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VVGPRTRGYAIHKLGFCSVVMLGINSIIGAGIFLTPGEVIGLAGPFAPMAYVLAGIFAGVVAIVFATAAR YVRTNGASYAYTTAAFGRRIGIYVGVTHAITASIAWGVLASFFVSTLLRVAFPDKAWADAEQLFSVKTLT FLGFIGVLLAINLFGNRAIKWANGTSTVGKAFALSAFIVGGLWIITTQHVNNYATAWSAYSATPYSLLGV AEIGKGTFSSMALATIVALYAFTGFESIANAAEEMDAPDRNLPRAIPIAIFSVGAIYLLTLTVAMLLGSN KIAASGDTVKLAAAIGNATFRTIIVVGALISMFGINVAASFGAPRLWTALADSGVLPTRLSRKNQYDVPM VSFAITASLALAFPLALRFDNLHLTGLAVIARFVQFIIVPIALIALARSQAVEHAAVRRNAFTDKVLPLV AIVVSVGLAVSYDYRCIFLVRGGPNYFSIALIVITFIVVPAMAYLHYYRIIRRVGDRPSTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2001c | - | - | 100% (481) | permease |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 7e-28 | 26.52% (396) | cationic amino acid transport integral membrane protein RocE |
| M. bovis AF2122 / 97 | Mb3281c | - | 5e-18 | 22.98% (409) | cationic amino acid transport integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4722 | - | 5e-24 | 25.06% (439) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1979c | - | 0.0 | 99.58% (481) | permease |
| M. leprae Br4923 | MLBr_01974 | - | 0.0 | 77.06% (462) | putative permease |
| M. abscessus ATCC 19977 | MAB_3842 | - | 9e-25 | 24.88% (406) | cationic amino acid transport integral membrane protein |
| M. marinum M | MMAR_3621 | rocE | 1e-30 | 27.03% (455) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 2e-28 | 24.63% (410) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_1412 | - | 6e-27 | 24.76% (424) | amino acid permease |
| M. thermoresistible (build 8) | TH_0471 | - | 5e-24 | 26.43% (401) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 3e-30 | 27.03% (455) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 4e-24 | 23.52% (438) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3621|M.marinum_M --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MAB_3842|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1412|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4722|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mb2001c|M.bovis_AF2122/97 --------------------------------------------------
Rv1979c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MMAR_3621|M.marinum_M MPATSIRLREQMLRRRPVGGAPVAEG------------------------
MUL_1244|M.ulcerans_Agy99 MPATSIRLREQMLRRRPAGGAPVAEG------------------------
MAV_2087|M.avium_104 ----------------------MAPG------------------------
MAB_3842|M.abscessus_ATCC_1997 MAPSSPSLAQQLLRRRPTSGAPTAHG------------------------
MSMEG_1412|M.smegmatis_MC2_155 MSAPPTSMAGQMMRRRPVIGAPVAHG------------------------
Mflv_4722|M.gilvum_PYR-GCK MTQEPVTQAPGRLRLKSVEQSIADTDE-----------------------
Mvan_1740|M.vanbaalenii_PYR-1 MVQEPGAQTVGRRRTKSVEQSIADTDE-----------------------
TH_0471|M.thermoresistible__bu --------MTDRLRVKSVEQSIADTDE-----------------------
Mb2001c|M.bovis_AF2122/97 ---MVG----PRTR------------------------------------
Rv1979c|M.tuberculosis_H37Rv ---MVG----PRTR------------------------------------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MMAR_3621|M.marinum_M ---AAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVP-EAGPAVIVSF
MUL_1244|M.ulcerans_Agy99 ---AAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVP-EAGPAVIVSF
MAV_2087|M.avium_104 ---TADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVP-EAGPAVIVSF
