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MPSTKTAETGSKKGAKSGAKKGVAQRLGRVLERVTRQSGRLPETPAYGSWLLGRVSESQQRRRIRIQTIL TVMVVVANLLGIAVSILLVTVAIPSPSVFTEAPWWITFVVVPSYIVVALALGTYWITRRTVLALRWAIEE RQPTPEDERNTFLAAWRVAVVDLILWGSGAVLLTTLYGMANTMFIPRFLFAVTFCGVLVATGSYLLTEFA LRPVAAQALAAGPPPRRLSSGIMGRTMMVWLLGSGVPVVGIALVAIFQIALRNLSETQFAVGVLIVSMAT LIFGFILMWIMSWLTATPVRVVRAALNRVANGDLRGDLVVFDGTELGELQRGFNTMVDGLRERERVRDLF GRHVGREVAIAAERERPKLGGEERHVAVVFIDIVGSTKLVTSQPPADVVALLNRFFAVVVDEVDRHRGLV NKFEGDASLAIFGAPNHLERPEDQALAAARTIAARLASEVPECQAGIGVAAGQVVAGNVGSKERFEYTVI GEPVNEAARLCELAKDHPGRLLASGAALDGASHDERARWSVGKTVTLRGHDQPTRLAAPI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4078 | - | - | 100% (550) | adenylate cyclase |
| M. marinum M | MMAR_4079 | - | 0.0 | 82.01% (528) | adenylate cyclase |
| M. marinum M | MMAR_4120 | - | 0.0 | 69.81% (520) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1352c | - | 0.0 | 77.63% (532) | adenylate cyclase |
| M. gilvum PYR-GCK | Mflv_2336 | - | 0.0 | 69.36% (532) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1318c | - | 0.0 | 77.63% (532) | adenylate cyclase |
| M. leprae Br4923 | MLBr_00201 | - | 4e-89 | 41.70% (446) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_1459c | - | 0.0 | 60.19% (530) | hypothetical protein MAB_1459c |
| M. avium 104 | MAV_1540 | - | 0.0 | 79.28% (531) | HAMP domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4924 | - | 0.0 | 67.17% (533) | adenylate cyclase, family protein 3 |
| M. thermoresistible (build 8) | TH_3474 | - | 0.0 | 68.88% (527) | PUTATIVE putative adenylate/guanylate cyclase |
| M. ulcerans Agy99 | MUL_3986 | - | 0.0 | 69.67% (521) | adenylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4309 | - | 0.0 | 71.19% (531) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4078|M.marinum_M MPSTKTAETGSKKGAKSGAKKGVAQRLGRVLERVTRQSGRLPETP-AYGS
MAV_1540|M.avium_104 ----------------MSATQSTAQRIGRVLEKITRQSGRLPETP-AYGS
Mb1352c|M.bovis_AF2122/97 ----------------MSAKKSTAQRLGRVLETVTRQSGRLPETP-AYGS
Rv1318c|M.tuberculosis_H37Rv ----------------MSAKKSTAQRLGRVLETVTRQSGRLPETP-AYGS
MUL_3986|M.ulcerans_Agy99 -----------------------------MVKTVTRHDGSLLESP-AYGS
Mflv_2336|M.gilvum_PYR-GCK ----------------MNATKSVPYRLGRVLERVTRQSGRLDTP--GYGS
Mvan_4309|M.vanbaalenii_PYR-1 ----------------MNATKSVPYRLGRVLERVTRQSGRLETP--DYGS
TH_3474|M.thermoresistible__bu ----------------MTPNNRLARRLGHLLETLTRQSGRLSGAN-EYGS
MSMEG_4924|M.smegmatis_MC2_155 ----------------MNADNSLARQLGRVLETVTRQNSRLPSGTPEYGS
MAB_1459c|M.abscessus_ATCC_199 --------------MANESIRAVSRRVGRALGAITGQTGNINTGN-GYGS
MLBr_00201|M.leprae_Br4923 ---------------------------------MATQAAGLPGRIGAFVR
:: : . : :
MMAR_4078|M.marinum_M WLLGRVSESQQRRRIRIQTILTVMVVVANLLGIAVSILLVTVAIPSPSVF
