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AVGGVLFDIDGVLVTSWKPIPGAAETLRTLADNQIACTYLTNTTTRTRSQIADLLTEAGMAVRADEVITA AVLTADYVRDRYPDARCFLVNSGQIAEDMPGIDIVYSSEFTGPRAPERPDVVLLGGAGPEYSHLTLSWVY DWMAQGVPVVAMHRSTAWTTVDGLRVDTGMYLIGMEQTSGRKAAAVGKPAPEGFLSAANRLGVDPEEMFI VGDDLNNDVLAGQVVGMTGVLVRTGKFRQDTLDRWAADEFAMQPNHVIDSIADLPALLGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0147 | - | - | 100% (271) | Fis family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3511 | - | 5e-14 | 24.46% (233) | HAD family hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1257c | - | 1e-103 | 66.30% (270) | hypothetical protein Mb1257c |
| M. tuberculosis H37Rv | Rv1225c | - | 1e-103 | 66.30% (270) | hypothetical protein Rv1225c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0641 | - | 2e-99 | 65.43% (269) | HAD-superfamily hydrolase |
| M. marinum M | MMAR_2497 | - | 4e-12 | 21.99% (241) | phosphatase |
| M. avium 104 | MAV_3079 | - | 6e-12 | 25.31% (241) | HAD-superfamily protein hydrolase, subfamily protein IIA |
| M. smegmatis MC2 155 | MSMEG_0867 | - | 1e-137 | 85.98% (271) | hydrolase |
| M. thermoresistible (build 8) | TH_1551 | - | 2e-15 | 26.27% (236) | PROBABLE PHOSPHATASE |
| M. ulcerans Agy99 | MUL_1681 | - | 1e-12 | 21.99% (241) | phosphatase |
| M. vanbaalenii PYR-1 | Mvan_0756 | - | 1e-148 | 93.36% (271) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0147|M.gilvum_PYR-GCK --------MAVGGVLFDIDGVLVTSWKPIPGAAETLRTLADNQIACTYLT
Mvan_0756|M.vanbaalenii_PYR-1 --------MAIGGVLFDIDGVLVTSWKPIPGAAETLRTLADNQIACAYLT
MSMEG_0867|M.smegmatis_MC2_155 --------MAIGGVLFDIDGVLVTSWQPIEGAAQTLRVLADNQIARSYLT
Mb1257c|M.bovis_AF2122/97 ---MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACAYLT
Rv1225c|M.tuberculosis_H37Rv ---MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACAYLT
MAB_0641|M.abscessus_ATCC_1997 --------MTVGGVLFDIDGVLVTSWEPIDGAAQALKALENDDIRRCFLT
MMAR_2497|M.marinum_M ---MKNIAQEYDCLLIDLDGTVFRGSQPTEGAVESLDEVTAR---KLFVT
MUL_1681|M.ulcerans_Agy99 ---MKNIAQEYDCLLIDLDGTVFRGSQPTEGAVESLDEVTAR---KLFVT
MAV_3079|M.avium_104 MSGVKTLAQQHDCLLIDLDGTAFRGRSPTEGAVQALARLPGR---ALFVT
TH_1551|M.thermoresistible__bu ---VNSVAQHHDCLLLDLDGTVFRGHEPTPGAVESLRTVAAR---TLYVT
:*:*:**. . . . **.::: : ::*
Mflv_0147|M.gilvum_PYR-GCK NTTTRTRSQIADLLTEAGMAVRADEVITAAVLTADYVRDRYP-DARCFLV
Mvan_0756|M.vanbaalenii_PYR-1 NTTTRTRVQIADLLTEAGMAVRADEVITAAVLTADYVRDRYP-DARCFLV
MSMEG_0867|M.smegmatis_MC2_155 NTTTKTRVQIAELLTAAGMDVSPDEVITAAVLTAEYVRDRFP-GARCFLV
