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MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGA MLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPL RVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPR SLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTA TPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERER PKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKS YPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPVQQLQMPAQSADIVGGALGDHQTHTIY RGAHPTD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1354c | - | - | 100% (567) | adenylate cyclase |
| M. bovis AF2122 / 97 | Mb1352c | - | 0.0 | 68.91% (534) | adenylate cyclase |
| M. bovis AF2122 / 97 | Mb1353c | - | 0.0 | 66.48% (534) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2336 | - | 0.0 | 61.57% (536) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1320c | - | 0.0 | 99.82% (567) | adenylate cyclase |
| M. leprae Br4923 | MLBr_00201 | - | 2e-86 | 41.09% (460) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_1459c | - | 1e-167 | 55.26% (532) | hypothetical protein MAB_1459c |
| M. marinum M | MMAR_4078 | - | 0.0 | 69.17% (532) | adenylate cyclase |
| M. avium 104 | MAV_1540 | - | 0.0 | 65.99% (541) | HAMP domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4924 | - | 1e-178 | 60.00% (535) | adenylate cyclase, family protein 3 |
| M. thermoresistible (build 8) | TH_3474 | - | 0.0 | 63.98% (533) | PUTATIVE putative adenylate/guanylate cyclase |
| M. ulcerans Agy99 | MUL_3986 | - | 0.0 | 64.00% (525) | adenylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4309 | - | 0.0 | 62.76% (537) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1354c|M.bovis_AF2122/97 ----------------MPSEKATTRHLPGAVETLSPRTGRRPETP-AYGS
Rv1320c|M.tuberculosis_H37Rv ----------------MPSEKATTRHLPGAVETLSPRTGRRPETP-AYGS
MUL_3986|M.ulcerans_Agy99 -----------------------------MVKTVTRHDGSLLESP-AYGS
MMAR_4078|M.marinum_M MPSTKTAETGSKKGAKSGAKKGVAQRLGRVLERVTRQSGRLPETP-AYGS
MAV_1540|M.avium_104 ----------------MSATQSTAQRIGRVLEKITRQSGRLPETP-AYGS
Mflv_2336|M.gilvum_PYR-GCK ----------------MNATKSVPYRLGRVLERVTRQSGRLDTP--GYGS
Mvan_4309|M.vanbaalenii_PYR-1 ----------------MNATKSVPYRLGRVLERVTRQSGRLETP--DYGS
TH_3474|M.thermoresistible__bu ----------------MTPNNRLARRLGHLLETLTRQSGRLSGAN-EYGS
MSMEG_4924|M.smegmatis_MC2_155 ----------------MNADNSLARQLGRVLETVTRQNSRLPSGTPEYGS
MAB_1459c|M.abscessus_ATCC_199 --------------MANESIRAVSRRVGRALGAITGQTGNINTGN-GYGS
MLBr_00201|M.leprae_Br4923 ---------------------------------MATQAAGLPGRIGAFVR
:: : . :
Mb1354c|M.bovis_AF2122/97 WLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVI
Rv1320c|M.tuberculosis_H37Rv WLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVI
MUL_3986|M.ulcerans_Agy99 WLLGDLNESQRDRRIRIRGMLTAVIAATNVIGICVGLVLATVAAPAPHVL
MMAR_4078|M.marinum_M WLLGRVSESQQRRRIRIQTILTVMVVVANLLGIAVSILLVTVAIPSPSVF
MAV_1540|M.avium_104 LLLGRVTESQHRRRIRIQIIMTVMVLGANLIGIGAALILVIVAIPAPSVF
Mflv_2336|M.gilvum_PYR-GCK WLLGRPAESQSRRRVRIQIILTFFILFTNIMGIAVSLLLNTIAIPVPSVF
Mvan_4309|M.vanbaalenii_PYR-1 WLLGKPEESQARRRIRIQVILTFLLLFTNILGIAVSLLLNTVAIPVPSVF
TH_3474|M.thermoresistible__bu WLLGRVSESQRRRRLRIQTILTTFIVGANVVGIAVAVTLVSFVFPVPSIF
MSMEG_4924|M.smegmatis_MC2_155 WILGRVTESQSRRRIRIQLILTTFVVIANLLGIAVSFLVLTVLFPSPSVF
MAB_1459c|M.abscessus_ATCC_199 WLLGTADESTFIQRIRIQLILTVFVVAANLIGIGVVILLVTVAFPTPNVF
MLBr_00201|M.leprae_Br4923 WGIRTPWPLFSLSMLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLA
: :: : : : *: : * :
Mb1354c|M.bovis_AF2122/97 LDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEAR
Rv1320c|M.tuberculosis_H37Rv LDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEAR
MUL_3986|M.ulcerans_Agy99 SDAPLWITFAVMPAYVVIAFALGSYWLARRTTQMLRWAIERREPSPTDQR
MMAR_4078|M.marinum_M TEAPWWITFVVVPSYIVVALALGTYWITRRTVLALRWAIEERQPTPEDER
MAV_1540|M.avium_104 NDAPAWITFGVGPAYVASALAVGTYWITRRTVLALRWAIEERKPTPTDER
Mflv_2336|M.gilvum_PYR-GCK SDAPAWLTFGVTPAYMLVALFFGTAWITSRTVRSLRWAIEERQPTSTDQR
Mvan_4309|M.vanbaalenii_PYR-1 SDAPAWLTFGVVPAYMVVALVLGTAWITSRTVGSLRWAIEERSPTRTDQR
TH_3474|M.thermoresistible__bu SDAPAWLTFGVSPALVGVALVVGTTWITRGIVRNLRWAIEERPPSRTDQR
MSMEG_4924|M.smegmatis_MC2_155 DARVAPYTYIVAPAYVVGALVVGVIWATNRVIGNVRWALEERPPTPQDQR
MAB_1459c|M.abscessus_ATCC_199 -DAPAWVNFVIVPVYIALAVLIGAVWGTRRIFKAVRWALDERPPTKADQR
MLBr_00201|M.leprae_Br4923 ISTLSVVVAFSTGFAVNLKLLMPVFRWQRRDN---RLAEADPAATELARS
. . * * .:
Mb1354c|M.bovis_AF2122/97 SAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVA
Rv1320c|M.tuberculosis_H37Rv SAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVA
MUL_3986|M.ulcerans_Agy99 NTLLAPFRFAIFHLLVWGTFTILLTALYGMANSMFIPRFLFALSFCGLGV
MMAR_4078|M.marinum_M NTFLAAWRVAVVDLILWGSGAVLLTTLYGMANTMFIPRFLFAVTFCGVLV
MAV_1540|M.avium_104 NTFLAPWRIALVDLVLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCGVLV
Mflv_2336|M.gilvum_PYR-GCK NVFLAPARVAQKLLLLWGVGAVLLTVLYGLQDTAFIPRFLFAVGFPGIVV
Mvan_4309|M.vanbaalenii_PYR-1 NVFVAPSRVAQMLLLFWGFGAALLTLLYGLQDSAFIPRFLFAVGFPGIVV
TH_3474|M.thermoresistible__bu NTFLAPWRVARAHLVLWGAGTAVLTTLYGLVDPAFIPRYLFTVSFAGIVV
MSMEG_4924|M.smegmatis_MC2_155 NTFFAPFRLTRVLLILWAAGTALLTTLYGMVDTNFIPKVLLGISFPGIVV
MAB_1459c|M.abscessus_ATCC_199 NAFAVPWRLTVIQSVLWAGGVALFTLLYGLYDPMYIPKIFFAVGFSGAVV
MLBr_00201|M.leprae_Br4923 RALRMPFYHTIISLVTWGIGGAVFIIASWSAARHSAPIVALATALGATAT
.: . : . *. : * : . . .
