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TQPNDPKKVVLELIEHTRKIADTQDRGDLVARLDRAARRVEDPQIRVVIAGQLKQGKSQLLNSLLNMPVA RVGDDESTVVATVVSYGEQPSARLVVAGGDGREPELIEIPTADLRNDLRRAPQAGGREVLRVEVTAPSPL LKGGLAFIDTPGVGGHGQPHLSATLGLLPDADAMLMISDVSQEFTEPEMTFMRQALDICPVAVIAATKTD LYPHWRRVVEANAAHLRRAGITTPMVPVSSTLRSHAVALNDKELNEESNFPAIVKFLSDEVLSRHNGGVR EQVVAEIRAAAEHLTLAAESERSALTDPHTRQRLTADLEARKQEAQDALQQTALWQQVLNDGIADLTADV DHDLRERFRNITFHTERVIETGDPTLHWAEIGAELEDAVATAVGDNFVWAYQRAEALAADVARTFTEAGL DAVRIPSLNARDMGADLGEFRSLAQLEAKPLKFGHKVVTGMRGSYGGVLIFGMLTSFAGLGMFNPLSLGA GFVLGRKAYKEDMENRLLRVRNDAKTNVRRFVDDVAFAVGKESRDRLKGIQRQLRDHYREIANQTTRSLN ESLQATLSAAKMEEAERTARVRELDRQLNVLRQVIDHIDHKLRAPAH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0273 | - | - | 100% (608) | hypothetical protein Mflv_0273 |
| M. gilvum PYR-GCK | Mflv_0272 | - | 8e-11 | 24.52% (363) | isoniazid inductible gene protein IniC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0349 | iniA | 0.0 | 66.56% (601) | isoniazid inductible gene protein INIA |
| M. tuberculosis H37Rv | Rv0342 | iniA | 0.0 | 66.89% (601) | isoniazid inductible gene protein INIA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4283c | - | 0.0 | 64.72% (598) | hypothetical protein MAB_4283c |
| M. marinum M | MMAR_0615 | iniA | 0.0 | 70.05% (601) | hypothetical protein MMAR_0615 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0695 | - | 0.0 | 80.10% (598) | isoniazid inductible protein IniA |
| M. thermoresistible (build 8) | TH_1302 | - | 0.0 | 75.71% (597) | ISONIAZID INDUCTIBLE GENE PROTEIN INIA |
| M. ulcerans Agy99 | MUL_0580 | iniA | 0.0 | 69.55% (601) | hypothetical protein MUL_0580 |
| M. vanbaalenii PYR-1 | Mvan_0624 | - | 0.0 | 83.33% (600) | hypothetical protein Mvan_0624 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0349|M.bovis_AF2122/97 MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLN
Rv0342|M.tuberculosis_H37Rv MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLN
MMAR_0615|M.marinum_M -----------------------MTQPDDPRRVGVIVELIDHTIAIAELN
MUL_0580|M.ulcerans_Agy99 -----------------------MTQPDDPRRVGVIVELIDHTIAIAELN
Mflv_0273|M.gilvum_PYR-GCK -----------------------MTQPNDP--KKVVLELIEHTRKIADTQ
Mvan_0624|M.vanbaalenii_PYR-1 -----------------------MTQPAN----TAILELIDHASRIAQAQ
MSMEG_0695|M.smegmatis_MC2_155 ----------------------------------MIVELIDHTSAIAAAK
