPPE
Mvan_6062|M.vanbaalenii_PYR-1 -----MP--ATIAWVSD--GEQAKPRRRRGRRRGRR--------AAGPPE
MLBr_02698|M.leprae_Br4923 -----MP--AIIAWVSD--GEQAKPRRRRKRRRGRD--------ATRSAE
MAV_5296|M.avium_104 --------------MSD--GEQGKPRRRRGRRRGRG--------AATSSE
Mb3938|M.bovis_AF2122/97 --------------MSD--GEQAKSRRRRGRRRGRR--------AAATAE
Rv3908|M.tuberculosis_H37Rv --------------MSD--GEQAKSRRRRGRRRGRR--------AAATAE
MMAR_5472|M.marinum_M --------------MSE--GEQAKPRRRRGRRRGRG--------AARSAE
MUL_5061|M.ulcerans_Agy99 --------------MSE--GEQAKPRRRRGRRRGRG--------AARSAE
MSMEG_6927|M.smegmatis_MC2_155 --------------MSD--GEQAKPRRRRGRRRGHRRAQRAAGPPAAGAE
TH_0513|M.thermoresistible__bu --------------------------------------------------
MAB_4935|M.abscessus_ATCC_1997 --MSDSSGGSRTGGSSDEPGSNPASARGRGSRRGRRNR------SQGRAQ
Mflv_0844|M.gilvum_PYR-GCK AGTDQAPGARQQN-SGARQQSSGAGTADQA--------------------
Mvan_6062|M.vanbaalenii_PYR-1 ALPDQAADHR--------QQAPPAGTAGQA--------------------
MLBr_02698|M.leprae_Br4923 NHTD--------------RQVANDATAT----------------------
MAV_5296|M.avium_104 KQTN--------------GQLTGDSTAT----------------------
Mb3938|M.bovis_AF2122/97 NHMD--------------AQPAGDATPTPA--------------------
Rv3908|M.tuberculosis_H37Rv NHMD--------------AQPAGDATPTPA--------------------
MMAR_5472|M.marinum_M NHTD--------------KAESTDPNPAP---------------------
MUL_5061|M.ulcerans_Agy99 NHTD--------------NAGSPDPNPAP---------------------
MSMEG_6927|M.smegmatis_MC2_155 HHTEPAADARTESRADTRSDTSSAPTPATQPGEKKPGPGRGSRAGAAKPT
TH_0513|M.thermoresistible__bu --------------------------------------------------
MAB_4935|M.abscessus_ATCC_1997 GRAQGAN-------TPAASPAAGAPAAPNG------------------AN
Mflv_0844|M.gilvum_PYR-GCK -GQPPKPQRTRTRRPQERLRTVHETSAGGLVIDGLDGPKDSQVAALIGRV
Mvan_6062|M.vanbaalenii_PYR-1 -RQTPKPQRTRTRRPPERLRTVHETSAGGLVIDGIDGPKDGQVAALIGRI
MLBr_02698|M.leprae_Br4923 ---KPRRSHSPHRA-PEQLRTVHETSAGGLVIYGIDGPRDAQVAALIGRI
MAV_5296|M.avium_104 ---KPRRSRAARRA-PDRLRTVHETSAGGLVIDGLDGPRESQVAALIGRI
Mb3938|M.bovis_AF2122/97 -TAKRSRSRSPRRG-STRMRTVHETSAGGLVIDGIDGPRDAQVAALIGRV
Rv3908|M.tuberculosis_H37Rv -TAKRSRSRSPRRG-STRMRTVHETSAGGLVIDGIDGPRDAQVAALIGRV
MMAR_5472|M.marinum_M --TKGRRPRLPRRGRPDRLRTVHETSAGGLVIDGIDGPRDEQVAALIGRI
MUL_5061|M.ulcerans_Agy99 --TKGRRPRLPRRGRPDRLRTVHETSAGGLVIDGIDGPRDAQVAALIGRI
MSMEG_6927|M.smegmatis_MC2_155 PKDQPKQRKNRPRRPPDRLRTVHETSAGGLVIDGIDGPKDSQVAALIGRL
TH_0513|M.thermoresistible__bu ------------------LRTVHETSAGGLVIDGLDGPKEKQVAALIGRL
MAB_4935|M.abscessus_ATCC_1997 TAAGKGRGRVKGRAAGTSLRTVRETSAGGLVIAGIDGPKDGQVAALIGRT
:***:********* *:***:: ********
Mflv_0844|M.gilvum_PYR-GCK DRRGRMLWSLPKGHIEMGETAEQTAIREVAEETGIEGSVLAALGSIDYWF
Mvan_6062|M.vanbaalenii_PYR-1 DRRGRMLWSLPKGHIEMGETAEQTAIREVAEETGIQGSVLAALGSIDYWF
MLBr_02698|M.leprae_Br4923 DRRGRMLWSLPKGHIEQGETAEQTAIREVAEETGIRGSVLAALGQIDYWF
MAV_5296|M.avium_104 DRRGRMLWSLPKGHIELGETAEQTAIREVAEETGIRGSVLAALGRIDYWF
Mb3938|M.bovis_AF2122/97 DRRGRLLWSLPKGHIELGETAEQTAIREVAEETGIRGSVLAALGRIDYWF
