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MSPIWSNWPGEQVCAPSAIVRPTSEAELADVIAQAAKRGERVRAVGSGHSFTDIACTDGVMIDMTGLQRV LDVDQPTGLVTVEGGAKLRALGPQLAQRRLGLENQGDVDPQSITGATATATHGTGVRFQNLSARIVSLRL VTAGGEVLSLSEGDDYLAARVSLGALGVISQVTLQTVPLFTLHRHDQRRSLAQTLERLDEFVDGNDHFEF FVFPYADKALTRTMHRSDEQPKPTPGWQRMVGENFENGGLSLICQTGRRFPSVAPRLNRLMTNMMSSSTV QDRAYKVFATQRKVRFTEMEYAIPRENGREALQRVIDLVRRRSLPIMFPIEVRFSAPDDSFLSTAYGRDT CYIAVHQYAGMEFESYFRAVEEIMDDYAGRPHWGKRHYQTAATLRERYPQWDRFAAVRDRLDPDRVFLND YTRRVLGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1800 | - | - | 100% (428) | oxidoreductase |
| M. bovis AF2122 / 97 | Mb1755 | - | 3e-09 | 27.37% (179) | oxidoreductase |
| M. bovis AF2122 / 97 | Mb0064 | - | 1e-07 | 27.81% (169) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1178 | - | 1e-06 | 26.09% (184) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1771 | - | 0.0 | 100.00% (428) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0105c | - | 4e-94 | 43.31% (411) | oxidoreductase |
| M. marinum M | MMAR_2648 | - | 0.0 | 75.47% (424) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 1e-06 | 28.00% (175) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0301 | - | 7e-07 | 28.57% (175) | oxidoreductase, FAD-binding |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3124 | - | 0.0 | 75.00% (424) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5627 | - | 2e-11 | 22.42% (446) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1800|M.bovis_AF2122/97 ------------------------------MSPIWSNWP-----------
Rv1771|M.tuberculosis_H37Rv ------------------------------MSPIWSNWP-----------
MMAR_2648|M.marinum_M ------------------------------MKTVWRNWA-----------
MUL_3124|M.ulcerans_Agy99 ------------------------------MKAVWRNWA-----------
MAB_0105c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1178|M.gilvum_PYR-GCK ----------MSTGPQAVPSVTMLSTEFPTTAQRLTGWG-----------
Mvan_5627|M.vanbaalenii_PYR-1 ----------------------MLSTEFPTTARRLTGWG-----------
MAV_0089|M.avium_104 MAREISRQTFLRGAVGALAAGAMLGAPRVGADPRPSGWEGLSTALGGKVL
MSMEG_0301|M.smegmatis_MC2_155 ------MDPALAELAADLPAHALLTDPDQIEGYRRDAAA-----------
