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RTRVAELLGVEFPICAFSHCRDVVAAVTNAGGFGILGATAHSPQRLDNELNWIEQQTGGKPYGVDLLLPP KYVGAEQGGIDAGQARTLLPDEHRAFVDDLLARYGVTAPAADIRAGGLNISPKTYQPLLDVAFAHDIRLI ASALGPPPPDLVERAHDRDVLVAALAGTTAHAQRHAAAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAV APVPVLAAGGIARGRQIAAALALGAEGVWCGSVWLTTEEAETVPVVKEKFLAATSSDTVRSRSMTGKPAR MLRTAWTDEWDRPENPDPLGMPLQTALITEPQLRINAAATQPGAKARELATYFVGQVVGSLDRIRPARAV VLDMVEEFIDTVGRLDGLIEN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3237 | - | - | 100% (372) | 2-nitropropane dioxygenase, NPD |
| M. avium 104 | MAV_2807 | - | 2e-92 | 47.62% (378) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. avium 104 | MAV_0607 | - | 1e-27 | 30.74% (296) | oxidoreductase, 2-nitropropane dioxygenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1560 | - | 0.0 | 85.29% (374) | hypothetical protein Mb1560 |
| M. gilvum PYR-GCK | Mflv_0037 | - | 1e-101 | 51.22% (369) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv1533 | - | 0.0 | 85.29% (374) | hypothetical protein Rv1533 |
| M. leprae Br4923 | MLBr_00387 | guaB2 | 8e-05 | 30.53% (131) | inosine 5'-monophosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0354c | - | 6e-89 | 46.15% (377) | 2-nitropropane dioxygenase family oxidoreductase |
| M. marinum M | MMAR_2346 | - | 0.0 | 84.13% (378) | dioxygenase |
| M. smegmatis MC2 155 | MSMEG_0992 | - | 1e-105 | 52.56% (371) | 2-nitropropane dioxygenase, NPD |
| M. thermoresistible (build 8) | TH_4620 | - | 1e-106 | 52.15% (372) | PUTATIVE 2-nitropropane dioxygenase, NPD |
| M. ulcerans Agy99 | MUL_1143 | - | 1e-92 | 47.34% (376) | hypothetical protein MUL_1143 |
| M. vanbaalenii PYR-1 | Mvan_0883 | - | 1e-103 | 52.30% (369) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1560|M.bovis_AF2122/97 --------------------------------------------------
Rv1533|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2346|M.marinum_M --------------------------------------------------
MAV_3237|M.avium_104 --------------------------------------------------
MSMEG_0992|M.smegmatis_MC2_155 --------------------------------------------------
TH_4620|M.thermoresistible__bu --------------------------------------------------
Mflv_0037|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0883|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0354c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_1143|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00387|M.leprae_Br4923 MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDV
Mb1560|M.bovis_AF2122/97 ---------------MRTRVAELLGAEFPICA----FSHCRDVVAAVSNA
Rv1533|M.tuberculosis_H37Rv ---------------MRTRVAELLGAEFPICA----FSHCRDVVAAVSNA
MMAR_2346|M.marinum_M ---------------MRTRVAEMLGVEFPICA----FSHCRDVVAAVTNA
MAV_3237|M.avium_104 ---------------MRTRVAELLGVEFPICA----FSHCRDVVAAVTNA
MSMEG_0992|M.smegmatis_MC2_155 ---------------MKPAICEQFGIDFPLFA----FSHCRDVVAAVTNA
TH_4620|M.thermoresistible__bu ---------------MTSALCEQFGIDFPLFA----FSHCRDVVAAVTNA
Mflv_0037|M.gilvum_PYR-GCK ------------MSMTSTALCEQFGIDFPLFA----FSHCRDVVAAVTNA
