For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQNALNLASWRR LKRLLDDLAGESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAA VRGLAVGGGCELATACDVCIATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEA ARWGLVQKVVAPQDLAAATAKLVGQVCRQSAVTMRAAKVVANMHGRALTGADTDALIRFGVEAYEGADLR EGVAAFSQGRPPKFDD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3408 | echA18 | - | 100% (296) | enoyl-CoA hydratase |
| M. bovis AF2122 / 97 | Mb1099c | echA8 | 8e-35 | 36.29% (259) | enoyl-CoA hydratase |
| M. bovis AF2122 / 97 | Mb0996c | echA7 | 8e-24 | 32.94% (252) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2036 | - | 5e-33 | 36.29% (259) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv3373 | echA18 | 1e-119 | 100.00% (213) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 3e-32 | 34.75% (259) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_1185c | - | 9e-32 | 35.11% (262) | enoyl-CoA hydratase |
| M. marinum M | MMAR_4396 | echA8 | 6e-36 | 38.22% (259) | enoyl-CoA hydratase EchA8 |
| M. avium 104 | MAV_1195 | - | 2e-35 | 37.45% (259) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_5277 | - | 2e-31 | 35.52% (259) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_4102 | - | 1e-34 | 36.68% (259) | PUTATIVE short chain enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_0210 | echA8 | 4e-36 | 38.22% (259) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4681 | - | 8e-33 | 36.29% (259) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2036|M.gilvum_PYR-GCK -----------------------------------MTFETILVDRDDRVA
Mvan_4681|M.vanbaalenii_PYR-1 --------------------------------MGSQNFETIIVERDDRVA
MSMEG_5277|M.smegmatis_MC2_155 ----------------------------------MSDFETILVTRTDRVA
TH_4102|M.thermoresistible__bu --------------------------------MSAKNYETILVTREDRVG
MMAR_4396|M.marinum_M -----------------------------------MSYETILVERDQRVG
MUL_0210|M.ulcerans_Agy99 -----------------------------------MSYETILVERDQRVG
MLBr_02402|M.leprae_Br4923 -----------------------------------MKYDTILVDGYQRVG
MAV_1195|M.avium_104 -----------------------------MTDSTDRTFETILVEREERVG
MAB_1185c|M.abscessus_ATCC_199 --------------------------------MTSHNFETILTERIDRVA
Mb3408|M.bovis_AF2122/97 MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVA
Rv3373|M.tuberculosis_H37Rv MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVA
: : .*.
Mflv_2036|M.gilvum_PYR-GCK TITLNRPKALNALNTQVMNEVTTAAAELDAEPGVGAIIVTGS-ERAFAAG
Mvan_4681|M.vanbaalenii_PYR-1 TITLNRPKALNALNSQVMDEVTTAAAELDADAGVGAIILTGS-EKAFAAG
MSMEG_5277|M.smegmatis_MC2_155 TIQLNRPKALNALNSQVMTEVTAAAAELDKDPGVGAIIVTGN-EKAFAAG
TH_4102|M.thermoresistible__bu IITLNRPKALNALNSQVMTEVTDAAAEFDSDPGIGAIIVTGN-EKAFAAG
MMAR_4396|M.marinum_M IITLNRPQALNALNSQVMNEVTSAAAELDNDPGIGAIIITGS-AKAFAAG
MUL_0210|M.ulcerans_Agy99 IITLNRPQALNALNSQVMNEVTSAAAELDNDPGIGAIIITGS-AKAFAAG
MLBr_02402|M.leprae_Br4923 IITLNRPQALNALNSQMMNEITNAAKELDIDPDVGAILITGS-PKVFAAG
MAV_1195|M.avium_104 IITLNRPKALNALNTQVMNEVTTAATDFDADPGIGAIIITGS-AKAFAAG
MAB_1185c|M.abscessus_ATCC_199 VITLNRPKALNALNSQVMNEVTTAAAEFDADHGIGAIIITGS-EKAFAAG
Mb3408|M.bovis_AF2122/97 LITLSHPQAQNALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAG
Rv3373|M.tuberculosis_H37Rv LITLSHPQAQNALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAG
* *.:*:* **** .:. :: : .: *::: * :.****
Mflv_2036|M.gilvum_PYR-GCK ADIKEMASLSFADVFSSDFFAAWG----KFAATRTPTIAAVAGYALGGGC
Mvan_4681|M.vanbaalenii_PYR-1 ADIKEMAGLSFADVFSSDFFAGWG----KFAATRTPTIAAVAGYALGGGC
MSMEG_5277|M.smegmatis_MC2_155 ADIKEMADLSFAEVFEADFFELWS----KFAATRTPTIAAVAGYALGGGC
TH_4102|M.thermoresistible__bu ADIKEMADLEFADVFAADFFAPWS----KFAATRTPTIAAVAGYALGGGC
MMAR_4396|M.marinum_M ADIKEMADLTFSEAFDADFFAAWG----KLAAVRTPTIAAVAGYALGGGC
MUL_0210|M.ulcerans_Agy99 ADIKEMADLTFSEAFDADFFAAWG----KLAAVRTPTIAAVAGYALGGGC
MLBr_02402|M.leprae_Br4923 ADIKEMASLTFTDAFDADFFSAWG----KLAAVRTPMIAAVAGYALGGGC
MAV_1195|M.avium_104 ADIKEMAELTFADAYGADFFAPWG----KLAALRTPTIAAVAGHALGGGC
MAB_1185c|M.abscessus_ATCC_199 ADIKEMSEQSFSDMFGSDFFSAWG----KLGAVRTPTIAAVSGYALGGGC
Mb3408|M.bovis_AF2122/97 ADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGC
Rv3373|M.tuberculosis_H37Rv ADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGC
*****:. :: ::: . : : * **** * *:****
Mflv_2036|M.gilvum_PYR-GCK ELAMMCDILIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
Mvan_4681|M.vanbaalenii_PYR-1 ELAMMCDILIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
MSMEG_5277|M.smegmatis_MC2_155 ELAMMCDILIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
TH_4102|M.thermoresistible__bu ELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
MMAR_4396|M.marinum_M EVAMMCDLIIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
MUL_0210|M.ulcerans_Agy99 EVAMMCDLIIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
MLBr_02402|M.leprae_Br4923 ELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
MAV_1195|M.avium_104 ELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
MAB_1185c|M.abscessus_ATCC_199 ELAMMCDVIIAAENATFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDMIL
Mb3408|M.bovis_AF2122/97 ELATACDVCIATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLF
Rv3373|M.tuberculosis_H37Rv ELATACDVCIATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLF
*:* **: **:: * ** * **** .*: :: ::* ** * :::
Mflv_2036|M.gilvum_PYR-GCK TGRNMDAEEAERAGLVSRVVPADSLLSEAKAVAQTIAGMSLSASRMAKEA
Mvan_4681|M.vanbaalenii_PYR-1 TGRNMGAEEAERAGLVSRVVPADTLLEEARSVAKTIAGMSLSASRMAKEA
MSMEG_5277|M.smegmatis_MC2_155 TGRTIDAAEAERAGLVSRLVPADTLIDEALAVAQTIAGMSLSASRMAKEA
TH_4102|M.thermoresistible__bu TGRTIDAEEAERSGLVSRVVPADKLLDEAKETAATIAAMSLSAARMAKEA
MMAR_4396|M.marinum_M TGRTIDAAEAERSGLVSRVVPADDLLTEAKAVATTISQMSRSAARMAKEA
MUL_0210|M.ulcerans_Agy99 TGRTIDAAEAERSGLVSRVVPADDLLTEAKAVATTISQMSRSAARMAKEA
MLBr_02402|M.leprae_Br4923 TGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQMSRSATRMAKEA
MAV_1195|M.avium_104 TGRTIDAAEAERSGLVSRVVPADDLLTEAKKVATTISQMSRSAARMAKEA
MAB_1185c|M.abscessus_ATCC_199 TGRNMDAAEAERSGLVSRVVATESLLDEAKAVAKTISEMSLSASMMAKEA
Mb3408|M.bovis_AF2122/97 SGELIGIEEAARWGLVQKVVAPQDLAAATAKLVGQVCRQSAVTMRAAKVV
Rv3373|M.tuberculosis_H37Rv SGELIGIEEAARW-------------------------------------
:*. :. ** *
Mflv_2036|M.gilvum_PYR-GCK VDRAFETTLSEGLLYERRLFHSAFATDDQTEGMNAFSEKRSPNFTHR
Mvan_4681|M.vanbaalenii_PYR-1 VDRAFETTLTEGLLYERRLFHSAFATDDQTEGMNAFTEKRSPNFTHR
MSMEG_5277|M.smegmatis_MC2_155 VNRAFETSLTEGLLYERRLFHSAFATADQKEGMAAFAEKRAANFTHR
TH_4102|M.thermoresistible__bu VNRAFETSLAEGLLFERRVFHSAFATADQSEGMAAFTEKRPPKFTHR
MMAR_4396|M.marinum_M VNRTFEATLAEGLLYERRLIHSAFATADQSEGMAAFIEKRPPNFTHR
MUL_0210|M.ulcerans_Agy99 VNRTFEATLAEGLLYERRLIHSAFATADQSEGMAAFIEKRPPNFTHR
MLBr_02402|M.leprae_Br4923 VNRSFESTLAEGLLHERRLFHSTFVTDDQSEGMAAFIEKRAPQFTHR
MAV_1195|M.avium_104 VNRAFETTLAEGLLYERRLFHSTFATADQSEGMAAFVEKRAPNFTHR
MAB_1185c|M.abscessus_ATCC_199 VNRAFESSLAEGLLFERRIFHSAFGTADQSEGMAAFVEKRPANFIHR
Mb3408|M.bovis_AF2122/97 ANMHGRALTGADTDALIRFGVEAYEGADLREGVAAFSQGRPPKFDD-
Rv3373|M.tuberculosis_H37Rv -----------------------------------------------