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ADFDIAIIGTGSGNSILDERYVDKRVAICEEGVFGGTCLNVGCIPTKMFVYAAGVAHDIRESSRFGVDSH IDDVRWTDIVSRVFGRIDPLASGGEHYRRSSPNVEVFASHARFVPGSGDGYRLCTADGDEFTAEQVVIAA GARATVPPAIADCGVKFHTSDTIMRISELPEHLVIVGGGFVAAEFAHVFSSLGSRVTIVLRGTTMLSHCD DTVCERFTDIAGKKWEIRSRRNVVGGQSDESGLTLRLDDDSTVHADALLVATGRVPNGDLLDAHHAGVEV ADGLVVVDEFQRTTARNIFALGDVSSPYQLKHVANHEARVVRHNLLQGWDDTENLMPANHRNVPSAVFTE PQIACVGLTENEARSAGYRIRSKVQDYGDVAYGWAMEDSTGFAKLIVDDDTGLLLGAHIMGHQASSIIQP IVQAMAFDLPAQDMARGQYWIHPALPEVVENALLALCGEPPWPPSKRH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2298 | - | - | 100% (469) | mycothione/glutathione reductase |
| M. vanbaalenii PYR-1 | Mvan_3468 | - | 3e-46 | 30.21% (470) | mercuric reductase |
| M. vanbaalenii PYR-1 | Mvan_0794 | - | 6e-42 | 28.78% (469) | dihydrolipoamide dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2880 | mtr | 0.0 | 69.87% (458) | mycothione reductase |
| M. gilvum PYR-GCK | Mflv_4054 | - | 0.0 | 88.51% (470) | mycothione/glutathione reductase |
| M. tuberculosis H37Rv | Rv2855 | mtr | 0.0 | 69.87% (458) | mycothione reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 7e-44 | 29.30% (471) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0062 | - | 1e-146 | 56.87% (466) | mycothione reductase |
| M. marinum M | MMAR_1875 | mtr | 0.0 | 70.31% (458) | NADPH-dependent mycothiol reductase Mtr |
| M. avium 104 | MAV_3710 | - | 0.0 | 69.43% (458) | mycothione/glutathione reductase |
| M. smegmatis MC2 155 | MSMEG_2611 | - | 0.0 | 69.74% (456) | mycothione/glutathione reductase |
| M. thermoresistible (build 8) | TH_3817 | - | 0.0 | 72.82% (471) | PUTATIVE pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_2214 | lpd | 8e-43 | 28.66% (471) | dihydrolipoamide dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2298|M.vanbaalenii_PYR-1 MADFDIAIIGTGSGNSILDERYVDK--RVAICEEGVFG----GTCLNVGC
Mflv_4054|M.gilvum_PYR-GCK MADFDLAIIGTGSGNSILDERYVDK--RVAICEQGVFG----GTCLNVGC
TH_3817|M.thermoresistible__bu MRHFDIAIIGTGSGNSLLDERYADK--KVAICEKAVFG----GTCLNVGC
Mb2880|M.bovis_AF2122/97 METYDIAIIGTGSGNSILDERYASK--RAAICEQGTFG----GTCLNVGC
Rv2855|M.tuberculosis_H37Rv METYDIAIIGTGSGNSILDERYASK--RAAICEQGTFG----GTCLNVGC
MMAR_1875|M.marinum_M METYDLAIIGTGSGNSILDERYAGK--RAAICEQGTFG----GTCLNVGC
MAV_3710|M.avium_104 METYDLAIIGTGSGNSLLDARFAGK--RTAICEHGTFG----GTCLNVGC
MSMEG_2611|M.smegmatis_MC2_155 MEHYDLAIIGTGSGNSIVDDRYAGK--KVAICEQGTFG----GTCLNVGC
MAB_0062|M.abscessus_ATCC_1997 --MYDLVIIGSGSANSLPDDRFADQ--EIAIVDRGVYGGAYGGTCLNVGC
MLBr_02387|M.leprae_Br4923 MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWG----GICLNVGC
MUL_2214|M.ulcerans_Agy99 MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWG----GVCLNVGC
:*:.::*:*... : * . *: : :* * ******
Mvan_2298|M.vanbaalenii_PYR-1 IPTKMFVYAAGVAHDIRESSRFGVDSHIDDVRWTDIVSRVFGRIDPLASG
Mflv_4054|M.gilvum_PYR-GCK IPTKMFVYAAGVAEQIRESARFGVDGRLDGVRWPDIVSRVFGRIDPLAGG
TH_3817|M.thermoresistible__bu IPTKMFVYTADVAQTVRDASRFGVDAELRAVRWPDIVSRVFGRIDPIAAS
Mb2880|M.bovis_AF2122/97 IPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALS
Rv2855|M.tuberculosis_H37Rv IPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALS
MMAR_1875|M.marinum_M LPTKMFVYAAEVAQTIRGASRYGVDAHIDRVRWDDIVSRVFGRIDPIAHS
MAV_3710|M.avium_104 IPTKMFVYAADVATTIREAARYGVDAHLDGVRWPDIVSRVFGRIDPIALS
MSMEG_2611|M.smegmatis_MC2_155 IPTKMFVYAAEVAHSVRTSARYGVDAHIDKVRWPDIVERVFGRIDPIAAG
MAB_0062|M.abscessus_ATCC_1997 IPTKMFVYPADLADEAREGARLGVDSSVNGTRWGDIRDRVFGRIDPIAAA
MLBr_02387|M.leprae_Br4923 IPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSR-KVSEGRVA
MUL_2214|M.ulcerans_Agy99 IPSKALLRNAELAHIFTKDAKAFGISGEATFDYGVAFDRSR-KVAEGRVA
:*:* :: * :* :: . : .* :: .