Mvan_0883|M.vanbaalenii_PYR-1 --------------MTSTALCEQFGIDFPLFA----FSHCRDVVAAVTNA
MAB_0354c|M.abscessus_ATCC_199 ---------------MHTPICDELGIEFPIFA----FTHCRDVVVAVSKA
MUL_1143|M.ulcerans_Agy99 ---------------MHTAICDELGIEFPIFA----FTHCRDVVLAVSKA
MLBr_00387|M.leprae_Br4923 LLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAMARA
. : . : ..*: : :. *::.*
Mb1560|M.bovis_AF2122/97 GGFGILG-------AVAHSPKRLESELTWIEEHTGGKP------------
Rv1533|M.tuberculosis_H37Rv GGFGILG-------AVAHSPKRLESELTWIEEHTGGKP------------
MMAR_2346|M.marinum_M GGFGILG-------ATAHSPKRLESELTWIEEQTRGKP------------
MAV_3237|M.avium_104 GGFGILG-------ATAHSPQRLDNELNWIEQQTGGKP------------
MSMEG_0992|M.smegmatis_MC2_155 GGFGVLG-------ATAYTPEQLDQELSWIDEQVGGKP------------
TH_4620|M.thermoresistible__bu GGFGVLG-------ATAYTPEQLDRELSWIDEQVNGKP------------
Mflv_0037|M.gilvum_PYR-GCK GGFGVLG-------ATAYSPDQLDQELAWIDEAVGGRP------------
Mvan_0883|M.vanbaalenii_PYR-1 GGFGVLG-------ATAYTPEQLDQELAWIDDAVGGKP------------
MAB_0354c|M.abscessus_ATCC_199 GGFGVLG-------AVGFTPEQLEIELNWIDEHIGDHP------------
MUL_1143|M.ulcerans_Agy99 GGFGVLG-------AVGFTPEQLEIELNWIDEHIGDHP------------
MLBr_00387|M.leprae_Br4923 GGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCA
**:*:* .. * : : :*
Mb1560|M.bovis_AF2122/97 ----------------YGVDVLLPPKYIGAEQGGIDAQQAR----ELIPE
Rv1533|M.tuberculosis_H37Rv ----------------YGVDVLLPPKYIGAEQGGIDAQQAR----ELIPE
MMAR_2346|M.marinum_M ----------------YGVDLLLPPKYVGAEQGGIDPVQAR----ELVPE
MAV_3237|M.avium_104 ----------------YGVDLLLPPKYVGAEQGGIDAGQAR----TLLPD
MSMEG_0992|M.smegmatis_MC2_155 ----------------YGADIIVPAKFEGKGE-NLTRDQLK----DRIPG
TH_4620|M.thermoresistible__bu ----------------YGADIIVPAKFEGKGEKDVTAQKLA----DRIPQ
Mflv_0037|M.gilvum_PYR-GCK ----------------YGVDLIVPAKFEGKGE-KLSSSDLA----ARIPQ
Mvan_0883|M.vanbaalenii_PYR-1 ----------------YGVDLIVPAKFEGKGE-KLSSSELA----ARIPQ
MAB_0354c|M.abscessus_ATCC_199 ----------------YGVDIVIPNKYEGMDA-NMSAEELTKMLQSMVPQ
MUL_1143|M.ulcerans_Agy99 ----------------YGVDIVIPNKYEGMDS-HLSAEELANTLRSMVPQ
MLBr_00387|M.leprae_Br4923 RFRISGLPVVDDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEG
* :: :
Mb1560|M.bovis_AF2122/97 GHRTFVDDLLVRYGIPAVTDR---QRSSSAGGLHISPKGYQPLLDVAFAH
Rv1533|M.tuberculosis_H37Rv GHRTFVDDLLVRYGIPAVTDR---QRSSSAGGLHISPKGYQPLLDVAFAH
MMAR_2346|M.marinum_M AHRAFVEELLARYGIAPSPEAGAERISRSGGGLNISPKGYEPLLDVAFSH
MAV_3237|M.avium_104 EHRAFVDDLLARYGVTAPAAD------IRAGGLNISPKTYQPLLDVAFAH
MSMEG_0992|M.smegmatis_MC2_155 EYRDFITGLLAEHGIEPDPKQ-------RLGGSSLSGDTGRELLDVALSH
TH_4620|M.thermoresistible__bu QYRDFINELLAAHDIEPEPKP-------KLGGTSLSGDTGKELLEVAMSH
Mflv_0037|M.gilvum_PYR-GCK TYKDLVDELLRKHDIEPEPER-------RIGKPMLSGNTGRELLDVALTH
Mvan_0883|M.vanbaalenii_PYR-1 AYRDLVDDLLRAHDIEPEPNR-------RLGGSSLSGNTGRELLDVALTH
MAB_0354c|M.abscessus_ATCC_199 EHLDFGRKLLADHGVPVEEGN-----DNALQLLGWTEATATPQVEIALRH
MUL_1143|M.ulcerans_Agy99 QHLDFARKILADHGVPIEDAD-----EDSLQLLGWTEATATPQVEVALKH
MLBr_00387|M.leprae_Br4923 VSADAALGLLRRNKIEKLPVVDG--HGRLTGLITVKDFVKTEQHPLATKD
:* : . :* .