MAB_3842|M.abscessus_ATCC_1997 ---AGGHLKQSMGTFQLTMIGVGATVGTGIFFILAESVP-KAGPAVMASF
MSMEG_1412|M.smegmatis_MC2_155 ---ASDHLKRSIGTFQLTLFGVGATVGTGIFLVLQEAVP-EAGPAVLVSF
Mflv_4722|M.gilvum_PYR-GCK ---PGTKLRKDLNWWDLTVFGVSVVIGAGIFTITASTAANITGPAISLSF
Mvan_1740|M.vanbaalenii_PYR-1 ---PSTRLRKELNWWDLTVFGVSVVIGAGIFTITASTAANITGPAISLSF
TH_0471|M.thermoresistible__bu ---PDSRLRKDLSWWDLTVFGVSVVIGAGIFTVTASTAGNITGPAISVSF
Mb2001c|M.bovis_AF2122/97 -----GYAIHKLGFCSVVMLGINSIIGAGIFLTPGEVIG-LAGPFAPMAY
Rv1979c|M.tuberculosis_H37Rv -----GYAIHKLGFCSVVMLGINSIIGAGIFLTPGEVIG-LAGPFAPMAY
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIK-IAGPFAPIAY
:. .:.::*:. :*:*** . :** ::
MMAR_3621|M.marinum_M IIAGVAAGLAAICYAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MUL_1244|M.ulcerans_Agy99 IIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLE
MAB_3842|M.abscessus_ATCC_1997 LVAGLAAGLAALCYAELASAVPVSGSSFSYAYTTLGELAAMVVAACLLLE
MSMEG_1412|M.smegmatis_MC2_155 VLAGVAAGLSALCYAEMASAVPVSGSTYSYAYTTMGEFVAMGVAACLLLE
Mflv_4722|M.gilvum_PYR-GCK IFAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
Mvan_1740|M.vanbaalenii_PYR-1 IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
TH_0471|M.thermoresistible__bu IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
Mb2001c|M.bovis_AF2122/97 VLAGIFAGVVAIVFATAARYVRTNGASYAYTTAAFGRRIGIYVGVTHAIT
Rv1979c|M.tuberculosis_H37Rv VLAGIFAGVVAIVFATAARYVRTNGASYAYTTAAFGRRIGIYVGVTHAIT
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
.*.: ..: *: * * * . *:::::: :::*. . :. :
MMAR_3621|M.marinum_M YGVATAAVAVGWSGYVNKLLHNVFGFQLPQALSEAPWD-ERPGEAAGYLN
MUL_1244|M.ulcerans_Agy99 YGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWD-ERPGEAAGYLN
MAV_2087|M.avium_104 YGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWD-AQPG----YVN
MAB_3842|M.abscessus_ATCC_1997 YGVSAAAVAVGWSQYLDKLLVNLFGWHLPHAISAAPWDSADPAAPHPWLN
MSMEG_1412|M.smegmatis_MC2_155 YGVSMSATSIGWGGYLNQLLDDVFGFRIPQALTSAPWG-ENPG----IMN
Mflv_4722|M.gilvum_PYR-GCK FAVAAAVVAKGWSSYLG----TVFGFAG-GTAEVAGFD----------LD
Mvan_1740|M.vanbaalenii_PYR-1 FAVAAAVVAKGWSSYLG----TVFGFAG-GTTEVAGFQ----------LD
TH_0471|M.thermoresistible__bu FSVAAAVVAKGWSSYLG----EVFEFAG-ATTRLGPIT----------LD
Mb2001c|M.bovis_AF2122/97 ASIAWGVLASFFVSTLLRVAFPDKAWADAEQLFS-------------VKT
Rv1979c|M.tuberculosis_H37Rv ASIAWGVLASFFVSTLLRVAFPDKAWADAEQLFS-------------VKT
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLRVAFPEKIWADNDELIS-------------VKT
.:: .. : : :
MMAR_3621|M.marinum_M LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MUL_1244|M.ulcerans_Agy99 LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
MAB_3842|M.abscessus_ATCC_1997 LPAVLLIIMCAILLIRGTSESALVNTVMVLLKLAVLSVFAIIAFTAFHAG
MSMEG_1412|M.smegmatis_MC2_155 LTATLLIVMCGLLLIRGASESALVNTIMVIIKLAVLALFVAVAFTAFTTD
Mflv_4722|M.gilvum_PYR-GCK WGALVIIAIVTAILAMGTKLSASVSLAITALKVSVVLLVVIVGAFYIKME
Mvan_1740|M.vanbaalenii_PYR-1 WGALVIIALVTLILVMGTKLSAGVSLAITAVKVSVVLLVVIVGAFYIKAE
TH_0471|M.thermoresistible__bu WGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAA
Mb2001c|M.bovis_AF2122/97 LTFLGFIGVLLAINLFGNRAIKWANGTSTVGKAFALSAFIVGGLWIITTQ
Rv1979c|M.tuberculosis_H37Rv LTFLGFIGVLLAINLFGNRAIKWANGTSTVGKAFALSAFIVGGLWIITTQ
MLBr_01974|M.leprae_Br4923 LTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQ
:* . : * .. . * .: . .