Mvan_2298|M.vanbaalenii_PYR-1 GEHYRRS-SPNVEVFASHARFV-PGSGDG----YRLCTADGDEFTAEQVV
Mflv_4054|M.gilvum_PYR-GCK GEQYRRS-SPNVEVFASHTRFAGPDSGDG----YRLHTDDGDEFTAEQVV
TH_3817|M.thermoresistible__bu GENYRRS-SPNVEVFDTHTRFGEPLGDGR----YVLRTEAGEEFSADQVV
Mb2880|M.bovis_AF2122/97 GEDYRRC-APNIDVYRTHTRFGPVQADGR----YLLRTDAGEEFTAEQVV
Rv2855|M.tuberculosis_H37Rv GEDYRRC-APNIDVYRTHTRFGPVQADGR----YLLRTDAGEEFTAEQVV
MMAR_1875|M.marinum_M GEDYRRS-APNIDVYGSHTRFGPTQADGR----YLLRTAAGDEFTADQVV
MAV_3710|M.avium_104 GEEYRRS-SVNIDLYRSHTRFGPVQSDGR----YLLRTDAGEQFTAEQVV
MSMEG_2611|M.smegmatis_MC2_155 GEDYRRS-DPNITVYSSHTRFGPKTDDGR----YTLRTESGEEFTSDQVV
MAB_0062|M.abscessus_ATCC_1997 GLRYRVEDCPNITVFQQEARFIEPGTDADGDSVHRLKLGDGTVLEARQVV
MLBr_02387|M.leprae_Br4923 GVHFLMK-KNKITEIHGYGRFTDANTLSVELS--EGVPETPLKVTFNNVI
MUL_2214|M.ulcerans_Agy99 GVHFLMK-KNKITEIHGYGKFTDANTLSVDLN--DGGTE---KVTFDNAI
* : :: :* . :.:
Mvan_2298|M.vanbaalenii_PYR-1 IAAGARATVPPAIADCGVKFHTSDTIMRISELPEHLVIVGGGFVAAEFAH
Mflv_4054|M.gilvum_PYR-GCK IAAGARATVPQAILECGVPYHTSDTIMRISDLPEHLVIVGGGFVAAEFAH
TH_3817|M.thermoresistible__bu IAAGSRAVVPEAIAACGVPYHTSDTIMRIAAIPEHLIIVGGGFVAAEFAH
Mb2880|M.bovis_AF2122/97 IAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAH
Rv2855|M.tuberculosis_H37Rv IAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAH
MMAR_1875|M.marinum_M IAAGSRPVVPQAIAESGLKYHTSDTVMRIAELPEHVVIVGSGFVAAEFAH
MAV_3710|M.avium_104 IAAGSRPVIPPAILESGVTYHTSDTIMRIPALPEHLVIVGSGFVAAEFAH
MSMEG_2611|M.smegmatis_MC2_155 IAAGSRTYIPPAVVDCGVKYHTSDDIMRIPELPTDLVIIGGGFVSAEFAH
MAB_0062|M.abscessus_ATCC_1997 IAAGSRPVIPPVIAASGVPYHTNDDIMRLPELPGRVLIVGSGFIAAEFAH
MLBr_02387|M.leprae_Br4923 IATGSKTRLVPGTLLS-TNVITYEEQILTRELPDSIVIVGAGAIGIEFGY
MUL_2214|M.ulcerans_Agy99 IATGSSTRLVPGTSLS-TNVVTYEEQILTRELPKSIIIAGAGAIGMEFGY
**:*: . : . * : : :* ::* *.* :. **.:
Mvan_2298|M.vanbaalenii_PYR-1 VFSSLGSRVTIVLRGTTMLSHCDDTVCERFTDIAGKK-WEIRSRRNVVGG
Mflv_4054|M.gilvum_PYR-GCK VFSALGSRVTIVLRGTTMLSHCDDTVCERFTDIAGKK-WEIRSRRNIVSG
TH_3817|M.thermoresistible__bu VFSALGSRVSIIIRGNTLLRGHDDDITTRFTDLAAKK-WEIHGQREVVDA
Mb2880|M.bovis_AF2122/97 VFSALGVRVTLVIRGSCLLRHCDDTICERFTRIASTK-WELRTHRNVVDG
Rv2855|M.tuberculosis_H37Rv VFSALGVRVTLVIRGSCLLRHCDDTICERFTRIASTK-WELRTHRNVVDG
MMAR_1875|M.marinum_M VFSTLGARVTLVIRGSCLLRHCDDTICERFTRIASTK-WELRTHRNIVGG
