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SSRKLQTISYPASGAHPYRRDEPPLAPFVIVLFGATGDLAKRKLLPGMAYLDQSELAPHIQVVGTSLEDL TDDEFRALAREAVDAHGTHKLTDEQWENFAKILTYVPQSAGPDALAAAVSEAESRLLAGYGSSDAGEVQR LHYLSVPPDAARAVITMLSEADLVRRSRVVMEKPFGTDLESAVGLNKFVHETFKERHIFRIDHFLGKEAA QNILAFRFANGLFEPIWNRNFIDHIQIDIPETLGLDERAGFYESTGAYKDMVVTHLFQVMAFVVMEPPTA LEPRAISEEKNKVFRSMLPIDCSTVVRGQFSGYRELDGVARDSDTETFIALKVGIDNWRWAGVPIYLRTG KRMAEGQRIISIAFKEAPRTMFPAGSGVGSQGPDHLTFDLADASKVSLSFYGKRPGPGMKLEKMSMQFST QETEQSNDVLEAYERLILDAMRGDHTLFTTAEGIESLWERSTDLLVDPPAVKMYQPGTWGPNSIHQLIGP NAWRLPFEREWRELRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4263 | - | - | 100% (507) | glucose-6-phosphate 1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0266 | - | e-101 | 42.83% (474) | glucose-6-phosphate 1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3694 | - | 3e-84 | 37.25% (502) | glucose-6-phosphate 1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1482c | zwf2 | 2e-82 | 37.09% (523) | glucose-6-phosphate 1-dehydrogenase |
| M. tuberculosis H37Rv | Rv1447c | zwf2 | 3e-82 | 37.09% (523) | glucose-6-phosphate 1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2761 | - | 2e-82 | 37.52% (517) | glucose-6-phosphate 1-dehydrogenase |
| M. marinum M | MMAR_2252 | zwf2 | 5e-79 | 35.96% (495) | glucose-6-phosphate 1-dehydrogenase Zwf2 |
| M. avium 104 | MAV_2733 | zwf | 0.0 | 81.03% (506) | glucose-6-phosphate 1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3101 | zwf | 2e-82 | 36.75% (498) | glucose-6-phosphate 1-dehydrogenase |
| M. thermoresistible (build 8) | TH_0337 | zwf2 | 1e-85 | 38.35% (498) | PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 (G6PD) |
| M. ulcerans Agy99 | MUL_1842 | zwf2 | 5e-79 | 35.96% (495) | glucose-6-phosphate 1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2718 | - | 1e-84 | 37.57% (519) | glucose-6-phosphate 1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3101|M.smegmatis_MC2_155 ---------MTAVNDRPDTTWHNPLRDKRDKRMPRIAGPCGVVIFGVTGD
Mvan_2718|M.vanbaalenii_PYR-1 ---------------MPES-WRNPLRDKRDKRMPRIAGPCSVVIFGVTGD
TH_0337|M.thermoresistible__bu MTDPAGFGPVAGLAEPAPPGWRNPLRDKRDKRMPRIAGPCSMVIFGVTGD
Mb1482c|M.bovis_AF2122/97 --------MKPAHA---AASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGD
Rv1447c|M.tuberculosis_H37Rv --------MKPAHA---AASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGD
MMAR_2252|M.marinum_M --------MSPPHSESGVAQWQNPLRDKLDKRLPRIAGSCGMVIFGVTGD
MUL_1842|M.ulcerans_Agy99 --------MSPPHSESGVAQWQNPLRDKLDKRLPRIAGSCGMVIFGVTGD
MAB_2761|M.abscessus_ATCC_1997 ---------MTEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGD
Mflv_4263|M.gilvum_PYR-GCK -----------MSSRKLQTISYPASGAHPYRRDEPPLAPFVIVLFGATGD
MAV_2733|M.avium_104 -----------MATQKPQTISYPAPEARPRRHHTDPLDPHVIVLFGATGD
. . : :: . :*:**.***
MSMEG_3101|M.smegmatis_MC2_155 LARKKLMPAIYDLANRGLLPASFALVGFARRDWEDEDFGQVVYDAVRQHA
Mvan_2718|M.vanbaalenii_PYR-1 LARKKLMPAIYDLANRGLLPPSFALVGFARRDWADEDFGEVVYEAVKKHA
TH_0337|M.thermoresistible__bu LSRKKLMPAIYDLANRGLLPASFSLVGFARRDWADEDFGQVVYEAVKTHA
Mb1482c|M.bovis_AF2122/97 LARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHC
Rv1447c|M.tuberculosis_H37Rv LARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHC
MMAR_2252|M.marinum_M LARKKVMPAIYDLANRGLLPPTFALVGFARRDWDTEDFGQVVYQAVKEHC
MUL_1842|M.ulcerans_Agy99 LARKKVMPAIYDLANRGLLPPTFALVGFARRDWDTEDFGQVVYQAVKEHC
MAB_2761|M.abscessus_ATCC_1997 LARKKLMPAIYDLANRGLLPPSFALVGFARRDWANEDFGQIVLDAVKAHS
Mflv_4263|M.gilvum_PYR-GCK LAKRKLLPGMAYLD-QSELAPHIQVVGTSLEDLTDDEFRALAREAVDAHG
MAV_2733|M.avium_104 LAKRKLIPGLAYLD-QSELAPDIQIVATSLEDLSNDEFRELAKNAIDSFG
*:::*::*.: * :. *.. : :*. : .* ::* :. :*: .