MAV_1540|M.avium_104 LLLGRVTESQHRRRIRIQIIMTVMVLGANLIGIGAALILVIVAIPAPSVF
Mb1352c|M.bovis_AF2122/97 WLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIV
Rv1318c|M.tuberculosis_H37Rv WLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIV
MUL_3986|M.ulcerans_Agy99 WLLGDLNESQRDRRIRIRGMLTAVIAATNVIGICVGLVLATVAAPAPHVL
Mflv_2336|M.gilvum_PYR-GCK WLLGRPAESQSRRRVRIQIILTFFILFTNIMGIAVSLLLNTIAIPVPSVF
Mvan_4309|M.vanbaalenii_PYR-1 WLLGKPEESQARRRIRIQVILTFLLLFTNILGIAVSLLLNTVAIPVPSVF
TH_3474|M.thermoresistible__bu WLLGRVSESQRRRRLRIQTILTTFIVGANVVGIAVAVTLVSFVFPVPSIF
MSMEG_4924|M.smegmatis_MC2_155 WILGRVTESQSRRRIRIQLILTTFVVIANLLGIAVSFLVLTVLFPSPSVF
MAB_1459c|M.abscessus_ATCC_199 WLLGTADESTFIQRIRIQLILTVFVVAANLIGIGVVILLVTVAFPTPNVF
MLBr_00201|M.leprae_Br4923 WGIRTPWPLFSLSMLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLA
: :: : : .: *: : * :
MMAR_4078|M.marinum_M TEAPWWITFVVVPSYIVVALALGTYWITRRTVLALRWAIEERQPTPEDER
MAV_1540|M.avium_104 NDAPAWITFGVGPAYVASALAVGTYWITRRTVLALRWAIEERKPTPTDER
Mb1352c|M.bovis_AF2122/97 RDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEER
Rv1318c|M.tuberculosis_H37Rv RDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEER
MUL_3986|M.ulcerans_Agy99 SDAPLWITFAVMPAYVVIAFALGSYWLARRTTQMLRWAIERREPSPTDQR
Mflv_2336|M.gilvum_PYR-GCK SDAPAWLTFGVTPAYMLVALFFGTAWITSRTVRSLRWAIEERQPTSTDQR
Mvan_4309|M.vanbaalenii_PYR-1 SDAPAWLTFGVVPAYMVVALVLGTAWITSRTVGSLRWAIEERSPTRTDQR
TH_3474|M.thermoresistible__bu SDAPAWLTFGVSPALVGVALVVGTTWITRGIVRNLRWAIEERPPSRTDQR
MSMEG_4924|M.smegmatis_MC2_155 DARVAPYTYIVAPAYVVGALVVGVIWATNRVIGNVRWALEERPPTPQDQR
MAB_1459c|M.abscessus_ATCC_199 -DAPAWVNFVIVPVYIALAVLIGAVWGTRRIFKAVRWALDERPPTKADQR
MLBr_00201|M.leprae_Br4923 ISTLSVVVAFSTGFAVNLKLLMPVFRWQRRDN---RLAEADPAATELARS
: . . * * .: .
MMAR_4078|M.marinum_M NTFLAAWRVAVVDLILWGSGAVLLTTLYGMANTMFIPRFLFAVTFCGVLV
MAV_1540|M.avium_104 NTFLAPWRIALVDLVLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCGVLV
Mb1352c|M.bovis_AF2122/97 RTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLV
Rv1318c|M.tuberculosis_H37Rv RTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLV
MUL_3986|M.ulcerans_Agy99 NTLLAPFRFAIFHLLVWGTFTILLTALYGMANSMFIPRFLFALSFCGLGV
Mflv_2336|M.gilvum_PYR-GCK NVFLAPARVAQKLLLLWGVGAVLLTVLYGLQDTAFIPRFLFAVGFPGIVV
Mvan_4309|M.vanbaalenii_PYR-1 NVFVAPSRVAQMLLLFWGFGAALLTLLYGLQDSAFIPRFLFAVGFPGIVV
TH_3474|M.thermoresistible__bu NTFLAPWRVARAHLVLWGAGTAVLTTLYGLVDPAFIPRYLFTVSFAGIVV
MSMEG_4924|M.smegmatis_MC2_155 NTFFAPFRLTRVLLILWAAGTALLTTLYGMVDTNFIPKVLLGISFPGIVV
MAB_1459c|M.abscessus_ATCC_199 NAFAVPWRLTVIQSVLWAGGVALFTLLYGLYDPMYIPKIFFAVGFSGAVV
MLBr_00201|M.leprae_Br4923 RALRMPFYHTIISLVTWGIGGAVFIIASWSAARHSAPIVALATALGATAT
..: . : : *. :: * : : . .
