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VRTHDLVVIGAGSGNMVVDDRFSDLDVAIIDDRKFGGTCVNYGCIPSKMLSYTAQVADTVAAAGDFDIHI DIDADTDTDADFGRLRWAQLRDRVFGRTDAIAADGEQGRRDSDFITVYNGHARFTQPGRLQVAVDGDTVE IAADRIVIAAGSRPVIPDVVAGSGLPYETSDTVMRVDAPPAHLAVLGGGYIAAELAHVFAAAGSRITVIE RSDRLLGGPQDDAVRTTYTELMRSRYNLRCGSQVTEISGAPGALRIRLDDGSIVDADMLLVAAGRRSNSD RLDVAKGDIDTHEDGRVVVDEYCRTTSDGVFALGDVSSEIPLKHVANREAAVVKHNLLHAANLRAVSHEL VPSAVFTHPQIASIGRTEKDCRDENLDYRTGVAEFSDVAYGWAMQDESGLCKVLAAPDGRILGAHVIGPQ AATLVQIFVVALNFGITAAELARRPYWIHPALTEVVENALLALDKDGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0265 | - | - | 100% (468) | mycothione/glutathione reductase |
| M. gilvum PYR-GCK | Mflv_4054 | - | e-109 | 45.09% (468) | mycothione/glutathione reductase |
| M. gilvum PYR-GCK | Mflv_3059 | - | 2e-46 | 27.37% (464) | mercuric reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2880 | mtr | 1e-116 | 47.35% (471) | mycothione reductase |
| M. tuberculosis H37Rv | Rv2855 | mtr | 1e-116 | 47.35% (471) | mycothione reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 4e-42 | 26.56% (482) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0062 | - | 1e-111 | 45.72% (479) | mycothione reductase |
| M. marinum M | MMAR_1875 | mtr | 1e-113 | 45.32% (470) | NADPH-dependent mycothiol reductase Mtr |
| M. avium 104 | MAV_3710 | - | 1e-117 | 47.35% (471) | mycothione/glutathione reductase |
| M. smegmatis MC2 155 | MSMEG_2611 | - | 1e-111 | 45.24% (473) | mycothione/glutathione reductase |
| M. thermoresistible (build 8) | TH_3817 | - | 1e-123 | 48.83% (471) | PUTATIVE pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_2214 | lpd | 2e-41 | 28.06% (474) | dihydrolipoamide dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2298 | - | 1e-109 | 45.40% (467) | mycothione/glutathione reductase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3817|M.thermoresistible__bu MRHFDIAIIGTGSGNSLLDERYADK--KVAICEKAVFG----GTCLNVGC
Mvan_2298|M.vanbaalenii_PYR-1 MADFDIAIIGTGSGNSILDERYVDK--RVAICEEGVFG----GTCLNVGC
Mb2880|M.bovis_AF2122/97 METYDIAIIGTGSGNSILDERYASK--RAAICEQGTFG----GTCLNVGC
Rv2855|M.tuberculosis_H37Rv METYDIAIIGTGSGNSILDERYASK--RAAICEQGTFG----GTCLNVGC
MMAR_1875|M.marinum_M METYDLAIIGTGSGNSILDERYAGK--RAAICEQGTFG----GTCLNVGC
MAV_3710|M.avium_104 METYDLAIIGTGSGNSLLDARFAGK--RTAICEHGTFG----GTCLNVGC