Mb1354c|M.bovis_AF2122/97 ATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNV
Rv1320c|M.tuberculosis_H37Rv ATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNV
MUL_3986|M.ulcerans_Agy99 TTASYMFTEFALRPVAAMALAAGPPLLRWAPGIRGRTIVVWLTGSGVPLI
MMAR_4078|M.marinum_M ATGSYLLTEFALRPVAAQALAAGPPPRRLSSGIMGRTMMVWLLGSGVPVV
MAV_1540|M.avium_104 ATACYLLAEFALRPVAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPVI
Mflv_2336|M.gilvum_PYR-GCK ATACYMITEFALRPIAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVL
Mvan_4309|M.vanbaalenii_PYR-1 ATACYMITEFALRPVAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVL
TH_3474|M.thermoresistible__bu ATICYLFTEFALRPVAAQALEAGPPPRRLAHGIMGRTMTVWLLGSGVPLL
MSMEG_4924|M.smegmatis_MC2_155 SVSCHLFTEFALRPVAAQALEAGPPPVRLAPGIMGRTMVVWALGSGVPIL
MAB_1459c|M.abscessus_ATCC_199 CAANYLFTEFAMRPVAARALEAGYRRRRLASGVMVRTVLAWMLGSGVPAA
MLBr_00201|M.leprae_Br4923 AIIGYLQSERVLRPVAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVL
:: :* .:**:*. ** * *: * : .* :***
Mb1354c|M.bovis_AF2122/97 GVALTAIFD-DTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATP
Rv1320c|M.tuberculosis_H37Rv GVALTAIFD-DTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATP
MUL_3986|M.ulcerans_Agy99 GMALVVIFD-ESLWQISQAEFSISVVIVSSAMLALGLLLMWILSWLTTTP
MMAR_4078|M.marinum_M GIALVAIFQ-IALRNLSETQFAVGVLIVSMATLIFGFILMWIMSWLTATP
MAV_1540|M.avium_104 GIALLALFE-IWLRNLTETEFAVGVLIVSTAALIFGCLLMWILAWLTATP
Mflv_2336|M.gilvum_PYR-GCK GILLLAVFS-LSLKNLSATQFAVAVIFIAAFALVFGLTLMWLLSWLIATP
Mvan_4309|M.vanbaalenii_PYR-1 GILLLAIFT-LSLRNLSATQFAVAVMIISVVALMFGLILMWLLSWLIATP
TH_3474|M.thermoresistible__bu GIMIAAAVS-LTQRHLSLVQFTIATMVLAAVALVFGFVLMWLVSWLTATP
MSMEG_4924|M.smegmatis_MC2_155 GILLAGVFA-VTLENLTPTQFAYAVMGLAVFALVFGFILMWILSWLTATP
MAB_1459c|M.abscessus_ATCC_199 GIVITGIGA-LVLHNLTVSQLAVAVIIIAGAIPSFGLILIWIASWLMATP
MLBr_00201|M.leprae_Br4923 AIVLAVVADKIALLHAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIADP
.: : . :: : : .* *: : : *
Mb1354c|M.bovis_AF2122/97 VRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRD
Rv1320c|M.tuberculosis_H37Rv VRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRD
MUL_3986|M.ulcerans_Agy99 VKVVCAALKRVEMGDLPGDLVVFDGTELGQLQRGFNAMVAGLRERERVRD
MMAR_4078|M.marinum_M VRVVRAALNRVANGDLRGDLVVFDGTELGELQRGFNTMVDGLRERERVRD
MAV_1540|M.avium_104 VRVVRAALKRVERGDLRGDLVVFDGTELGELQRGFNAMVDGLRERERVRD
Mflv_2336|M.gilvum_PYR-GCK VRVVRSALKQVEDGDLDCNLVVFDGTELGELQRGFNSMVHGLRERERVRD
Mvan_4309|M.vanbaalenii_PYR-1 VRVVRSALKHVEDGDLDCNVVVFDGTELGELQRGFNSMVHGLRERERVRD