Rv3908|M.tuberculosis_H37Rv DRRGRLLWSLPKGHIELGETAEQTAIREVAEETGIRGSVLAALGRIDYWF
MMAR_5472|M.marinum_M DRRGRMLWSLPKGHIEMGETAEQTAIREVAEETGISGGVLAALGRIDYWF
MUL_5061|M.ulcerans_Agy99 DRRGRMLWSLPKGHIEMGETAEQTAIREVAEETGIRGGVLAALGRIDYWF
MSMEG_6927|M.smegmatis_MC2_155 DRRGRMLWSLPKGHIELGETAEQTAIREVAEETGIQGSVLAALGSIDYWF
TH_0513|M.thermoresistible__bu DRRGRMLWSLPKGHIEMGETAEQTAIREVAEETGVQGAVLAALGSIDYWF
MAB_4935|M.abscessus_ATCC_1997 DRRGRMLWSLPKGHIEQGETAEQTAIREVAEETGIRGTVLAALGSIDYWF
*****:********** *****************: * ****** *****
Mflv_0844|M.gilvum_PYR-GCK VTEGRRVHKTVHHYLMRFLGGELSDEDVEVTEVAWVPLKDLPSRLAYADE
Mvan_6062|M.vanbaalenii_PYR-1 VTEGRRVHKTVHHYLMRFSGGELSDEDVEVTEVAWVPVKDLPSRLAYADE
MLBr_02698|M.leprae_Br4923 VTDDCRVHKTVHHYLMRFSGGELSDDDLEVTEVAWVPIRELPSRLAYADE
MAV_5296|M.avium_104 VTDGRRVHKTVHHYLMRFSGGELSDEDLEVAEVAWVPMRELPSRLAYADE
Mb3938|M.bovis_AF2122/97 VTDGRRVHKTVHHYLMRFLGGELSDEDLEVAEVAWVPIRELPSRLAYADE
Rv3908|M.tuberculosis_H37Rv VTDGRRVHKTVHHYLMRFLGGELSDEDLEVAEVAWVPIRELPSRLAYADE
MMAR_5472|M.marinum_M VTDGRRVHKTVHHYLMRFLGGELSDNDLEVTEVAWVPIPELPSRLAYADE
MUL_5061|M.ulcerans_Agy99 VTDGRRVHKTVHHYLMRFLGGELSDNDLEVTEVAWVPIPELPSRLAYADE
MSMEG_6927|M.smegmatis_MC2_155 VTEGRRVHKTVHHYLMRFLGGELSDDDVEVTEVAWVPLRELPSRLAYADE
TH_0513|M.thermoresistible__bu VTEGRRVHKTVHHYLMRFLGGELSDDDVEVSEVAWVPLSELPTRLAYADE
MAB_4935|M.abscessus_ATCC_1997 VTEGRRVHKTVHHYLMRSLGGELSDDDVEVTEVAWVPLGELPTRLAYADE
**:. ************ ******:*:**:******: :**:*******
Mflv_0844|M.gilvum_PYR-GCK RKLAEVADELIDKLHTEGPGALPPLPHSAPRRRGQTHSHTR----KHRSD
Mvan_6062|M.vanbaalenii_PYR-1 RRLAEVADELIDKLHTDGPGALPPLPRTTPRRRGQTHSHTR----RHRPD
MLBr_02698|M.leprae_Br4923 RRLAEVAYELINKLQTGGPAALPPLPPSLPRRQSQTHFRT-----RHSNN
MAV_5296|M.avium_104 RRLARVADELIDKLQSDGPAALPPLPPSSPRRRPQTHSRTRHSETRHSDK
Mb3938|M.bovis_AF2122/97 RRLAEVADELIDKLQSDGPAALPPLPPSSPRRRPQTHSRA-----RHADD
Rv3908|M.tuberculosis_H37Rv RRLAEVADELIDKLQSDGPAALPPLPPSSPRRRPQTHSRA-----RHADD
MMAR_5472|M.marinum_M RRLAEVADELIDKLQTDGPTALPPLPPSAPRRRPQTHSRT-----RHAAE
MUL_5061|M.ulcerans_Agy99 RRLAEVADELIDKLQTDGPTALPPLPPSAPRRRPQTHSRT-----RHAAE
MSMEG_6927|M.smegmatis_MC2_155 RRLAEVAGELIDKLHTGGPAALPPLPHSAPRRRAQTHSHT-----RNRRD
TH_0513|M.thermoresistible__bu RRLAEVAGELIDTLQTHGPQALPPLPQMAPRRRPQTHSRTRSS--RRRDD
MAB_4935|M.abscessus_ATCC_1997 RRLAEVAGDLIDKLHTEGPAALPPLPPSAPRRRPQTHSST------HRTP
*:**.** :**:.*:: ** ****** ***: *** : .
Mflv_0844|M.gilvum_PYR-GCK PSAQQQP-----------GRRTNGCGQGP
Mvan_6062|M.vanbaalenii_PYR-1 PTAQPQP-----------GRRTNGCGQGP
MLBr_02698|M.leprae_Br4923 -SANSR---------------KNGHGQGP
MAV_5296|M.avium_104 -PATGR---------------KNGHGPGP
Mb3938|M.bovis_AF2122/97 -SAPGQ---------------HNGPGPGP
Rv3908|M.tuberculosis_H37Rv -SAPGQ---------------HNGPGPGP
MMAR_5472|M.marinum_M GSPPGR---------------KNGHGPGP
MUL_5061|M.ulcerans_Agy99 GSPPGR---------------KNGHGPGP
MSMEG_6927|M.smegmatis_MC2_155 DTAQPQA-----------RRRTNGCGQGP
TH_0513|M.thermoresistible__bu SAAHSRGEGRERGAANSSGRRTNGCGKGP
MAB_4935|M.abscessus_ATCC_1997 ----GR---------------RSGRGQQQ
: .* *