Mb1800|M.bovis_AF2122/97 ----------------GEQVCAPSAIVRPTSEAELADVIAQAAKRG---E
Rv1771|M.tuberculosis_H37Rv ----------------GEQVCAPSAIVRPTSEAELADVIAQAAKRG---E
MMAR_2648|M.marinum_M ----------------GEQYCAPSEIVRPASEAELAELVAKAGQRG---E
MUL_3124|M.ulcerans_Agy99 ----------------REQYCAPSEIVRPASEAELAELVAKAGQRG---E
MAB_0105c|M.abscessus_ATCC_199 ------------------------MLVRPRSEDELAFALRRSAGR-----
Mflv_1178|M.gilvum_PYR-GCK ----------------RTAPSVAQVLSTPDPEVIVKAVTRAAENP---GR
Mvan_5627|M.vanbaalenii_PYR-1 ----------------RTAPSVARVLATPDPEVIVKAVARAAESGKGGGR
MAV_0089|M.avium_104 LPDSPQFAGAKQVFNTNYNGSTPAAVVTPTSAADVQKAMAFAAAHN---L
MSMEG_0301|M.smegmatis_MC2_155 ----------------DPLAGRPRAVVRATCTADVQSVMRWATRHR---V
: . : :
Mb1800|M.bovis_AF2122/97 RVRAVGSGHSFTDIACTDG-VMIDMTGLQRVLDVDQPTGLVTVEGGAKLR
Rv1771|M.tuberculosis_H37Rv RVRAVGSGHSFTDIACTDG-VMIDMTGLQRVLDVDQPTGLVTVEGGAKLR
MMAR_2648|M.marinum_M RVRAVGSGHSFTDCACTDG-VMVDMAGMQRIVNVDPEAGLATVEGGAKLR
MUL_3124|M.ulcerans_Agy99 RVRAVGSGHSFTDCACTDG-VMVDMAGMQRIVNVDPEAGLATVEGGAKLR
MAB_0105c|M.abscessus_ATCC_199 TVRPIGSSHSFTQLCVTED-VQIDVSEMRRLISIDAQD-RVRVQAGISLH
Mflv_1178|M.gilvum_PYR-GCK GVLARGLGRSYGDNAQNGGGLVIDMSSLDRIHSMDADSRLVDVDGGVNLD
Mvan_5627|M.vanbaalenii_PYR-1 GVIARGLGRSYGDNAQNGGGLVVDMSVLNRIHSMDSDSHLVDVDGGVNLD
MAV_0089|M.avium_104 KVAPRSGGHSYTGASTANGTMVLDLRQLPGDANYDAATGQVTVTPATSLY
MSMEG_0301|M.smegmatis_MC2_155 AVVPRGAGSGLSGGASAVDGCVVLSTERMRAIRIDPATRVAVVQPGALNA
* . . . . . . : * . * .
Mb1800|M.bovis_AF2122/97 ALGPQLAQRRLGLEN-QGDVDPQSITGATATATHGTGVR-FQNLSARIVS
Rv1771|M.tuberculosis_H37Rv ALGPQLAQRRLGLEN-QGDVDPQSITGATATATHGTGVR-FQNLSARIVS
MMAR_2648|M.marinum_M PLFSQLAEHGLALEN-QGDIDKQSITGATATATHGTGAR-FANVSAQIVA
MUL_3124|M.ulcerans_Agy99 PLFSQLAEHGLALEN-QGDIDKQSITGATATATHGTGAR-FANVAAQIVA
MAB_0105c|M.abscessus_ATCC_199 ELNRTLLRHGLALPN-LGDIDVQTLAGAAATGTHGTGLK-FGNISQTILS
Mflv_1178|M.gilvum_PYR-GCK QLMRAALPLGLWVPV-LPGTRQVTIGGAIACDIHGKNHHSAGSFGNHVRS
Mvan_5627|M.vanbaalenii_PYR-1 QLMRAALPLGLWVPV-LPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRS
MAV_0089|M.avium_104 TMHRTLAAVGRGVP--TGTCPSVGAAGHALGGGMGAQSRHAGLLCDQLTS
MSMEG_0301|M.smegmatis_MC2_155 EVKQAAAEHSLWYPPDPASVDISSIGGNAATNAGGLCCVKYGVTTDYVLG