MMAR_4078|M.marinum_M ATGSYLLTEFALRPVAAQALAAGPPPRRLSSGIMGRTMMVWLLGSGVPVV
MAV_1540|M.avium_104 ATACYLLAEFALRPVAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPVI
Mb1352c|M.bovis_AF2122/97 ATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVV
Rv1318c|M.tuberculosis_H37Rv ATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVV
MUL_3986|M.ulcerans_Agy99 TTASYMFTEFALRPVAAMALAAGPPLLRWAPGIRGRTIVVWLTGSGVPLI
Mflv_2336|M.gilvum_PYR-GCK ATACYMITEFALRPIAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVL
Mvan_4309|M.vanbaalenii_PYR-1 ATACYMITEFALRPVAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVL
TH_3474|M.thermoresistible__bu ATICYLFTEFALRPVAAQALEAGPPPRRLAHGIMGRTMTVWLLGSGVPLL
MSMEG_4924|M.smegmatis_MC2_155 SVSCHLFTEFALRPVAAQALEAGPPPVRLAPGIMGRTMVVWALGSGVPIL
MAB_1459c|M.abscessus_ATCC_199 CAANYLFTEFAMRPVAARALEAGYRRRRLASGVMVRTVLAWMLGSGVPAA
MLBr_00201|M.leprae_Br4923 AIIGYLQSERVLRPVAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVL
:: :* .:**.*. ** :* : *: * : .* .:***
MMAR_4078|M.marinum_M GIALVAIFQ-IALRNLSETQFAVGVLIVSMATLIFGFILMWIMSWLTATP
MAV_1540|M.avium_104 GIALLALFE-IWLRNLTETEFAVGVLIVSTAALIFGCLLMWILAWLTATP
Mb1352c|M.bovis_AF2122/97 GIALMAMFE-MVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATP
Rv1318c|M.tuberculosis_H37Rv GIALMAMFE-MVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATP
MUL_3986|M.ulcerans_Agy99 GMALVVIFD-ESLWQISQAEFSISVVIVSSAMLALGLLLMWILSWLTTTP
Mflv_2336|M.gilvum_PYR-GCK GILLLAVFS-LSLKNLSATQFAVAVIFIAAFALVFGLTLMWLLSWLIATP
Mvan_4309|M.vanbaalenii_PYR-1 GILLLAIFT-LSLRNLSATQFAVAVMIISVVALMFGLILMWLLSWLIATP
TH_3474|M.thermoresistible__bu GIMIAAAVS-LTQRHLSLVQFTIATMVLAAVALVFGFVLMWLVSWLTATP
MSMEG_4924|M.smegmatis_MC2_155 GILLAGVFA-VTLENLTPTQFAYAVMGLAVFALVFGFILMWILSWLTATP
MAB_1459c|M.abscessus_ATCC_199 GIVITGIGA-LVLHNLTVSQLAVAVIIIAGAIPSFGLILIWIASWLMATP
MLBr_00201|M.leprae_Br4923 AIVLAVVADKIALLHAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIADP
.: : : :: : :: .* *: : : *
MMAR_4078|M.marinum_M VRVVRAALNRVANGDLRGDLVVFDGTELGELQRGFNTMVDGLRERERVRD
MAV_1540|M.avium_104 VRVVRAALKRVERGDLRGDLVVFDGTELGELQRGFNAMVDGLRERERVRD
Mb1352c|M.bovis_AF2122/97 VRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRD
Rv1318c|M.tuberculosis_H37Rv VRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRD
MUL_3986|M.ulcerans_Agy99 VKVVCAALKRVEMGDLPGDLVVFDGTELGQLQRGFNAMVAGLRERERVRD
Mflv_2336|M.gilvum_PYR-GCK VRVVRSALKQVEDGDLDCNLVVFDGTELGELQRGFNSMVHGLRERERVRD