TH_1302|M.thermoresistible__bu -----MTQPNEPRPQPVPASRAPAGGPANP--VPVIVELIDHTSRIAELN
MAB_4283c|M.abscessus_ATCC_199 ---------------------MSDTAQDGQQQLALINELLGHVRKIAGEN
: **: *. ** :
Mb0349|M.bovis_AF2122/97 ERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLSSLLNLPAARVGD
Rv0342|M.tuberculosis_H37Rv ERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGD
MMAR_0615|M.marinum_M ERNDLVGRLRRARQRITDPQIRVVIAGQLKQGKSQLLNALLNLPVARVGD
MUL_0580|M.ulcerans_Agy99 ERNDLVGRLRRARQRITDPQIRVVIAGQLKQGKSQLLNALLNLPVARVGD
Mflv_0273|M.gilvum_PYR-GCK DRGDLVARLDRAARRVEDPQIRVVIAGQLKQGKSQLLNSLLNMPVARVGD
Mvan_0624|M.vanbaalenii_PYR-1 DRGDLTDRLARARSRLQDPQIRVVIAGQLKQGKSQLLNSLLNMPVARVGD
MSMEG_0695|M.smegmatis_MC2_155 DRADLVERLRAAKARISDPQIRVVIAGQLKQGKSQLLNSLLNIPVARVGD
TH_1302|M.thermoresistible__bu QRGDLAERLRRAKARITDPQIRVVIAGHLKQGKSLLLNALLNMPVARVGD
MAB_4283c|M.abscessus_ATCC_199 DRGDLIDRLDRADQLLVDRPLRVVVAGQLKQGKSQLVNSLLNMPVARVGD
:* ** ** * : * :***:** ****** *:.:***:*.*****
Mb0349|M.bovis_AF2122/97 DEATVVITVVSYSAQPSARLVLAAGPD-------GTTAAVDIPVDDISTD
Rv0342|M.tuberculosis_H37Rv DEATVVITVVSYSAQPSARLVLAAGPD-------GTTAAVDIPVDDISTD
MMAR_0615|M.marinum_M DEATVVVTVVSYSPQPSARIIVAAGPN-------GETTSIDVPVDDINTD
MUL_0580|M.ulcerans_Agy99 DEATVVVTVVSYSPQPSARIIVAAGPN-------GETTSIDVPVDDINTD
Mflv_0273|M.gilvum_PYR-GCK DESTVVATVVSYGEQPSARLVVAGGDG-------REPELIEIPTADLRND
Mvan_0624|M.vanbaalenii_PYR-1 DESTVLPTVVSYGEQASARLVVARPDG-------EEPELVEIPTADLRND
MSMEG_0695|M.smegmatis_MC2_155 DESTVLATVVSYGEQASARLVVARPDG-------AEPELIEIPPSEVTTD
TH_1302|M.thermoresistible__bu DESTVLTTVVSYGDQPSARLVVAQPDG-------AEPEVVEIPTTELKND
MAB_4283c|M.abscessus_ATCC_199 DETTSVTTVIGYGEQPSAALVVAPAEQYDGGGLAGEPEIIPIPVADIGKD
**:* : **:.*. *.** :::* . : :* :: .*
Mb0349|M.bovis_AF2122/97 VRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGL
Rv0342|M.tuberculosis_H37Rv VRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGL
MMAR_0615|M.marinum_M LRRAPQAGGREVLRVEIGAPSPLLQGGLAFIDTPGVGGHGQPHLSATLGL
MUL_0580|M.ulcerans_Agy99 LRRAPQAGGREVLRVEIGAPSPLLQGGLAFIDTPGVGGHGQPHLSATLGL
Mflv_0273|M.gilvum_PYR-GCK LRRAPQAGGREVLRVEVTAPSPLLKGGLAFIDTPGVGGHGQPHLSATLGL
Mvan_0624|M.vanbaalenii_PYR-1 LRRAPQAGGREVLRVEVNAPSPLLKGGLAFIDTPGVGGHGQPHLSATLGL
MSMEG_0695|M.smegmatis_MC2_155 LRRAPQASGRQVLRVEVTAPSPLLKGGLAFVDTPGVGGHGQPHLSATLGL
TH_1302|M.thermoresistible__bu LRRAPQARGRQVLRVEVTAPSPILKSGLAFVDTPGVGGHGQPHLSATLGL