MMAR_3621|M.marinum_M HLKDFAP---------------------------FGVAGVGAAAGTIFFS
MUL_1244|M.ulcerans_Agy99 HLKDFAP---------------------------FGVAGVGAAAGTIFFS
MAV_2087|M.avium_104 HLDDFAP---------------------------FGVAGVGTAAGTIFFS
MAB_3842|M.abscessus_ATCC_1997 NFSDFAP---------------------------FGVSGIGAAAGTIFFT
MSMEG_1412|M.smegmatis_MC2_155 HFAGFWD---------------------------KGFAGITAAAGSIFFT
Mflv_4722|M.gilvum_PYR-GCK NFSPFIPAPEPGEAGGTGAEQSLFSLMTGAEGSHYGWYGLLAGASIVFFA
Mvan_1740|M.vanbaalenii_PYR-1 NFSPFVPAPEEGGSGGTGTEQSLFSLLTGAEGSHYGWYGVLAGASIVFFA
TH_0471|M.thermoresistible__bu NYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFFA
Mb2001c|M.bovis_AF2122/97 HVNNYATAWS-------AYSATPYSLLGVAEIGKGTFSSMALATIVALYA
Rv1979c|M.tuberculosis_H37Rv HVNNYATAWS-------AYSATPYSLLGVAEIGKGTFSSMALATIVALYA
MLBr_01974|M.leprae_Br4923 HVNNYVTSRS-------AYQPTTYSLLGVTEIGKSTAASMTLATIVALYA
: : .: .: :::
MMAR_3621|M.marinum_M FIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQ
MUL_1244|M.ulcerans_Agy99 FIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQ
MAV_2087|M.avium_104 YIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQ
MAB_3842|M.abscessus_ATCC_1997 YVGLDTVSTAGEEVKDPQRTMPRALIAALLIVTAFYLVVALAALGAQPWK
MSMEG_1412|M.smegmatis_MC2_155 FIGLDAVSTAGDEVKNPQKTMPRAILGALVVVASVYILVAFAGLGTQSAD
Mflv_4722|M.gilvum_PYR-GCK FIGFDIVATTAEETKVPQRDVPRGILASLGIVTVLYVAVAIVLSGMVSYK
Mvan_1740|M.vanbaalenii_PYR-1 FIGFDIVATTAEETRNPQRDVPRGILASLAIVTVLYVAVAVVLTGMVSYT
TH_0471|M.thermoresistible__bu FIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHYT
Mb2001c|M.bovis_AF2122/97 FTGFESIANAAEEMDAPDRNLPRAIPIAIFSVGAIYLLTLTVAMLLGSNK
Rv1979c|M.tuberculosis_H37Rv FTGFESIANAAEEMDAPDRNLPRAIPIAIFSVGAIYLLTLTVAMLLGSNK
MLBr_01974|M.leprae_Br4923 FTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDK
: *:: ::.:.:* *:: :.:.: :: * .*: . .
