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MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVAL LVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLP FRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPP RRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLT AAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERE RPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAK SHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1353c | - | - | 100% (535) | adenylate cyclase |
| M. bovis AF2122 / 97 | Mb1352c | - | 0.0 | 70.97% (534) | adenylate cyclase |
| M. bovis AF2122 / 97 | Mb1354c | - | 0.0 | 66.48% (534) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2336 | - | 0.0 | 64.04% (534) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1319c | - | 0.0 | 100.00% (535) | adenylate cyclase |
| M. leprae Br4923 | MLBr_00201 | - | 7e-90 | 41.33% (450) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_1459c | - | 1e-171 | 56.79% (530) | hypothetical protein MAB_1459c |
| M. marinum M | MMAR_4078 | - | 0.0 | 71.62% (532) | adenylate cyclase |
| M. avium 104 | MAV_1540 | - | 0.0 | 71.35% (534) | HAMP domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4924 | - | 0.0 | 62.99% (535) | adenylate cyclase, family protein 3 |
| M. thermoresistible (build 8) | TH_3474 | - | 0.0 | 66.48% (534) | PUTATIVE putative adenylate/guanylate cyclase |
| M. ulcerans Agy99 | MUL_3944 | - | 0.0 | 64.42% (534) | adenylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4309 | - | 0.0 | 64.42% (534) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1353c|M.bovis_AF2122/97 ----------------MPAKKTMAQRLGQALETMTRQCGQLPETP-AYGS
Rv1319c|M.tuberculosis_H37Rv ----------------MPAKKTMAQRLGQALETMTRQCGQLPETP-AYGS
MMAR_4078|M.marinum_M MPSTKTAETGSKKGAKSGAKKGVAQRLGRVLERVTRQSGRLPETP-AYGS
MAV_1540|M.avium_104 ----------------MSATQSTAQRIGRVLEKITRQSGRLPETP-AYGS
MUL_3944|M.ulcerans_Agy99 ----------------MVATNTVVQRLRRALEKITQQSDQLTENY-AYGS
Mflv_2336|M.gilvum_PYR-GCK ----------------MNATKSVPYRLGRVLERVTRQSGRLDTP--GYGS
Mvan_4309|M.vanbaalenii_PYR-1 ----------------MNATKSVPYRLGRVLERVTRQSGRLETP--DYGS
TH_3474|M.thermoresistible__bu ----------------MTPNNRLARRLGHLLETLTRQSGRLSGAN-EYGS
MSMEG_4924|M.smegmatis_MC2_155 ----------------MNADNSLARQLGRVLETVTRQNSRLPSGTPEYGS
MAB_1459c|M.abscessus_ATCC_199 --------------MANESIRAVSRRVGRALGAITGQTGNINTGN-GYGS
MLBr_00201|M.leprae_Br4923 ---------------------------------MATQAAGLPGRIGAFVR
:: * : :
Mb1353c|M.bovis_AF2122/97 WLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIY
Rv1319c|M.tuberculosis_H37Rv WLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIY
MMAR_4078|M.marinum_M WLLGRVSESQQRRRIRIQTILTVMVVVANLLGIAVSILLVTVAIPSPSVF
MAV_1540|M.avium_104 LLLGRVTESQHRRRIRIQIIMTVMVLGANLIGIGAALILVIVAIPAPSVF
MUL_3944|M.ulcerans_Agy99 RLLGQLTETPQRRRVRIQLMLTSSIMAANLVAIGVALLLVFVAIPEPNVI
Mflv_2336|M.gilvum_PYR-GCK WLLGRPAESQSRRRVRIQIILTFFILFTNIMGIAVSLLLNTIAIPVPSVF
Mvan_4309|M.vanbaalenii_PYR-1 WLLGKPEESQARRRIRIQVILTFLLLFTNILGIAVSLLLNTVAIPVPSVF
TH_3474|M.thermoresistible__bu WLLGRVSESQRRRRLRIQTILTTFIVGANVVGIAVAVTLVSFVFPVPSIF
MSMEG_4924|M.smegmatis_MC2_155 WILGRVTESQSRRRIRIQLILTTFVVIANLLGIAVSFLVLTVLFPSPSVF
MAB_1459c|M.abscessus_ATCC_199 WLLGTADESTFIQRIRIQLILTVFVVAANLIGIGVVILLVTVAFPTPNVF
MLBr_00201|M.leprae_Br4923 WGIRTPWPLFSLSMLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLA
: :: . : : :: .: : :* .:
Mb1353c|M.bovis_AF2122/97 TDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADG
Rv1319c|M.tuberculosis_H37Rv TDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADG
MMAR_4078|M.marinum_M TEAPWWITFVVVPSYIVVALALGTYWITRRTVLA-LRWAIEERQPTPEDE
MAV_1540|M.avium_104 NDAPAWITFGVGPAYVASALAVGTYWITRRTVLA-LRWAIEERKPTPTDE
MUL_3944|M.ulcerans_Agy99 TEAPRWLTFGVGAGYDVTAFVVGSFWITSNTVRA-LRWYIEGRPPNRAVS
Mflv_2336|M.gilvum_PYR-GCK SDAPAWLTFGVTPAYMLVALFFGTAWITSRTVRS-LRWAIEERQPTSTDQ
Mvan_4309|M.vanbaalenii_PYR-1 SDAPAWLTFGVVPAYMVVALVLGTAWITSRTVGS-LRWAIEERSPTRTDQ
TH_3474|M.thermoresistible__bu SDAPAWLTFGVSPALVGVALVVGTTWITRGIVRN-LRWAIEERPPSRTDQ
MSMEG_4924|M.smegmatis_MC2_155 DARVAPYTYIVAPAYVVGALVVGVIWATNRVIGN-VRWALEERPPTPQDQ
MAB_1459c|M.abscessus_ATCC_199 -DAPAWVNFVIVPVYIALAVLIGAVWGTRRIFKA-VRWALDERPPTKADQ
MLBr_00201|M.leprae_Br4923 ISTLSVVVAFSTGFAVNLKLLMPVFRWQRR--DN--RLAEADPAATELAR
. . * ..
Mb1353c|M.bovis_AF2122/97 RNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVL
Rv1319c|M.tuberculosis_H37Rv RNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVL
MMAR_4078|M.marinum_M RNTFLAAWRVAVVDLILWGSGAVLLTTLYGMANTMFIPRFLFAVTFCGVL
MAV_1540|M.avium_104 RNTFLAPWRIALVDLVLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCGVL
MUL_3944|M.ulcerans_Agy99 RETFLVPSRIAAVHLFLWGLGTLLFTTLYGLIDIRFIPKYLFSVSFCGIL
Mflv_2336|M.gilvum_PYR-GCK RNVFLAPARVAQKLLLLWGVGAVLLTVLYGLQDTAFIPRFLFAVGFPGIV
Mvan_4309|M.vanbaalenii_PYR-1 RNVFVAPSRVAQMLLLFWGFGAALLTLLYGLQDSAFIPRFLFAVGFPGIV
TH_3474|M.thermoresistible__bu RNTFLAPWRVARAHLVLWGAGTAVLTTLYGLVDPAFIPRYLFTVSFAGIV
MSMEG_4924|M.smegmatis_MC2_155 RNTFFAPFRLTRVLLILWAAGTALLTTLYGMVDTNFIPKVLLGISFPGIV
MAB_1459c|M.abscessus_ATCC_199 RNAFAVPWRLTVIQSVLWAGGVALFTLLYGLYDPMYIPKIFFAVGFSGAV
MLBr_00201|M.leprae_Br4923 SRALRMPFYHTIISLVTWGIGGAVFIIASWSAARHSAPIVALATALGATA
..: . : . * * :: . : : .
Mb1353c|M.bovis_AF2122/97 VATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPV
Rv1319c|M.tuberculosis_H37Rv VATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPV
MMAR_4078|M.marinum_M VATGSYLLTEFALRPVAAQALAAGPPPRRLSSGIMGRTMMVWLLGSGVPV
MAV_1540|M.avium_104 VATACYLLAEFALRPVAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPV
MUL_3944|M.ulcerans_Agy99 VATGSYLLTEFALRPLTAQALETGPPPRRIVSGIMGRTILIWLLGSGVPV
Mflv_2336|M.gilvum_PYR-GCK VATACYMITEFALRPIAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPV
Mvan_4309|M.vanbaalenii_PYR-1 VATACYMITEFALRPVAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPV
TH_3474|M.thermoresistible__bu VATICYLFTEFALRPVAAQALEAGPPPRRLAHGIMGRTMTVWLLGSGVPL
MSMEG_4924|M.smegmatis_MC2_155 VSVSCHLFTEFALRPVAAQALEAGPPPVRLAPGIMGRTMVVWALGSGVPI
MAB_1459c|M.abscessus_ATCC_199 VCAANYLFTEFAMRPVAARALEAGYRRRRLASGVMVRTVLAWMLGSGVPA
MLBr_00201|M.leprae_Br4923 TAIIGYLQSERVLRPVAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPV
.. :: :* .:**::. ** :* *: * : * .:***
Mb1353c|M.bovis_AF2122/97 TGIATTALYV-LLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAA
Rv1319c|M.tuberculosis_H37Rv TGIATTALYV-LLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAA
MMAR_4078|M.marinum_M VGIALVAIFQ-IALRNLSETQFAVGVLIVSMATLIFGFILMWIMSWLTAT
MAV_1540|M.avium_104 IGIALLALFE-IWLRNLTETEFAVGVLIVSTAALIFGCLLMWILAWLTAT
MUL_3944|M.ulcerans_Agy99 VDIALLAVFE-IALLHLSEVEFAVGVLIASSATLVFGLLLIAISAWLTAT
Mflv_2336|M.gilvum_PYR-GCK LGILLLAVFS-LSLKNLSATQFAVAVIFIAAFALVFGLTLMWLLSWLIAT
Mvan_4309|M.vanbaalenii_PYR-1 LGILLLAIFT-LSLRNLSATQFAVAVMIISVVALMFGLILMWLLSWLIAT
TH_3474|M.thermoresistible__bu LGIMIAAAVS-LTQRHLSLVQFTIATMVLAAVALVFGFVLMWLVSWLTAT
MSMEG_4924|M.smegmatis_MC2_155 LGILLAGVFA-VTLENLTPTQFAYAVMGLAVFALVFGFILMWILSWLTAT
MAB_1459c|M.abscessus_ATCC_199 AGIVITGIGA-LVLHNLTVSQLAVAVIIIAGAIPSFGLILIWIASWLMAT
MLBr_00201|M.leprae_Br4923 LAIVLAVVADKIALLHAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIAD
* : : :: : : .* : : *
Mb1353c|M.bovis_AF2122/97 PVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVR
Rv1319c|M.tuberculosis_H37Rv PVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVR
MMAR_4078|M.marinum_M PVRVVRAALNRVANGDLRGDLVVFDGTELGELQRGFNTMVDGLRERERVR
MAV_1540|M.avium_104 PVRVVRAALKRVERGDLRGDLVVFDGTELGELQRGFNAMVDGLRERERVR
MUL_3944|M.ulcerans_Agy99 PVRVVRAALKRVERGDLRGDVVVFDGSELGELQSGFNSMVEGLRERERVR
Mflv_2336|M.gilvum_PYR-GCK PVRVVRSALKQVEDGDLDCNLVVFDGTELGELQRGFNSMVHGLRERERVR
Mvan_4309|M.vanbaalenii_PYR-1 PVRVVRSALKHVEDGDLDCNVVVFDGTELGELQRGFNSMVHGLRERERVR
TH_3474|M.thermoresistible__bu PVRVVREALKQVENGNLDCNVVVFDGTELGELQRGFNAMVDGLRERERVR
MSMEG_4924|M.smegmatis_MC2_155 PIRVVRAALNRVEQGDLDTNLVVFDGTELGQLQRGFNSMVHGLRERERVR
MAB_1459c|M.abscessus_ATCC_199 PVKEVQTAIKRVAQNDLDIDLVVYDGTELGELQAGFNTMVEGLRERERVR
MLBr_00201|M.leprae_Br4923 PLRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLR
*:: :: *:..* .: .: ::*.:*** ** *** ** * **:*:*
Mb1353c|M.bovis_AF2122/97 DLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAH
Rv1319c|M.tuberculosis_H37Rv DLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAH
MMAR_4078|M.marinum_M DLFGRHVGREVAIAAERERPKLGGEERHVAVVFIDIVGSTKLVTSQPPAD
MAV_1540|M.avium_104 DLFGRHVGREVALAAERERPKLGGEERHVAVVFIDIVGSTQLVTRRPPAE
MUL_3944|M.ulcerans_Agy99 DLFGRHVGREVAAAAERKPPQLGGEERYVAVVFVDIIGSTQLVSNRPATD
Mflv_2336|M.gilvum_PYR-GCK DLFGRHVGREVALAAEKQQVELGGEERRAAVIFVDIIGSTKLVTSRPAAE
Mvan_4309|M.vanbaalenii_PYR-1 DLFGRHVGREVARAAEKQKIELGGEERHAAVIFVDIIGSTQLVTSRPAVE
TH_3474|M.thermoresistible__bu DLFGRHVGREVARAAEEQQLELGGEERHVAVIFVDIVGSTQLVTTRPAAE
MSMEG_4924|M.smegmatis_MC2_155 DLFGRHVGREVAVLAEQQKFTLGGEERHAAVVFVDVIGSTQLVTSRPAVE
MAB_1459c|M.abscessus_ATCC_199 DLFGKHVGREVAAAAEQQQPELGGEERHIAVLFADIVGSTRLAATRPAVE
MLBr_00201|M.leprae_Br4923 DLFGRYVGEDVARRALEHGTELGGQERDVAVLFVDLIGSTQLAETKPPTK
****::**.:** * .. ***::* **:* *::***:*. :*...
Mb1353c|M.bovis_AF2122/97 VVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALA
Rv1319c|M.tuberculosis_H37Rv VVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALA
MMAR_4078|M.marinum_M VVALLNRFFAVVVDEVDRHRGLVNKFEGDASLAIFGAPNHLERPEDQALA
MAV_1540|M.avium_104 VVSVLNQFFGIVVEEVDRHCGLVNKFEGDATLAIFGAPNHLDCPEDAALT
MUL_3944|M.ulcerans_Agy99 VVQLLDRFFAVIVDEVERHRGLVNKFEGDASLAIFGAPNPLECPEVAALS
Mflv_2336|M.gilvum_PYR-GCK VVELLNRFFDVVVDEVDKHHGLVNKFEGDAVLAVFGAPVSLDNAEAEALA
Mvan_4309|M.vanbaalenii_PYR-1 VVELLNRFFDVVVEEVDNHHGLVNKFEGDAVLAVFGAPVSLDSAETEALS
TH_3474|M.thermoresistible__bu VVSLLNRFFAVIVEEVDRHRGLVNKFEGDATLAIFGAPNRLDNPEDAALA
MSMEG_4924|M.smegmatis_MC2_155 VVELLNRFFAVIVDEVDAHRGLVNKFEGDAVLAVFGAPVALDNAEDEALG
MAB_1459c|M.abscessus_ATCC_199 VVALLNRFFTVVVEEIDRYEGMVNKFEGDATLAVFGAPVRQDRPESQALA
MLBr_00201|M.leprae_Br4923 VVHLLNEFFRVVVDTVGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALS
** :*:.** ::*: : : *::*** *** **:**** . **
Mb1353c|M.bovis_AF2122/97 AARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQA
Rv1319c|M.tuberculosis_H37Rv AARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQA
MMAR_4078|M.marinum_M AARTIAARLASEVPECQAGIGVAAGQVVAGNVGSKERFEYTVIGEPVNEA
MAV_1540|M.avium_104 AARAIADRLANEMPQCRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNEA
MUL_3944|M.ulcerans_Agy99 AARAIAGRLCTEVPECPAGIGVAAGQVVAGNVGANERFEYTVIGGPVNEA
Mflv_2336|M.gilvum_PYR-GCK AARAMSRRLAAEVPECTAGIGVASGQVVAGNVGAKERFEYTVIGEPVNEA
Mvan_4309|M.vanbaalenii_PYR-1 AARAMARRLRTEVPECPAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEA
TH_3474|M.thermoresistible__bu AARAIAARLRTEVPEVRAGIGVASGQVVAGNVGARERFEYTVIGEPVNEG
MSMEG_4924|M.smegmatis_MC2_155 AARGIARRLREEVPELDAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEA
MAB_1459c|M.abscessus_ATCC_199 AARAIARRLRTEVPECQAGIGVASGQAVAGNIGAHDRFEYTVIGDPVNEA
MLBr_00201|M.leprae_Br4923 AARELHDELLPVLGSAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEA
*** : .* : . ****::*: :**::*:. ******:* ***:.
Mb1353c|M.bovis_AF2122/97 ARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLA
Rv1319c|M.tuberculosis_H37Rv ARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLA
MMAR_4078|M.marinum_M ARLCELAKDHPGRLLASGAALDGASHDERARWSVGKTVTLRGHDQPTRLA
MAV_1540|M.avium_104 ARLCELAKSHSGRLLATGDAIEGASEKERARWSLGDTVTLRGHERPTRLA
MUL_3944|M.ulcerans_Agy99 ARLCELAKSYSTRLVASSETVAGATETERAHWNLAETVTLRGRDRPTRLA
Mflv_2336|M.gilvum_PYR-GCK ARLCELSKKIDGHLVASADAVHNATETERRHWELGETVTLRGHAEPTTLA
Mvan_4309|M.vanbaalenii_PYR-1 ARLCELAKNVPALLVASADAVGGATESERALWKLGETVTLRGHDQPTRLA
TH_3474|M.thermoresistible__bu ARLCELAKTKPGLLVASADAVANAGEQERAHWVLGETVTLRGHNQPTRLA
MSMEG_4924|M.smegmatis_MC2_155 ARLCEFAKSVPGHVVASSDTLANASESERARWSLGESVTLRGLDEPTRLA
MAB_1459c|M.abscessus_ATCC_199 ARLCELSKTVPGHLVASLDTVLRAHHREALHWRSGDTVTLRGRTEPTELA
MLBr_00201|M.leprae_Br4923 ARLTELAKLEDGHVLASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLA
*** *::* ::*: :: * . * * .. * *** ** **
Mb1353c|M.bovis_AF2122/97 VPT--------------
Rv1319c|M.tuberculosis_H37Rv VPT--------------
MMAR_4078|M.marinum_M API--------------
MAV_1540|M.avium_104 SPAGAADRPAGTD----
MUL_3944|M.ulcerans_Agy99 IPASSPRP---------
Mflv_2336|M.gilvum_PYR-GCK TPVDRD-----------
Mvan_4309|M.vanbaalenii_PYR-1 TPAGEL-----------
TH_3474|M.thermoresistible__bu LPA--------------
MSMEG_4924|M.smegmatis_MC2_155 VPV--------------
MAB_1459c|M.abscessus_ATCC_199 VPV--------------
MLBr_00201|M.leprae_Br4923 RPLNLAVPEQITSEVTG
*