MAB_4283c|M.abscessus_ATCC_199 LKRAPQAQGREVLRVEVKVASPILKSGLCLVDTPGVGGFGQPHLSSTLGL
::***:* **:*****: ..**:*:.**.::******* ******:****
Mb0349|M.bovis_AF2122/97 LPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPRWRE
Rv0342|M.tuberculosis_H37Rv LPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPRWRE
MMAR_0615|M.marinum_M LPDADAMLMVSDASQEFTEPEMWFLRKAHQLCPAGVVVATKTDLYPHWRE
MUL_0580|M.ulcerans_Agy99 LPDADAMLMVSDASQEFTEPEMWFLRKAHQLCPAGVVVATKTDLYPHWRE
Mflv_0273|M.gilvum_PYR-GCK LPDADAMLMISDVSQEFTEPEMTFMRQALDICPVAVIAATKTDLYPHWRR
Mvan_0624|M.vanbaalenii_PYR-1 LPDADAMLMISDTSQEFTEPEMTFIRQALEVCPVALIVGTKTDLYPHWRQ
MSMEG_0695|M.smegmatis_MC2_155 LPDADAMLMISDTSQEFTEPEMKFIRQALEICPVAAIVATKTDLYPHWRQ
TH_1302|M.thermoresistible__bu LPDADALLMISDTSQEFTEPEMRFIRQALEICPLALIVATKIDLYPHWRD
MAB_4283c|M.abscessus_ATCC_199 LPDADVMLMVSDLSSEFTEPELVFIQQALDLCPVAAIVNTKTDLYPHWRA
**:**.:*::** *.******: *:::* ::** . :. ** ****:**
Mb0349|M.bovis_AF2122/97 IVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFL
Rv0342|M.tuberculosis_H37Rv IVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFL
MMAR_0615|M.marinum_M IVNTNAAHLQRARVPMPIIPVSSLLRSHAVTLNDKELNEESNFPAIVKFL
MUL_0580|M.ulcerans_Agy99 IVNSNAAHLQRARVPMPIIPVSSLLRSHAVTLSEKELNEESNFPAIVKFL
Mflv_0273|M.gilvum_PYR-GCK VVEANAAHLRRAGITTPMVPVSSTLRSHAVALNDKELNEESNFPAIVKFL
Mvan_0624|M.vanbaalenii_PYR-1 VVDANRAHLQRAGVTAPLIPVSSTLRSHAVALNDKELNEESNFPAIVKFL
MSMEG_0695|M.smegmatis_MC2_155 IVDANIAHLQRAGLNVPVIPASSVLRSHAISLNDKELNEESNFPAIVKFL
TH_1302|M.thermoresistible__bu IMRANAEHLRRAGITTPMVPASSVLRSHAVQLNDKELNEESNFPAIVKFL
MAB_4283c|M.abscessus_ATCC_199 VVAANSAHLQRAKIAVPAIAVSSALRSHALQLNDKELNTESNFPALVTFL
:: :* **:** : * :..** *****: *.:**** ******:*.**
Mb0349|M.bovis_AF2122/97 SEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASD
Rv0342|M.tuberculosis_H37Rv SEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASD
MMAR_0615|M.marinum_M SEKVLSRETDRVRDEVLREIRSAAEQLTISVDSELAVINDPALRDRLASD
MUL_0580|M.ulcerans_Agy99 SEKVLSRETDRVRDEVLREIRSAAEQLTISVDSELAVINDPALRDRLAGD
Mflv_0273|M.gilvum_PYR-GCK SDEVLSRHNGGVREQVVAEIRAAAEHLTLAAESERSALTDPHTRQRLTAD
Mvan_0624|M.vanbaalenii_PYR-1 SEEVLASQRGRVRDQVVGEIRSAAEHLRMSVQSELSALNDPTAREQLTAD
MSMEG_0695|M.smegmatis_MC2_155 SEHVLSRQNDRIRDQIVDEIRSAAEHLLLAVESELSSFNDPGERERLTAE
TH_1302|M.thermoresistible__bu SEQVLSGAKIRVRDQVLSDIRSAAEHLKLSIESELSSLNDPEARERLTEE
