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MADVAESQENAPAERAELTVPEMRQWLRNWVGKAVGKAPDSIDESVPMVELGLSSRDAVAMAADIEDLTG VTLSVAVAFAHPTIESLATRIIEGEPETDLAGDDAEDWSRTGPAERVDIAIVGLSTRFPGEMNTPEQTWQ ALLEGRDGITDLPDGRWSEFLEEPRLAARVAGARTRGGYLKDIKGFDSEFFAVAKTEADNIDPQQRMALE LTWEALEHARIPASSLRGQAVGVYIGSSTNDYSFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDFHGPS VTIDTACSSSLVAIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGAVLAPDGRIKSFSADADGYT RSEGGGMLVLKRVDDARRDGDAILAVIAGSAVNHDGRSNGLIAPNQDAQADVLRRAYKDAGIDPRTVDYI EAHGTGTILGDPIEAEALGRVVGRGRPADRPALLGAVKTNVGHLESAAGAASMAKVVLALQHDKLPPSIN FAGPSPYIDFDAMRLKMITTPTDWPRYGGYALGGVSSFGFGGANAHVVVREVLPRDVVEKEPEPEPEPKA AAEPAEAPTLAGHALRFDEFGNIITDSAVAEEPEPELPGVTEEALRLKEAALEELAAQEVTAPLVPLAVS AFLTSRKKAAAAELADWMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGKQAPN VFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVDALVQDELGYSVLELILDDAQDYGIE TTQVTIFAIQIALGELLRHHGAKPAAVIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGE YIRLMALVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFARKFATKGASHT SQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPIHDVEYWKKGLRHSVYFTHGIRNAVDSG HTTFLELAPNPVALMQVALTTADAGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLFSRASG PQDYANIPPTRFKRKEHWLPAHFSGDGSTYMPGTHVALPDGRHVWEYAPRDGNVDLAALVRAAAAHVLPD AQLTAAEQRAVPGDGARLVTTMTRHPGGASVQVHARIDESFTLVYDALVSRAGSESVLPTAVGAATAIAV ADGAPVAPETPAEDADAETLSDSLTTRYMPSGMTRWSPDSGETIAERLGLIVGSAMGYEPEDLPWEVPLI ELGLDSLMAVRIKNRVEYDFDLPPIQLTAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQKTQTAEEIARA QAELLHGKVGKTEPVDSEAGVALPSPQNGEQPNPTGPALNVDVPPRDAAERVTFATWAIVTGKSPGGIFN ELPRLDDEAAAKIAQRLSERAEGPITAEDVLTSSNIEALADKVRTYLEAGQIDGFVRTLRARPEAGGKVP VFVFHPAGGSTVVYEPLLGRLPADTPMYGFERVEGSIEERAQQYVPKLIEMQGDGPYVLVGWSLGGVLAY ACAIGLRRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEKTFNVTIPAIPYEQLEELDDEGQ VRFVLDAVSQSGVQIPAGIIEHQRTSYLDNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPD GGWGEYVSDLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADRTSEVGKQ
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3830c | pks13 | - | 100% (1733) | polyketide synthase PKS13 |
M. bovis AF2122 / 97 | Mb2956 | ppsA | 0.0 | 36.89% (1079) | phenolpthiocerol synthesis type-I polyketide synthase PPSA |
M. bovis AF2122 / 97 | Mb2959 | ppsD | e-158 | 36.26% (1026) | phenolpthiocerol synthesis type-I polyketide synthase PPSD |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_1169 | - | 0.0 | 71.48% (1781) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv3800c | pks13 | 0.0 | 99.94% (1733) | polyketide synthase PKS13 |
M. leprae Br4923 | MLBr_00101 | pks13 | 0.0 | 83.41% (1748) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_0180 | - | 0.0 | 69.97% (1765) | polyketide synthase PKS13 |
M. marinum M | MMAR_5364 | pks13 | 0.0 | 84.68% (1782) | polyketide synthase Pks13 |
M. avium 104 | MAV_0218 | - | 0.0 | 81.37% (1793) | polyketide synthase |
M. smegmatis MC2 155 | MSMEG_6392 | - | 0.0 | 71.33% (1821) | polyketide synthase |
M. thermoresistible (build 8) | TH_4178 | - | 0.0 | 70.75% (1846) | PUTATIVE mycolic acid condensase |
M. ulcerans Agy99 | MUL_4983 | pks13 | 0.0 | 84.72% (1780) | polyketide synthase Pks13 |
M. vanbaalenii PYR-1 | Mvan_5640 | - | 0.0 | 68.56% (1845) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_1169|M.gilvum_PYR-GCK ------------------------------MAQAQDDSAKSGPD------ Mvan_5640|M.vanbaalenii_PYR-1 ------------------------------MAEAQDGSSKAGPD------ MSMEG_6392|M.smegmatis_MC2_155 -------------------------------------------------- TH_4178|M.thermoresistible__bu MTENPNDSQPPVTGDEAGPQNPAEEVRLADVLPADGPLQPAQTD------ Mb3830c|M.bovis_AF2122/97 -------------------------MADVAESQ--ENAPAERAE------ Rv3800c|M.tuberculosis_H37Rv -------------------------MADVAESQ--ENAPAERAE------ MMAR_5364|M.marinum_M -------------------------MADTDQPQSNEDAQANKSD------ MUL_4983|M.ulcerans_Agy99 -------------------------MADTDQPQSNEDAQANKSD------ MLBr_00101|M.leprae_Br4923 -------------------------MADVDAPQLNQDPPQLNQDPQANLP MAV_0218|M.avium_104 -------------------------MADIDEPQ--ENTPAKKSDMRAG-- MAB_0180|M.abscessus_ATCC_1997 ---------------MTDTQQDSTPETSLETPAPEVAAPTGGAG------ Mflv_1169|M.gilvum_PYR-GCK -------------------------ITVAEMREWLRNWVGNATGQSPDSI Mvan_5640|M.vanbaalenii_PYR-1 -------------------------MTVAEMREWLRNWVGNATGQAPDSI MSMEG_6392|M.smegmatis_MC2_155 -------------------------MTVNEMREWLRNWVANATGQSADAI TH_4178|M.thermoresistible__bu -------------------------MTVAEMKDWLRNWISNATGQPADRI Mb3830c|M.bovis_AF2122/97 -------------------------LTVPEMRQWLRNWVGKAVGKAPDSI Rv3800c|M.tuberculosis_H37Rv -------------------------LTVPEMRQWLRNWVGKAVGKAPDSI MMAR_5364|M.marinum_M -------------------------MTVPEMRQWLRNWVGKAVGKSPDSI MUL_4983|M.ulcerans_Agy99 -------------------------MTVPEMRQWLRNWVGKAVGKSPDSI MLBr_00101|M.leprae_Br4923 AEKTKMRFGDDAERSDEEVRRITRITTVPEMRQWLRNWVGKVVGKSPDDI MAV_0218|M.avium_104 ------------DDAERSDAEERRPTTVPEMREWLRNWVGRAVGKSPDEI MAB_0180|M.abscessus_ATCC_1997 -------------------------LTVPEMREWLRNWIAKATGVSPDRI ** **::*****:....