: * * : .
Mb1800|M.bovis_AF2122/97 LRLVTAGGEVLSLS-------EGDDYLAARVSLG-ALGVISQVTLQTVP-
Rv1771|M.tuberculosis_H37Rv LRLVTAGGEVLSLS-------EGDDYLAARVSLG-ALGVISQVTLQTVP-
MMAR_2648|M.marinum_M LRLVTASGEVLELS-------EGDDYLAARVSIG-ALGVISQLTLKVVP-
MUL_3124|M.ulcerans_Agy99 LRLVTASGEVLELS-------EGDDYLAARVSIG-ALGVISQLTLKVVP-
MAB_0105c|M.abscessus_ATCC_199 MRIMTADGTIHELD-------DGDALRAARISLG-ALGVVTEFTLQCVP-
Mflv_1178|M.gilvum_PYR-GCK IDLLTADGRVRTITPD---GPESPLFWATVGGNG-LTGIILRATIEMTPT
Mvan_5627|M.vanbaalenii_PYR-1 MDLLTADGEVRTLTPS---GPDADLFWATVGGNG-LTGIILRATIEMTPT
MAV_0089|M.avium_104 ASVVLPSGQAVTASTA---S-NPDLFWALRGGGGGNFGVTTSLTFATFPT
MSMEG_0301|M.smegmatis_MC2_155 MQVVLADGTAVTLGGPRLKDVAGLSLTKLFVGSEGILGVITEVTLRLIP-
:: ..* . *: *: *
Mb1800|M.bovis_AF2122/97 --LFTLHRHDQRRSLAQTLERLDEFVDGNDHFEFFVF------PYADKAL
Rv1771|M.tuberculosis_H37Rv --LFTLHRHDQRRSLAQTLERLDEFVDGNDHFEFFVF------PYADKAL
MMAR_2648|M.marinum_M --LFTLHRDDELKPLAETLERLDEHVDNNDHFEFFVF------PYAETAL
MUL_3124|M.ulcerans_Agy99 --LFTLHRDDELKPLAETLERLDEHVDNNDHFEFFVF------PYAETAL
MAB_0105c|M.abscessus_ATCC_199 --AFRLHRSQSVHDLDTVLADLPTLLADTDHLELYLF------PHTRRVL
Mflv_1178|M.gilvum_PYR-GCK ETAYFIADGDVTSGLDETIAFHSDGTEDNYTYSSAWFDAISPPPKLGRAA
Mvan_5627|M.vanbaalenii_PYR-1 ETAYFIADGDVTSGLEETIAFHSDGTEDNYTYSSAWFDAISAPPKLGRAV
MAV_0089|M.avium_104 KDVDAVNLNFPPQSFAQVLVGWQNWLRTADPNSWALA---------DATV
MSMEG_0301|M.smegmatis_MC2_155 ---AQASPSTVVAMFDTVQDAANAVVAITASVRPAML-----------EL
: .
Mb1800|M.bovis_AF2122/97 TRTMHRSDEQPKPTPGWQRMVG-ENFENGGLSLICQTGRRFPSVAPRLNR
Rv1771|M.tuberculosis_H37Rv TRTMHRSDEQPKPTPGWQRMVG-ENFENGGLSLICQTGRRFPSVAPRLNR
MMAR_2648|M.marinum_M TRTTRRSEEPPMPVPEWRRRVG-DQFENVGLGLVCRTGRQFPSTAPKLNR
MUL_3124|M.ulcerans_Agy99 TRTTRRSEEPPMPVPEWRRRVG-DQFENVGLGLVCRTGRQFPSTAPKLNR
MAB_0105c|M.abscessus_ATCC_199 LLQSTRTDEAPWPRNPVKHWVERDLVENGALGALMWTAGRLPAAAPRISK
Mflv_1178|M.gilvum_PYR-GCK ISRGSLATVDQLPKKLQKNPLKFDAPQLLTFPDLFPNGLANKYTFGPIGE
Mvan_5627|M.vanbaalenii_PYR-1 ISRGSLATVDQLPRKLQKNPLKFDAPQYFTAPEIFPNGLGNKYTFGPMTE
MAV_0089|M.avium_104 DAMGVHCRILATCPAGSGNSAAAAITQAVGIQPSGVETHTFNYMDLVNYL
MSMEG_0301|M.smegmatis_MC2_155 MDHASINAVEDYGRMGLDRSAQALLLVQSDAPGDAASEVAHIVEACEKSG
.
