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MTSIESHPEQYWAAAGRPGPVPLALGPVHPGGPTLIDLLMALFGLSTNADLGGTNADIEGDDTDRRAHAA DAARKFSANEANAAEQMQGVGAQGMAQMASGIGGALSGALGGVMGPLTQLPQQAMQAGQGAMQPLMSAMQ QAQGADGLAAVDGARLLDSIGGEPGLGSGAGGGDVGGGGAGGTTPTGYLGPPPVPTSSPPTTPAGAPTKS ATMPPPGGASPASAHMGAAGMPMVPPGAMGARGEGSGQEKPVEKRVTAPAVPNGQPVKGRLTVPPSAPTT KPTDGKPVVRRRILLPEHKDFGRIAPDEKTDAGE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2109 | - | - | 100% (314) | hypothetical protein Mb2109 |
| M. bovis AF2122 / 97 | Mb3927c | - | 1e-95 | 64.98% (297) | hypothetical protein Mb3927c |
| M. bovis AF2122 / 97 | Mb2517c | PE_PGRS43b | 5e-11 | 33.16% (193) | hypothetical protein Mb2517c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2790 | - | 1e-11 | 31.31% (198) | hypothetical protein Mflv_2790 |
| M. tuberculosis H37Rv | Rv2083 | - | 0.0 | 99.36% (314) | hypothetical protein Rv2083 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3746c | - | 6e-08 | 27.44% (266) | hypothetical protein MAB_3746c |
| M. marinum M | MMAR_3067 | - | 1e-120 | 68.01% (322) | hypothetical protein MMAR_3067 |
| M. avium 104 | MAV_5287 | - | 4e-84 | 58.48% (289) | hypothetical protein MAV_5287 |
| M. smegmatis MC2 155 | MSMEG_5989 | - | 9e-09 | 31.51% (219) | hypothetical protein MSMEG_5989 |
| M. thermoresistible (build 8) | TH_4387 | - | 8e-09 | 33.52% (176) | PUTATIVE putative PPE family protein |
| M. ulcerans Agy99 | MUL_2312 | - | 1e-117 | 66.77% (322) | hypothetical protein MUL_2312 |
| M. vanbaalenii PYR-1 | Mvan_3258 | - | 1e-11 | 31.64% (177) | hypothetical protein Mvan_3258 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2109|M.bovis_AF2122/97 --------------MTSIESHPEQYWAAAGRPG--PVPLALGPVHPGGPT
Rv2083|M.tuberculosis_H37Rv --------------MTSIESHPEQYWAAAGRPG--PVPLALGPVHPGGPT
MMAR_3067|M.marinum_M ---------------MTINSVPESYGHATGMPA--PIPLAPGPVHPGGTS
MUL_2312|M.ulcerans_Agy99 ---------------MTINSVPESYGHATGMPA--PIPLAPGPVHPGGTS
MAV_5287|M.avium_104 ---------MGGPGGIIKNDLPTTTAIVGGPPA--SIPRPF-PVPPGGTS
MSMEG_5989|M.smegmatis_MC2_155 --------------MGIMPDSSPFGSQTVMGPA--WPNVDEEQLTAAAAS
TH_4387|M.thermoresistible__bu --------------MGIMPDTSPYGGQTVTGPG--WPNVDEDALGAAAAA
Mflv_2790|M.gilvum_PYR-GCK ---------MRVQLMPAVGGSAGSYGRLIVTPD--MEPPDAGHWDDQEQT
Mvan_3258|M.vanbaalenii_PYR-1 --------------MPAVGGSAGSYGRLIVTPD--MEPPDAGHWDAQEQT
MAB_3746c|M.abscessus_ATCC_199 MANKWDIEALRGEGLQAIANSQNYVTAAIRGNGKSPVTITNPDLTANERQ
.