MAV_3710|M.avium_104 IFSALGVHVTVVIRSGRMLRQYDDMICERFTRLAAAK-WELRTQRNVVGG
MSMEG_2611|M.smegmatis_MC2_155 VFSALGVHVTIVVRGDGLLTHCDETICHRFNEIAATK-WDIRTHENVIGS
MAB_0062|M.abscessus_ATCC_1997 VFSGLGSKVTVIARGPRLLRAQDETISRRFTEIVGQR-WDVRLNTEAVGL
MLBr_02387|M.leprae_Br4923 VLKNYGVDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESI
MUL_2214|M.ulcerans_Agy99 VLKNYGVDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESI
::. * *::: : * : .: .: : .
Mvan_2298|M.vanbaalenii_PYR-1 QSDESG-LTLRLDDDS--TVHADALLVATGRVPNGDLLDAHHAGVEVAD-
Mflv_4054|M.gilvum_PYR-GCK ESDGSG-VSLRLDDGA--TLRADVLLVATGRVPNGDRLDAHLAGVEVTD-
TH_3817|M.thermoresistible__bu RALDGG-VEVRCDDGS--TLRGDVLLVATGRVPNGDLLDAELAGVQVREH
Mb2880|M.bovis_AF2122/97 QQRGSG-VALRLDDGC--TINADLLLVATGRVSNADLLDAEQAGVDVE-D
Rv2855|M.tuberculosis_H37Rv QQRGSG-VALRLDDGC--TINADLLLVATGRVSNADLLDAEQAGVDVE-D
MMAR_1875|M.marinum_M ENRGSG-VVLQLDDGS--TIDADLLLVATGRVSNADLIDAEQAGVAVA-D
MAV_3710|M.avium_104 NNRGSG-VTLRLDDGS--TLDADVLLVATGRISNADLLDAGQAGVDVE-N
MSMEG_2611|M.smegmatis_MC2_155 HQDGDR-IVLELDDGK--TVAADTLLVATGRVPNGDLLDAELAGVEVDED
MAB_0062|M.abscessus_ATCC_1997 RETGSGGVEVDLSDGS--TVTGDVLLVATGRTPNGDQLDVAAAGLTLDAK
MLBr_02387|M.leprae_Br4923 SDNGSHVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTAD
MUL_2214|M.ulcerans_Agy99 SDDGSAVTVVVSKGGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDR
. ... : .* :* * * .* : . .*: :
Mvan_2298|M.vanbaalenii_PYR-1 GLVVVDEFQRTTARNIFALGDVSSPYQLKHVANHEARVVRHNLLQGWDDT
Mflv_4054|M.gilvum_PYR-GCK GLVTVDEFQRTTARNVFALGDVSSPYQLKHVANHEARVVKHNLLQDWDDT
TH_3817|M.thermoresistible__bu GQVVVDEYQRTTARGIYALGDVSSDHQLKHVANHEARVVKHNLLQDWDDT
Mb2880|M.bovis_AF2122/97 GRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDT
Rv2855|M.tuberculosis_H37Rv GRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDT
MMAR_1875|M.marinum_M GRVVVDQYQRTSARGVFALGDVSSPYQLKHVANHEARVVQQNLLCDWDDT
MAV_3710|M.avium_104 GRVVVDEYQRTSARGVFALGDVSSPYQLKHVANHEARVVRHNLLCDWDDT
MSMEG_2611|M.smegmatis_MC2_155 GRVIVDQYQRTTARGVFALGDVSSDYQLKHVANHEARVVKENLLRDWDDT
MAB_0062|M.abscessus_ATCC_1997 GSVPVDQYQRTAVRGIYALGDVSSKYLLKHVANHEARVVQANLLSGWDSP
MLBr_02387|M.leprae_Br4923 KAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIAG----A
MUL_2214|M.ulcerans_Agy99 KAIGIGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIAG----A
: :.:: :* . ::*:***:. * ***: . *. : .