Mvan_4309|M.vanbaalenii_PYR-1 VRVVRSALKHVEDGDLDCNVVVFDGTELGELQRGFNSMVHGLRERERVRD
TH_3474|M.thermoresistible__bu VRVVREALKQVENGNLDCNVVVFDGTELGELQRGFNAMVDGLRERERVRD
MSMEG_4924|M.smegmatis_MC2_155 IRVVRAALNRVEQGDLDTNLVVFDGTELGQLQRGFNSMVHGLRERERVRD
MAB_1459c|M.abscessus_ATCC_199 VKEVQTAIKRVAQNDLDIDLVVYDGTELGELQAGFNTMVEGLRERERVRD
MLBr_00201|M.leprae_Br4923 LRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRD
:: : *: .* .: .: ::*.:*** ** *** ** * **:*:**
MMAR_4078|M.marinum_M LFGRHVGREVAIAAERERPKLGGEERHVAVVFIDIVGSTKLVTSQPPADV
MAV_1540|M.avium_104 LFGRHVGREVALAAERERPKLGGEERHVAVVFIDIVGSTQLVTRRPPAEV
Mb1352c|M.bovis_AF2122/97 LFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADV
Rv1318c|M.tuberculosis_H37Rv LFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADV
MUL_3986|M.ulcerans_Agy99 LFGRHVGREVAAAAERERPKLGGEDRHIAVVFIDIVGSTRLVTTQPPAEV
Mflv_2336|M.gilvum_PYR-GCK LFGRHVGREVALAAEKQQVELGGEERRAAVIFVDIIGSTKLVTSRPAAEV
Mvan_4309|M.vanbaalenii_PYR-1 LFGRHVGREVARAAEKQKIELGGEERHAAVIFVDIIGSTQLVTSRPAVEV
TH_3474|M.thermoresistible__bu LFGRHVGREVARAAEEQQLELGGEERHVAVIFVDIVGSTQLVTTRPAAEV
MSMEG_4924|M.smegmatis_MC2_155 LFGRHVGREVAVLAEQQKFTLGGEERHAAVVFVDVIGSTQLVTSRPAVEV
MAB_1459c|M.abscessus_ATCC_199 LFGKHVGREVAAAAEQQQPELGGEERHIAVLFADIVGSTRLAATRPAVEV
MLBr_00201|M.leprae_Br4923 LFGRYVGEDVARRALEHGTELGGQERDVAVLFVDLIGSTQLAETKPPTKV
***::**.:** * .. ***::* **:* *::***:*. :*...*
MMAR_4078|M.marinum_M VALLNRFFAVVVDEVDRHRGLVNKFEGDASLAIFGAPNHLERPEDQALAA
MAV_1540|M.avium_104 VSVLNQFFGIVVEEVDRHCGLVNKFEGDATLAIFGAPNHLDCPEDAALTA
Mb1352c|M.bovis_AF2122/97 VKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAA
Rv1318c|M.tuberculosis_H37Rv VKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAA
MUL_3986|M.ulcerans_Agy99 VKLLNRFFAIVVDEVDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAA
Mflv_2336|M.gilvum_PYR-GCK VELLNRFFDVVVDEVDKHHGLVNKFEGDAVLAVFGAPVSLDNAEAEALAA
Mvan_4309|M.vanbaalenii_PYR-1 VELLNRFFDVVVEEVDNHHGLVNKFEGDAVLAVFGAPVSLDSAETEALSA
TH_3474|M.thermoresistible__bu VSLLNRFFAVIVEEVDRHRGLVNKFEGDATLAIFGAPNRLDNPEDAALAA
MSMEG_4924|M.smegmatis_MC2_155 VELLNRFFAVIVDEVDAHRGLVNKFEGDAVLAVFGAPVALDNAEDEALGA
MAB_1459c|M.abscessus_ATCC_199 VALLNRFFTVVVEEIDRYEGMVNKFEGDATLAVFGAPVRQDRPESQALAA
MLBr_00201|M.leprae_Br4923 VHLLNEFFRVVVDTVGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALSA
* :**.** ::*: :. : *:**** *** *::**** . ** *
MMAR_4078|M.marinum_M ARTIAARLASEVPECQAGIGVAAGQVVAGNVGSKERFEYTVIGEPVNEAA