Mb2109|M.bovis_AF2122/97 LIDLLMALFG---------------------------------------L
Rv2083|M.tuberculosis_H37Rv LIDLLMALFG---------------------------------------L
MMAR_3067|M.marinum_M PVDAAMAGFG---------------------------------------M
MUL_2312|M.ulcerans_Agy99 PVDAAMAGFG---------------------------------------M
MAV_5287|M.avium_104 PADAGQGMVG---------------------------------------G
MSMEG_5989|M.smegmatis_MC2_155 YEKLATTISGNIVPQQTNQLMKLTEVWQGAG-------SLAASGEATTMI
TH_4387|M.thermoresistible__bu YEALAAKLTGTVVPQQQGQMMQLSDTWEGSG-------ATAAVGEASTII
Mflv_2790|M.gilvum_PYR-GCK YRAGATSWDG-IHQQIVTDSARFREAADSQGFDEVHRVNAVLAEEAKTIA
Mvan_3258|M.vanbaalenii_PYR-1 YRVGATTWDG-IHQKIVTDNAEFRDAADSQGFDEAHRAGAVLAEEAKTIA
MAB_3746c|M.abscessus_ATCC_199 LFDWYDMDAG---------------------------MDLNTLGGDLELF
*
Mb2109|M.bovis_AF2122/97 STNADLGGTNADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVGAQGM
Rv2083|M.tuberculosis_H37Rv STNADLGGANADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVGAQGM
MMAR_3067|M.marinum_M ATNADLGPVNGEIAADDADRRAHAADAAAKFPANEADAAQQFQGVGADGM
MUL_2312|M.ulcerans_Agy99 ATNADLGPVNGEIAADDADRRAHAADAAAKFPANEADAAQQFQGVGADGM
MAV_5287|M.avium_104 AGNANVPKDAADAAAADADRKARAADAAAKFPANEANGSQEMQML-----
MSMEG_5989|M.smegmatis_MC2_155 AGHEANAAQAQAIAAQLTQMAAAVVKTKMAVNAAAQEVQHEVEALQALPF
TH_4387|M.thermoresistible__bu AGHEANAAHAAAIAAKLRSMEAAVIKAKTMANAVAVETQRECEAIAAAPF
Mflv_2790|M.gilvum_PYR-GCK EWHAKVADKCGDIATVLRETRSGQEQVVREADAKIASAKLPGEVETLVTQ
Mvan_3258|M.vanbaalenii_PYR-1 EWHDKCANKCADIATVLRDTRAGQEQLVREADAKIASAKLPGEAEALVTQ
MAB_3746c|M.abscessus_ATCC_199 KNATATMKAAAERQHGQLQRLIGLWEGKGSESANDFLKTHNSTADAVTDE
. . *
Mb2109|M.bovis_AF2122/97 A----QMASGIGGALSGALGGVMGPLTQLP---QQAMQAGQGAMQPLMSA
Rv2083|M.tuberculosis_H37Rv A----QMASGIGGALSGALGGVMGPLTQLP---QQAMQAGQGAMQPLMSA
MMAR_3067|M.marinum_M AQMIPQMASGIGGALSGALGGVLGPLTQIP---QQALQAGQGALQPLMGA
MUL_2312|M.ulcerans_Agy99 AQMIPQMASGIGGALSGALGGVLGPLTQIP---QQALQAGQGALQPLMGA
MAV_5287|M.avium_104 ----QQMLSSVTGALGGAMGGVMGPLTQLP---QQAMQAGQSALQPLMSA
MSMEG_5989|M.smegmatis_MC2_155 GNKQELIESRIKMGLSQNIATVTASTTELASALGTTANIPQMTTPPTAQA
TH_4387|M.thermoresistible__bu PNRQELLQSRIAMGLAQNVGQVTASSTELANTLGVPPTIPTAGGAPAAGA
Mflv_2790|M.gilvum_PYR-GCK YHGIARYRTEAGVTAAMASHTSFKRSTENTRALDLLTRWGDALAAPPVQP
Mvan_3258|M.vanbaalenii_PYR-1 YHGIARYQTEAGVTAAMASHTAFKASTENTRALDLLTKWGDAPTAPPVQP
MAB_3746c|M.abscessus_ATCC_199 FGKVSTGLDGLRNALWNIVDLKKQASTMVDGLVTDRTHFDSAVATYKTGM
*
Mb2109|M.bovis_AF2122/97 MQQAQGADGLAAVDGARLLDSIGGE-PGLGSGAGG---------------
Rv2083|M.tuberculosis_H37Rv MQQAQGADGLAAVDGARLLDSIGGE-PGLGSGAGG---------------
MMAR_3067|M.marinum_M LQQSAGVEGLEAADGARLVDSLESE-PGLGGGGAGEL-------------