* ..* * Mflv_1169|M.gilvum_PYR-GCK SETAPLVELGLSSRDAVAMASDIEDLTGVTLTATVAFRHPTIEALATVIV Mvan_5640|M.vanbaalenii_PYR-1 NESAPLVELGLSSRDAVAMASDIEDLTGVTLTATVAFRHPTIESLATVII MSMEG_6392|M.smegmatis_MC2_155 DESTPMVELGLSSRDAVAMASDIEDLTGVTLTATVAFRHPTIESLATVII TH_4178|M.thermoresistible__bu DDSTPMVELGLSSRDAVAMASDIEDLTGVTLTATVAFRHPTIESLATVII Mb3830c|M.bovis_AF2122/97 DESVPMVELGLSSRDAVAMAADIEDLTGVTLSVAVAFAHPTIESLATRII Rv3800c|M.tuberculosis_H37Rv DESVPMVELGLSSRDAVAMAADIEDLTGVTLSVAVAFAHPTIESLATRII MMAR_5364|M.marinum_M DESVPMVELGLSSRDAVAMAADIEDMTGVTLSVAVAFQHPTIESLATRII MUL_4983|M.ulcerans_Agy99 DESVPMVGLGLSSRDAVAMAADIEDMTGVTLSVAVAFQHPTIESLATRII MLBr_00101|M.leprae_Br4923 DESAPMVELGLASRDAVAMAADIEDLTGVTLSVAVAFQYPTIESLANRII MAV_0218|M.avium_104 DESVPMVELGLSSRDAVAMAADIEDMTGVTLSVAVAFQHPTIESLATRII MAB_0180|M.abscessus_ATCC_1997 DDSAPMVEMGLSSRDAVAMAADIEDLTGVTLTATVAFQHPTIESLATRII .::.*:* :**:********:****:*****:.:*** :****:**. *: Mflv_1169|M.gilvum_PYR-GCK EGEPEEDR-TADGADWSRDVDEGRANIAIVGVGTRFPGDMNTPDEMWQAL Mvan_5640|M.vanbaalenii_PYR-1 EGEPEADISALDDEDWSREVDEGVANIAIVGVGTRFPGDMNTPDEMWQAL MSMEG_6392|M.smegmatis_MC2_155 EGEPEPEP-YDEDEDWSRTRD--VEDIAIVGVATRFPGDLNTPDEMWEAL TH_4178|M.thermoresistible__bu EGEQETGA-DDDDADWS-RPDADERAIAIVGLSTRFPGEMNTPAETWQAL Mb3830c|M.bovis_AF2122/97 EGEPETDLAGDDAEDWSRTGPAERVDIAIVGLSTRFPGEMNTPEQTWQAL Rv3800c|M.tuberculosis_H37Rv EGEPETDLAGDDAEDWSRTGPAERVDIAIVGLSTRFPGEMNTPEQTWQAL MMAR_5364|M.marinum_M EGEPEVADDGIDNIDWTRNGPAERVDIAIVGLATRLPGEMNSPEETWRAL MUL_4983|M.ulcerans_Agy99 EGEPEVADDGIDNIDWTRNGPAERVDIAIVGLATRLPGEMNSPEETWRAL MLBr_00101|M.leprae_Br4923 EGESETIDDDTDAFDWSRTGSAERIDIAVVGLSTRLPGDMNSPEETWRAL MAV_0218|M.avium_104 EGEPEAVDAG-DDMDWSRSGPAERVDIAIVGLSTRLPGDMNSPDETWQAL MAB_0180|M.abscessus_ATCC_1997 EGEPEVPDAGDEDWSRDPKIAAGEFDIAVVGLSARLPGDVNSPAQLWEAL *** * : . **:**:.:*:**::*:* : *.** Mflv_1169|M.gilvum_PYR-GCK LEGRDAITDLPEGRWSEFLSEPRIAERVAKARTRGGYLSDIKGFDAEFFA Mvan_5640|M.vanbaalenii_PYR-1 LEARDAITDLPEGRWSEFLSEPRIAERVAKARTRGGYLSDIKGFDAEFFA MSMEG_6392|M.smegmatis_MC2_155 LEGKDCVTDLPEDRWTEFLDEPRIAERVKKARTRGGYLTDIKGFDSEFFA TH_4178|M.thermoresistible__bu LEGRDAITDLPEGRWSEFLSEPRIAERVAKAATRGGYLSDIKGFDAEFFA Mb3830c|M.bovis_AF2122/97 LEGRDGITDLPDGRWSEFLEEPRLAARVAGARTRGGYLKDIKGFDSEFFA Rv3800c|M.tuberculosis_H37Rv LEGRDGITDLPDGRWSEFLEEPRLAARVAGARTRGGYLKDIKGFDSEFFA MMAR_5364|M.marinum_M LEGRDAITDLPEGRWSEFLEEPRIAERVANARTRGGYLSDIKGFDSEFFA MUL_4983|M.ulcerans_Agy99 LEGRDAITDLPEGRWSEFLEEPRIAERVANARTRGGYLSDIKGFDSEFFA MLBr_00101|M.leprae_Br4923 LEGRDAITDLPAGRWSEFLGEPRLAQRIAQARTRGGYLKDIKGFDSDFFA MAV_0218|M.avium_104 MEGRDAITDLPEGRWSEFLEEPRIAARVAGARTRGGYLKDIKGFDSEFFA MAB_0180|M.abscessus_ATCC_1997 LEGRDAITDLPEGRWEEFTAEPRIAERVAQAATRGGYLKDIKGFDAEFFT :*.:* :**** .** ** ***:* *: * ******.******::**: Mflv_1169|M.gilvum_PYR-GCK LSKMEADNIDPQQRMALELTWEALEHARIPASSLRGESVGVYLGSSVNDY Mvan_5640|M.vanbaalenii_PYR-1 LSKMEADNIDPQQRMALELTWEALEDARIPASSLRGENVGVYVGSSTNDY MSMEG_6392|M.smegmatis_MC2_155 LSKMEADNIDPQQRMALELTWEALEHARIPASSLRGESVGVYIGSSTNDY TH_4178|M.thermoresistible__bu LSKMEADNLDPQQRMALELTWEALEDARIPASELRGENVGVYIGASNNDY Mb3830c|M.bovis_AF2122/97 VAKTEADNIDPQQRMALELTWEALEHARIPASSLRGQAVGVYIGSSTNDY Rv3800c|M.tuberculosis_H37Rv VAKTEADNIDPQQRMALELTWEALEHARIPASSLRGQAVGVYIGSSTNDY MMAR_5364|M.marinum_M VAKTEADNIDPQQRMALELTWEALEHARIPPSSLRGGPVGVYVGVSNNDY MUL_4983|M.ulcerans_Agy99 VAKTEADNIDPQQRMALELTWEALEHARIPPSSLRGGPVGVYVGVSNNDY MLBr_00101|M.leprae_Br4923 VAKTEAENIDPQQRMALELTWEALEHARIPASSLRGEAVGVYIGSSTNDY MAV_0218|M.avium_104 VAKTEADNIDPQQRMALELTWEALEHARIPASSLRGEAVGVYVGFSNNDY MAB_0180|M.abscessus_ATCC_1997 LSKMEADNMDPQQRIALELTWEALENARIPASSLKGESVGVYIGSSNNDY ::* **:*:*****:**********.****.*.*:* ****:* * *** Mflv_1169|M.gilvum_PYR-GCK MFISVADPAVAHPYAITGNSSAVVANRVSYFYDFRGPSMAIDTACSSSLV Mvan_5640|M.vanbaalenii_PYR-1 SFLGVADPSTAHPYAITGTASSIIANRVSYFYDFRGPSMAIDTACSSSLV MSMEG_6392|M.smegmatis_MC2_155 SFLAMSDPSIAHPYAITGTASSIIANRVSYFYDFRGPSVAVDTACSSSLV TH_4178|M.thermoresistible__bu SFLAVSDPTVAHPYAITGTASSIIANRVSYFFDFRGPSVAVDTACSSSLV Mb3830c|M.bovis_AF2122/97 SFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDFHGPSVTIDTACSSSLV Rv3800c|M.tuberculosis_H37Rv SFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDFHGPSVTIDTACSSSLV MMAR_5364|M.marinum_M SFLAVSDPTIAHPYAITGTATSIIANRVSYFYDFRGPSVAIDTACSSSLV MUL_4983|M.ulcerans_Agy99 SFLAVSDPTIAHPYAITGTATSIIANRVSYFYDFRGPSVAIDTACSSSLV MLBr_00101|M.leprae_Br4923 SFLAVSDPTIAHPYAITGTSSSIIANRVSYFYDFRGPSVTIDTACSSSLV MAV_0218|M.avium_104 QFLAVSDPTVAHPYAITGTASSIIANRVSYFYDFRGPSVAVDTACSSSLV MAB_0180|M.abscessus_ATCC_1997 SYLSVADPTVTHPYAITGNASSIIANRVSYFYDFRGPSVAVDTACSSSLV ::.::**: :*******.:::::*******:**:***:::********* Mflv_1169|M.gilvum_PYR-GCK AVHEGIKALRGGDADVVIAGGVNALITPLVTLGFDEVGGVLAPDGRIKSF Mvan_5640|M.vanbaalenii_PYR-1 AVHEGVKALRSGDADVVLAGGVNALVTPLVTVGFDEVGGVLAPDGRIKSF MSMEG_6392|M.smegmatis_MC2_155 