Mb1800|M.bovis_AF2122/97 LMTNMMSSSTVQDRAYKVFATQRKVR-----------FTEMEYAIPRENG
Rv1771|M.tuberculosis_H37Rv LMTNMMSSSTVQDRAYKVFATQRKVR-----------FTEMEYAIPRENG
MMAR_2648|M.marinum_M LLTSLMSPSSVQDRGWKVYPSPRNVK-----------FTEMEYAIPRENA
MUL_3124|M.ulcerans_Agy99 LLTSLMSPSSVQDRGWKVYPSPRNVK-----------FTEMEYAIPRENA
MAB_0105c|M.abscessus_ATCC_199 LVAALASSNESQDESAAVFASPRKVK-----------FTEMEYSLPLTNA
Mflv_1178|M.gilvum_PYR-GCK LWYRKSGTYRGKVQNLTQFYHPLDMFGEWNRAYGAAGFTQYQFVVP-TTA
Mvan_5627|M.vanbaalenii_PYR-1 VWYRLGKTYRGKAQNLTQFYHPLDMVGDWNRAYGSVGFAQYQFVVP-TEA
MAV_0089|M.avium_104 AVGNLNPQPLGYVGGSDVFP---------------------TVNAAVAQG
MSMEG_0301|M.smegmatis_MC2_155 ASEVFATDDPAEGAGFTAARRLVAPA-------------LMQLGTVLLED
Mb1800|M.bovis_AF2122/97 REALQRVIDLVRRRSLPIMFPIEVRFSAPDDSFLSTAYGRDTCYIAVHQY
Rv1771|M.tuberculosis_H37Rv REALQRVIDLVRRRSLPIMFPIEVRFSAPDDSFLSTAYGRDTCYIAVHQY
MMAR_2648|M.marinum_M REAVRRVIEVVRRRDLPIMYPLEVRFSAPDDAFLSTAYERDTCYIAVHQY
MUL_3124|M.ulcerans_Agy99 REAVRRVIEVVRRRDLPIMYPLEVRFSAPDDAFLSTAYERDTCYIAVHQY
MAB_0105c|M.abscessus_ATCC_199 REAIETALATIERDRHQVAFPLEVRFTQADDALLAPAYGRESVYLAVHQT
Mflv_1178|M.gilvum_PYR-GCK VDEFKAIIVDIQRSGFYSFLNVFKLFGPGNQAPLS--FPIPGWNVCVDFP
Mvan_5627|M.vanbaalenii_PYR-1 VDEFKRIMYDIQRSGHYSFLNVFKLFGPGNDAPLS--FPIPGWNVCVDFQ
MAV_0089|M.avium_104 IAAAVNAFPRNAGRMLAIMHALDGALATVAPAATAFPWRRQSALVQWYVE
MSMEG_0301|M.smegmatis_MC2_155 VTVPIPTLPALLAGINRISAECDVLICVVAHAGDGNTHPVVVFDPDDAES
: : : .
Mb1800|M.bovis_AF2122/97 AGMEFESYFRAVEEIMDDYAGRPHWGKRHYQTAATLRERY--PQWDRFAA
Rv1771|M.tuberculosis_H37Rv AGMEFESYFRAVEEIMDDYAGRPHWGKRHYQTAATLRERY--PQWDRFAA
MMAR_2648|M.marinum_M TGMEFETYFRAVEAIMDEYGGRPHWGKRHYQRAASLRERY--PAWDRFTA
MUL_3124|M.ulcerans_Agy99 TGMEFETYFRAVEAIMDEYRGRPHWGKRHYQRAASLRERY--PAWDRFTA
MAB_0105c|M.abscessus_ATCC_199 VHGSWESYFGGLEPILIGLGGRPHWGKRHTLTAQQLSERY--PEWGTFQD
Mflv_1178|M.gilvum_PYR-GCK ITAGLNEFLNGLDKRVLQFGGRLYTAKDSRTTAETFHAMY--PRIDEWIA
Mvan_5627|M.vanbaalenii_PYR-1 INPGLNEFLNGLDKRVLEFGGRLYTAKDSRTTAETFHAMY--PRIDEWIA
MAV_0089|M.avium_104 TSGDPAAATNWLASAHQAVQQYSVGGYVNYLEANQSPARYFGPNLSRLSA
MSMEG_0301|M.smegmatis_MC2_155 QARAERAFSEVMDLAIAMGGTITGEHGVGRLKRDWLPKQLGDDVMWVTRR
:
Mb1800|M.bovis_AF2122/97 VRDRLDPDRVFLNDYTRRVLGP---
Rv1771|M.tuberculosis_H37Rv VRDRLDPDRVFLNDYTRRVLGP---
MMAR_2648|M.marinum_M VRDRLDPNRVFLNDYTRRVLGA---
MUL_3124|M.ulcerans_Agy99 VRDRLDPNRVFLNDYTRRVLGA---
MAB_0105c|M.abscessus_ATCC_199 IRARLDPGGTFSGGYLNRLLGPVSP
Mflv_1178|M.gilvum_PYR-GCK VRRNVDPDGVFASDMARRLELL---
Mvan_5627|M.vanbaalenii_PYR-1 LRRKVDPDGVFASDMARRLELL---
MAV_0089|M.avium_104 VRQKYDPGRVMFSGLNY--------
MSMEG_0301|M.smegmatis_MC2_155 VKDALDPLGILNPGAVLRP------
:: ** : .