Mvan_2298|M.vanbaalenii_PYR-1 ENLMPANHRNVPSAVFTEPQIACVGLTENEARSAGYRIRSKVQDYGDVAY
Mflv_4054|M.gilvum_PYR-GCK EALMPANHDNVPSAVFTEPQIACVGLTENEARAAGYRIRSKVQDYGDVAY
TH_3817|M.thermoresistible__bu AALAASDHRYVPSAVFTDPQIASVGLTENEARSRGLPIKVKIQDYSDVAY
Mb2880|M.bovis_AF2122/97 QSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAY
Rv2855|M.tuberculosis_H37Rv QSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAY
MMAR_1875|M.marinum_M ESMAVTDHRFVPAAVFTGPQLAGVGLTENEAVAKGLDITVAIQEYADVGY
MAV_3710|M.avium_104 ESMAVTDHRYVPSAVFTDPQLATVGLTENQAIARGFDISVAIQNYGDVAY
MSMEG_2611|M.smegmatis_MC2_155 ASLVASDHRFVPSAVFTDPQVATVGLTEAEARAAGHDIVVKVQNYGDTAY
MAB_0062|M.abscessus_ATCC_1997 T--TASDHRYVPGAVFTRPQVASVGLSEEQARERGLDIAVKVQTYGDIAY
MLBr_02387|M.leprae_Br4923 ETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAK
MUL_2214|M.ulcerans_Agy99 ETLPLGDYRMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGK
:: :* *.* *::* .**:* :* * : : .
Mvan_2298|M.vanbaalenii_PYR-1 GWAMEDSTGFAKLIVDDDTGLLLGAHIMGHQASSIIQPIVQAMAFDLPAQ
Mflv_4054|M.gilvum_PYR-GCK GWAMEDSTGFAKLIVDDETGLLLGAHIMGHQASSIIQPLIQAMAFGLPAQ
TH_3817|M.thermoresistible__bu GWAMEDTTGFVKVIVDDSTGLIAGAHIMGHQAASLIQPLIQAMSFGLPAR
Mb2880|M.bovis_AF2122/97 GWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAA
Rv2855|M.tuberculosis_H37Rv GWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAA
MMAR_1875|M.marinum_M GWAMEDTTGFVKLVGDRATGRLLGAHIMGYHASTVIQPLIQAMSFGLTAA
MAV_3710|M.avium_104 GWAMEDTTGVVKLIAERTSGRLLGAHIMGPQASSIIQPLIQAMSFGLTAA
MSMEG_2611|M.smegmatis_MC2_155 GWAMEDTTGIAKLIGERGTGKLLGAHILGHQASSIIQPLIQAMSLGQTAQ
MAB_0062|M.abscessus_ATCC_1997 GWAMEDTEGLCKLIADRATGLLVGAHIIGYQASALIQSLITAMSFSIPAR
MLBr_02387|M.leprae_Br4923 AHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTAT
MUL_2214|M.ulcerans_Agy99 AHGLGDPSGFVKLVADGKHGELLGGHLVGHDVSELLPELTLAQKWDLTAT
. .: *. *. *:: : * : *.*::* ..: :: : * . .*
Mvan_2298|M.vanbaalenii_PYR-1 DMARGQYWIHPALPEVVENALLALCGEPPWPPSKRH
Mflv_4054|M.gilvum_PYR-GCK DMARGQYWIHPALPEVVENALLSLCGEPPWPRPRRH
TH_3817|M.thermoresistible__bu DMARGQYWIHPALPEVVENALLALCGEPPWPPAKRH
Mb2880|M.bovis_AF2122/97 EMARGQYWIHPALPEVVENALLGLR-----------
Rv2855|M.tuberculosis_H37Rv EMARGQYWIHPALPEVVENALLGLR-----------
MMAR_1875|M.marinum_M EMARGQYWIHPALPEVIENALLNLR-----------
MAV_3710|M.avium_104 QMARGQYWIHPALPEVVENALLGLY-----------
MSMEG_2611|M.smegmatis_MC2_155 EIARGQYWIHPALPEVIENALLGLQE----------
MAB_0062|M.abscessus_ATCC_1997 EMARGQYWIHPALPELVENALLGLDL----------
MLBr_02387|M.leprae_Br4923 ELVR-NVHTHPTLSEALQECFHGLIGHMINF-----
MUL_2214|M.ulcerans_Agy99 ELAR-NVHTHPTMSEALQECFHGLAGHMINF-----
::.* : **::.* :::.: *