Mb1257c|M.bovis_AF2122/97 NTTTRTRRQIAEALGAAGIPVAADDVITAGVLTAEYLHGAYP-GARCFLV
Rv1225c|M.tuberculosis_H37Rv NTTTRTRRQIAEALGAAGIPVAADDVITAGVLTAEYLHGAYP-GARCFLV
MAB_0641|M.abscessus_ATCC_1997 NTTSRTRVQIAELLSAAGLAVPADEVITAAMLTADHVITQHP-GARCYLL
MMAR_2497|M.marinum_M NNASRSAGEVAVHLRELGFTATSEDVVTSAQSAAHLLAAALPPGSKVLVV
MUL_1681|M.ulcerans_Agy99 NNASRSAGEVAVHLRELGFTATSEDVVTSAQSAAHLLAAALPPGSKVLVV
MAV_3079|M.avium_104 NNASRSAGEVAAHLTELGFTATADDVATSAQSAAHLLAGQLPAGAPVLIV
TH_1551|M.thermoresistible__bu NNASRAPGEVAEHLRSLGFAAAAEDVVTSAQSAARLLATTLPAGAPVLVL
*.:::: ::* * *: . .::* *:. :* : * .: ::
Mflv_0147|M.gilvum_PYR-GCK NSGQIAEDMPGIDIVYSSEFTGPRAPERPDVVLLGGAGPEYSHLTLSWVY
Mvan_0756|M.vanbaalenii_PYR-1 NSGQIGEDMPGIDLVYSSEFSGPRAPDAPDVVLLGGAGPEYSHLTLSWVY
MSMEG_0867|M.smegmatis_MC2_155 NSGRIDEDMPGVDVVYSSEFSGPRAPEAPDVVLLGGAGPEYSHLTLSWVY
Mb1257c|M.bovis_AF2122/97 NNGDITEDLPGIDVVLSTEIGPEDCPEAPDVVVLGSAGPQFDHRTLSRVY
Rv1225c|M.tuberculosis_H37Rv NNGDITEDLPGIDVVLSTEIGPEDCPEAPDVVVLGSAGPQFDHRTLSRVY
MAB_0641|M.abscessus_ATCC_1997 NDGDITADMAGVDFVES-------LSDDPDVIILGGAGPQFDHVALSRVY
MMAR_2497|M.marinum_M GTDALADEISAAGLRPVR-----RFEDQPDAVVQG-LSLTIGWPELAEAA
MUL_1681|M.ulcerans_Agy99 GTDALADEISAAGLRPVR-----RFEDQPDAVVQG-LSLTIGWPELAEAA
MAV_3079|M.avium_104 GTEALAGEIAAVGLRPVR-----RYDDGPVAVVQG-LSMTIGWPDLAEAA
TH_1551|M.thermoresistible__bu GTEALAEEVRAVGLEPVR-----QFADRPVAVVQG-ISQQTGWPELAEAA
. : :: . .. : * .:: * . . *: .
Mflv_0147|M.gilvum_PYR-GCK DWMAQGVPVVAMHRSTAWTTVDGLRVDTGMYLIGMEQTSGRKAAAVGKPA
Mvan_0756|M.vanbaalenii_PYR-1 DWMAQGVPVVAMHRSTAWTTTDGLRIDTGMYLIGMEQTSGRKATAVGKPA
MSMEG_0867|M.smegmatis_MC2_155 DWMAQGVPVVAMHRSTSWTTTDGLRVDTGMYLIGMEETSGRKATAVGKPA
Mb1257c|M.bovis_AF2122/97 GWMLDGVPVVAMHRNMTWNTTDGLRIDTGMYLTGMEQACGKTATAIGKPA
Rv1225c|M.tuberculosis_H37Rv GWMLDGVPVVAMHRNMTWNTTDGLRIDTGMYLTGMEQACGKTATAIGKPA
MAB_0641|M.abscessus_ATCC_1997 ELMAQGIPVVAMHRNAVWSTREGLRVDTGVYLAGMEQVSGRKAVAVGKPA
MMAR_2497|M.marinum_M LAIRAGALWVAANVDKTLPTERGLLPGNGSLVAALRTATGAQPQVAGKPG
MUL_1681|M.ulcerans_Agy99 LAIRAGALWVAANVDKTLPTERGLLPGNGSFVAALRTATGAQPQVAGKPG
MAV_3079|M.avium_104 LAIRAGAVWVAANIDLTLPTERGLLPGNGSLVAAVAAATGATPQVAGKPA
TH_1551|M.thermoresistible__bu LAIRAGAWWVATNADRTLPSERGLLPGNGAMIAALRAATDREPEVAGKPQ
: * ** : . : ** ..* : .: . . . . ***
Mflv_0147|M.gilvum_PYR-GCK PEGFLSAANRLGVDPEEMFIVGDDLNNDVLAGQVVGMTGVLVRTGKFRQD
Mvan_0756|M.vanbaalenii_PYR-1 PEGFLSAAARLGVDPEEMYMVGDDLNNDVLAAQVVGMSGVLVRTGKFRQD
MSMEG_0867|M.smegmatis_MC2_155 PEGFLAAASRLGVDPDEMYMIGDDLNNDVLAAQVVGMTGVLVRTGKFRQS