MSMEG_2611|M.smegmatis_MC2_155 MEHYDLAIIGTGSGNSIVDDRYAGK--KVAICEQGTFG----GTCLNVGC
MAB_0062|M.abscessus_ATCC_1997 --MYDLVIIGSGSANSLPDDRFADQ--EIAIVDRGVYGGAYGGTCLNVGC
Mflv_0265|M.gilvum_PYR-GCK MRTHDLVVIGAGSGNMVVDDRFSDL--DVAIIDDRKFG----GTCVNYGC
MLBr_02387|M.leprae_Br4923 MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWG----GICLNVGC
MUL_2214|M.ulcerans_Agy99 MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWG----GVCLNVGC
.*:.::*:*... : * *: : :* * *:* **
TH_3817|M.thermoresistible__bu IPTKMFVYTADVAQTVRDA----------SRFGVDAELRAVRWPDIVSRV
Mvan_2298|M.vanbaalenii_PYR-1 IPTKMFVYAAGVAHDIRES----------SRFGVDSHIDDVRWTDIVSRV
Mb2880|M.bovis_AF2122/97 IPTKMFVYAAEVAKTIRGA----------SRYGIDAHIDRVRWDDVVSRV
Rv2855|M.tuberculosis_H37Rv IPTKMFVYAAEVAKTIRGA----------SRYGIDAHIDRVRWDDVVSRV
MMAR_1875|M.marinum_M LPTKMFVYAAEVAQTIRGA----------SRYGVDAHIDRVRWDDIVSRV
MAV_3710|M.avium_104 IPTKMFVYAADVATTIREA----------ARYGVDAHLDGVRWPDIVSRV
MSMEG_2611|M.smegmatis_MC2_155 IPTKMFVYAAEVAHSVRTS----------ARYGVDAHIDKVRWPDIVERV
MAB_0062|M.abscessus_ATCC_1997 IPTKMFVYPADLADEAREG----------ARLGVDSSVNGTRWGDIRDRV
Mflv_0265|M.gilvum_PYR-GCK IPSKMLSYTAQVADTVAAAGDFDIHIDIDADTDTDADFGRLRWAQLRDRV
MLBr_02387|M.leprae_Br4923 IPSKVLLHNAELAHIFTKE----------AKTFGISGDASFDYGIAYDRS
MUL_2214|M.ulcerans_Agy99 IPSKALLRNAELAHIFTKD----------AKAFGISGEATFDYGVAFDRS
:*:* : * :* : : : .*
TH_3817|M.thermoresistible__bu FGRIDPIAASGENYRRSS-PNVEVFDTHTRFGEP----LGDGRYVLRTE-
Mvan_2298|M.vanbaalenii_PYR-1 FGRIDPLASGGEHYRRSS-PNVEVFASHARFVPG----SGDG-YRLCTA-
Mb2880|M.bovis_AF2122/97 FGRIDPIALSGEDYRRCA-PNIDVYRTHTRFGPV----QADGRYLLRTD-
Rv2855|M.tuberculosis_H37Rv FGRIDPIALSGEDYRRCA-PNIDVYRTHTRFGPV----QADGRYLLRTD-
MMAR_1875|M.marinum_M FGRIDPIAHSGEDYRRSA-PNIDVYGSHTRFGPT----QADGRYLLRTA-
MAV_3710|M.avium_104 FGRIDPIALSGEEYRRSS-VNIDLYRSHTRFGPV----QSDGRYLLRTD-
MSMEG_2611|M.smegmatis_MC2_155 FGRIDPIAAGGEDYRRSD-PNITVYSSHTRFGPK----TDDGRYTLRTE-
MAB_0062|M.abscessus_ATCC_1997 FGRIDPIAAAGLRYRVEDCPNITVFQQEARFIEPGTDADGDSVHRLKLG-
Mflv_0265|M.gilvum_PYR-GCK FGRTDAIAADGEQGRRDS-DFITVYNGHARFTQP-------GRLQVAVDG
MLBr_02387|M.leprae_Br4923 R-KVSEGRVAGVHFLMKK-NKITEIHGYGRFTDAN---TLSVELSEGVPE
MUL_2214|M.ulcerans_Agy99 R-KVAEGRVAGVHFLMKK-NKITEIHGYGKFTDAN---TLSVDLNDGGTE
: * : :*
TH_3817|M.thermoresistible__bu AGEEFSADQVVIAAGSRAVVPEAIAACGVPYHTSDTIMRIAAIPEHLIIV
