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SMTSTALCEQFGIDFPLFAFSHCRDVVAAVTNAGGFGVLGATAYSPDQLDQELAWIDEAVGGRPYGVDLI VPAKFEGKGEKLSSSDLAARIPQTYKDLVDELLRKHDIEPEPERRIGKPMLSGNTGRELLDVALTHPVKL IANALGVPPDYMIEAGKERGIPVAALVGAKEHAVKQAAAGVDLIVAQGTEAGGHCGEVSTLVVVPEVLEG LAALGVSTPVLAAGGIVTGRQMAGMVAMGASGAWTGSVWLTTEEAETAPHTVAKMLAATSRDTVRSAGRT GKPSRQLVSDWTKAWAPSKDGEQPLGLPLQSMLCEPVIRRIDVLASQGHEGAQALATYFVGQGVGLMNKV KPAREVVREFIEDYLAAAERLSSSLPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0037 | - | - | 100% (378) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_3286 | - | 7e-82 | 43.88% (376) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_1544 | - | 5e-74 | 40.79% (380) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1560 | - | 5e-96 | 50.00% (372) | hypothetical protein Mb1560 |
| M. tuberculosis H37Rv | Rv1533 | - | 5e-96 | 50.00% (372) | hypothetical protein Rv1533 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0354c | - | 7e-83 | 44.00% (375) | 2-nitropropane dioxygenase family oxidoreductase |
| M. marinum M | MMAR_2346 | - | 1e-101 | 52.13% (376) | dioxygenase |
| M. avium 104 | MAV_3237 | - | 1e-101 | 51.22% (369) | 2-nitropropane dioxygenase, NPD |
| M. smegmatis MC2 155 | MSMEG_0992 | - | 1e-174 | 80.32% (371) | 2-nitropropane dioxygenase, NPD |
| M. thermoresistible (build 8) | TH_4620 | - | 1e-172 | 77.54% (374) | PUTATIVE 2-nitropropane dioxygenase, NPD |
| M. ulcerans Agy99 | MUL_1143 | - | 3e-87 | 46.52% (374) | hypothetical protein MUL_1143 |
| M. vanbaalenii PYR-1 | Mvan_0883 | - | 0.0 | 93.62% (376) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1560|M.bovis_AF2122/97 ---MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPKRL
Rv1533|M.tuberculosis_H37Rv ---MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPKRL
MAV_3237|M.avium_104 ---MRTRVAELLGVEFPICAFSHCRDVVAAVTNAGGFGILGATAHSPQRL
MMAR_2346|M.marinum_M ---MRTRVAEMLGVEFPICAFSHCRDVVAAVTNAGGFGILGATAHSPKRL
Mflv_0037|M.gilvum_PYR-GCK MSMTSTALCEQFGIDFPLFAFSHCRDVVAAVTNAGGFGVLGATAYSPDQL
Mvan_0883|M.vanbaalenii_PYR-1 --MTSTALCEQFGIDFPLFAFSHCRDVVAAVTNAGGFGVLGATAYTPEQL
MSMEG_0992|M.smegmatis_MC2_155 ---MKPAICEQFGIDFPLFAFSHCRDVVAAVTNAGGFGVLGATAYTPEQL
TH_4620|M.thermoresistible__bu ---MTSALCEQFGIDFPLFAFSHCRDVVAAVTNAGGFGVLGATAYTPEQL
MAB_0354c|M.abscessus_ATCC_199 ---MHTPICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFTPEQL
MUL_1143|M.ulcerans_Agy99 ---MHTAICDELGIEFPIFAFTHCRDVVLAVSKAGGFGVLGAVGFTPEQL
. :.: :* :**: **:****** **::*****:***...:*.:*
Mb1560|M.bovis_AF2122/97 ESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQAR----ELIPEG
Rv1533|M.tuberculosis_H37Rv ESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQAR----ELIPEG
MAV_3237|M.avium_104 DNELNWIEQQTGGKPYGVDLLLPPKYVGAEQGGIDAGQAR----TLLPDE