MAB_4283c|M.abscessus_ATCC_199 SNAIADQQAS-TRQQAIAEIGSASEHLTLTLEAELSALQDPQSRDELTSD
*: : * : :* :*:*:* :: :* : . ** *:.*: :
Mb0349|M.bovis_AF2122/97 LERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAER
Rv0342|M.tuberculosis_H37Rv LERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAER
MMAR_0615|M.marinum_M LERRKREANDALQQTALWQQVLNDGFTDLSTDVDHDLRARFRAVTEDAER
MUL_0580|M.ulcerans_Agy99 LERRKREANDALQQTALWQQVLNDGFTDLSTDVDHDLRARFRAVTEDAER
Mflv_0273|M.gilvum_PYR-GCK LEARKQEAQDALQQTALWQQVLNDGIADLTADVDHDLRERFRNITFHTER
Mvan_0624|M.vanbaalenii_PYR-1 LERRKQEAQEALQHTALWQQVLNDGIADLTADVDHDLRHRFRNITFHAEE
MSMEG_0695|M.smegmatis_MC2_155 LERRKQEAQDALQQTALWQQVLSDGIADLTADVDHDLRHRFRIIAAHTEK
TH_1302|M.thermoresistible__bu LERRKREAQDALQQTALWQQVLNDGIADLTADVDHDLRQRFRNITNYTEQ
MAB_4283c|M.abscessus_ATCC_199 LERRKREAEEALAHTALWQQVLGDGITDVSTDVEHDLQSRFRRILQRTEE
** **:**::*: :********.**: *:::**:***: *** : :*.
Mb0349|M.bovis_AF2122/97 QIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFAD
Rv0342|M.tuberculosis_H37Rv QIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFAD
MMAR_0615|M.marinum_M QIDSCDPTLHWAEIGTDVENAIATAVGDNFVWAYQRGEALADDVARSFAD
MUL_0580|M.ulcerans_Agy99 QIDSCDPTLHWAEIGTDVENAIATAVGDNFVWAYQRGEALADDVAKSFAD
Mflv_0273|M.gilvum_PYR-GCK VIETGDPTLHWAEIGAELEDAVATAVGDNFVWAYQRAEALAADVARTFTE
Mvan_0624|M.vanbaalenii_PYR-1 VIDSSDPTQNWAAIGAELEDAIATAVGDNFVWAYQRAEALAAEVARTFRE
MSMEG_0695|M.smegmatis_MC2_155 VIDGCDPTLHWAEIGAELEDAVATAVGDNFVWAYQRAEALAAEVARTFTE
TH_1302|M.thermoresistible__bu VIDSCDPTNHWAEIATELENAVATAVGDNFVWAYQRAEALAREVARTFVE
MAB_4283c|M.abscessus_ATCC_199 VIDRTDPTKNWAEVGAKLEQAVANSVGNNFVWAHQRAMHLAAQVAETFAI
*: *** :** :. .:*:*:*.:**:*****:**. ** :**.:*
Mb0349|M.bovis_AF2122/97 AGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRGQKMIIGMRGSYGG
Rv0342|M.tuberculosis_H37Rv AGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGG
MMAR_0615|M.marinum_M AGLDSVLSPELSKRAMGAEFGQLKAPAQLEAKPAGKAQKVVTGLRGSYGG
MUL_0580|M.ulcerans_Agy99 AGLDSVLSPELSKRAMGAEFGQLKAPAQLEAKPAGKAQKVVTGLRGSYGG
Mflv_0273|M.gilvum_PYR-GCK AGLDAVRIPSLNARDMGADLGEFRSLAQLEAKPLKFGHKVVTGMRGSYGG
Mvan_0624|M.vanbaalenii_PYR-1 AGLDAVRMPAIDAREMGADFGEFKSLAQLEAKPLKFGHKVVTGMRGSYGG
MSMEG_0695|M.smegmatis_MC2_155 AGLDAVQMPQIDARDMGAGFGELNSLARLEAKPIKIGHKVVTGMRGSYGG
TH_1302|M.thermoresistible__bu AGLDAVPMPKIDARQMGAELGDLKSLNQLEAKPIRFGDRAVSGLRGSFGG
MAB_4283c|M.abscessus_ATCC_199 DGLESIKMPRLRASEMGADLSDLKSLSKLEAKQIKLGHKAITGLRGSYGG
