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NRTPSPVDPCDFVIFGGTGDLAARKLLPALYLRDRDGQLAGATRIIGVAKAGLDDAGYRNTVRAGLARHV EPDLLDSDVVDRFLSRLRFVSVDLTEPSDYAAVGDVLTSPDGGSGHDIRVFYLACAPALFGPICGALGAQ GLVTESSRVVLEKPIGRDLASAQQINEAVGAVFAEHQIFRIDHYLGKESVQQLLVTRFGNTWLEPLWNSS RIDHVQITAAESLGVGARGDYYDQSGALRDMLQNHLLQVLCLVAMEPPTHVNRESVRDEKRKVLEALEPL TAEQTQRDTVTGQYGPGLVGDEVVGSYREEVADPHSRTETFVAVKAHIRNWRWAGVPFYLRTGKRMSQRF SEIVVQFKPVPLPMFPGIEGTSEPNRLIISLQPDEAIRLEMTAKEPGSGGRLRPVSLALNYTEAFPERSP DAYERLLMDVVRGDPTLFMRRDEVEAAWAWAEPILRHWQDADRVPRTYPAGTDGPVDAATLIERDGRRWH GGAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0314 | zwf | - | 100% (495) | glucose-6-phosphate 1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3101 | zwf | e-102 | 41.53% (496) | glucose-6-phosphate 1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1482c | zwf2 | 1e-101 | 41.94% (496) | glucose-6-phosphate 1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3694 | - | 4e-99 | 41.00% (500) | glucose-6-phosphate 1-dehydrogenase |
| M. tuberculosis H37Rv | Rv1447c | zwf2 | 1e-101 | 41.94% (496) | glucose-6-phosphate 1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2761 | - | 1e-100 | 41.57% (498) | glucose-6-phosphate 1-dehydrogenase |
| M. marinum M | MMAR_2252 | zwf2 | 1e-102 | 42.54% (496) | glucose-6-phosphate 1-dehydrogenase Zwf2 |
| M. avium 104 | MAV_3329 | zwf | 2e-99 | 41.57% (498) | glucose-6-phosphate 1-dehydrogenase |
| M. thermoresistible (build 8) | TH_0337 | zwf2 | 1e-101 | 42.34% (496) | PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 (G6PD) |
| M. ulcerans Agy99 | MUL_1842 | zwf2 | 1e-102 | 42.54% (496) | glucose-6-phosphate 1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2718 | - | 1e-100 | 41.13% (496) | glucose-6-phosphate 1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1482c|M.bovis_AF2122/97 MKPAHA-----------AASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGD
Rv1447c|M.tuberculosis_H37Rv MKPAHA-----------AASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGD
MAV_3329|M.avium_104 MSPART-----------AQQWHNPLRDKRDKRLPRIAGPCGMVIFGVTGD
MMAR_2252|M.marinum_M MSPPHSE--------SGVAQWQNPLRDKLDKRLPRIAGSCGMVIFGVTGD
MUL_1842|M.ulcerans_Agy99 MSPPHSE--------SGVAQWQNPLRDKLDKRLPRIAGSCGMVIFGVTGD
Mflv_3694|M.gilvum_PYR-GCK MTEP----------------WRNPLRDKRDKRMPRIAGPCSVIIFGVTGD
Mvan_2718|M.vanbaalenii_PYR-1 MPES----------------WRNPLRDKRDKRMPRIAGPCSVVIFGVTGD
TH_0337|M.thermoresistible__bu MTDPAGFGPVAGLAEPAPPGWRNPLRDKRDKRMPRIAGPCSMVIFGVTGD
MAB_2761|M.abscessus_ATCC_1997 MTEVLPP---------DSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGD
MSMEG_0314|M.smegmatis_MC2_155 -----------------------------MNRTPSPVDPCDFVIFGGTGD
:* * ...*..:*** ***
Mb1482c|M.bovis_AF2122/97 LARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHC
Rv1447c|M.tuberculosis_H37Rv LARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHC
MAV_3329|M.avium_104 LARKKVMPAIYDLANRGLLPPSFSLVGFARRDWSTQDFGKVVYEAVKEHC
MMAR_2252|M.marinum_M LARKKVMPAIYDLANRGLLPPTFALVGFARRDWDTEDFGQVVYQAVKEHC
MUL_1842|M.ulcerans_Agy99 LARKKVMPAIYDLANRGLLPPTFALVGFARRDWDTEDFGQVVYQAVKEHC
Mflv_3694|M.gilvum_PYR-GCK LARKKLMPAIYDLANRGLLPPSFALVGFARRDWADEDFGQVVYEAVKKHA
Mvan_2718|M.vanbaalenii_PYR-1 LARKKLMPAIYDLANRGLLPPSFALVGFARRDWADEDFGEVVYEAVKKHA
TH_0337|M.thermoresistible__bu LSRKKLMPAIYDLANRGLLPASFSLVGFARRDWADEDFGQVVYEAVKTHA
MAB_2761|M.abscessus_ATCC_1997 LARKKLMPAIYDLANRGLLPPSFALVGFARRDWANEDFGQIVLDAVKAHS
MSMEG_0314|M.smegmatis_MC2_155 LAARKLLPALYLRDRDGQLAGATRIIGVAKAGLDDAGYRNTVRAGLARHV
*: :*::**:* . * *. : ::*.*: . .: : * .: *
Mb1482c|M.bovis_AF2122/97 RTPFRQ-QNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNH
Rv1447c|M.tuberculosis_H37Rv RTPFRQ-QNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNH
MAV_3329|M.avium_104 RTPFRQ-ENWDRLAEGFRFVPGAFDDDEAFGRLAETLDKLDAERGTGGNH
MMAR_2252|M.marinum_M RTPFRQ-ANWDRLAEGFRFVSGSFDDDEAFGRLAETLEKLDTERGTGGNH
MUL_1842|M.ulcerans_Agy99 RTPFRQ-ANWDRLAEGFRFVSGSFDDDEAFGRLAETLEKLDTERGTGGNH
Mflv_3694|M.gilvum_PYR-GCK RTPFRQ-EVWDRLAEGFRFVQGTFDDDDSFARLAETLNTLDVERGTGGNH
Mvan_2718|M.vanbaalenii_PYR-1 RTPFRQ-EVWDRLAEGFRFVQGTFDDDASFDRLSETLEKLDAERGTGGNH
TH_0337|M.thermoresistible__bu RTPFRQ-EVWDRLAEGFRFVQGTFDDDAAFARLTEVLEKLDVQRGTGGNH
MAB_2761|M.abscessus_ATCC_1997 RTPFRQ-HVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGGNH
MSMEG_0314|M.smegmatis_MC2_155 EPDLLDSDVVDRFLSRLRFVSVDLTEPSDYAAVGDVLTSPDGGSGHD-IR
.. : : **: . :*** : : : : ..* . * * . :
Mb1482c|M.bovis_AF2122/97 AFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASAREL
Rv1447c|M.tuberculosis_H37Rv AFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASAREL
MAV_3329|M.avium_104 AFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLESAQSL
MMAR_2252|M.marinum_M AFYLAIPPKSFPVVCGQLHKSGLARPQGDRWSRVVIEKPFGHDLQSARDL
MUL_1842|M.ulcerans_Agy99 AFYLAIPPKSFPVVCGQLHKSGLARPQGDRWSRVVIEKPFGHDLQSARDL
Mflv_3694|M.gilvum_PYR-GCK AFYLSIPPNAFPVVCEQLQKSGLARQKDHSWSRVVIEKPFGHDLDSAREL
Mvan_2718|M.vanbaalenii_PYR-1 AFYLSIPPNAFPVVCEQLQRSGLARQKDHSWSRVVIEKPFGHDLASAREL
TH_0337|M.thermoresistible__bu AFYLSIPPKAFPLVCEQLRRSGLARPQPGRWSRVVVEKPFGHDLQSAVEL
MAB_2761|M.abscessus_ATCC_1997 GFYLSIPPNAFPTVCEQLSKSGLAQPVDGAWRRVVIEKPFGHDLASAREL
MSMEG_0314|M.smegmatis_MC2_155 VFYLACAPALFGPICGALGAQGLVTES----SRVVLEKPIGRDLASAQQI
***: .* * :* * .**. ***:***:*:** ** .:
Mb1482c|M.bovis_AF2122/97 NKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHV
Rv1447c|M.tuberculosis_H37Rv NKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHV
MAV_3329|M.avium_104 NKAVNAVFPEESVFRIDHYLGKETVRNILALRFANQLFDPIWNSHYVDHV
MMAR_2252|M.marinum_M NRAVNAVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHV
MUL_1842|M.ulcerans_Agy99 NRAVNAVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHV
Mflv_3694|M.gilvum_PYR-GCK NNVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPIWNSHYVDHV
Mvan_2718|M.vanbaalenii_PYR-1 NAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWNAHYVDHV
TH_0337|M.thermoresistible__bu NAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPIWNNHYVDHV
MAB_2761|M.abscessus_ATCC_1997 NAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHV
MSMEG_0314|M.smegmatis_MC2_155 NEAVGAVFAEHQIFRIDHYLGKESVQQLLVTRFGNTWLEPLWNSSRIDHV
* .*. **.*. :**********:*:::*. **.* :*:** :***
Mb1482c|M.bovis_AF2122/97 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAA
Rv1447c|M.tuberculosis_H37Rv QITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAA
MAV_3329|M.avium_104 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFSPLA
MMAR_2252|M.marinum_M QITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFNPTA
MUL_1842|M.ulcerans_Agy99 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFNPTA
Mflv_3694|M.gilvum_PYR-GCK QITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALTAMEEPVNFSPHE
Mvan_2718|M.vanbaalenii_PYR-1 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALTAMEEPVNFSPHE
TH_0337|M.thermoresistible__bu QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPRQ
MAB_2761|M.abscessus_ATCC_1997 QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAE
MSMEG_0314|M.smegmatis_MC2_155 QITAAESLGVGARGDYYDQSGALRDMLQNHLLQVLCLVAMEPPTHVNRES
*** **.:*:*.*..*** ** **::****:*:*.:.*** * .
Mb1482c|M.bovis_AF2122/97 LQAEKIKVLSATR--LAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAE
Rv1447c|M.tuberculosis_H37Rv LQAEKIKVLSATR--LAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAE
MAV_3329|M.avium_104 LQAEKIKVLSATH--LAHPLDETTSRGQYTAGWQGGEKVVGLLDEEGFAK
MMAR_2252|M.marinum_M LQTEKIKVLSATQ--LAEPLDETTSRGQYTAGWQGGEKVVGLLDEEGFSK
MUL_1842|M.ulcerans_Agy99 LQTEKIKVLSATQ--LAEPLDETTSRGQYTTGWQGGEKVVGLLDEEGFSK
Mflv_3694|M.gilvum_PYR-GCK LQAEKIKVLGATR--PLGPLDQTTARGQYAAGWQGSERVPGLLEEDGFAT
Mvan_2718|M.vanbaalenii_PYR-1 LQAEKIKVLSATR--PLQPLDQTTARGQYAAGWQGSEKVPGLLEEGGFAH
TH_0337|M.thermoresistible__bu LQAEKIKVLSAVR--LAQPLDQTTARGQYTAGWQGGERVVGLLEEEGFAK
MAB_2761|M.abscessus_ATCC_1997 LQAEKIKVLSATR--LAEPLAETTARGQYGPGWQGSQQVPGLLEEEGFSK
MSMEG_0314|M.smegmatis_MC2_155 VRDEKRKVLEALEPLTAEQTQRDTVTGQYGPGLVG-DEVVGSYREEVADP
:: ** *** * . . * *** .* * :.* * *
Mb1482c|M.bovis_AF2122/97 DSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLP
Rv1447c|M.tuberculosis_H37Rv DSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLP
MAV_3329|M.avium_104 DSITETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLP
MMAR_2252|M.marinum_M TSTTETFAAITLEVNSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLP
MUL_1842|M.ulcerans_Agy99 TSTTETFAAITLEVNSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLP
Mflv_3694|M.gilvum_PYR-GCK DSVTETFAAITLEVDTRRWAGVPFFLRTGKRLARRVTEVALVFKRAPHLP
Mvan_2718|M.vanbaalenii_PYR-1 DSVTETFAAITLEVDTRRWAGVPFFLRTGKRLPRRVTEVALVFKRAPHLP
TH_0337|M.thermoresistible__bu DSTTETFAAITLEIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLP
MAB_2761|M.abscessus_ATCC_1997 TSTTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLP
MSMEG_0314|M.smegmatis_MC2_155 HSRTETFVAVKAHIRNWRWAGVPFYLRTGKRMSQRFSEIVVQFKPVP-LP
* ****.*:. .: . *******:******: :*.:*:.: *: .* **
Mb1482c|M.bovis_AF2122/97 FDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGS
Rv1447c|M.tuberculosis_H37Rv FDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGS
MAV_3329|M.avium_104 FDATMTDELGANAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGS
MMAR_2252|M.marinum_M FDATMTDELGTNALVIRVQPDEGMTLRFGSKVPGSAMEVRDVNMDFSYGS
MUL_1842|M.ulcerans_Agy99 FDATMTDELGTNALVIRVQPDEGMTLRFGSKVPGSAMEVRDVNMDFSYGS
Mflv_3694|M.gilvum_PYR-GCK FDATMTEELGKNALVLRIQPDEGITMRFGSKVPGSAMEVRDVNMDFSYGS
Mvan_2718|M.vanbaalenii_PYR-1 FDSTMTEELGKNALVIRIQPDEGITMRFGSKVPGSAMEVRDVNMDFSYGS
TH_0337|M.thermoresistible__bu FDATMTEELGQNALVIRIQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYGS
MAB_2761|M.abscessus_ATCC_1997 FDSTMTEELGANALVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYEQ
MSMEG_0314|M.smegmatis_MC2_155 MFPGIEGTSEPNRLIISLQPDEAIRLEMTAKEPGSGGRLRPVSLALNYTE
: . : * ::: :****.: :.: :* **:. .:* *.: :.* .
Mb1482c|M.bovis_AF2122/97 AFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWA----
Rv1447c|M.tuberculosis_H37Rv AFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWA----
MAV_3329|M.avium_104 AFAEESPEAYEQLILDVLLGEPSLFPVNAEVELAWHILDPVLDNWA----
MMAR_2252|M.marinum_M AFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALDNWA----
MUL_1842|M.ulcerans_Agy99 AFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPVLDNWA----
Mflv_3694|M.gilvum_PYR-GCK AFAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWEILDPVLENWAQNDD
Mvan_2718|M.vanbaalenii_PYR-1 AFAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWEILDPVLDNWS----
TH_0337|M.thermoresistible__bu AFAEDSPEAYERLILDVLLGEPSLFPVNAEVELSWKILDPILEYWA----
MAB_2761|M.abscessus_ATCC_1997 AFTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPALDFWA----
MSMEG_0314|M.smegmatis_MC2_155 AFPERSPDAYERLLMDVVRGDPTLFMRRDEVEAAWAWAEPILRHWQD---
**.* **:***:*::**: *:*:** . *** :* :* * *
Mb1482c|M.bovis_AF2122/97 AHGTPDAYEAGTWGPESSLEMLRRTGREWRRP----
Rv1447c|M.tuberculosis_H37Rv AHGTPDAYEAGTWGPESSLEMLRRTGREWRRP----
MAV_3329|M.avium_104 SGGRPEPYEAGTWGPDSAFEMLHRTGREWRGHDTQR
MMAR_2252|M.marinum_M SSGKPDPYEAGTWGPESAFEMLRRTGREWRRP----
MUL_1842|M.ulcerans_Agy99 SSGKPDPYEAGTWGPESAFEMLRRTGREWRRP----
Mflv_3694|M.gilvum_PYR-GCK ASAPLDPYVSGTWGPPSANDMVRRLDREWRRP----
Mvan_2718|M.vanbaalenii_PYR-1 AQGRPEPYESGTWGPPSAYDMVHLLDREWRRP----
TH_0337|M.thermoresistible__bu SHGKPDPYEAGTWGPESAFEMLRRTGREWRRP----
MAB_2761|M.abscessus_ATCC_1997 SQGRPDTYESGTWGPQSAVEMLARSGREWRRP----
MSMEG_0314|M.smegmatis_MC2_155 ADRVPRTYPAGTDGPVDAATLIERDGRRWHGGAA--
: .* :** ** .: :: .*.*: