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M. bovis AF2122 / 97 Mb1097c (PE_PGRS20)

annotation: PE-PGRS family protein
coordinates: 1191217 - 1193508
length: 763

MSYMIAVPDMLSSAAGDLASIGSSINASTRAAAAATTRLLPAAADEVSAHIAALFSGHGEGYQAIARQMA
AFHDQFTLALTSSAGAYASAEATNVEQQVLGLINAPTQALWGRPLIGNGADGTAANPNGGAGGLLYGNGG
NGFSQTTAGLTGGTGGSAGLIGNGGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPAGAIGAPGVAG
GAGGAGGSAGLFGNGGAGGAGGAGGQGGAGIGGADGTKGGDAGAGGAGGAGGWIHGHGGVGGDGGTGGQG
GDGVQGEPGDTGAAGGAGGAGGRGGDGGSAGWLSGNGGDAGTGGGGGNAGAGGEGGIFGGNGGNGGTGGT
AGGGGNGGRGAALFGHGGNAGHGGAGGNGAAGGNGADTQLGISGKGGTGGGGGGAGAGGTGGDGGLLYGN
GGAGGNGGNGGAAGKGGIGAPGLSTAQGGDGGNGGSGGNAGNGGNGGRGSVLFGHGGNAGHGGAGGNGAV
SGNGGSSITAVGGKGGTGGGGGGGAGGTGGDAGLLYGNGGAGGTGGSGGAGARGGDGGAGSGTAQGGDGG
AGGVGGNAGNGGNGGSAGWLSGNGGTGGGGGTAGAGGQGGNGNSGIDPGNGGQGADTGNAGNGGHGGSAA
KLFGDGGAGGAGGMGSTGGTGGGGGFGGGTGGNGGNGHAGGAGGSGGTAGLLGSGGTGGDGGNGGLGAGS
GAKGNGGNGGDGGKGGDAQLIGNGGNGGNGGKGGTGLMPGINGTGGAGGSRGQISGNPGTPGQ
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1097cPE_PGRS20-100% (763)PE-PGRS family protein
M. bovis AF2122 / 97Mb1096cPE_PGRS190.066.67% (699) PE-PGRS family protein
M. bovis AF2122 / 97Mb1121PE_PGRS220.052.67% (860) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_5091-1e-16248.23% (734) triple helix repeat-containing collagen
M. tuberculosis H37RvRv1067cPE_PGRS190.065.90% (698) PE-PGRS family protein
M. leprae Br4923MLBr_01183-1e-1342.39% (92) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-5e-5534.55% (440) hypothetical protein MAB_4284c
M. marinum MMMAR_3316-0.050.88% (849) PE-PGRS family protein
M. avium 104MAV_4827-2e-2341.71% (187) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-13944.01% (784) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-6e-4640.92% (303) PUTATIVE -
M. ulcerans Agy99MUL_4367-0.047.99% (896) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-1e-16446.65% (761) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Mb1097c|M.bovis_AF2122/97           --------------------------------------------------
Rv1067c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_3316|M.marinum_M               --------------------------------------------------
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mb1097c|M.bovis_AF2122/97           ------------------MSYMIAVPDMLSSAAGDLASIGSSINASTRAA
Rv1067c|M.tuberculosis_H37Rv        ------------------MSFVLVSPSQLMAAAADVAGIGSAISAANAAA
MMAR_3316|M.marinum_M               ------------------MAFVLVAPEMVTAAASDLANIGSAINTANTAV
MUL_4367|M.ulcerans_Agy99           ------------------MSFVSVGPGLLEAAARDLAGLGAGLREANLAA
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------MSIIDFILNLFRDPVEAASYVADPEAALANAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEED
                                                                                      

Mb1097c|M.bovis_AF2122/97           AAATTRLLPAAADEVSAHIAALFSGHGEGYQAIARQMAAFHDQFTLALTS
Rv1067c|M.tuberculosis_H37Rv        LAPTSVLAAAGADEVSAAVAALFSAHAGQYQQLGARAALFHEQFVQALTG
MMAR_3316|M.marinum_M               AAPTAELLAAGTDEVSEAIASLFSGHALDYQNLGARMTAFHDQFVAALTA
MUL_4367|M.ulcerans_Agy99           AGATVGVLPAAGDEVSAAIAELFGGFGREYQAMGARVALLHDDFVRALTA
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                AIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA
                                                                                      

Mb1097c|M.bovis_AF2122/97           SAG-------------------------------------AYASAEATNV
Rv1067c|M.tuberculosis_H37Rv        AAS-------------------------------------AYASAEATNV
MMAR_3316|M.marinum_M               GGG-------------------------------------LYSSAEAAAA
MUL_4367|M.ulcerans_Agy99           GGS-------------------------------------AYGQAEALNM
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      QPDGP-----------------------------------SILSPSLLSP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                AALR----------------------------------------------
                                                                                      