MUL_2312|M.ulcerans_Agy99 LQQSAGVEGLEAADGARLVDSLESE-PGLGGGGAGEL-------------
MAV_5287|M.avium_104 VQGAHGAASLA--DNAHLVDSVGGAGSGLGGGAGAG--------------
MSMEG_5989|M.smegmatis_MC2_155 QQAVQKGADQGAQMAMQMASQLPQMLGQLPQMLG------------QVPQ
TH_4387|M.thermoresistible__bu PG--QEAAGDAAQQAAQLAGMAAQIPAQVGQMAG------------QVPQ
Mflv_2790|M.gilvum_PYR-GCK LDSPSPGIAQGDNNPKKAPPQEEDSSKSTPLQEGSDQSPPAMSPTDSAGT
Mvan_3258|M.vanbaalenii_PYR-1 VDHTSPGIEQDENPYSDTEKREAGADAPKPVDD---------APTDPAGT
MAB_3746c|M.abscessus_ATCC_199 GDKSQADETNATMIGPHVKNNIEGQLLPAFKKAWS---------------
Mb2109|M.bovis_AF2122/97 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MSMEG_5989|M.smegmatis_MC2_155 QLAQP--------------LQQLTQPLQQLTS------------------
TH_4387|M.thermoresistible__bu QLSQP--------------LQQLSQPLQQITS------------------
Mflv_2790|M.gilvum_PYR-GCK STTQP----GIKSVTSDEGIKVATGPL-QPTPGVASPGAGASPLGGGGMS
Mvan_3258|M.vanbaalenii_PYR-1 STTQPGVSPGSKSAAGDESIKAATGPVTQPTPGVTSS-PAASALGGAGMP
MAB_3746c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2109|M.bovis_AF2122/97 -------GDVGGGG-------AGGTTPTGYLGPPPVPTSSP--PTTPAGA
Rv2083|M.tuberculosis_H37Rv -------GDVGGGG-------AGGTTPTGYLGPPPVPTSSP--PTTPAGA
MMAR_3067|M.marinum_M -------GTGGGGG-------GGGTIPTGYLGPPPVPTSSP--PTTPAGA
MUL_2312|M.ulcerans_Agy99 -------GTGGGGG-------GGGTISTGYLGPPPVPTSSP--PTTPAGA
MAV_5287|M.avium_104 -------GGGAGLG-------GGGTVPTSSLGPPPVPTSSP--PTTPAGA
MSMEG_5989|M.smegmatis_MC2_155 -----MLGSVGKGG-----TGAG-PSPFSAFSNHPLAGGSG--PSSGAGL
TH_4387|M.thermoresistible__bu -----LFGAVGGKG-----PGALNANPFSSLSNHPLAGGSG--PSGGAGM
Mflv_2790|M.gilvum_PYR-GCK SMGGMVGGGMGSGG-APKLPGGLGSGGLPGMGSNPLGSGVDQMPSAGSGL
Mvan_3258|M.vanbaalenii_PYR-1 SMGGIGGGGMGSGGGIPKMPGGLGSGGMPGMGSNPLSGGVGQMPGAASGL
MAB_3746c|M.abscessus_ATCC_199 ---------AGGGAYDTLINGLKQELPPDFKLPPGVFGPDYDTTDEPAKT
. . : . :
Mb2109|M.bovis_AF2122/97 PTKSATMPPPGGASPA-----------------------------SAHMG
Rv2083|M.tuberculosis_H37Rv PTKSATMPPPGGASPA-----------------------------SAHMG
MMAR_3067|M.marinum_M PTKPASMMSTGGTPSS-----------------------------STPMG
MUL_2312|M.ulcerans_Agy99 PTKPASMMSTSGTPSS-----------------------------STPMG
MAV_5287|M.avium_104 --KAAMMPPTGGMPAM-----------------------------PGQTG
MSMEG_5989|M.smegmatis_MC2_155 VKAAGMPGGGGGVGAQ-----------------------------TPVLS
TH_4387|M.thermoresistible__bu VRAASLPG-AGGSSPQ-----------------------------TPLIA
Mflv_2790|M.gilvum_PYR-GCK PSAGGVPGDGSGAGSPAVAFSQGMSTGGAIGGGMPAAPAPAPASPSPALS
Mvan_3258|M.vanbaalenii_PYR-1 PNPGAVPGAGS-ASPLSSAFNQGMATTAGMGGGIPSAPPPAPASPSPALS
MAB_3746c|M.abscessus_ATCC_199 TKGKGKQDDKDGGETSG---------------------------ESGESG
. . . . .