TH_3474|M.thermoresistible__bu VRVVREALKQVENGNLDCNVVVFDGTELGELQRGFNAMVDGLRERERVRD
MSMEG_4924|M.smegmatis_MC2_155 IRVVRAALNRVEQGDLDTNLVVFDGTELGQLQRGFNSMVHGLRERERVRD
MAB_1459c|M.abscessus_ATCC_199 VKEVQTAIKRVAQNDLDIDLVVYDGTELGELQAGFNTMVEGLRERERVRD
MLBr_00201|M.leprae_Br4923 LRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRD
:: : *:..* .: .: ::*.:*** ** *** ** * **:*:**
Mb1354c|M.bovis_AF2122/97 LFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEV
Rv1320c|M.tuberculosis_H37Rv LFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEV
MUL_3986|M.ulcerans_Agy99 LFGRHVGREVAAAAERERPKLGGEDRHIAVVFIDIVGSTRLVTTQPPAEV
MMAR_4078|M.marinum_M LFGRHVGREVAIAAERERPKLGGEERHVAVVFIDIVGSTKLVTSQPPADV
MAV_1540|M.avium_104 LFGRHVGREVALAAERERPKLGGEERHVAVVFIDIVGSTQLVTRRPPAEV
Mflv_2336|M.gilvum_PYR-GCK LFGRHVGREVALAAEKQQVELGGEERRAAVIFVDIIGSTKLVTSRPAAEV
Mvan_4309|M.vanbaalenii_PYR-1 LFGRHVGREVARAAEKQKIELGGEERHAAVIFVDIIGSTQLVTSRPAVEV
TH_3474|M.thermoresistible__bu LFGRHVGREVARAAEEQQLELGGEERHVAVIFVDIVGSTQLVTTRPAAEV
MSMEG_4924|M.smegmatis_MC2_155 LFGRHVGREVAVLAEQQKFTLGGEERHAAVVFVDVIGSTQLVTSRPAVEV
MAB_1459c|M.abscessus_ATCC_199 LFGKHVGREVAAAAEQQQPELGGEERHIAVLFADIVGSTRLAATRPAVEV
MLBr_00201|M.leprae_Br4923 LFGRYVGEDVARRALEHGTELGGQERDVAVLFVDLIGSTQLAETKPPTKV
***::**.:** * .. ***::* **:* *::***:*. :*...*
Mb1354c|M.bovis_AF2122/97 VMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALAT
Rv1320c|M.tuberculosis_H37Rv VMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALAT
MUL_3986|M.ulcerans_Agy99 VKLLNRFFAIVVDEVDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAA
MMAR_4078|M.marinum_M VALLNRFFAVVVDEVDRHRGLVNKFEGDASLAIFGAPNHLERPEDQALAA
MAV_1540|M.avium_104 VSVLNQFFGIVVEEVDRHCGLVNKFEGDATLAIFGAPNHLDCPEDAALTA
Mflv_2336|M.gilvum_PYR-GCK VELLNRFFDVVVDEVDKHHGLVNKFEGDAVLAVFGAPVSLDNAEAEALAA
Mvan_4309|M.vanbaalenii_PYR-1 VELLNRFFDVVVEEVDNHHGLVNKFEGDAVLAVFGAPVSLDSAETEALSA
TH_3474|M.thermoresistible__bu VSLLNRFFAVIVEEVDRHRGLVNKFEGDATLAIFGAPNRLDNPEDAALAA
MSMEG_4924|M.smegmatis_MC2_155 VELLNRFFAVIVDEVDAHRGLVNKFEGDAVLAVFGAPVALDNAEDEALGA
MAB_1459c|M.abscessus_ATCC_199 VALLNRFFTVVVEEIDRYEGMVNKFEGDATLAVFGAPVRQDRPESQALAA
MLBr_00201|M.leprae_Br4923 VHLLNEFFRVVVDTVGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALSA
* :**.** ::*: :. : *:**** *** **:**** . ** :
Mb1354c|M.bovis_AF2122/97 ARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAA
Rv1320c|M.tuberculosis_H37Rv ARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAA
MUL_3986|M.ulcerans_Agy99 ARAIARRLAAEVPECQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAA
MMAR_4078|M.marinum_M ARTIAARLASEVPECQAGIGVAAGQVVAGNVGSKERFEYTVIGEPVNEAA
MAV_1540|M.avium_104 ARAIADRLANEMPQCRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNEAA
Mflv_2336|M.gilvum_PYR-GCK ARAMSRRLAAEVPECTAGIGVASGQVVAGNVGAKERFEYTVIGEPVNEAA
Mvan_4309|M.vanbaalenii_PYR-1 ARAMARRLRTEVPECPAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEAA
TH_3474|M.thermoresistible__bu ARAIAARLRTEVPEVRAGIGVASGQVVAGNVGARERFEYTVIGEPVNEGA
MSMEG_4924|M.smegmatis_MC2_155 ARGIARRLREEVPELDAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEAA
MAB_1459c|M.abscessus_ATCC_199 ARAIARRLRTEVPECQAGIGVASGQAVAGNIGAHDRFEYTVIGDPVNEAA
MLBr_00201|M.leprae_Br4923 ARELHDELLPVLGSAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAA
** : .* : . ****::*:.:**::*:. *****.**:****.*
Mb1354c|M.bovis_AF2122/97 RLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLAS
Rv1320c|M.tuberculosis_H37Rv RLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTS
MUL_3986|M.ulcerans_Agy99 RLCELAKSFPGRLLASAETLAGASESVSAQWCLGDSTLLRGLDQPTRLAT
MMAR_4078|M.marinum_M RLCELAKDHPGRLLASGAALDGASHDERARWSVGKTVTLRGHDQPTRLAA
MAV_1540|M.avium_104 RLCELAKSHSGRLLATGDAIEGASEKERARWSLGDTVTLRGHERPTRLAS
Mflv_2336|M.gilvum_PYR-GCK RLCELSKKIDGHLVASADAVHNATETERRHWELGETVTLRGHAEPTTLAT
Mvan_4309|M.vanbaalenii_PYR-1 RLCELAKNVPALLVASADAVGGATESERALWKLGETVTLRGHDQPTRLAT
TH_3474|M.thermoresistible__bu RLCELAKTKPGLLVASADAVANAGEQERAHWVLGETVTLRGHNQPTRLAL
MSMEG_4924|M.smegmatis_MC2_155 RLCEFAKSVPGHVVASSDTLANASESERARWSLGESVTLRGLDEPTRLAV
MAB_1459c|M.abscessus_ATCC_199 RLCELSKTVPGHLVASLDTVLRAHHREALHWRSGDTVTLRGRTEPTELAV
MLBr_00201|M.leprae_Br4923 RLTELAKLEDGHVLASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLAR
** *::* . ::*: :: * . * *. . *** * *:
Mb1354c|M.bovis_AF2122/97 PVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD
Rv1320c|M.tuberculosis_H37Rv PVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD
MUL_3986|M.ulcerans_Agy99 PIETAELDE--------------------------
MMAR_4078|M.marinum_M PI---------------------------------
MAV_1540|M.avium_104 PAGAADRPAGTD-----------------------
Mflv_2336|M.gilvum_PYR-GCK PVDRD------------------------------
Mvan_4309|M.vanbaalenii_PYR-1 PAGEL------------------------------
TH_3474|M.thermoresistible__bu PA---------------------------------
MSMEG_4924|M.smegmatis_MC2_155 PV---------------------------------
MAB_1459c|M.abscessus_ATCC_199 PV---------------------------------
MLBr_00201|M.leprae_Br4923 PLNLAVPEQITSEVTG-------------------
*