ATHQGVQALRAGEADVAIVGGVNALVTPLVTVGFDEVGGVLAPDGRIKSF TH_4178|M.thermoresistible__bu AVHQGVQALRSGEADVVVAGGVNALVTPMVTIGFDEVGGVLAPDGRIKSF Mb3830c|M.bovis_AF2122/97 AIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGAVLAPDGRIKSF Rv3800c|M.tuberculosis_H37Rv AIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGAVLAPDGRIKSF MMAR_5364|M.marinum_M AVHQGVQALRNGEADVVVAGGVNALVTPMVTLGFDEIGAVLAPDGRIKSF MUL_4983|M.ulcerans_Agy99 AVHQGVQALRNGEADVVVAGGVNALVTPMVTLGFDEIGAVLAPDGRIKSF MLBr_00101|M.leprae_Br4923 AIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGSVLAPDGRIKSF MAV_0218|M.avium_104 ATHQAVQALRNGECDVAIAGGVNALLTPLVTLGFDEIGQVLAPDGRIKSF MAB_0180|M.abscessus_ATCC_1997 AVHQGVKALRSGEADVVVAGGVNALITPVVTVGFDEVGGVLAPDGRIKSF * *:.::*** *:.**.:.******:**:**:****:* *********** Mflv_1169|M.gilvum_PYR-GCK SKDADGYARSEGGGVVVLKRLEDARRDGDQILAVIAGGAVNHDGRSNGML Mvan_5640|M.vanbaalenii_PYR-1 SKDADGYARSEGGGMLVLKRLADARRDGDQIYAVIAGAAINHDGRSNGML MSMEG_6392|M.smegmatis_MC2_155 SSDADGYARSEGGGMLVLKRISDARRDGDQILAVIAGSAVNHDGRSNGLL TH_4178|M.thermoresistible__bu SSDANGYSRSEGGGMLVLKRLADARRDGDEIYAIIAGSAVNHDGRSNGML Mb3830c|M.bovis_AF2122/97 SADADGYTRSEGGGMLVLKRVDDARRDGDAILAVIAGSAVNHDGRSNGLI Rv3800c|M.tuberculosis_H37Rv SADADGYTRSEGGGMLVLKRVDDARRDGDAILAVIAGSAVNHDGRSNGLI MMAR_5364|M.marinum_M SADADGYTRSEGAGMLVLKRVDDARRDGDQILAVIAGSAVNHDGRSNGLI MUL_4983|M.ulcerans_Agy99 SADADGYTRSEGAGMLVLKRVDDARRDGDQILAVIAGSAVNHDGRSNGLI MLBr_00101|M.leprae_Br4923 SSDADGYTRSEGGGVLVLKRVNDARRDGDQILAVIAGSAVNHDGRSNGLI MAV_0218|M.avium_104 SADADGYTRSEGGGMFVLKRVDDARRDGDQILAVIAGSAVNHDGRSNGLI MAB_0180|M.abscessus_ATCC_1997 SQDANGYSRSEGGGMLVLKRLSDARRDGDPIMAIIAGSAVNHDGRSNGLL * **:**:****.*:.****: ******* * *:***.*:********:: Mflv_1169|M.gilvum_PYR-GCK APNPDAQEAVLRKAYKDAGIDPRDVDYVEAHGTGTILGDPIEADALGRVI Mvan_5640|M.vanbaalenii_PYR-1 APNPDAQEAVLRKAYKDAGINPRTVDYVEAHGTGTILGDPIEADALGRVI MSMEG_6392|M.smegmatis_MC2_155 APNPDAQAEVLRKAYKDAGINPRDVDYIEAHGTGTILGDPIEADALGRIV TH_4178|M.thermoresistible__bu APNPDAQADVLRKAYQDAGINPRDVDYIEAHGTGTILGDPIEADALGRVV Mb3830c|M.bovis_AF2122/97 APNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTILGDPIEAEALGRVV Rv3800c|M.tuberculosis_H37Rv APNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTILGDPIEAEALGRVV MMAR_5364|M.marinum_M APNQDAQADVLRRAYKDAGIDPRNVDYIEAHGTGTILGDPIEAEALGRVV MUL_4983|M.ulcerans_Agy99 APNQDAQADVLRRAYKDAGIDPRNVDYIEAHGTGTILGDPIEAEALGRVV MLBr_00101|M.leprae_Br4923 APNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTVLGDPIEAEALGRVV MAV_0218|M.avium_104 APNQDAQAEVLRRAYKDAGIDPRTVDYIEAHGTGTVLGDPIEAEALGRVV MAB_0180|M.abscessus_ATCC_1997 APNPDAQAEVLRKAYKDAGIDPRSVDVIEAHGTGTILGDPIEADGLGRVV *** *** ***:**:****:** ** :*******:*******:.***:: Mflv_1169|M.gilvum_PYR-GCK GRGRAADKPALLGAVKSNIGHLESAAGAASLAKVALALHYNKIPASINYT Mvan_5640|M.vanbaalenii_PYR-1 GRGRAADRPALLGAVKSNVGHLESAAGAASLAKVALSLQRNKIPPSINYS MSMEG_6392|M.smegmatis_MC2_155 GKGRPADKPALLGAVKSNLGHLESAAGAASLAKMTLALANDKLPPSINYA TH_4178|M.thermoresistible__bu GRNRPADRPALLGAVKSNLGHLESAAGAASLAKVSLALKHNKLPPSINFA Mb3830c|M.bovis_AF2122/97 GRGRPADRPALLGAVKTNVGHLESAAGAASMAKVVLALQHDKLPPSINFA Rv3800c|M.tuberculosis_H37Rv GRGRPADRPALLGAVKTNVGHLESAAGAASMAKVVLALQHDKLPPSINFA MMAR_5364|M.marinum_M GKGRPADRPALLGAVKTNIGHLESAAGAASMAKVVLALQHDKLPPSINFA MUL_4983|M.ulcerans_Agy99 GKGRPADRPALLGAVKTNIGHLESAAGAASMAKVVLALQHDKLPPSINFA MLBr_00101|M.leprae_Br4923 GRGRPADRPALLGAVKTNVGHLESAAGAASMVKVVLALQHDKLPPSINFA MAV_0218|M.avium_104 GRGRPADRPALLGAVKTNVGHLESAAGAASLAKVVLALQHDKLPPSINFA MAB_0180|M.abscessus_ATCC_1997 GRGRDADKPALLGSAKSNFGHLESAAGAASLSKIVLALQNNKVPPSINYT *:.* **:*****:.*:*.***********: *: *:* :*:*.***:: Mflv_1169|M.gilvum_PYR-GCK GPNPYIDFDREHLKVADTLSDWPRYSGHAVAGVSGFGFGGANAHLVVREV Mvan_5640|M.vanbaalenii_PYR-1 GPNPYIDFDKEHLKVADTVTDWPRYSGHAIAGVSGFGFGGANAHLVLREV MSMEG_6392|M.smegmatis_MC2_155 GPNPYIDFEKERLKVNDTVSDWPRYSGKAIAGVSGFGFGGANAHVVMREV TH_4178|M.thermoresistible__bu GPNPYIDFEGLRLKVADTVTDWPRYSGKAIAGVSGFGFGGANAHLVLREV Mb3830c|M.bovis_AF2122/97 GPSPYIDFDAMRLKMITTPTDWPRYGGYALGGVSSFGFGGANAHVVVREV Rv3800c|M.tuberculosis_H37Rv GPSPYIDFDAMRLKMITTPTDWPRYGGYALAGVSSFGFGGANAHVVVREV MMAR_5364|M.marinum_M GPSPYIDFDAMRLKVVDAATDWPRYGGYALAGVSSFGFGGANAHVVVREV MUL_4983|M.ulcerans_Agy99 GPSPYIDFDAMRLKVVDAATDWPRYGGYALAGVSSFGFGGANAHVVVREV MLBr_00101|M.leprae_Br4923 GPSPYIDFDAMRLKVIDTATDWPRYGGYALAGVSSFGFGGANAHLVVREV MAV_0218|M.avium_104 GPSPYIDFDGMRLKVIDSPTDWPRYGGYALAGVSSFGFGGANAHLVVREV MAB_0180|M.abscessus_ATCC_1997 GPNPYIDFDAIHLKVVDQVSEWPRYSGHAIAGVSGFGFGGANAHIVVREV **.*****: :**: ::****.* *:.***.*********:*:*** Mflv_1169|M.gilvum_PYR-GCK LPTDLVEPAPEPDVAVVTPASD---AKPAVYVGGMLVEDD----EDE--- Mvan_5640|M.vanbaalenii_PYR-1 LPTDLVEPAPEPDVAVVTPAND---DAKAVYVGGVRMDEYGEFVSDEPLA MSMEG_6392|M.smegmatis_MC2_155 LAGDLVEPEPEP-EPEAKPEKS---EADAVYVGGVRMDEYGEFIDED--- TH_4178|M.thermoresistible__bu LPSDLVEPEPAPEPAADKPAKS---DADAVYIGGVRVDADDHDDAADHDA Mb3830c|M.bovis_AF2122/97 LPRDVVEKEPEPEPEPKAAAEP--AEAPTLAGHALRFDEFGNIITDS--- Rv3800c|M.tuberculosis_H37Rv LPRDVVEKEPEPEPEPKAAAEP--AEAPTLAGHALRFDEFGNIITDS--- MMAR_5364|M.marinum_M LPRDVIEREPDPESAPAAPAQAGESEAASAEGHALRFDEYGEIITDAP-- MUL_4983|M.ulcerans_Agy99 LPRDVIEREPDPESAPAAPAQAGESEAASAEGHALRFDEYGEIITDAP-- MLBr_00101|M.leprae_Br4923 LPRDVIEPERQPESPVPAAATT---ETAMLEGRVLRFDECGEIITDV--- MAV_0218|M.avium_104 LPRDVIEREPEPTPAPQAAAEP--TESPEPQAHALRFDDFGNVIPDP--- MAB_0180|M.abscessus_ATCC_1997 LPIDLVEPSESTEPESDDADTN--GKHAVAEADTADGDEFSVSRFDEYG- *. *::* . . : Mflv_1169|M.gilvum_PYR-GCK ------YQDDDRGDDEFYGRVV--DEEPELPGLTDEALRLLEVAREELAA Mvan_5640|M.vanbaalenii_PYR-1 RRESGFDEDDDRGDDEFYGRLP--EEEPELPGLTDEALRLLEVAREELAA MSMEG_6392|M.smegmatis_MC2_155 -------EPAEGGD--AYPSYD--EDSYELPGITEAAQRLLEQAREELEA TH_4178|M.thermoresistible__bu DG-AEYAERRDRMDFYGDDTYVPSDAEPELPGMTEEAQRLLEAARAELES Mb3830c|M.bovis_AF2122/97 --------------------AVAEEPEPELPGVTEEALRLKEAALEELAA Rv3800c|M.tuberculosis_H37Rv --------------------AVAEEPEPELPGVTEEALRLKEAALEELAA MMAR_5364|M.marinum_M ------------------SYGQAEEAEPELPGVTEEALRLKEVALEELAA MUL_4983|M.ulcerans_Agy99 ------------------SYGQAEEAEPELPGVTEEALRLKEVALEELAA MLBr_00101|M.leprae_Br4923 --------------------ADFGESEPELPGMTDEALQLKQAALEALAV MAV_0218|M.avium_104 --------------------EAPEEGEHELPGLTEEALRLKAIALEELAA MAB_0180|M.abscessus_ATCC_1997 -----------------EFTGGYSDEPYELPGLTDEAKRLKEEGLAALAA : ****:*: * :* . * Mflv_1169|M.gilvum_PYR-GCK AEA-ADPPTQLVPLAVSGFLSSRKKATAAELADWVDSPEGRAASLESIGR Mvan_5640|M.vanbaalenii_PYR-1 AEA-ENPTTPIVPIAVSGFLTSRKRATAAELADWIDSPEGRASSLEAIGR MSMEG_6392|M.smegmatis_MC2_155 KEA-EEPTKQLVPLAVSAFLTSRKRQAAAELADWIDSPEGRASSLESIGR TH_4178|M.thermoresistible__bu QEQ-SKP---LVPLAVSAFLTSRKKAAAAELADWIDSPAGRAASLESIGR Mb3830c|M.bovis_AF2122/97 QEV----TAPLVPLAVSAFLTSRKKAAAAELADWMQSPEGQASSLESIGR Rv3800c|M.tuberculosis_H37Rv QEV----TAPLVPLAVSAFLTSRKKAAAAELADWMQSPEGQASSLESIGR MMAR_5364|M.marinum_M KEEAEGPTKPLIPLAVSAFLTSRKKAAAAELADWMESPEGQASSLESIGR MUL_4983|M.ulcerans_Agy99 KEEPEGPTKPLIPLAVSAFLTSRKKAAAAELADWMESPEGQASSLESIGR MLBr_00101|M.leprae_Br4923 KQV----TAPLIPLVVSSFLTSRKKAAAAELADWMDSPQGRASSLESIGR MAV_0218|M.avium_104 QQESE-PTKPLIPLAVSAFLTSRKKAAAAELADWMESPEGQASSLESIGR MAB_0180|M.abscessus_ATCC_1997 EEP----VAPVVPLFISGFLSSRKKAAAAALADWMETEEGQSYSLESIGR : ::*: :*.**:***: :** ****::: *:: ***:*** Mflv_1169|M.gilvum_PYR-GCK SLSRRNHGRSRAVVLAHDHDEAVKGLRAVAEGKTHPSVISSDGPVTNGPV Mvan_5640|M.vanbaalenii_PYR-1 SLSRRNHGRSRAVVLAHDHDEAVKGLRSIAEGKPNPIVISADGPVTNGPV MSMEG_6392|M.smegmatis_MC2_155 SLSRRNHGRSRAVVLAHDHDEAIKGLRALAEGKQHPSVLSADGPVTNGPV TH_4178|M.thermoresistible__bu SLSRRNHARSRAVVLARDHDEAIKGLRALAEGKQHPSLLTADGPVANGPV Mb3830c|M.bovis_AF2122/97 SLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGKQAPNVFSVDGPVTTGPV Rv3800c|M.tuberculosis_H37Rv SLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGKQAPNVFSVDGPVTTGPV MMAR_5364|M.marinum_M SLSRRNHGRSRAVVLAHDHEEAIKGLRAVAEGKQRPGVFSVDGPVTNGPV MUL_4983|M.ulcerans_Agy99 SLSRRNHGRSRAVVLAHDHEEAIKGLRAVAEGKQRPGVFSVDGPVTNGPV MLBr_00101|M.leprae_Br4923 SLSRRNHGRSRAVVLAHYHDEAIEGFRAIAEGKQRPHVFSVDGPVTNGPV MAV_0218|M.avium_104 ALSRRNHGRSRAVVLAHDHEEAIKGLRAVAEGKQRPNVFSTDGPVTNGPV MAB_0180|M.abscessus_ATCC_1997 SLSRRNHGRSRAVVLAHDHEEAIKGLRAVAEGKQKPYVYSADGPVSNGPV :******.********: *:**::*:*::* ** * : : ****:.*** Mflv_1169|M.gilvum_PYR-GCK WVLAGFGAQHRKMAKSLYLRDEIFADWINKVDSLIQDERGHSILELILDD Mvan_5640|M.vanbaalenii_PYR-1 WVLAGFGAQHRKMAKSLYLRDQTFAEWINKVDSLIQDERGHSIVELILDD MSMEG_6392|M.smegmatis_MC2_155 WVLAGFGAQHRKMGKSLYLRNEVFAEWINKVDALIQDERGYSILELILDD TH_4178|M.thermoresistible__bu WVLAGFGAQHRKMGKSLYLRNEVFAEWINKVDALIQDERGYSILELILDD Mb3830c|M.bovis_AF2122/97 WVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVDALVQDELGYSVLELILDD Rv3800c|M.tuberculosis_H37Rv WVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVDALVQDELGYSVLELILDD MMAR_5364|M.marinum_M WVLAGFGAQHRKMGKSLYLRNPVFAEWIEKVDALVQDELGYSVLELILDD MUL_4983|M.ulcerans_Agy99 WVLAGFGAQHRKMGKSLYLRNPVFAEWIEKVDALVQDELGYSVLELILDD MLBr_00101|M.leprae_Br4923 WVFAGFGAQHREMGKSLYLRNQVFAEWIEKVDALVQDERGYSVLELILDD MAV_0218|M.avium_104 WAMAGFGAQHRKMGKNLYLRNEVFAEWIEKVDALIQDERGYSVLELILDD MAB_0180|M.abscessus_ATCC_1997 WVMAGFGAQHRKMGKSLYLRDPIFAEWIDKVDSYVQEERGYSVVELILDD *.:********:*.*.****: ** **:***: :*:* *:*::****** Mflv_1169|M.gilvum_PYR-GCK AIDYSDETTELPIEKVQLVIFGIQIALGELLKAHGARPGALIGQSLGEAA Mvan_5640|M.vanbaalenii_PYR-1 AIDYTDETTELPIEKVQLVIFAIQVALGELLKAHGAKPGALIGQSLGEAA MSMEG_6392|M.smegmatis_MC2_155 NVDYTDATCEYPIEVVQLVIFAIQIALGELLRHHGAKPAAVVGQSLGEAA TH_4178|M.thermoresistible__bu SVDYTDATCEYPIEVVQLVIFAIQIALGELLRHHGAKPAAVIGQSLGEAA Mb3830c|M.bovis_AF2122/97 AQDYG-------IETTQVTIFAIQIALGELLRHHGAKPAAVIGQSLGEAA Rv3800c|M.tuberculosis_H37Rv AQDYG-------IETTQVTIFAIQIALGELLRHHGAKPAAVIGQSLGEAA MMAR_5364|M.marinum_M SQDYG-------IETTQVTIFAIQIALGELLKHHGAKPAAVVGQSLGEAA MUL_4983|M.ulcerans_Agy99 SQDYG-------IETTQVTIFAIQIALGELLKHHGAKPAAVVGQSLGEAA MLBr_00101|M.leprae_Br4923 AQDYG-------IETTQVTIFAIQIALGELLKHHGAKPAAVVGQSLGEAA MAV_0218|M.avium_104 SHEYG-------IETSNVVIFAIQIALGELLRHHGAKPAAVVGQSLGEPA MAB_0180|M.abscessus_ATCC_1997 SHEYG-------IETSNIAIFAIQIGLGEVLKAHGAKPTAVIGQSLGEPA :* ** ::.**.**:.***:*: ***:* *::******.* Mflv_1169|M.gilvum_PYR-GCK AAYFSGGLSLEDATRTICSRAHLMGEGEAMLFGEYIRLMALVEYSADEIE Mvan_5640|M.vanbaalenii_PYR-1 AAYFSGGLSLEDATRTICSRSHLMGEGEAMLFGEYIRLMALVEYSAEEIV MSMEG_6392|M.smegmatis_MC2_155 ASYFAGGLSLADATRTICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK TH_4178|M.thermoresistible__bu AAYFCGGLSLADATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK Mb3830c|M.bovis_AF2122/97 SAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIR Rv3800c|M.tuberculosis_H37Rv SAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIR MMAR_5364|M.marinum_M SAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK MUL_4983|M.ulcerans_Agy99 SAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK MLBr_00101|M.leprae_Br4923 CAYFVGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK MAV_0218|M.avium_104 SAYFSGGLSLADATRVICSRSHLMGEGEAMLFGEYIRFMALVEYSADELK MAB_0180|M.abscessus_ATCC_1997 SAYFAGGLSLADATRVICSRAHLMGEGEAMLFGDYIRLMALVEYSADELK .:** ***** ****.****:************:***:********:*: Mflv_1169|M.gilvum_PYR-GCK TVFSD---YKNLEVCVYAAPNQTVIGGPPDQVDAIIERAESEGKFARKFQ Mvan_5640|M.vanbaalenii_PYR-1 SVFGEDEAFNNLEVCVYAAPTQSVIGGPPDQVDAIIARAESEGKFARKFQ MSMEG_6392|M.smegmatis_MC2_155 TVFSD---YPDLEVCVYAAPTQTVIGGPPDQVDAIIARAESEGKFARKFQ TH_4178|M.thermoresistible__bu TVFAD---YPDLEVCVYAAPTQTVIGGPPDQVDAIIARAEQEGKFARKFQ Mb3830c|M.bovis_AF2122/97 EVFSD---FPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFARKFA Rv3800c|M.tuberculosis_H37Rv EVFSD---FPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFARKFA MMAR_5364|M.marinum_M TVFSD---FPDLEVCVYAAPTQTVIGGPPEQVDAIIARAESEGKFARKFQ MUL_4983|M.ulcerans_Agy99 TVFSD---FPDLEVCVYAAPTQTVIGGPPEQVDAIIARAESEGKFARKFQ MLBr_00101|M.leprae_Br4923 TVFSD---FPDLEVCVYAAPTQIVIGGPPEQVDAIIARAKAEGKFARKFA MAV_0218|M.avium_104 TVFAD---FPGLEVCVYAAPSQTVIGGPPEQIDAIVARAEAEGRFARKLQ MAB_0180|M.abscessus_ATCC_1997 TVFAD---FPDLEVCVYAAPSQTVIGGPPAQVDAIVARCEAEGKFARKLQ **.: : .*********.* ****** *:***: *.: **:****: Mflv_1169|M.gilvum_PYR-GCK TKGASHTTQMDPLLGELAAELQGIEAHPVQVPYYSTVHEGSLVRAGSDAI Mvan_5640|M.vanbaalenii_PYR-1 TKGASHTSQMDPLLGELAAELQGIEAHPVQVPYYSTVHEGSLIRAGSDPI MSMEG_6392|M.smegmatis_MC2_155 TKGASHTQQMDPLLGELAAELQGIEPKPLTTGYFSTVHEGTFIRPGSAPI TH_4178|M.thermoresistible__bu TKGASHTQQMDPLLGELAAELQGIQPLPTTVGLYSTVHEGTFVRPGS-VV Mb3830c|M.bovis_AF2122/97 TKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPI Rv3800c|M.tuberculosis_H37Rv TKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPI MMAR_5364|M.marinum_M TKGASHTQQMDPLLGELAAELQGIKPMSPTAGIFSTVHEGSYVKPGSDPI MUL_4983|M.ulcerans_Agy99 TKGASHTQQMDPLLGELAAGLQGIKPMSPTAGIFSTVHEGSYVKPGSDPI MLBr_00101|M.leprae_Br4923 TKGASHTQQMDPLLGELAAELQGIKPMSPTAGIYSTVHEGSYIKPGSDPI MAV_0218|M.avium_104 TKGAGHTSQMDPLLGEFSAELQGIKPMSPTVGIFSTVHEGTYIKPGSEPV MAB_0180|M.abscessus_ATCC_1997 TKGAGHTSQMDPLLGEFAAELQGIEPMSPKIGIFSTVHEGTFIRGGGEPV ****.** ********::* ****:. . :****** :: *. : Mflv_1169|M.gilvum_PYR-GCK HDVEYWKKGLRHSVYFTHGIRNAVDNGHTTFLELAPNPVALMQVGLTTAA Mvan_5640|M.vanbaalenii_PYR-1 HDVDYWKKGLRHSVYFTHGIRNAVDNGHTTFLELAPNPVALMQVGLTTAA MSMEG_6392|M.smegmatis_MC2_155 HDVDYWKKGLRHSVYFTQGIRNAVDNGHTTFLELAPNPVALMQVGLTTAS TH_4178|M.thermoresistible__bu HDVDYWKKGLRHSVYFTQGVRNAVDNGHTTFLELAPNPVALMQVGLTTAA Mb3830c|M.bovis_AF2122/97 HDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVALTTAD Rv3800c|M.tuberculosis_H37Rv HDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVALTTAD MMAR_5364|M.marinum_M HDVDYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVGLTTAS MUL_4983|M.ulcerans_Agy99 HDVDYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVGLTTAS MLBr_00101|M.leprae_Br4923 HDVDYWKKGLRHSVHFTQGIRNAVDNGHTTFLELAPNAVALMQVGLTTAA MAV_0218|M.avium_104 HDVAYWVKGMRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQIGLTTAA MAB_0180|M.abscessus_ATCC_1997 HDVDYWKKGMRHSVYFTHGTRNAVDAGHTTFLELAPNPVALMQVGLTTMA *** ** **:****:**:* ***** ***********.*****:.*** Mflv_1169|M.gilvum_PYR-GCK AGLHDAQLIPTLARKQDEVDSMTSAMAHLFVHGHDLDFRTLFTKAED--- Mvan_5640|M.vanbaalenii_PYR-1 AGLHDAQLIPTLARKQDEVDSMTTAMAHLYVYGHDLDMRTLFPLPADRPV MSMEG_6392|M.smegmatis_MC2_155 AGLHDAQLIATLARKQDEVESMISAMAQLYVHGHDLDFRTLFPRRSKG-L TH_4178|M.thermoresistible__bu AGLHDAQLIATLARKQDEVDSMTTAMAHLFVHGHDLDIRTLFG------- Mb3830c|M.bovis_AF2122/97 AGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLFSRASGP-- Rv3800c|M.tuberculosis_H37Rv AGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLFSRASGP-- MMAR_5364|M.marinum_M AGLHDAQLIPTLARKQDEVESMISTLAQLYVHGHDLDMRTLFPGPAGP-- MUL_4983|M.ulcerans_Agy99 AGLHDAQLIPTLARKQDEVESMISTLAQLYVHGHDLDMRTLFQGPAGP-- MLBr_00101|M.leprae_Br4923 VGLHDAQLIPTLSRNQDEVESMISTMAQLYVYGHDLDIWTLFSRAVGP-- MAV_0218|M.avium_104 AGLHDAQLIPTLAKKQDDVESMISAMAQLYVYGHDLDIRTLFTRAKGP-- MAB_0180|M.abscessus_ATCC_1997 SGLPDAQLIATLARKEDEVESMVKAMAQLYVHGHALDPRTLFSRAAKS-- ** *****.