Mb2109|M.bovis_AF2122/97 AAGMPMVPPGAMGARG-----EGSGQEKPVEKRVTAPAVPNGQPVK----
Rv2083|M.tuberculosis_H37Rv AAGMPMVPPGAMGARG-----EGSGQEKPVEKRLTAPAVPNGQPVK----
MMAR_3067|M.marinum_M ATGMPMMPPGAMGAGG-----TGGSKEKPAEKRVTAPGVPNGQPVK----
MUL_2312|M.ulcerans_Agy99 ATGMPMMPPGAMGAGG-----TGGSKEKPAEKRVTAPGVPNGQSVK----
MAV_5287|M.avium_104 MTGMPMMPPGAMGAGG-----EGGNKDKPVEKRVTAPGVPNGQPVK----
MSMEG_5989|M.smegmatis_MC2_155 KLVG--TAPVSVDPG-------ATAGGAVVGGVAPVAAGAMGGGMG----
TH_4387|M.thermoresistible__bu NMLGGKVSPVSVDTG-------AAAGATVVG-AAPVAAG-MGGGMG----
Mflv_2790|M.gilvum_PYR-GCK AG--AQAAPVPATAGGGV--PPAAAQSGLVAPAAP----PTGAGMGTGGG
Mvan_3258|M.vanbaalenii_PYR-1 AGGGHAAPPVSAAPGGGV--SPAGAQAGMVSPATPAAAAPTGAGIG-GGG
MAB_3746c|M.abscessus_ATCC_199 NSGVNSGAGGGTASGGMQGTATPASATGNAGGQLSGAGQQQGAGQGQQGM
. . . . *
Mb2109|M.bovis_AF2122/97 GRLTVPPSAPTTKPTDGKP----------------------------VVR
Rv2083|M.tuberculosis_H37Rv GRLTVPPSAPTTKPTDGKP----------------------------VVR
MMAR_3067|M.marinum_M GRLTVPPSVP-VKSVDGKPP--------------------------VVTR
MUL_2312|M.ulcerans_Agy99 GRLTVPPSVP-VKSVDGKPP--------------------------VVTR
MAV_5287|M.avium_104 GRLTIPPSAPGSKPGEAKPT--------------------------VVTN
MSMEG_5989|M.smegmatis_MC2_155 ----GPMGMMGGPRG------------------------------GGGGG
TH_4387|M.thermoresistible__bu ----MAPGMMG-ARG------------------------------TSGG-
Mflv_2790|M.gilvum_PYR-GCK APMMLPPGSMGPPAGPVPPPAATVPAGALGAGSNAPSAAPPAAAAGAGPT
Mvan_3258|M.vanbaalenii_PYR-1 APMMLPPGSMGPPAG-APPPAPTVPAGTVGSTNAPAAPAPSAASAAAGPT
MAB_3746c|M.abscessus_ATCC_199 DPSQMLSGMTGALTGALSSIG--------------------QAASGIVSA
.