**::: . : **: :. :.: ::*:* ..: : *:***:**
Mb0349|M.bovis_AF2122/97 VVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKAN
Rv0342|M.tuberculosis_H37Rv VVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKAN
MMAR_0615|M.marinum_M VVMIGMLSSVAGLGLFNPVSVGAGLILGRMAYKEDRENRLLRARAEAKTN
MUL_0580|M.ulcerans_Agy99 VVMIGMLSSVAGLGLFNPVSVGAGLILGRMAYKEDRENRLLRARAEAKTN
Mflv_0273|M.gilvum_PYR-GCK VLIFGMLTSFAGLGMFNPLSLGAGFVLGRKAYKEDMENRLLRVRNDAKTN
Mvan_0624|M.vanbaalenii_PYR-1 VLMFGMLTSFAGLGMFNPLSLGAGFVLGRKAYKEDMENRMLRVRSEAKAN
MSMEG_0695|M.smegmatis_MC2_155 VLMFGMLTSFAGLGMFNPLSLGAGFVLGRKAYKEDMENRMLRVRNEAKAN
TH_1302|M.thermoresistible__bu VLMFGMLSSFAGLGMFNPLSLGAGLLMGRKTYKEEMENRILRIRNEAKMN
MAB_4283c|M.abscessus_ATCC_199 VIMFGMLTSVAGLGMFNLISLGAGAMLGKKTYNEDMENRMLRIRGEAKTN
*:::***:*..***:** :*:*** ::*: :*:*: :**:** * :** *
Mb0349|M.bovis_AF2122/97 VRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATI
Rv0342|M.tuberculosis_H37Rv VRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATI
MMAR_0615|M.marinum_M VRRFVDDVSFVVGKESRDRLKMIQRTLRDHYREIANEITRSLNESLQATV
MUL_0580|M.ulcerans_Agy99 VRRFVDDVSFVVGKESRDRLKMIQRTLRDHYREIANEITRSLNESLQATV
Mflv_0273|M.gilvum_PYR-GCK VRRFVDDVAFAVGKESRDRLKGIQRQLRDHYREIANQTTRSLNESLQATL
Mvan_0624|M.vanbaalenii_PYR-1 VRRFVDDVAFVVGKESRDRLKGIQRQLRDHYREIANQTTRSLNESLQATL
MSMEG_0695|M.smegmatis_MC2_155 VRKFVDDVAFVVGKESRDRLKGIQRQLRDHYREIANQTTRSLNESLQAAI
TH_1302|M.thermoresistible__bu VRKFVDDVAFVVSKESRDRLKGIQRMLRDYYRGIADQTTRSLNESLQAAI
MAB_4283c|M.abscessus_ATCC_199 VRRFLDDVSFVVLKESRDRLRLVQRQLRDHFREIANQTTRSLNESLQAAI
**:*:**::*.* *:*****: :** ***::* **:: ****.*****::
Mb0349|M.bovis_AF2122/97 AAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA--
Rv0342|M.tuberculosis_H37Rv AAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA--
MMAR_0615|M.marinum_M TASHLEEAERDNRVRELERQRNILGQVTDNLLKLGPGVSPRANLGRA--
MUL_0580|M.ulcerans_Agy99 TASHLEEAERDNRVRELERQRNILGQVTDNLLKL----SPRANLGRA--
Mflv_0273|M.gilvum_PYR-GCK SAAKMEEAERTARVRELDRQLNVLRQVIDHIDHKLRAPAH---------
Mvan_0624|M.vanbaalenii_PYR-1 AAAKLEETERNARVKELERQLNVLRQVLDHTEKLAS-------------
MSMEG_0695|M.smegmatis_MC2_155 AAAKVEEAERNTRVKELERQQNILKQVVDHAAKLAQDPAPSPA------
TH_1302|M.thermoresistible__bu AAAKLEETERDNRVRELERQLNILNQVLDHAERLATSSG----------
MAB_4283c|M.abscessus_ATCC_199 ASARLEAEDRDARTNEVERQLHILRQVNSHVEGLQPADEQVGRRATRDV
::::: :* * .*::** :* ** .: