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M. bovis AF2122 / 97 Mb2908 (-)

annotation: transcriptional regulatory protein
coordinates: 3149908 - 3150666
length: 252

MPTGPTTGKWHPHEVWRYLLEVLLLTDEADLESALPELESFAQSVQRAPLDDPGAAKGADADVAIIDARA
DLAAARRVCRRLTTSAPALAVVAVVAPANFVAVDGDWIFDDVLLNAAGGAELQARLRLAITRRRSTLAGT
LQFGDLVLHPASYTASLGDRDLGLTLTEFKLMNFLVQHAGRAFTRTRLMREVWGYECHGRIRTVDVHVRR
LRAKLGAEHESMIDTVRGVGYMAVTPPQPRWIISESILNRCK
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2908--100% (252)transcriptional regulatory protein
M. bovis AF2122 / 97Mb0841-2e-5347.35% (226) transcriptional regulatory protein
M. bovis AF2122 / 97Mb1062ctrcR2e-1839.10% (133) two component transcriptional regulator TRCR

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_1650-4e-5550.67% (225) response regulator receiver protein
M. tuberculosis H37RvRv2884-1e-144100.00% (252) transcriptional regulatory protein
M. leprae Br4923MLBr_00174-2e-1833.88% (183) putative two-component response regulator
M. abscessus ATCC 19977MAB_0744-1e-5449.33% (225) transcriptional regulatory protein
M. marinum MMMAR_1825-4e-8666.39% (238) transcriptional regulatory protein
M. avium 104MAV_3735-2e-7764.73% (224) transcriptional regulator GlnR
M. smegmatis MC2 155MSMEG_5784-5e-5449.77% (221) transcriptional regulatory protein
M. thermoresistible (build 8)TH_4312-5e-1829.39% (228) PUTATIVE two component transcriptional regulator, winged helix
M. ulcerans Agy99MUL_2073-1e-8065.04% (226) transcriptional regulatory protein
M. vanbaalenii PYR-1Mvan_5097-1e-5450.22% (225) response regulator receiver protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb2908|M.bovis_AF2122/97            MPTGPTTGKWHPHEVWRYLLEVLLLTDEADLESALP---ELESFAQSVQR
Rv2884|M.tuberculosis_H37Rv         MPTGPTTGKWHPHEVWRYLLEVLLLTDEADLESALP---ELESFAQSVQR
MMAR_1825|M.marinum_M               MRTGVAG---TPRGVGRCFLRVLLLSNAADFESTLP---TLKSFASVIQH
MUL_2073|M.ulcerans_Agy99           -----------------------MLSNAADFESTLP---TLKSFASVIQH
MAV_3735|M.avium_104                -----------------MSLDVVVLTNEDDFESALP---DLSRFARPARR
Mflv_1650|M.gilvum_PYR-GCK          ----MRCPGERAPRLLEGQLDLLLLTVDPHPESVLP---SLSLLAHAVRT
Mvan_5097|M.vanbaalenii_PYR-1       -------------------MDLLLLTVDPHPESVLP---SLALLAHNVRT
MSMEG_5784|M.smegmatis_MC2_155      -------------------MDLLLLTVDPHPESVLP---SLSLLAHTVRT
MAB_0744|M.abscessus_ATCC_1997      --------------MLEGSLDLLLLTADPNPDGVLP---SLSLLAHTVRP
MLBr_00174|M.leprae_Br4923          -------------------MRILAVDDDRAVRESLRRSLSFNGYSVELAN
TH_4312|M.thermoresistible__bu      ------------------MTSVLIVEDEESLADPLAFLLRKEGFETTIVT
                                                            :         *               

Mb2908|M.bovis_AF2122/97            APLDDPGAAKGADADVAIIDARADLAAARRVCRRLTTSAPALAVVAVVAP
Rv2884|M.tuberculosis_H37Rv         APLDDPGAAKGADADVAIIDARADLAAARRVCRRLTTSAPALAVVAVVAP
MMAR_1825|M.marinum_M               ARLDAAGPPDWAGPDVAMIDARSDLATARSTCRRLTANAPSVAVVAVVAA
MUL_2073|M.ulcerans_Agy99           ARLDAADPPDWAGPDVAMIDARSDLTTARSACRRLTANAPSVAVVAVVAA
MAV_3735|M.avium_104                AALSTDGDGQFGPADVAIIDARSNVAAAQAVSHRLTADHPATAVVALVAP
Mflv_1650|M.gilvum_PYR-GCK          APTEVSSLLEAGTADVAIVDARTDLAAARGLCRLLGTTGTSVPVVAVVNE
Mvan_5097|M.vanbaalenii_PYR-1       APTEVSSLLEAGTADVAIVDARTDLAAARGLCRLLGTTGTSVPVVAVVNE
MSMEG_5784|M.smegmatis_MC2_155      APTEVSSLLETGSADVAIVDARTDLAAARGLCRLLGTTGTSVPVVAVINE
MAB_0744|M.abscessus_ATCC_1997      VPSEVSSLLEAGAADVAIVDARTDLASARGLCRLLGAAGSSVPVVAVVNE
MLBr_00174|M.leprae_Br4923          DGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTAR
TH_4312|M.thermoresistible__bu      DGPSALAEFERSGADIILLDLMLPGMSGTDVCRRLRAK-SKVPVIMVTAR
                                       .         .*  ::*       .   .: * :     .:: :   

Mb2908|M.bovis_AF2122/97            AN--FVAVDGDWIFDDVLLNAAGGAELQARLRLAITRRRS-TLA----GT
Rv2884|M.tuberculosis_H37Rv         AN--FVAVDGDWIFDDVLLNAAGGAELQARLRLAITRRRS-TLA----GT
MMAR_1825|M.marinum_M               AD--FVDIDIDWHFDDVLLAAAGAAELRARLRLAVTRRRR-ARK----GT
MUL_2073|M.ulcerans_Agy99           AD--FVDIDIDWHFDDVLLAAAGAAELRARLRLAVMRRRR-ARK----GT
MAV_3735|M.avium_104                AD--CAAVDVDCNFDDVMLPGTCAEELQARLRLAIGRRRG-GLD----GT
Mflv_1650|M.gilvum_PYR-GCK          GG--LVAVNVEWGLDEILLPSTGPAEIDARLRLLVGRRGG-MANQENLGK
Mvan_5097|M.vanbaalenii_PYR-1       GG--LVAVNVEWGLDEILLPSTGPAEIDARLRLLVGRRGG-MANQENLGK
MSMEG_5784|M.smegmatis_MC2_155      GG--LVAVNHEWGLDEILLPSTGPAEIDARLRLLVGRRGG-NANQENVGK
MAB_0744|M.abscessus_ATCC_1997      GS--LVAVNVDWGLDDILLPGTGPAEIDARLRLLVGRRAG-AVNVENASK
MLBr_00174|M.leprae_Br4923          DSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKPDDAAES--VA
TH_4312|M.thermoresistible__bu      DSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRGSDLDGADVDDSV
                                     .      . :   *: :       *: **:*  : *             

Mb2908|M.bovis_AF2122/97            LQFGDLVLHPASYTASLGDRDLGLTLTEFKLMNFLVQHAGRAFTRTRLMR
Rv2884|M.tuberculosis_H37Rv         LQFGDLVLHPASYTASLGDRDLGLTLTEFKLMNFLVQHAGRAFTRTRLMR
MMAR_1825|M.marinum_M               LEFGDLAIHPDSCTVTVAGEALGLTLTEFRLFHFLVRHAGQAFTRTRLMH
MUL_2073|M.ulcerans_Agy99           LEFGDLAIHPDSCTVTVAGEALGLTLTEFRLFHFLVRHAGQAFTHTRLMH
MAV_3735|M.avium_104                LKFGDLLLHPASFTASLDGRELNLTLTEFKLLNFLVQHAGQAFTRTRLMQ
Mflv_1650|M.gilvum_PYR-GCK          ISLGELVIDEGTYTARLRGRPLDLTYKEFELLKYLAQHAGRVFTRAQLLQ
Mvan_5097|M.vanbaalenii_PYR-1       ISLGELVIDEGTYTARLRGRPLDLTYKEFELLKYLAQHAGRVFTRAQLLQ
MSMEG_5784|M.smegmatis_MC2_155      ITLGELVIDEGTYTARLRGKPLDLTYKEFELLKYLAQHAGRVFTRAQLLQ
MAB_0744|M.abscessus_ATCC_1997      VVLGELVIDEGTYTARLRGRPLDLTYKEFELLKYLAQHAGRVFTRAQLLQ
MLBr_00174|M.leprae_Br4923          MSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPRRVLTRSRILE
TH_4312|M.thermoresistible__bu      LEAGPVRMDVDRHVVTVRGEPITLPLKEFELLEYLLRNSGRVLTRGQLID
                                    :  . : :.     .    . : *. .** *:. *  :. :.:*: ::: 

Mb2908|M.bovis_AF2122/97            EVWGYECHGRIRTVDVHVRRLRAKLGAE--HESMIDTVRGVGYMAVTPPQ
Rv2884|M.tuberculosis_H37Rv         EVWGYECHGRIRTVDVHVRRLRAKLGAE--HESMIDTVRGVGYMAVTPPQ
MMAR_1825|M.marinum_M               EVWGYDCNGRARTVDVHVRRLRAKLGAD--HESMVDTVRGVGYMAVTPPL
MUL_2073|M.ulcerans_Agy99           EVWGYDCNGRARTVDVHVRRLRAKLGAD--HESMVDTERGVGYMAVTPPP
MAV_3735|M.avium_104                QAWGYEGNGRARTVDVHIRRLRAKLGTR--HQSLVGTVRGVGYRVPTPPQ
Mflv_1650|M.gilvum_PYR-GCK          EVWGYDFFGGTRTVDVHVRRLRAKLGPE--YESLIGTVRNVGYKAVRPAR
Mvan_5097|M.vanbaalenii_PYR-1       EVWGYDFFGGTRTVDVHVRRLRAKLGPE--YEALIGTVRNVGYKAVRPAR
MSMEG_5784|M.smegmatis_MC2_155      EVWGYDFFGGTRTVDVHVRRLRAKLGPE--YEALIGTVRNVGYKAVRPSR
MAB_0744|M.abscessus_ATCC_1997      EVWGYDFFGGTRTVDVHVRRLRAKLGGE--YESLIGTVRNVGYKAVRPPR
MLBr_00174|M.leprae_Br4923          EVWGFDFPTSGNALEVYVGYLRRKTEAD-GESRLIHTVRGVGYVLRETPP
TH_4312|M.thermoresistible__bu      RVWGADYVGDTKTLDVHVKRLRSKIEEDPANPVHLVTVRGLGYKLEG---
                                    ..** :     .:::*::  ** *          : * *.:**       

Mb2908|M.bovis_AF2122/97            PRWIISESILNRCK-------------------------------
Rv2884|M.tuberculosis_H37Rv         PRWIISESILNRCK-------------------------------
MMAR_1825|M.marinum_M               PRWTARQPVLSPGSGPEPQDISVPTEQVLAR--------------
MUL_2073|M.ulcerans_Agy99           PRWTARQPVLSPGSGPEPQDISVPTEQVLVR--------------
MAV_3735|M.avium_104                PEWIVGHQKP-----------------------------------
Mflv_1650|M.gilvum_PYR-GCK          GR-PPAP--ESEADDLD-DDPYADDE-PLASDEVPQALGDALRSP
Mvan_5097|M.vanbaalenii_PYR-1       GR-APAAGADLPSDDLDGDDPYEDGVGSLDRDGVPEALGDALRSQ
MSMEG_5784|M.smegmatis_MC2_155      GK-PPAA--DASGEDVP-DGPDEGFG---DDVDVDGPLAGRLTSQ
MAB_0744|M.abscessus_ATCC_1997      AKGEPGPSAADDDDESDIDDLDDDGT----DQDIASEPG-AINAG
MLBr_00174|M.leprae_Br4923          ---------------------------------------------
TH_4312|M.thermoresistible__bu      ---------------------------------------------