Mb1560|M.bovis_AF2122/97 D--IRLIASALGPP---------------PPDLVERAHNHDVLVAALAG-
Rv1533|M.tuberculosis_H37Rv D--IRLIASALGPP---------------PPDLVERAHNHDVLVAALAG-
MMAR_2346|M.marinum_M D--IRLIASALGPP---------------PSDLVERAHKKEVLVAALAG-
MAV_3237|M.avium_104 D--IRLIASALGPP---------------PPDLVERAHDRDVLVAALAG-
MSMEG_0992|M.smegmatis_MC2_155 P--IKLIANALGVP---------------PDYMIEAGRERGVPVAALVG-
TH_4620|M.thermoresistible__bu P--IKLIANALGVP---------------PDYMLEAGREHGVPVAALVG-
Mflv_0037|M.gilvum_PYR-GCK P--VKLIANALGVP---------------PDYMIEAGKERGIPVAALVG-
Mvan_0883|M.vanbaalenii_PYR-1 P--VKLIANALGVP---------------PDYMIEAGKERGIPVAALVG-
MAB_0354c|M.abscessus_ATCC_199 PK-MTLIANALGTP---------------PADMIKHIHDAGRKVAALCG-
MUL_1143|M.ulcerans_Agy99 SK-VTMIANALGTP---------------PAEMIAHIHERGRKVAALCG-
MLBr_00387|M.leprae_Br4923 NDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGK
::. *:* :: : * : *
Mb1560|M.bovis_AF2122/97 -----------------TAQHARRHAAAGVDLIVAQGTEAGGHTGEVATM
Rv1533|M.tuberculosis_H37Rv -----------------TAQHARRHAAAGVDLIVAQGTEAGGHTGEVATM
MMAR_2346|M.marinum_M -----------------TTQHARRHAAAGVDLIVAQGTEAGGHTGEVATM
MAV_3237|M.avium_104 -----------------TTAHAQRHAAAGVDLIVAQGTEAGGHTGEVATM
MSMEG_0992|M.smegmatis_MC2_155 -----------------AREHALKQVQAGVDLIVAQGTEAGGHCGEVSTL
TH_4620|M.thermoresistible__bu -----------------AREHAVKQVRAGVDLIIAQGTEAGGHTGEVTTM
Mflv_0037|M.gilvum_PYR-GCK -----------------AKEHAVKQAAAGVDLIVAQGTEAGGHCGEVSTL
Mvan_0883|M.vanbaalenii_PYR-1 -----------------AKEHAVKQAAAGVDLIVAQGTEAGGHCGEVSTL
MAB_0354c|M.abscessus_ATCC_199 -----------------SPKQARKHADAGVDIVIAQGGEGGGHCGEVGSI
MUL_1143|M.ulcerans_Agy99 -----------------SPSQARKHANAGVDIIIAQGGEAGGHCGEVGSI
MLBr_00387|M.leprae_Br4923 LKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVAG
: * . **.* : . .. .* :
Mb1560|M.bovis_AF2122/97 VLVPEVVDAVSPT--------PVLAAGGIARGRQIAAALALGAEGVWCGS
Rv1533|M.tuberculosis_H37Rv VLVPEVVDAVSPT--------PVLAAGGIARGRQIAAALALGAEGVWCGS
MMAR_2346|M.marinum_M VLVPEVVDAVAPT--------PVLAAGGIARGRQIAAALALGAEGVWCGS
MAV_3237|M.avium_104 VLVPEVVDAVAPV--------PVLAAGGIARGRQIAAALALGAEGVWCGS
MSMEG_0992|M.smegmatis_MC2_155 VLVPEVIDTLAQAGSD----IPVLAAGGIVTGRQMAAAVAMGAAGAWTGS
TH_4620|M.thermoresistible__bu VLIPEVIEAIEAEGAN----VPVLAAGGIVTGRQMAAAVAMGAAGAWTGS
Mflv_0037|M.gilvum_PYR-GCK VVVPEVLEGLAALGVS----TPVLAAGGIVTGRQMAGMVAMGASGAWTGS
Mvan_0883|M.vanbaalenii_PYR-1 VVVPEVLEALAGIGSS----TPVLAAGGIVTGRQMAGMVAMGAAGAWTGS
MAB_0354c|M.abscessus_ATCC_199 VLWPQVVKEIAPV--------PVLAAGGIGSGYQIAAALAMGAQGAWSGS
MUL_1143|M.ulcerans_Agy99 VLWPQVVKEVAPV--------PVLAAGGIGSGQQIAAALALGCQGAWTGS
MLBr_00387|M.leprae_Br4923 VGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGS
* *:: : **:* **: . ::* :* *. . **
Mb1560|M.bovis_AF2122/97 VWLTTEEAETPPVVKDKFLAATSS--DTVRSRSLTGKPARMLRTAWTDEW
Rv1533|M.tuberculosis_H37Rv VWLTTEEAETPPVVKDKFLAATSS--DTVRSRSLTGKPARMLRTAWTDEW
MMAR_2346|M.marinum_M VWLTTEEAETVPAVKDKFLAATSS--DTVRSRSMTGKPARMLRTAWTDEW
MAV_3237|M.avium_104 VWLTTEEAETVPVVKEKFLAATSS--DTVRSRSMTGKPARMLRTAWTDEW
MSMEG_0992|M.smegmatis_MC2_155 VWLTTEEAETAPATVQKMLAATSR--DTIRSTGRTGKPARQLVSDWTKAW
TH_4620|M.thermoresistible__bu VWLTTEEAETAPYTVQKLLAASSR--DTIRSAGRTGKPSRQLKSAWTEAW
Mflv_0037|M.gilvum_PYR-GCK VWLTTEEAETAPHTVAKMLAATSR--DTVRSAGRTGKPSRQLVSDWTKAW
Mvan_0883|M.vanbaalenii_PYR-1 VWLTTEEAETAPHTVAKMLAATSR--DTVRSAGRTGKPSRQLVSDWTNAW
MAB_0354c|M.abscessus_ATCC_199 QWLMVEEAENTAVQQETYVKATSR--DTVRSRSFTGKPCRMLKNDWTEAW
MUL_1143|M.ulcerans_Agy99 QWLMVEEASNTPVQQAAYAKASSR--DTVRSRSFTGKPARMLRNDWTEAW
MLBr_00387|M.leprae_Br4923 LLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADD
. ** : .:: : * :
Mb1560|M.bovis_AF2122/97 D-RPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQVVG
Rv1533|M.tuberculosis_H37Rv D-RPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQVVG
MMAR_2346|M.marinum_M A-RPDTPEPLGMPLQTTLITDSQIRINQAAVQPGAKARELATYFVGQVVG
MAV_3237|M.avium_104 D-RPENPDPLGMPLQTALITEPQLRINAAATQPGAKARELATYFVGQVVG
MSMEG_0992|M.smegmatis_MC2_155 APTPGGHPTLPLPLQNMLAEPVIRRIDVLAAQGHQGAQELATYFVGQGVG
TH_4620|M.thermoresistible__bu LPSDGGRQPLPLPLQSMISEPVLRRIDALAAQGHKGAQQLATYFVGQGVG
Mflv_0037|M.gilvum_PYR-GCK APSKDGEQPLGLPLQSMLCEPVIRRIDVLASQGHEGAQALATYFVGQGVG
Mvan_0883|M.vanbaalenii_PYR-1 VPAKDGHQPLGLPLQSMLCEPVIRRIDVLASQGHEGAQALATYFVGQGVG
MAB_0354c|M.abscessus_ATCC_199 Q-TEGNPEPLGMPLQYMVSGMAVAATHKFPDQT----IDVAFNPIGQVVG
MUL_1143|M.ulcerans_Agy99 E-QADNPKPLGMPLQYMVSGMAVRATNKYPNET----VDVAFNPVGQVVG
MLBr_00387|M.leprae_Br4923 ALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGGLR-AAMGYTGSPTIEVLQ
. : : . . : : :
Mb1560|M.bovis_AF2122/97 SLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR----
Rv1533|M.tuberculosis_H37Rv SLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR----
MMAR_2346|M.marinum_M SLDRVRPTRSVVLEMVEEFIDTIGRLERLAD-----
MAV_3237|M.avium_104 SLDRIRPARAVVLDMVEEFIDTVGRLDGLIEN----
MSMEG_0992|M.smegmatis_MC2_155 LMNKVKPAKEVVREFIEDYLAATERLSNSLPD----
TH_4620|M.thermoresistible__bu LMNKVKPAREVVREFIEDYLAATERLSNSLPS----
Mflv_0037|M.gilvum_PYR-GCK LMNKVKPAREVVREFIEDYLAAAERLSSSLPG----
Mvan_0883|M.vanbaalenii_PYR-1 LMNKVKPAREVVREFIEDYLAAAERLSNSLPG----
MAB_0354c|M.abscessus_ATCC_199 QFTKVEKSAAVIERWVQEYLEATNTLNELNEAAASV
MUL_1143|M.ulcerans_Agy99 QFTKVEKAATVIERWVQEYLEATNRLDELNAAAV--
MLBr_00387|M.leprae_Br4923 QAQFVRITPAGLKESHPHDVAMTVEAPNYYPR----
:. : : . :