Mvan_2298|M.vanbaalenii_PYR-1 DGDEFTAEQVVIAAGARATVPPAIADCGVKFHTSDTIMRISELPEHLVIV
Mb2880|M.bovis_AF2122/97 AGEEFTAEQVVIAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIV
Rv2855|M.tuberculosis_H37Rv AGEEFTAEQVVIAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIV
MMAR_1875|M.marinum_M AGDEFTADQVVIAAGSRPVVPQAIAESGLKYHTSDTVMRIAELPEHVVIV
MAV_3710|M.avium_104 AGEQFTAEQVVIAAGSRPVIPPAILESGVTYHTSDTIMRIPALPEHLVIV
MSMEG_2611|M.smegmatis_MC2_155 SGEEFTSDQVVIAAGSRTYIPPAVVDCGVKYHTSDDIMRIPELPTDLVII
MAB_0062|M.abscessus_ATCC_1997 DGTVLEARQVVIAAGSRPVIPPVIAASGVPYHTNDDIMRLPELPGRVLIV
Mflv_0265|M.gilvum_PYR-GCK DTVEIAADRIVIAAGSRPVIPDVVAGSGLPYETSDTVMRVDAPPAHLAVL
MLBr_02387|M.leprae_Br4923 TPLKVTFNNVIIATGSKTRLVPGTLLS-TNVITYEEQILTRELPDSIVIV
MUL_2214|M.ulcerans_Agy99 ---KVTFDNAIIATGSSTRLVPGTSLS-TNVVTYEEQILTRELPKSIIIA
. . :**:*: . : . * : : * : :
TH_3817|M.thermoresistible__bu GGGFVAAEFAHVFSALGSRVSIIIRGNTLLR-GHDDDITTRFTDLAAKKW
Mvan_2298|M.vanbaalenii_PYR-1 GGGFVAAEFAHVFSSLGSRVTIVLRGTTMLS-HCDDTVCERFTDIAGKKW
Mb2880|M.bovis_AF2122/97 GSGFIAAEFAHVFSALGVRVTLVIRGSCLLR-HCDDTICERFTRIASTKW
Rv2855|M.tuberculosis_H37Rv GSGFIAAEFAHVFSALGVRVTLVIRGSCLLR-HCDDTICERFTRIASTKW
MMAR_1875|M.marinum_M GSGFVAAEFAHVFSTLGARVTLVIRGSCLLR-HCDDTICERFTRIASTKW
MAV_3710|M.avium_104 GSGFVAAEFAHIFSALGVHVTVVIRSGRMLR-QYDDMICERFTRLAAAKW
MSMEG_2611|M.smegmatis_MC2_155 GGGFVSAEFAHVFSALGVHVTIVVRGDGLLT-HCDETICHRFNEIAATKW
MAB_0062|M.abscessus_ATCC_1997 GSGFIAAEFAHVFSGLGSKVTVIARGPRLLR-AQDETISRRFTEIVGQRW
Mflv_0265|M.gilvum_PYR-GCK GGGYIAAELAHVFAAAGSRITVIERSDRLLGGPQDDAVRTTYTELMRSRY
MLBr_02387|M.leprae_Br4923 GAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGI
MUL_2214|M.ulcerans_Agy99 GAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDAEVSKEIERQFKKLGV
*.* :. *:.::: * :::: : : :
TH_3817|M.thermoresistible__bu EIHGQREVVDARALDGG-VEVRCDDGS--TLRGDVLLVATGRVPNGDLLD
Mvan_2298|M.vanbaalenii_PYR-1 EIRSRRNVVGGQSDESG-LTLRLDDDS--TVHADALLVATGRVPNGDLLD
Mb2880|M.bovis_AF2122/97 ELRTHRNVVDGQQRGSG-VALRLDDGC--TINADLLLVATGRVSNADLLD
Rv2855|M.tuberculosis_H37Rv ELRTHRNVVDGQQRGSG-VALRLDDGC--TINADLLLVATGRVSNADLLD
MMAR_1875|M.marinum_M ELRTHRNIVGGENRGSG-VVLQLDDGS--TIDADLLLVATGRVSNADLID
MAV_3710|M.avium_104 ELRTQRNVVGGNNRGSG-VTLRLDDGS--TLDADVLLVATGRISNADLLD
MSMEG_2611|M.smegmatis_MC2_155 DIRTHENVIGSHQDGDR-IVLELDDGK--TVAADTLLVATGRVPNGDLLD