**::::*:*.** .::*:*:*:** ** *** Mflv_1169|M.gilvum_PYR-GCK -PETDFAAIPPTRFKRKPHWLDVNFTGDSSSVMPGNHVATPDGRHVWEYS Mvan_5640|M.vanbaalenii_PYR-1 DPATDYADIPPTRFKRKPHWLEAHFTGDSSAVMPGNHVATPDGRHVWEYL MSMEG_6392|M.smegmatis_MC2_155 AGALDFANIPPTRFKRKEHWLPAHFTGDSSAVMPGNHVATPDGRHVWEFV TH_4178|M.thermoresistible__bu --KGEFADIPPTRFRRKEHWLDAKFTGDSSVLMPGNHVATPDGRHVWEYA Mb3830c|M.bovis_AF2122/97 ---QDYANIPPTRFKRKEHWLPAHFSGDGSTYMPGTHVALPDGRHVWEYA Rv3800c|M.tuberculosis_H37Rv ---QDYANIPPTRFKRKEHWLPAHFSGDGSTYMPGTHVALPDGRHVWEYA MMAR_5364|M.marinum_M ---ADYAIIPPTRFKRKEHWLDAKFSGDASVIMPGNHVALPDGRHVWEFA MUL_4983|M.ulcerans_Agy99 ---ADYAIIPPTRFKRKEHWLDAKFSGDASVIMPGNHVALPDGRHVWEFA MLBr_00101|M.leprae_Br4923 ---EDYADIPPTRFKRKEHWLDVHFAGDGSVSMPGNHVALPDSRHVWEFA MAV_0218|M.avium_104 ---QDYANIPPTRFKRKEHWLDVHFSGDGSVIMPGTHVALPDGRHVWEYA MAB_0180|M.abscessus_ATCC_1997 ---SDYAPIPATEFKRKPHWLPAHFSADGSTRIPGTHVSLPDGKHVWEWS ::* **.*.*:** *** .:*:.*.* :**.**: **.:****: Mflv_1169|M.gilvum_PYR-GCK ARGAVDGQALAALVKAAAVAVIPDSTLTASEQRAVPADGSRLVTTLTRHP Mvan_5640|M.vanbaalenii_PYR-1 PKGETD---LAALVKAAAAVVLPDAKLTASEQRAVPGEGSRLVTTLTRHP MSMEG_6392|M.smegmatis_MC2_155 PRGKTD---LAALVKAAAAQVLPDAKLAAFEQRAVPADNARLVTTLTRHP TH_4178|M.thermoresistible__bu PKGETD---LAALVKSAAAQVLPDAKLVAYEQRAVPAEGARLVTTLTRHP Mb3830c|M.bovis_AF2122/97 P--RDGNVDLAALVRAAAAHVLPDAQLTAAEQRAVPGDGARLVTTMTRHP Rv3800c|M.tuberculosis_H37Rv P--RDGNVDLAALVRAAAAHVLPDAQLTAAEQRAVPGDGARLVTTMTRHP MMAR_5364|M.marinum_M P--REA-TDLAALVRAAATQVLPDARLSAAEQRALPGEGARLVTTLARHP MUL_4983|M.ulcerans_Agy99 P--REA-TDLAALVRAAATQVLPDARLSAAEQRALPGEGARLVTTLARHP MLBr_00101|M.leprae_Br4923 P--RDK-TDLAALVRAAVSQVLPGAHLTAAEQRAMPGAGARLVTMLTRHP MAV_0218|M.avium_104 P--RNGETDLAALVRSAATQVLPDAQLVASEQRAVPGPGARLVTTMTRHP MAB_0180|M.abscessus_ATCC_1997 PR-EVAGVDFAELVKTAATSVLPGAQLTAFEQRAIPGEGSTLVTTLSRHP . :* **::*. *:*.: * * ****:*. .: *** ::*** Mflv_1169|M.gilvum_PYR-GCK GGASVQVHARIEESFTLVYDAIVTRGGQQ--TALPTAVGA-----GTVAE Mvan_5640|M.vanbaalenii_PYR-1 GGAGVQVHARIEESFTLVYDAIVTRGGQQ--TALPTAVGA-----TTVAE MSMEG_6392|M.smegmatis_MC2_155 GGATVQVHARVEESFTLVYDAIVARANGAGVTALPVAVGAGVAVSGDVAG TH_4178|M.thermoresistible__bu GGASVQVHARIDESFTLVYDAIVTRGDQP--GVLPAAVGAG----AAIGA Mb3830c|M.bovis_AF2122/97 GGASVQVHARIDESFTLVYDALVSRAGS--ESVLPTAVGAATAIAVADGA Rv3800c|M.tuberculosis_H37Rv GGASVQVHARIDESFTLVYDALVSRAGS--ESVLPTAVGAATAIAVADGA MMAR_5364|M.marinum_M GGASVQVHARIDESFTLVYDALVARGGQ--DAVLPAAVGAGTAVAAGVDG MUL_4983|M.ulcerans_Agy99 GGASVQVHARIDESFTLVYDALVARGGQ--DAVLPAAVGAGTAVAAAVDG MLBr_00101|M.leprae_Br4923 GGASVQVHARIDESFTLVYDALVARGGQ--ESVLPTAVGAGTAIASITVP MAV_0218|M.avium_104 GGASVQVHARIDESFTLVYDALVSRAGQN-VAALPTAVGAGAAIAVAPTV MAB_0180|M.abscessus_ATCC_1997 GGATVQVHARIGESFTLVYDAVVSRAGQG--GALPFATAAGVATNGSAVV *** ******: *********:*:*.. .** *..* Mflv_1169|M.gilvum_PYR-GCK AVAAPVEQ----EQEK-APEFEADNLTAGANLGASFAKWSPDSGETIGDR Mvan_5640|M.vanbaalenii_PYR-1 VATAPVAV----EEPSGAPEFEADNLTAGANLGASFAKWSPESGETIGER MSMEG_6392|M.smegmatis_MC2_155 EGAGASVI----EDDEPDAEILQDNLTAGAGMGADFQKWDPNSGETIGQR TH_4178|M.thermoresistible__bu PQVGSGVE----EEPEEQPEILTDNLTQGANLGAQVAKWSPDSGETVRDR Mb3830c|M.bovis_AF2122/97 PVAPETP------AEDADAETLSDSLTT-RYMPSGMTRWSPDSGETIAER Rv3800c|M.tuberculosis_H37Rv PVAPETP------AEDADAETLSDSLTT-RYMPSGMTRWSPDSGETIAER MMAR_5364|M.marinum_M AVDAVAPSASADVTEESDAETLTDSLTN-RYMPSGMGRWTPDTGETIADR MUL_4983|M.ulcerans_Agy99 AVDAVAP--SADATEESDAETLTDSLTN-RYMPSGMGRWTPDTGETIADR MLBr_00101|M.leprae_Br4923 ADAVTVA------AEESDAEILSDSLTN-RYLPSDMGKWSPDSGETIGHR MAV_0218|M.avium_104 AAPEQPAEAP--VEEDTNAETLSDSLTA-RYLPAGTGKWSPDSGETVAER MAB_0180|M.abscessus_ATCC_1997 SASAAPSH-AVAVVEEEVPEEIHDNLLSGAGAGADFKKWSKESGEPVIDR . .* *.* : :* ::**.: .* Mflv_1169|M.gilvum_PYR-GCK LGAIVGAAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL Mvan_5640|M.vanbaalenii_PYR-1 LGTIVGAAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL MSMEG_6392|M.smegmatis_MC2_155 LGTIVGAAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL TH_4178|M.thermoresistible__bu LALIVGGAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL Mb3830c|M.bovis_AF2122/97 LGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL Rv3800c|M.tuberculosis_H37Rv LGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL MMAR_5364|M.marinum_M LGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL MUL_4983|M.ulcerans_Agy99 LGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL MLBr_00101|M.leprae_Br4923 LSTIVAAAMGYEPEDLPWEVPLVELGLDSLMAVRIKNRVEYDFDLPPIQL MAV_0218|M.avium_104 LGLIVSAAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL MAB_0180|M.abscessus_ATCC_1997 LATIVSMAMGYEPEDVPREVPLIELGLDSLMAVRIKNRVEFDFDLPPIQL *. **. ********:* ****:*****************:********* Mflv_1169|M.gilvum_PYR-GCK TAVRDANLYAVEKLIAYAVENRDQVEELAETQKGQSAEEIAAAQAELMGG Mvan_5640|M.vanbaalenii_PYR-1 TAVRDANLYAVEKLIAYAVENRDQVEELAETQKGQTAEEIAAAQAELMGG MSMEG_6392|M.smegmatis_MC2_155 TAVRDANLYNVEELIRYAIEHRDEVEQIAESQKGKTAEEIAAEQSELLGG TH_4178|M.thermoresistible__bu TAVRDASLRDVEQLITYAIEHRDEVDQLAEAQKGKTAEEIAAEQAELMGG Mb3830c|M.bovis_AF2122/97 TAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQKTQTAEEIARAQAELLHG Rv3800c|M.tuberculosis_H37Rv TAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQKTQTAEEIARAQAELLHG MMAR_5364|M.marinum_M TAVRDANLYNVEKLIEYAVEHRDEVEQLHEHQKTQTAEEIARAQAELMHA MUL_4983|M.ulcerans_Agy99 TAVRDANLYNVEKLIEYAVEHRDEVEQLHEHQKTQTAEEIARAQAELMHA MLBr_00101|M.leprae_Br4923 QAVRDANLYNVEKLIEYAIKHRDDVEQLHEYQKTQTAAAIAKAQMELLSG MAV_0218|M.avium_104 TAVRDANLYNIEQLITYAIEHRDEVEALHEHQKTLTPEEIAKEQAQLLSG MAB_0180|M.abscessus_ATCC_1997 QAVRDANLLDVERLVIYALENPDAVHELHDYQQTDEFKAAAPTGGMLSKA *****.* :*.*: **::: * *. : : *: * * . Mflv_1169|M.gilvum_PYR-GCK ATTVAELEAKLAEVGHPIA----------------EVPPP---------- Mvan_5640|M.vanbaalenii_PYR-1 ATTVAELEAKLAEAGHPIAADKSTDEVVTA--AGTEAPPSDVAVPAPPSD MSMEG_6392|M.smegmatis_MC2_155 ASTVAELEAKLAEAGHPLAAKDSEDSENSEDNAAGAAAAAEASAVEGLEI TH_4178|M.thermoresistible__bu ASTVAEIQEKLVAAGLAVDTGQDGSEQAPDQAAEQAAVLSGATEATATTA Mb3830c|M.bovis_AF2122/97 KVG---------KTEPVDS------------------------------- Rv3800c|M.tuberculosis_H37Rv KVG---------KTEPVDS------------------------------- MMAR_5364|M.marinum_M KHDSAPAPAAEAEAEAPES------------------------------- MUL_4983|M.ulcerans_Agy99 KHDSAPAPAAEAEAEAPES------------------------------- MLBr_00101|M.leprae_Br4923 VSP----------VTLPAS------------------------------- MAV_0218|M.avium_104 ATPASVAAPAPDPQAEPET------------------------------- MAB_0180|M.abscessus_ATCC_1997 DIEAALTAGAAESVPAEVP------------------------------- Mflv_1169|M.gilvum_PYR-GCK ---PTDPTGPSAPSIPAPPTDPSGPTG--------------AKPSAAG-- Mvan_5640|M.vanbaalenii_PYR-1 VAVPAPPTDPSGPSIPAPPTDPLGPSAPTAERSSAADGSSRERSSAAG-- MSMEG_6392|M.smegmatis_MC2_155 PPPPTDPTGPGGAPIPPPPSDPSGPAQAASATDAPAG--TVNKATAAA-- TH_4178|M.thermoresistible__bu VVDPQAEPSTQDDAIPPPPTDPRGPVSDSAPAPVANIPPPPTDPSGPNKP Mb3830c|M.bovis_AF2122/97 ---EAG------VALPSP-QNGEQPNPTG--------------------- Rv3800c|M.tuberculosis_H37Rv ---EAG------VALPSP-QNGEQPNPTG--------------------- MMAR_5364|M.marinum_M ---EAAAPPASDVPLPPPPTNPAGPSPNGQSSSTPDLK------------ MUL_4983|M.ulcerans_Agy99 ---EAAAPPASDVPLPPPPTNPAGPSPNGQSSSTPDLK------------ MLBr_00101|M.leprae_Br4923 ---EAP--------IPPPPTDPTDPPSNG---VQPNLV------------ MAV_0218|M.avium_104 ---QPAPPPPSDTPIPPPPTDPSGPSANG----GQPKP------------ MAB_0180|M.abscessus_ATCC_1997 --AAEPAADSAPPAIAQEATISAETSELAK-------------------- :. . Mflv_1169|M.gilvum_PYR-GCK --LAAKVLTQEAVTEALGADVPPRDAAERVTFATWAIVTGKSPGGIFNEL Mvan_5640|M.vanbaalenii_PYR-1 --LAAKVLTQEAVTEALGADVPPRDAAERVTFATWAIVTGKSPGGIFNEL MSMEG_6392|M.smegmatis_MC2_155 --AAAKVLTQEAVTEALGADVPPRDAAERVTFATWAIVTGKSPGGIFNEL TH_4178|M.thermoresistible__bu PAAERRVLTQEAVTEALGADVPPQDAAERVTFATWAIVTGKSPGGIFNEL Mb3830c|M.bovis_AF2122/97 --------------PALNVDVPPRDAAERVTFATWAIVTGKSPGGIFNEL Rv3800c|M.tuberculosis_H37Rv --------------PALNVDVPPRDAAERVTFATWAIVTGKSPGGIFNEL MMAR_5364|M.marinum_M --GAADALNQEAVAKALNSDVPPRDAAERVVFATWAIVTGKSAGGIFNPL MUL_4983|M.ulcerans_Agy99 --GAADALNQEAVAKALNADVPPRDAAERVVFATWAIVTGKSAGGIFNPL MLBr_00101|M.leprae_Br4923 --AAAEALTSEAVAKVLNSDVPPRDAAERVTFAAWAIVTGKSPGGIFDTL MAV_0218|M.avium_104 --SLAEALSSEAVTKALNSDVPPRDAAERVTFATWAIVTGKSAGGIFNPL MAB_0180|M.abscessus_ATCC_1997 ---AAAAMNQEAIAEALNADVPPRDAAERVAFATWAIVTGESPGSIFNAL .*. ****:******.**:******:*.*.**: * Mflv_1169|M.gilvum_PYR-GCK PSIADDVAEKIAARLSERADG-TVTAEQVRAARTIQDLSVAVRDEMDSGE Mvan_5640|M.vanbaalenii_PYR-1 PSIADDVAEKIAQRLSERAEG-TITAEQVKVARTIQDLSSHVRDEMDAGE MSMEG_6392|M.smegmatis_MC2_155 PTVSEETAKKMAERLSERAEG-TITVEDVLGAKTIEGLATIVREQLEEGV TH_4178|M.thermoresistible__bu PAIDDATAAKIAERLTERVDEGTISAEDVKAAKTIEELGTTVREYLEGGK Mb3830c|M.bovis_AF2122/97 PRLDDEAAAKIAQRLSERAEG-PITAEDVLTSSNIEALADKVRTYLEAGQ Rv3800c|M.tuberculosis_H37Rv PRLDDEAAAKIAQRLSERAEG-PITAEDVLTSSNIEALADKVRTYLEAGQ MMAR_5364|M.marinum_M PKLDKDKAAKMAQRLSERAEG-SITTEDVLSSQNIEALAEKVRGYLEAGT MUL_4983|M.ulcerans_Agy99 PKLDKDKAAKMAQRLSERAEG-SITTEDVLSSQNIEALAEKVRGYLEAGT MLBr_00101|M.leprae_Br4923 PKLDGDTAAKMAQRLSERAEG-TITAEDVLTSENIEALAGKVRNYLEAGQ MAV_0218|M.avium_104 PKLDADTAAKMAQRLSERADG-PITVEDVQTAETIEALAERVRTYLEAGQ MAB_0180|M.abscessus_ATCC_1997 PKIDDATAEKLAERLSQRADG-EIPAEEVKLAPTIEALGEVVRSRLEAGK * : * *:* **::*.: :..*:* : .