Mb2109|M.bovis_AF2122/97 --RRILLPEHKDFGRIAPDEKTDAGE------------------------
Rv2083|M.tuberculosis_H37Rv --RRILLPEHKDFGRIAPDEKTDAGE------------------------
MMAR_3067|M.marinum_M STRRILLPDRNEIGRNISDEKTDGSE------------------------
MUL_2312|M.ulcerans_Agy99 STRPILLPDRNEIGRNISDEKTDGNE------------------------
MAV_5287|M.avium_104 ------RPNRRIVIMPSDDEPKE---------------------------
MSMEG_5989|M.smegmatis_MC2_155 TAASLAVPAPLEHEIDEVDDDDDW--------------------------
TH_4387|M.thermoresistible__bu TRPGIAAPEMLEHDLGE-DEDDDW--------------------------
Mflv_2790|M.gilvum_PYR-GCK LIPASVVAAGQTAAARERRESADAAAAKELVWKLQHASYMAGNYLTGWAV
Mvan_3258|M.vanbaalenii_PYR-1 LIPASVVAAGQTAAARERRESADAAAAKELVWKLQHAAYVALNPAAGWAV
MAB_3746c|M.abscessus_ATCC_199 ITEGISSIPFDQMGQGLGDDQFDGRADEAADKKDEAAADGKKDPDAKMAA
: :
Mb2109|M.bovis_AF2122/97 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MSMEG_5989|M.smegmatis_MC2_155 --------------------------------------------------
TH_4387|M.thermoresistible__bu --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK GVFRSPSGTETVITSNDGASYIPAGVFVPRSVRVLATDLVIHDSFRQLWF
Mvan_3258|M.vanbaalenii_PYR-1 GVFRSPSGTETVITSNDGSSYIPAGVFVPRSVRVLATDPLVDDSFRQRWF
MAB_3746c|M.abscessus_ATCC_199 AKDAAIEEARADSGATFATDGKPAPGIQLAGAGGLEATPTAAPGQTTPGA
Mb2109|M.bovis_AF2122/97 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MSMEG_5989|M.smegmatis_MC2_155 --------------------------------------------------
TH_4387|M.thermoresistible__bu --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK GWSDPARVLVEYAQQRAEWGWRLVAAASTLPTPALRDAGVEHPPACTRET
Mvan_3258|M.vanbaalenii_PYR-1 GWGDPARVLVEYAQLRAQWGWKLVAAATTAGVSVLRDAGVEHPPSCSGDT
MAB_3746c|M.abscessus_ATCC_199 PLG-----------------------ATPTGTIPPAAGGLSAAQPAGSSA
Mb2109|M.bovis_AF2122/97 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MSMEG_5989|M.smegmatis_MC2_155 --------------------------------------------------
TH_4387|M.thermoresistible__bu --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK NPLLQPGVQVPAPVLDDMHVHRLAVLWPEVYPRLLRVMDADPICQDRIVS
Mvan_3258|M.vanbaalenii_PYR-1 NPLLQQGVDVPAPVLDDMHIHRLAVLWPEVYPRLLRIMDADPLCQDRIVS
MAB_3746c|M.abscessus_ATCC_199 SLTPHPVQAQPPTVPQHPEPQSAAARQPSPLPSVGPTDASAQPQEAKTEA
Mb2109|M.bovis_AF2122/97 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MSMEG_5989|M.smegmatis_MC2_155 --------------------------------------------------
TH_4387|M.thermoresistible__bu --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK GVSAALMVAATTQAQAVE--IPDALRHIWVARGGDREPSTQQWAKYNEEA
Mvan_3258|M.vanbaalenii_PYR-1 AVTAAMINAATTQAQVIDGGIDEALRLVWAVRGSDREPTVQQWADYDKAA
MAB_3746c|M.abscessus_ATCC_199 GETPCEIAADELPKAGR---------------------------------
Mb2109|M.bovis_AF2122/97 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MSMEG_5989|M.smegmatis_MC2_155 --------------------------------------------------
TH_4387|M.thermoresistible__bu --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK QTFNGTTAMSRPAFLT--GGAGHPRDSSEELANYRGHWLVARTIEHIGGW
Mvan_3258|M.vanbaalenii_PYR-1 KALNVMTAMRRPAFATNTGAVADPSDTTEFLADYRAHWLVARTAEHIGGW
MAB_3746c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2109|M.bovis_AF2122/97 -------------------------------------------
Rv2083|M.tuberculosis_H37Rv -------------------------------------------
MMAR_3067|M.marinum_M -------------------------------------------
MUL_2312|M.ulcerans_Agy99 -------------------------------------------
MAV_5287|M.avium_104 -------------------------------------------
MSMEG_5989|M.smegmatis_MC2_155 -------------------------------------------
TH_4387|M.thermoresistible__bu -------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK ANRPLPLPDMCYAAAATGDPDLHDKIVKALVSVEDDLAVGS--
Mvan_3258|M.vanbaalenii_PYR-1 SRRPLPLPDMCYAAAATGDPDLRDMIVKALVSVEEDLQYEAPR
MAB_3746c|M.abscessus_ATCC_199 -------------------------------------------