MSMEG_3101|M.smegmatis_MC2_155 RTPFRQEVWDRLAEGIRFVQGTFDDDTAFTRLAETLDKLDIERGTGG---
Mvan_2718|M.vanbaalenii_PYR-1 RTPFRQEVWDRLAEGFRFVQGTFDDDASFDRLSETLEKLDAERGTGG---
TH_0337|M.thermoresistible__bu RTPFRQEVWDRLAEGFRFVQGTFDDDAAFARLTEVLEKLDVQRGTGG---
Mb1482c|M.bovis_AF2122/97 RTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGG---
Rv1447c|M.tuberculosis_H37Rv RTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGG---
MMAR_2252|M.marinum_M RTPFRQANWDRLAEGFRFVSGSFDDDEAFGRLAETLEKLDTERGTGG---
MUL_1842|M.ulcerans_Agy99 RTPFRQANWDRLAEGFRFVSGSFDDDEAFGRLAETLEKLDTERGTGG---
MAB_2761|M.abscessus_ATCC_1997 RTPFRQHVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGG---
Mflv_4263|M.gilvum_PYR-GCK THKLTDEQWENFAKILTYVPQSAGPDALAAAVSEAESRLLAGYGSSDAGE
MAV_2733|M.avium_104 THKLTPDQWRNFADIITYIPQSAGSDALAAAVAEAEAKLGP--------N
: * .:*. : :: : . * : :. *
MSMEG_3101|M.smegmatis_MC2_155 -NHAFYLSIPPNAFPVVCEQLRKSGLAKPRDGRWSRVVIEKPFGHDLGSA
Mvan_2718|M.vanbaalenii_PYR-1 -NHAFYLSIPPNAFPVVCEQLQRSGLARQKDHSWSRVVIEKPFGHDLASA
TH_0337|M.thermoresistible__bu -NHAFYLSIPPKAFPLVCEQLRRSGLARPQPGRWSRVVVEKPFGHDLQSA
Mb1482c|M.bovis_AF2122/97 -NHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASA
Rv1447c|M.tuberculosis_H37Rv -NHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASA
MMAR_2252|M.marinum_M -NHAFYLAIPPKSFPVVCGQLHKSGLARPQGDRWSRVVIEKPFGHDLQSA
MUL_1842|M.ulcerans_Agy99 -NHAFYLAIPPKSFPVVCGQLHKSGLARPQGDRWSRVVIEKPFGHDLQSA
MAB_2761|M.abscessus_ATCC_1997 -NHGFYLSIPPNAFPTVCEQLSKSGLAQPVDGAWRRVVIEKPFGHDLASA
Mflv_4263|M.gilvum_PYR-GCK VQRLHYLSVPPDAARAVITMLSEADLVRR-----SRVVMEKPFGTDLESA
MAV_2733|M.avium_104 VRRLHYLSVPPKAARAVITMLRDAKLVER-----SRVVMEKPFGTDLASA
.: .**::**.: * * : *.. ***:***** ** **
MSMEG_3101|M.smegmatis_MC2_155 RELNSVVNSVFPEESVFRIDHYLGKETVQNILALRFANALYEPIWNNNYV
Mvan_2718|M.vanbaalenii_PYR-1 RELNAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWNAHYV
TH_0337|M.thermoresistible__bu VELNAVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPIWNNHYV
Mb1482c|M.bovis_AF2122/97 RELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYV
Rv1447c|M.tuberculosis_H37Rv RELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYV
MMAR_2252|M.marinum_M RDLNRAVNAVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYV
MUL_1842|M.ulcerans_Agy99 RDLNRAVNAVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYV
MAB_2761|M.abscessus_ATCC_1997 RELNAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFV
Mflv_4263|M.gilvum_PYR-GCK VGLNKFVHETFKERHIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFI
MAV_2733|M.avium_104 VALNDFVHQTFEESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFI
** *: .* * :*****:****:.*****:**** *::*:** :::
MSMEG_3101|M.smegmatis_MC2_155 DHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTALEEPVSFS
Mvan_2718|M.vanbaalenii_PYR-1 DHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALTAMEEPVNFS
TH_0337|M.thermoresistible__bu DHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFH
Mb1482c|M.bovis_AF2122/97 DHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFH
Rv1447c|M.tuberculosis_H37Rv DHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFH
MMAR_2252|M.marinum_M DHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFN
MUL_1842|M.ulcerans_Agy99 DHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFN
MAB_2761|M.abscessus_ATCC_1997 DHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFS
Mflv_4263|M.gilvum_PYR-GCK DHIQIDIPETLGLDERAGFYESTGAYKDMVVTHLFQVMAFVVMEPPTALE
MAV_2733|M.avium_104 DHIQIDIPEALGLDQRASFYEDTGAYKDMVVTHLFQVMAFVVMEPPTALE
**:** :.* :**. **.:*:. ** :*:: .**:*::*:..:* * :
MSMEG_3101|M.smegmatis_MC2_155 PHELQTEKIKILSAVKLAEPLDETTARGQYAAGWQGGEKVVGLLDEEGFA
Mvan_2718|M.vanbaalenii_PYR-1 PHELQAEKIKVLSATRPLQPLDQTTARGQYAAGWQGSEKVPGLLEEGGFA
TH_0337|M.thermoresistible__bu PRQLQAEKIKVLSAVRLAQPLDQTTARGQYTAGWQGGERVVGLLEEEGFA
Mb1482c|M.bovis_AF2122/97 PAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFA
Rv1447c|M.tuberculosis_H37Rv PAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFA
MMAR_2252|M.marinum_M PTALQTEKIKVLSATQLAEPLDETTSRGQYTAGWQGGEKVVGLLDEEGFS
MUL_1842|M.ulcerans_Agy99 PTALQTEKIKVLSATQLAEPLDETTSRGQYTTGWQGGEKVVGLLDEEGFS
MAB_2761|M.abscessus_ATCC_1997 PAELQAEKIKVLSATRLAEPLAETTARGQYGPGWQGSQQVPGLLEEEGFS
Mflv_4263|M.gilvum_PYR-GCK PRAISEEKNKVFRSMLPID--CSTVVRGQFSG----------YRELDGVA
MAV_2733|M.avium_104 PFAISEEKNKVFRSMLPVK--PSNVVRGQYIG----------YREEDGVA
* :. ** *:: : . ... ***: : *.:
MSMEG_3101|M.smegmatis_MC2_155 KDSTTETYAAITLEVNTRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHL
Mvan_2718|M.vanbaalenii_PYR-1 HDSVTETFAAITLEVDTRRWAGVPFFLRTGKRLPRRVTEVALVFKRAPHL
TH_0337|M.thermoresistible__bu KDSTTETFAAITLEIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHL
Mb1482c|M.bovis_AF2122/97 EDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHL
Rv1447c|M.tuberculosis_H37Rv EDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHL
MMAR_2252|M.marinum_M KTSTTETFAAITLEVNSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHL
MUL_1842|M.ulcerans_Agy99 KTSTTETFAAITLEVNSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHL
MAB_2761|M.abscessus_ATCC_1997 KTSTTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHL
Mflv_4263|M.gilvum_PYR-GCK RDSDTETFIALKVGIDNWRWAGVPIYLRTGKRMAEGQRIISIAFKEAPRT
MAV_2733|M.avium_104 KDSDTETFIALKVGIDNWRWAGVPVYLRTGKRMAEGIRIISIAFKEAPRT