MMAR_3621|M.marinum_M MFA--GQEEAGLATILDNVTH-SAWASTVLAMGAVISIFTVTLVTMYGQT
MUL_1244|M.ulcerans_Agy99 MFA--GQEEAGLATILDNVTH-SAWASTVLAMGAVISIFTVTLVTMYGQT
MAV_2087|M.avium_104 DFG--GQQEAGLATILDHVTH-GSWASTILAAGAVISIFSVTLVTMYGIT
MAB_3842|M.abscessus_ATCC_1997 EFE--GQS-AGLALILDKVTG-STSASTFLAAGAVISIFSITLVSMYGQT
MSMEG_1412|M.smegmatis_MC2_155 EFGSEEQSEAGLAVILTNILHGQTWASTILSFGAVISIFSVTLVVMYGQT
Mflv_4722|M.gilvum_PYR-GCK DLR-DA-ESPNLATAFS--LNGVDWAAKVISIGALAGLTTVVIVLVLGQT
Mvan_1740|M.vanbaalenii_PYR-1 ELR-DA-ETQNLATAFS--LNGVDWAAKVISIGALAGLTTVVIVLVLGQT
TH_0471|M.thermoresistible__bu ELR-AAGENANLATAFA--ANGIDWAAKVISIGALAGLTTVVIVLVLGQT
Mb2001c|M.bovis_AF2122/97 IAA--SGDTVKLAAAIG-----NATFRTIIVVGALISMFGINVAASFGAP
Rv1979c|M.tuberculosis_H37Rv IAA--SDDTVKLAAAIG-----NATFRTIIVVGALISMFGINVAASFGAP
MLBr_01974|M.leprae_Br4923 IVA--TNHTVKLAAAVG-----NNTFRTIIVVGALVSMFGINVAASFGAP
** . ..: **: .: : :. * .
MMAR_3621|M.marinum_M RILFAMGRDGLLPARFAAVHPRFQTPVSNTVVVAIAAAVLAAL-VPLNRL
MUL_1244|M.ulcerans_Agy99 RILFAMGRDGLLPARFAAVHPRFQTPVSNTVVVAIAAAVLAAL-VPLNRL
MAV_2087|M.avium_104 RILFAMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAATLAAF-IPLQNL
MAB_3842|M.abscessus_ATCC_1997 RILFAIGRDGLLPSVFAQVNPRTLTPVNNTIIVAVVVGFMAAF-VPLDSL
MSMEG_1412|M.smegmatis_MC2_155 RILFAMGRDGLLPSMFARVNSHTMTPINNTIVVALVTGTLAGF-VPLDYL
Mflv_4722|M.gilvum_PYR-GCK RVLFAMSRDGLLPRQLAKTGEH-GTPVRITLLVGAVVAVTATV-FPIDKL
Mvan_1740|M.vanbaalenii_PYR-1 RVLFAMSRDGLLPRQLAKTGEH-GTPVRITLIVGAVVAVTATV-FPIGKL
TH_0471|M.thermoresistible__bu RVLFAMSRDGLLPRPLSKTGPR-GTPVRITVLVGALVAIAASV-FPVGNL
Mb2001c|M.bovis_AF2122/97 RLWTALADSGVLPTRLSRKNQYDVPMVSFAITASLALAFPLALRFDNLHL
Rv1979c|M.tuberculosis_H37Rv RLWTALADSGVLPTRLSRKNQYDVPMVSFAITASLALAFPLALRFDNLHL
MLBr_01974|M.leprae_Br4923 RLWTALSDGRILPTRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLNL
*: *:. . :** :: . : : . . . . *
MMAR_3621|M.marinum_M ADMVSIGTLTAFIVVSVGVIILRVREPALPRGFWVPGYP--VTPILSILA
MUL_1244|M.ulcerans_Agy99 ADMVSIGTLTAFIVVSVGVIILRVREPALPRGFWVPGYP--VTPILSILA
MAV_2087|M.avium_104 ADMVSIGTLTAFVVVSVGVIVLRVREPDLPRGFRVPGYP--VTPVLSIMA