*: *. ** :: * Mflv_1169|M.gilvum_PYR-GCK VDGFVRTIRARQEGSNR-------IPVFVFHPAGGSTVVYEPLLKRLPAD Mvan_5640|M.vanbaalenii_PYR-1 LDGFVRILRARPEGSTR-------VPVFVFHPAGGTTVVYEPLMKRLPAD MSMEG_6392|M.smegmatis_MC2_155 VDGFVRTLRPPKEGSNA-------VPLFVFHPAGGSTVVYEPLMKRLPAD TH_4178|M.thermoresistible__bu VDGFVRTIRAPQEGSDR-------LPVFVFHPAGGSTVVYEPLLNRLPPD Mb3830c|M.bovis_AF2122/97 IDGFVRTLRARPEAGGK-------VPVFVFHPAGGSTVVYEPLLGRLPAD Rv3800c|M.tuberculosis_H37Rv IDGFVRTLRARPEAGGK-------VPVFVFHPAGGSTVVYEPLLGRLPAD MMAR_5364|M.marinum_M IDGFVRTLRPRPEGSSK-------VPVFVFHPAGGSTVVYEPLLNRLPAD MUL_4983|M.ulcerans_Agy99 IDGFVRTLRPRPEGSSK-------VPVFVFHPAGGSTVVYEPLLNRLPAD MLBr_00101|M.leprae_Br4923 IDGFVRAIRPRAEDSAEGPAGESRVPVFVFHPAGGSTVVYEPLLKRLPAD MAV_0218|M.avium_104 IDGFVRTLRARPEGSTK-------IPVFVFHPAGGSTVVYEPLLKRLPPD MAB_0180|M.abscessus_ATCC_1997 IDGFVRTLAPRQEGSTA-------VPVFVFHPAGGSTVVYEPLLKRLPEG :***** : . * . :*:********:*******: *** . Mflv_1169|M.gilvum_PYR-GCK TPMYGFERVEGSVEERAAEYIPKLREIQG------DGPYILVGWSLGGAL Mvan_5640|M.vanbaalenii_PYR-1 TPVYGIERVEGSIEERAREYVPKLMEIQG------NGPYILAGWSLGGAL MSMEG_6392|M.smegmatis_MC2_155 VPVYGLERVEGSIEERAAEYVPKLLEMH-------KGPFVLAGWSLGGAL TH_4178|M.thermoresistible__bu TPMYGFERVEGSIEERARQYVPKLLELNGWIDGRRGEPFILAGWSLGGVL Mb3830c|M.bovis_AF2122/97 TPMYGFERVEGSIEERAQQYVPKLIEMQG------DGPYVLVGWSLGGVL Rv3800c|M.tuberculosis_H37Rv TPMYGFERVEGSIEERAQQYVPKLIEMQG------DGPYVLVGWSLGGVL MMAR_5364|M.marinum_M TPMYGFERVEGSIEERAAQYVPKLIEMQG------DGPYILVGWSLGGVL MUL_4983|M.ulcerans_Agy99 TPMYGFERVEGSIEERAAQYVPKLIEMQG------DGPYILVGWSLGGVL MLBr_00101|M.leprae_Br4923 TPMYGFERVEGSIEERVAVYVPKLIEMQG------DGPYILAGWSLGGVL MAV_0218|M.avium_104 TPMYGFERVEGSVQERAAQYVPKLLELNE------DNPFVLVGWSLGGAL MAB_0180|M.abscessus_ATCC_1997 TPMFGFERVEGTIEERAAKYVPKLMELHD-------GPFILAGWSLGAVL .*::*:*****:::**. *:*** *:: *::*.*****..* Mflv_1169|M.gilvum_PYR-GCK AYACAIGLKREGADVRFVGLIDMVRPGEEIPQTKEETRARWDRYALFAQR Mvan_5640|M.vanbaalenii_PYR-1 AYACAVGLKSQGADVKFVGLIDTVRAGEEVPQTKEEIRARWDRYALFAQR MSMEG_6392|M.smegmatis_MC2_155 AYACAIGLKQSGADVRFVGLIDTVLPGEPIDQSKEGMRARWDRYARFAER TH_4178|M.thermoresistible__bu AYACAIGLKQAGADVRFVGLIDAVRAGEEVPQTKEETRARWERYARFAER Mb3830c|M.bovis_AF2122/97 AYACAIGLRRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEK Rv3800c|M.tuberculosis_H37Rv AYACAIGLRRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEK MMAR_5364|M.marinum_M AYACAIGLKRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAKFAEK MUL_4983|M.ulcerans_Agy99 AYACAIGLKRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAKFAEK MLBr_00101|M.leprae_Br4923 AYACAIGLRSAGKEVAWVGLIDAVRAGEEIPQTKEEIRKRWDRYARFAER MAV_0218|M.avium_104 AYACAIGLKRAGADVRFVGLIDTVRAGEEIPQTKEETRKRWDRYARFAER MAB_0180|M.abscessus_ATCC_1997 AYACAVGLKEAGAEVAWVGNIDGVRPGTPILQTKEETRKRWDRYAAFAQK *****:**: * :* :** ** * .* : *:** * **:*** **:: Mflv_1169|M.gilvum_PYR-GCK TFNVEIPEIPYEELEALDDGGQVQFILDAVRESGVDIPGGIIEHQRTSYL Mvan_5640|M.vanbaalenii_PYR-1 TFNVEIPAIPYEQLEELDDEGQVKFVLDAVKDSGVDIPGGIIEHQRTSYL MSMEG_6392|M.smegmatis_MC2_155 TFNVEIPAIPYEELEKLDDEGQVKYVLEIVKESGVQIPGGIIEHQRTSYL TH_4178|M.thermoresistible__bu TFNVEIPEIPYEQLEELDDEGQVQLVLDAIAESGVQIPGGIIEHQRTSYL Mb3830c|M.bovis_AF2122/97 TFNVTIPAIPYEQLEELDDEGQVRFVLDAVSQSGVQIPAGIIEHQRTSYL Rv3800c|M.tuberculosis_H37Rv TFNVTIPAIPYEQLEELDDEGQVRFVLDAVSQSGVQIPAGIIEHQRTSYL MMAR_5364|M.marinum_M TFNVTVPAIPYEHLEELDDEGQVRFVLEAVSQSGVEIPAGIIEHQRTSYL MUL_4983|M.ulcerans_Agy99 TFNVTVPAIPYEHLEELDDEGQVRFVLEAVSQSGVEIPAGIIEHQRTSYL MLBr_00101|M.leprae_Br4923 TFNVTVPEIPYEQLEELDDEGQVRFVLDVVSQSGVQIPAGIIDHQRTSYL MAV_0218|M.avium_104 TFNVEIPAIPYEQLEELDDEGQVKFVLDIVQQSGVQIPGGIVEHQRTSYL MAB_0180|M.abscessus_ATCC_1997 TFNVEIPAIPYEQLEELDDAGQVTFVLEAVKASGVQIPGGIIEHQRTSYL **** :* ****.** *** *** :*: : ***:**.**::******* Mflv_1169|M.gilvum_PYR-GCK DNRLLETAEIQPYDGHVTLYMADRYHDDAIFFEPRYAIRQPDGGWGEFVD Mvan_5640|M.vanbaalenii_PYR-1 DNRALDTAVIENYDGHVTLYMADRYHDDAIMFEPRYATRQPDGGWGRFVA MSMEG_6392|M.smegmatis_MC2_155 DNRALDTVDIKPYDGHVTLYMADRYHDDAIVFEPAYATRKPDGGWGSFVS TH_4178|M.thermoresistible__bu DNRMIDTAEIQPYDGHVTLYMADRYHDDAIYFEPRYAIRQPDGGWGEYVS Mb3830c|M.bovis_AF2122/97 DNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVS Rv3800c|M.tuberculosis_H37Rv DNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVS MMAR_5364|M.marinum_M DNRAIDTAEIHPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVS MUL_4983|M.ulcerans_Agy99 DNRAIDTAEIHPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVS MLBr_00101|M.leprae_Br4923 DNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRKPDGGWGEYVS MAV_0218|M.avium_104 DNRALETVQIEPYDGHVTLYMADRYHDDVIEFEPRYAIRQPDGGWGEYVA MAB_0180|M.abscessus_ATCC_1997 DQRAIDTSTPVKFDGHMTLYMADRYHDDAITFEPAYATRQPDGGWGEFVS *:* ::* :***:***********.* *** ** *:****** :* Mflv_1169|M.gilvum_PYR-GCK DLEVVPIGGEHIQAIDEPYIAKVGAHMSEAINLIEAGN--D------ Mvan_5640|M.vanbaalenii_PYR-1 DLEVVPIGGEHIQAIDEPYIAKVGAHMSEAINAIEAES--EGK---- MSMEG_6392|M.smegmatis_MC2_155 DLEVVHIGGEHIQAIDEPYIAKVGAHMSEALNRIEAQA--SKEDGAK TH_4178|M.thermoresistible__bu DLEIVHIGGEHIQVIDEPYIAKVGAHMSEAINRIEAEE--QVK---- Mb3830c|M.bovis_AF2122/97 DLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADR--TSEVGKQ Rv3800c|M.tuberculosis_H37Rv DLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADR--TSEVGKQ MMAR_5364|M.marinum_M DLEVVPIGGEHIQAIDEPIIAKVGEHMSRAVDNIKAEP--TSEVGK- MUL_4983|M.ulcerans_Agy99 DLEVVPIGGEHIQAIDEPIIAKVGEHMSRAVDNIKAEP--TSEVGK- MLBr_00101|M.leprae_Br4923 DLEVVPIGGEHIQAIDEPIIAKVGEHMSQALNKIEAEQ--KAPK--- MAV_0218|M.avium_104 DLEVVPIGGEHIQVIDEPIIGKVGAHLTDVLNKVEAQTSQTSEVGK- MAB_0180|M.abscessus_ATCC_1997 DLEVVPVGGEHIQVIDEPIIAKVGAHMSQALRTINAQQAQQA----- ***:* :******.**** *.*** *:: .: ::*