Mb1257c|M.bovis_AF2122/97 AEGFLAAADRVGVDPQQMVMIGDDLHNDVLAAQAVGMTGVLVRTGKFRQQ
Rv1225c|M.tuberculosis_H37Rv AEGFLAAADRVGVDPQQMVMIGDDLHNDVLAAQAVGMTGVLVRTGKFRQQ
MAB_0641|M.abscessus_ATCC_1997 PAGFQLAAERMGCEPDQVVMVGDDLHVDVLAAQVVGMTGVLVRTGKFRQD
MMAR_2497|M.marinum_M PQLMKDAVGRGDFRAP--LVIGDRLDTDIEGANAAGLPSLMVLTGVSSAR
MUL_1681|M.ulcerans_Agy99 PQLMKDAVGRGDFRAP--LVIGDRLDTDIEGANAAGLPSLMVLTGVSSAR
MAV_3079|M.avium_104 PALLRDAAARGDFRAP--LVIGDRLDTDIEGANAAGLPSLLVLTGVNSAR
TH_1551|M.thermoresistible__bu ATLMLDALSRGSFERP--LVVGDRLDTDIAGANNAGLPSLLVLTGVNDAA
. : * * . ::** *. *: ..: .*:..::* **
Mflv_0147|M.gilvum_PYR-GCK TLDRWAADEFAMQPNHVIDSIADLPALLGL--------------------
Mvan_0756|M.vanbaalenii_PYR-1 TLDRWAADEFAMQPNHVIDSVADFPALLGL--------------------
MSMEG_0867|M.smegmatis_MC2_155 VLDRWAADDFAMQPNHVIDSVADLPALLGL--------------------
Mb1257c|M.bovis_AF2122/97 TLDRWLAGASATRPHHVIDSVAGLPPLLGC--------------------
Rv1225c|M.tuberculosis_H37Rv TLDRWLAGASATRPHHVIDSVAGLPPLLGC--------------------
MAB_0641|M.abscessus_ATCC_1997 TLDRWAADQYAMQPAYVVDSVADLPPLLSGL-------------------
MMAR_2497|M.marinum_M DAVHADPVCRPTYIGHDLRSLRQDRATLAVAPQAGWRVQVD-GAAVTVSA
MUL_1681|M.ulcerans_Agy99 DAVHADPVCRPTYIGHDLRSLRQDRATLAVAPQAGWRVQVD-GAAVTVSA
MAV_3079|M.avium_104 DAVYAKPARRPTYIGHDLRALHQDAAALAVAPQPGWRVDVG-DTAITVSG
TH_1551|M.thermoresistible__bu DAIWAVPGERPDLIAADLRSLHTPAEELRVAPHPAWRVDLNDGGTIRVTS
. . : :: *
Mflv_0147|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0756|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0867|M.smegmatis_MC2_155 --------------------------------------------------
Mb1257c|M.bovis_AF2122/97 --------------------------------------------------
Rv1225c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0641|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2497|M.marinum_M NG--EQAGDDLSIVRAVACAVWDA----QFDGRPFTVNGGDDHAWEGLHR
MUL_1681|M.ulcerans_Agy99 NG--EQAGDDLSIVRAVACAVWDA----QFDGRPFTVNGGDDHAWERLHR
MAV_3079|M.avium_104 DGRDDGSGDGLSVVRAVASAVWGS----PDAG-TLPIRAGDDRARAALAR
TH_1551|M.thermoresistible__bu TG--ADPGDPLSVVRAVAHAVWTADLVTTGDTAGLPIIGADDAARAALHR
Mflv_0147|M.gilvum_PYR-GCK ---------
Mvan_0756|M.vanbaalenii_PYR-1 ---------
MSMEG_0867|M.smegmatis_MC2_155 ---------
Mb1257c|M.bovis_AF2122/97 ---------
Rv1225c|M.tuberculosis_H37Rv ---------
MAB_0641|M.abscessus_ATCC_1997 ---------
MMAR_2497|M.marinum_M WSLVHSE--
MUL_1681|M.ulcerans_Agy99 WSLVHSE--
MAV_3079|M.avium_104 WSLVRTD--
TH_1551|M.thermoresistible__bu WALSPFRID