MAB_3842|M.abscessus_ATCC_1997 ANMVSIGTLTAFIVVSIGVIILRVREPELPRAFRVPGYP--VTPVLSVIA
MSMEG_1412|M.smegmatis_MC2_155 WDLVSIGTLVAFIVVSAGVVLLRVREPDLPRSFKVPGYP--VTPVLSIIA
Mflv_4722|M.gilvum_PYR-GCK EEMVNIGTLFAFVLVSAGVIVLRRTRPDLKRGFRTPWVP--VLPILSIIA
Mvan_1740|M.vanbaalenii_PYR-1 EEMVNIGTLFAFVLVSAGVLVLRRTRPDLKRGFRTPWVP--LLPILAIAA
TH_0471|M.thermoresistible__bu EEMVNIGTLFAFALVSAGVIVLRRTRPDLKRGFRVPFVP--WLPLAAIAA
Mb2001c|M.bovis_AF2122/97 TGLAVIARFVQFIIVPIALIALARSQAVEHAAVRRNAFTDKVLPLVAIVV
Rv1979c|M.tuberculosis_H37Rv TGLAVIARFVQFIIVPIALIALARSQAVEHAAVRRNAFTDKVLPLVAIVV
MLBr_01974|M.leprae_Br4923 TGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAVVV
:. *. : * :*. .:. * .. . . *: :: .
MMAR_3621|M.marinum_M CGYLLYSLHWYTWIAFGG---WVGIALIFYLFWGRHHSRLN---APALHD
MUL_1244|M.ulcerans_Agy99 CGYLLYSLHWYTWIAFGG---WVGIALIFYLFWGRHHSRLN---APALHD
MAV_2087|M.avium_104 CGYILASLHWYTWIAFSG---WVLLALIFYFVWGRHHSALN---DAAVD-
MAB_3842|M.abscessus_ATCC_1997 CGYILFSLPWITWIAFGA---WVAIVLVFYLVWGRHHSALN---DLPSDP
MSMEG_1412|M.smegmatis_MC2_155 CLFVLYGLPAVTWLWFSV---WVGAVLLFYLLWGRRHSALNDGGDGYIPG
Mflv_4722|M.gilvum_PYR-GCK CVWLMLNLTGLTWIRFSV---WMAIGVVLYFVYGRRHSLVA---RRQRER
Mvan_1740|M.vanbaalenii_PYR-1 CVWLMLNLTGLTWIRFLI---WMAIGVVVYFLYGRRHSLVG---RRMG--
TH_0471|M.thermoresistible__bu CLWLMLNLTGLTWVRFLG---WMALGLVLYFFYGRHHSMLG---RGMTDI
Mb2001c|M.bovis_AF2122/97 SVGLAVSYDYRCIFLVRGGPNYFSIALIVITFIVVPAMAYLHYYRIIRRV
Rv1979c|M.tuberculosis_H37Rv SVGLAVSYDYRCIFLVRGGPNYFSIALIVITFVVVPAMAYLHYYRIIRRV
MLBr_01974|M.leprae_Br4923 SAGLMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRTSGIK
. : . . :. :: .
MMAR_3621|M.marinum_M NPTGEER----------
MUL_1244|M.ulcerans_Agy99 NPTGEER----------
MAV_2087|M.avium_104 -PSGQER----------
MAB_3842|M.abscessus_ATCC_1997 AELSEKEPV--------
MSMEG_1412|M.smegmatis_MC2_155 AAAGEDDVMTGHPEDRA
Mflv_4722|M.gilvum_PYR-GCK AGLHTDTP---------
Mvan_1740|M.vanbaalenii_PYR-1 -----------------
TH_0471|M.thermoresistible__bu SARRTG-----------
Mb2001c|M.bovis_AF2122/97 GDRPSTR----------
Rv1979c|M.tuberculosis_H37Rv GDRPSTR----------
MLBr_01974|M.leprae_Br4923 -----------------