MAV_1540|M.avium_104 ARAIADRLANEMPQCRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNEAA
Mb1352c|M.bovis_AF2122/97 ARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAA
Rv1318c|M.tuberculosis_H37Rv ARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAA
MUL_3986|M.ulcerans_Agy99 ARAIARRLAAEVPECQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAA
Mflv_2336|M.gilvum_PYR-GCK ARAMSRRLAAEVPECTAGIGVASGQVVAGNVGAKERFEYTVIGEPVNEAA
Mvan_4309|M.vanbaalenii_PYR-1 ARAMARRLRTEVPECPAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEAA
TH_3474|M.thermoresistible__bu ARAIAARLRTEVPEVRAGIGVASGQVVAGNVGARERFEYTVIGEPVNEGA
MSMEG_4924|M.smegmatis_MC2_155 ARGIARRLREEVPELDAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEAA
MAB_1459c|M.abscessus_ATCC_199 ARAIARRLRTEVPECQAGIGVASGQAVAGNIGAHDRFEYTVIGDPVNEAA
MLBr_00201|M.leprae_Br4923 ARELHDELLPVLGSAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAA
** : .* : . ****::*:.:**::*:. *****.**:****.*
MMAR_4078|M.marinum_M RLCELAKDHPGRLLASGAALDGASHDERARWSVGKTVTLRGHDQPTRLAA
MAV_1540|M.avium_104 RLCELAKSHSGRLLATGDAIEGASEKERARWSLGDTVTLRGHERPTRLAS
Mb1352c|M.bovis_AF2122/97 RLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAK
Rv1318c|M.tuberculosis_H37Rv RLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAK
MUL_3986|M.ulcerans_Agy99 RLCELAKSFPGRLLASAETLAGASESVSAQWCLGDSTLLRGLDQPTRLAT
Mflv_2336|M.gilvum_PYR-GCK RLCELSKKIDGHLVASADAVHNATETERRHWELGETVTLRGHAEPTTLAT
Mvan_4309|M.vanbaalenii_PYR-1 RLCELAKNVPALLVASADAVGGATESERALWKLGETVTLRGHDQPTRLAT
TH_3474|M.thermoresistible__bu RLCELAKTKPGLLVASADAVANAGEQERAHWVLGETVTLRGHNQPTRLAL
MSMEG_4924|M.smegmatis_MC2_155 RLCEFAKSVPGHVVASSDTLANASESERARWSLGESVTLRGLDEPTRLAV
MAB_1459c|M.abscessus_ATCC_199 RLCELSKTVPGHLVASLDTVLRAHHREALHWRSGDTVTLRGRTEPTELAV
MLBr_00201|M.leprae_Br4923 RLTELAKLEDGHVLASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLAR
** *::* . ::*: :: * . * * . *** *. **
MMAR_4078|M.marinum_M PI--------------
MAV_1540|M.avium_104 PAGAADRPAGTD----
Mb1352c|M.bovis_AF2122/97 PVGLTKPRR-------
Rv1318c|M.tuberculosis_H37Rv PVGLTKPRR-------
MUL_3986|M.ulcerans_Agy99 PIETAELDE-------
Mflv_2336|M.gilvum_PYR-GCK PVDRD-----------
Mvan_4309|M.vanbaalenii_PYR-1 PAGEL-----------
TH_3474|M.thermoresistible__bu PA--------------
MSMEG_4924|M.smegmatis_MC2_155 PV--------------
MAB_1459c|M.abscessus_ATCC_199 PV--------------
MLBr_00201|M.leprae_Br4923 PLNLAVPEQITSEVTG
*