MAB_0062|M.abscessus_ATCC_1997 DVRLNTEAVGLRETGSGGVEVDLSDGS--TVTGDVLLVATGRTPNGDQLD
Mflv_0265|M.gilvum_PYR-GCK NLRCGSQVTEISG-APGALRIRLDDGS--IVDADMLLVAAGRRSNSDRLD
MLBr_02387|M.leprae_Br4923 KILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYG
MUL_2214|M.ulcerans_Agy99 KIRTGTKVESISDDGSAVTVVVSKGGKSEELKADKVLQAIGFAPNVEGYG
.: : ... : .* :* * * .* : .
TH_3817|M.thermoresistible__bu AELAGVQVREHGQVVVDEYQRTTARGIYALGDVSSDHQLKHVANHEARVV
Mvan_2298|M.vanbaalenii_PYR-1 AHHAGVEVAD-GLVVVDEFQRTTARNIFALGDVSSPYQLKHVANHEARVV
Mb2880|M.bovis_AF2122/97 AEQAGVDVE-DGRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVV
Rv2855|M.tuberculosis_H37Rv AEQAGVDVE-DGRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVV
MMAR_1875|M.marinum_M AEQAGVAVA-DGRVVVDQYQRTSARGVFALGDVSSPYQLKHVANHEARVV
MAV_3710|M.avium_104 AGQAGVDVE-NGRVVVDEYQRTSARGVFALGDVSSPYQLKHVANHEARVV
MSMEG_2611|M.smegmatis_MC2_155 AELAGVEVDEDGRVIVDQYQRTTARGVFALGDVSSDYQLKHVANHEARVV
MAB_0062|M.abscessus_ATCC_1997 VAAAGLTLDAKGSVPVDQYQRTAVRGIYALGDVSSKYLLKHVANHEARVV
Mflv_0265|M.gilvum_PYR-GCK VAKGDIDTHEDGRVVVDEYCRTTSDGVFALGDVSSEIPLKHVANREAAVV
MLBr_02387|M.leprae_Br4923 LDKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVA
MUL_2214|M.ulcerans_Agy99 LDKAGVALTDRKAIGIGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVA
.: : :.:: :* ::*:***:. * ***: . *.
TH_3817|M.thermoresistible__bu KHNLLQDWDDTAALAASDHRYVPSAVFTDPQIASVGLTENEARSRGLPIK
Mvan_2298|M.vanbaalenii_PYR-1 RHNLLQGWDDTENLMPANHRNVPSAVFTEPQIACVGLTENEARSAGYRIR
Mb2880|M.bovis_AF2122/97 QHNLLCDWEDTQSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDIS
Rv2855|M.tuberculosis_H37Rv QHNLLCDWEDTQSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDIS
MMAR_1875|M.marinum_M QQNLLCDWDDTESMAVTDHRFVPAAVFTGPQLAGVGLTENEAVAKGLDIT
MAV_3710|M.avium_104 RHNLLCDWDDTESMAVTDHRYVPSAVFTDPQLATVGLTENQAIARGFDIS
MSMEG_2611|M.smegmatis_MC2_155 KENLLRDWDDTASLVASDHRFVPSAVFTDPQVATVGLTEAEARAAGHDIV
MAB_0062|M.abscessus_ATCC_1997 QANLLSGWDSPT--TASDHRYVPGAVFTRPQVASVGLSEEQARERGLDIA
Mflv_0265|M.gilvum_PYR-GCK KHNLLH----AANLRAVSHELVPSAVFTHPQIASIGRTEKDCRDENLDYR
MLBr_02387|M.leprae_Br4923 AEAIAG----AETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVV
MUL_2214|M.ulcerans_Agy99 AETIAG----AETLPLGDYRMLPRATFCQPQVASFGLTEQQARDEGYDVK
: . .:. :* *.* *::* .* :* :. .