. * ***: *:.: ::. ******.:******: . :::.*:.**:
MSMEG_3101|M.smegmatis_MC2_155 PFD-ATMTEELGQNALVIRVQPDEGITLRFGSKVPGSAMEVRDVNMDFSY
Mvan_2718|M.vanbaalenii_PYR-1 PFD-STMTEELGKNALVIRIQPDEGITMRFGSKVPGSAMEVRDVNMDFSY
TH_0337|M.thermoresistible__bu PFD-ATMTEELGQNALVIRIQPDEGVTLRFGSKVPGSAMEVRDVNMDFSY
Mb1482c|M.bovis_AF2122/97 PFD-ATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSY
Rv1447c|M.tuberculosis_H37Rv PFD-ATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSY
MMAR_2252|M.marinum_M PFD-ATMTDELGTNALVIRVQPDEGMTLRFGSKVPGSAMEVRDVNMDFSY
MUL_1842|M.ulcerans_Agy99 PFD-ATMTDELGTNALVIRVQPDEGMTLRFGSKVPGSAMEVRDVNMDFSY
MAB_2761|M.abscessus_ATCC_1997 PFD-STMTEELGANALVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSY
Mflv_4263|M.gilvum_PYR-GCK MFPAGSGVGSQGPDHLTFDLADASKVSLSFYGKRPGPGMKLEKMSMQFST
MAV_2733|M.avium_104 MFPPGSGVGTQGPDHLTFDLADNSRVSLSFYGKRPGPGMKLDKLSMQFST
* .: . * : :.: : . ::: * .* **..*:: .:.*:**
MSMEG_3101|M.smegmatis_MC2_155 GSAFAE-DSPEAYERLILDVLLGEPSLFPVNEEVELSWEILDPVLEYWAQ
Mvan_2718|M.vanbaalenii_PYR-1 GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELSWEILDPVLDNWSA
TH_0337|M.thermoresistible__bu GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELSWKILDPILEYWAS
Mb1482c|M.bovis_AF2122/97 GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAA
Rv1447c|M.tuberculosis_H37Rv GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAA
MMAR_2252|M.marinum_M GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALDNWAS
MUL_1842|M.ulcerans_Agy99 GSAFAE-DSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPVLDNWAS
MAB_2761|M.abscessus_ATCC_1997 EQAFTE-ESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPALDFWAS
Mflv_4263|M.gilvum_PYR-GCK QETEQSNDVLEAYERLILDAMRGDHTLFTTAEGIESLWERSTDLLVDPPA
MAV_2733|M.avium_104 QEIETAVDVLEAYERLILDAMRGDHTLFTTAEGIESLWERSEELLNDPPP
. : *********.: *: :**.. :* *. * .
MSMEG_3101|M.smegmatis_MC2_155 HGKPEPYESGTWGPPSADAMLRR------TGREWRRP--------
Mvan_2718|M.vanbaalenii_PYR-1 QGRPEPYESGTWGPPSAYDMVHL------LDREWRRP--------
TH_0337|M.thermoresistible__bu HGKPDPYEAGTWGPESAFEMLRR------TGREWRRP--------
Mb1482c|M.bovis_AF2122/97 HGTPDAYEAGTWGPESSLEMLRR------TGREWRRP--------
Rv1447c|M.tuberculosis_H37Rv HGTPDAYEAGTWGPESSLEMLRR------TGREWRRP--------
MMAR_2252|M.marinum_M SGKPDPYEAGTWGPESAFEMLRR------TGREWRRP--------
MUL_1842|M.ulcerans_Agy99 SGKPDPYEAGTWGPESAFEMLRR------TGREWRRP--------
MAB_2761|M.abscessus_ATCC_1997 QGRPDTYESGTWGPQSAVEMLAR------SGREWRRP--------
Mflv_4263|M.gilvum_PYR-GCK ---VKMYQPGTWGPNSIHQLIGPNAWRLPFEREWRELRD------
MAV_2733|M.avium_104 ---AKLYQPGTWGPNAIHQLIAPNAWRLPFEREWRDPRPYPGVGG
. *:.***** : :: ****