MMAR_2346|M.marinum_M ESELTWIEEQTRGKPYGVDLLLPPKYVGAEQGGIDPVQAR----ELVPEA
Mflv_0037|M.gilvum_PYR-GCK DQELAWIDEAVGGRPYGVDLIVPAKFEGKGE-KLSSSDLA----ARIPQT
Mvan_0883|M.vanbaalenii_PYR-1 DQELAWIDDAVGGKPYGVDLIVPAKFEGKGE-KLSSSELA----ARIPQA
MSMEG_0992|M.smegmatis_MC2_155 DQELSWIDEQVGGKPYGADIIVPAKFEGKGE-NLTRDQLK----DRIPGE
TH_4620|M.thermoresistible__bu DRELSWIDEQVNGKPYGADIIVPAKFEGKGEKDVTAQKLA----DRIPQQ
MAB_0354c|M.abscessus_ATCC_199 EIELNWIDEHIGDHPYGVDIVIPNKYEGMDA-NMSAEELTKMLQSMVPQE
MUL_1143|M.ulcerans_Agy99 EIELNWIDEHIGDHPYGVDIVIPNKYEGMDS-HLSAEELANTLRSMVPQQ
: ** **:: .:***.*:::* *: * : . :*
Mb1560|M.bovis_AF2122/97 HRTFVDDLLVRYGIP---AVTDRQRSSSAGGLHISPKGYQPLLDVAFAHD
Rv1533|M.tuberculosis_H37Rv HRTFVDDLLVRYGIP---AVTDRQRSSSAGGLHISPKGYQPLLDVAFAHD
MAV_3237|M.avium_104 HRAFVDDLLARYGVT---APAADIR---AGGLNISPKTYQPLLDVAFAHD
MMAR_2346|M.marinum_M HRAFVEELLARYGIAPSPEAGAERISRSGGGLNISPKGYEPLLDVAFSHD
Mflv_0037|M.gilvum_PYR-GCK YKDLVDELLRKHDIE----PEPERR---IGKPMLSGNTGRELLDVALTHP
Mvan_0883|M.vanbaalenii_PYR-1 YRDLVDDLLRAHDIE----PEPNRR---LGGSSLSGNTGRELLDVALTHP
MSMEG_0992|M.smegmatis_MC2_155 YRDFITGLLAEHGIE----PDPKQR---LGGSSLSGDTGRELLDVALSHP
TH_4620|M.thermoresistible__bu YRDFINELLAAHDIE----PEPKPK---LGGTSLSGDTGKELLEVAMSHP
MAB_0354c|M.abscessus_ATCC_199 HLDFGRKLLADHGVP---VEEGNDN--ALQLLGWTEATATPQVEIALRHP
MUL_1143|M.ulcerans_Agy99 HLDFARKILADHGVP---IEDADED--SLQLLGWTEATATPQVEVALKHS
: : :* :.: : :::*: *
Mb1560|M.bovis_AF2122/97 -IRLIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHAAAGVDLIVA
Rv1533|M.tuberculosis_H37Rv -IRLIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHAAAGVDLIVA
MAV_3237|M.avium_104 -IRLIASALGPPPPDLVERAHDRDVLVAALAGTTAHAQRHAAAGVDLIVA
MMAR_2346|M.marinum_M -IRLIASALGPPPSDLVERAHKKEVLVAALAGTTQHARRHAAAGVDLIVA
Mflv_0037|M.gilvum_PYR-GCK -VKLIANALGVPPDYMIEAGKERGIPVAALVGAKEHAVKQAAAGVDLIVA
Mvan_0883|M.vanbaalenii_PYR-1 -VKLIANALGVPPDYMIEAGKERGIPVAALVGAKEHAVKQAAAGVDLIVA
MSMEG_0992|M.smegmatis_MC2_155 -IKLIANALGVPPDYMIEAGRERGVPVAALVGAREHALKQVQAGVDLIVA
TH_4620|M.thermoresistible__bu -IKLIANALGVPPDYMLEAGREHGVPVAALVGAREHAVKQVRAGVDLIIA
MAB_0354c|M.abscessus_ATCC_199 KMTLIANALGTPPADMIKHIHDAGRKVAALCGSPKQARKHADAGVDIVIA
MUL_1143|M.ulcerans_Agy99 KVTMIANALGTPPAEMIAHIHERGRKVAALCGSPSQARKHANAGVDIIIA
: :**.*** ** :: :. **** *: :* ::. ****:::*
Mb1560|M.bovis_AF2122/97 QGTEAGGHTGEVATMVLVPEVVDAVSPT----PVLAAGGIARGRQIAAAL
Rv1533|M.tuberculosis_H37Rv QGTEAGGHTGEVATMVLVPEVVDAVSPT----PVLAAGGIARGRQIAAAL
MAV_3237|M.avium_104 QGTEAGGHTGEVATMVLVPEVVDAVAPV----PVLAAGGIARGRQIAAAL
MMAR_2346|M.marinum_M QGTEAGGHTGEVATMVLVPEVVDAVAPT----PVLAAGGIARGRQIAAAL
Mflv_0037|M.gilvum_PYR-GCK QGTEAGGHCGEVSTLVVVPEVLEGLAALGVSTPVLAAGGIVTGRQMAGMV
Mvan_0883|M.vanbaalenii_PYR-1 QGTEAGGHCGEVSTLVVVPEVLEALAGIGSSTPVLAAGGIVTGRQMAGMV
MSMEG_0992|M.smegmatis_MC2_155 QGTEAGGHCGEVSTLVLVPEVIDTLAQAGSDIPVLAAGGIVTGRQMAAAV
TH_4620|M.thermoresistible__bu QGTEAGGHTGEVTTMVLIPEVIEAIEAEGANVPVLAAGGIVTGRQMAAAV
MAB_0354c|M.abscessus_ATCC_199 QGGEGGGHCGEVGSIVLWPQVVKEIAPV----PVLAAGGIGSGYQIAAAL
MUL_1143|M.ulcerans_Agy99 QGGEAGGHCGEVGSIVLWPQVVKEVAPV----PVLAAGGIGSGQQIAAAL
** *.*** *** ::*: *:*:. : ******** * *:*. :
Mb1560|M.bovis_AF2122/97 ALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGKPARM
Rv1533|M.tuberculosis_H37Rv ALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGKPARM
MAV_3237|M.avium_104 ALGAEGVWCGSVWLTTEEAETVPVVKEKFLAATSSDTVRSRSMTGKPARM
MMAR_2346|M.marinum_M ALGAEGVWCGSVWLTTEEAETVPAVKDKFLAATSSDTVRSRSMTGKPARM
Mflv_0037|M.gilvum_PYR-GCK AMGASGAWTGSVWLTTEEAETAPHTVAKMLAATSRDTVRSAGRTGKPSRQ
Mvan_0883|M.vanbaalenii_PYR-1 AMGAAGAWTGSVWLTTEEAETAPHTVAKMLAATSRDTVRSAGRTGKPSRQ
MSMEG_0992|M.smegmatis_MC2_155 AMGAAGAWTGSVWLTTEEAETAPATVQKMLAATSRDTIRSTGRTGKPARQ
TH_4620|M.thermoresistible__bu AMGAAGAWTGSVWLTTEEAETAPYTVQKLLAASSRDTIRSAGRTGKPSRQ
MAB_0354c|M.abscessus_ATCC_199 AMGAQGAWSGSQWLMVEEAENTAVQQETYVKATSRDTVRSRSFTGKPCRM
MUL_1143|M.ulcerans_Agy99 ALGCQGAWTGSQWLMVEEASNTPVQQAAYAKASSRDTVRSRSFTGKPARM
*:*. *.* ** ** .***.. . *:* **:** . ****.*
Mb1560|M.bovis_AF2122/97 LRTAWTDEWD-RPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELA
Rv1533|M.tuberculosis_H37Rv LRTAWTDEWD-RPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELA
MAV_3237|M.avium_104 LRTAWTDEWD-RPENPDPLGMPLQTALITEPQLRINAAATQPGAKARELA
MMAR_2346|M.marinum_M LRTAWTDEWA-RPDTPEPLGMPLQTTLITDSQIRINQAAVQPGAKARELA
Mflv_0037|M.gilvum_PYR-GCK LVSDWTKAWAPSKDGEQPLGLPLQSMLCEPVIRRIDVLASQGHEGAQALA
Mvan_0883|M.vanbaalenii_PYR-1 LVSDWTNAWVPAKDGHQPLGLPLQSMLCEPVIRRIDVLASQGHEGAQALA
MSMEG_0992|M.smegmatis_MC2_155 LVSDWTKAWAPTPGGHPTLPLPLQNMLAEPVIRRIDVLAAQGHQGAQELA
TH_4620|M.thermoresistible__bu LKSAWTEAWLPSDGGRQPLPLPLQSMISEPVLRRIDALAAQGHKGAQQLA
MAB_0354c|M.abscessus_ATCC_199 LKNDWTEAWQ-TEGNPEPLGMPLQYMVSGMAVAATHKFPDQT----IDVA
MUL_1143|M.ulcerans_Agy99 LRNDWTEAWE-QADNPKPLGMPLQYMVSGMAVRATNKYPNET----VDVA
* . **. * .* :*** : . . : :*
Mb1560|M.bovis_AF2122/97 TYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR----
Rv1533|M.tuberculosis_H37Rv TYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR----
MAV_3237|M.avium_104 TYFVGQVVGSLDRIRPARAVVLDMVEEFIDTVGRLDGLIEN----
MMAR_2346|M.marinum_M TYFVGQVVGSLDRVRPTRSVVLEMVEEFIDTIGRLERLAD-----
Mflv_0037|M.gilvum_PYR-GCK TYFVGQGVGLMNKVKPAREVVREFIEDYLAAAERLSSSLPG----
Mvan_0883|M.vanbaalenii_PYR-1 TYFVGQGVGLMNKVKPAREVVREFIEDYLAAAERLSNSLPG----
MSMEG_0992|M.smegmatis_MC2_155 TYFVGQGVGLMNKVKPAKEVVREFIEDYLAATERLSNSLPD----
TH_4620|M.thermoresistible__bu TYFVGQGVGLMNKVKPAREVVREFIEDYLAATERLSNSLPS----
MAB_0354c|M.abscessus_ATCC_199 FNPIGQVVGQFTKVEKSAAVIERWVQEYLEATNTLNELNEAAASV
MUL_1143|M.ulcerans_Agy99 FNPVGQVVGQFTKVEKAATVIERWVQEYLEATNRLDELNAAAV--
:** ** : ::. : *: ::::: : *.