TH_3817|M.thermoresistible__bu VKIQDYSDVAYGWAMEDTTGFVKVIVDDSTGLIAGAHIMGHQAASLIQPL
Mvan_2298|M.vanbaalenii_PYR-1 SKVQDYGDVAYGWAMEDSTGFAKLIVDDDTGLLLGAHIMGHQASSIIQPI
Mb2880|M.bovis_AF2122/97 VKIQDYGDVAYGWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPL
Rv2855|M.tuberculosis_H37Rv VKIQDYGDVAYGWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPL
MMAR_1875|M.marinum_M VAIQEYADVGYGWAMEDTTGFVKLVGDRATGRLLGAHIMGYHASTVIQPL
MAV_3710|M.avium_104 VAIQNYGDVAYGWAMEDTTGVVKLIAERTSGRLLGAHIMGPQASSIIQPL
MSMEG_2611|M.smegmatis_MC2_155 VKVQNYGDTAYGWAMEDTTGIAKLIGERGTGKLLGAHILGHQASSIIQPL
MAB_0062|M.abscessus_ATCC_1997 VKVQTYGDIAYGWAMEDTEGLCKLIADRATGLLVGAHIIGYQASALIQSL
Mflv_0265|M.gilvum_PYR-GCK TGVAEFSDVAYGWAMQDESGLCKVLAAPD-GRILGAHVIGPQAATLVQIF
MLBr_02387|M.leprae_Br4923 VAKFPFTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLPEL
MUL_2214|M.ulcerans_Agy99 VAKFPFTANGKAHGLGDPSGFVKLVADGKHGELLGGHLVGHDVSELLPEL
: . . .: * *. *:: * : *.*::* ..: :: :
TH_3817|M.thermoresistible__bu IQAMSFGLPARDMARGQYWIHPALPEVVENALLALCGEPPWPPAKRH
Mvan_2298|M.vanbaalenii_PYR-1 VQAMAFDLPAQDMARGQYWIHPALPEVVENALLALCGEPPWPPSKRH
Mb2880|M.bovis_AF2122/97 IQAMSFGLTAAEMARGQYWIHPALPEVVENALLGLR-----------
Rv2855|M.tuberculosis_H37Rv IQAMSFGLTAAEMARGQYWIHPALPEVVENALLGLR-----------
MMAR_1875|M.marinum_M IQAMSFGLTAAEMARGQYWIHPALPEVIENALLNLR-----------
MAV_3710|M.avium_104 IQAMSFGLTAAQMARGQYWIHPALPEVVENALLGLY-----------
MSMEG_2611|M.smegmatis_MC2_155 IQAMSLGQTAQEIARGQYWIHPALPEVIENALLGLQE----------
MAB_0062|M.abscessus_ATCC_1997 ITAMSFSIPAREMARGQYWIHPALPELVENALLGLDL----------
Mflv_0265|M.gilvum_PYR-GCK VVALNFGITAAELARRPYWIHPALTEVVENALLALDKDGS-------
MLBr_02387|M.leprae_Br4923 TLAQKWDLTATELVR-NVHTHPTLSEALQECFHGLIGHMINF-----
MUL_2214|M.ulcerans_Agy99 TLAQKWDLTATELAR-NVHTHPTMSEALQECFHGLAGHMINF-----
* . .* ::.* **::.* :::.: *