Mb1097c|M.bovis_AF2122/97           E---------------------QQVLGLINAPTQALWGRPLIGNGADGTA
Rv1067c|M.tuberculosis_H37Rv        E---------------------QQVLGLINAPTQALLGRPLIGNGADGTA
MMAR_3316|M.marinum_M               TPL-------------------QDLLNVVNAPTQALLGRPLIGDGADGTA
MUL_4367|M.ulcerans_Agy99           WPLQE---------------LEQQALGVVNAPSMALFGRPSIGNGVDGVA
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      RDNDFLSHN-------------DTDFASHNPIASGNQVMSPSGNVDSFNR
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------------------DALAARRIDNVMLVSAFLAAAALAQNV
                                                                                      

Mb1097c|M.bovis_AF2122/97           AN-PNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIG-NGGNGGAGGA
Rv1067c|M.tuberculosis_H37Rv        AN-PNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIG-NGGNGGAGGA
MMAR_3316|M.marinum_M               PG-QAGGAGGLLYGNGGNGAAGTNPGVAGGAGGAAGLIG-NGGAGGIGGA
MUL_4367|M.ulcerans_Agy99           GTGQAGGAGGILWGNGGNGGLG-AAGANGGAGGSAGLIG-TGGVGGAGGV
Mflv_5091|M.gilvum_PYR-GCK          QN------GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG
Mvan_1264|M.vanbaalenii_PYR-1       QN------GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG
MSMEG_0868|M.smegmatis_MC2_155      DNPNGG-TGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA
TH_3810|M.thermoresistible__bu      -----------VDGDGG----------SGGRTGLFSKLS-RGGDGGDGGL
MAB_4284c|M.abscessus_ATCC_199      GPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASG-QGSTAVNGDV
MLBr_01183|M.leprae_Br4923          ---------MPLFLNAEPQALTAAANTLEGLSAATVASN-AAAAQLTTEI
MAV_4827|M.avium_104                GGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQ
                                                  :              .            .       

Mb1097c|M.bovis_AF2122/97           GAN------GGAGGNGG--WLYGSGGNGGAGGAGPAG-----AIGAPGVA
Rv1067c|M.tuberculosis_H37Rv        GAN------GGAGGNGG--WLYGSGGNGGAGGAGPAG-----AIGAPGVA
MMAR_3316|M.marinum_M               GGS------GGAGGTGG--WLYGNGGAGGAGGAGAPG-----LVSFNGSN
MUL_4367|M.ulcerans_Agy99           GAAGMTGGSGGAGGGGG--WLWGAGGSGGAAGAGGSGGSGGWLWGNAGQT
Mflv_5091|M.gilvum_PYR-GCK          GGN------GGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVA
Mvan_1264|M.vanbaalenii_PYR-1       SGD------GGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVA
MSMEG_0868|M.smegmatis_MC2_155      GLD------GGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTG
TH_3810|M.thermoresistible__bu      GGN------GGHGGGTGIISLLSLAGNGGNGGNGYRTT------DNNALD
MAB_4284c|M.abscessus_ATCC_199      RDS------NIINADHG--SNVGVDQSQTRVGGDYTNVSGHGSADIDKSV
MLBr_01183|M.leprae_Br4923          APP--------AADDVS--ILLAHFFSG--HGRQYQA---------HASQ
MAV_4827|M.avium_104                LSAMVAG-LEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPE
                                                    .     .                           

Mb1097c|M.bovis_AF2122/97           GGA--GGAGGSAGLFGNGG----------------AGGAGGAGG------
Rv1067c|M.tuberculosis_H37Rv        GGA--GGAGGTAGLFGNGG----------------VGGVGGDGG------
MMAR_3316|M.marinum_M               GGN--GGNGGAAGWWGTGG----------------AGGAGGEGG------
MUL_4367|M.ulcerans_Agy99           AGAGVGGAGGAGGAGDAGDQGVSGVAPGEAGAVGFAGGAGGAGG------
Mflv_5091|M.gilvum_PYR-GCK          GAT--GATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------
Mvan_1264|M.vanbaalenii_PYR-1       GAT--GATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------
MSMEG_0868|M.smegmatis_MC2_155      GTG--GGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGY
TH_3810|M.thermoresistible__bu      GGH--GGNGGNVGFFSLFN----------------LGGAGGWGG------
MAB_4284c|M.abscessus_ATCC_199      TVVDDHSQRNTTNINDSFN----------------TDRSTNIGS------
MLBr_01183|M.leprae_Br4923          GAT--NHQDLIQSLLTSSS---------------------AYAG------
MAV_4827|M.avium_104                TALARGAALAAANAPLFAS----------------STAALAYAQ------
                                                .     .                       .       

Mb1097c|M.bovis_AF2122/97           --------------QGGAGIG-GADGTK--GGDAGAGGAGGAG-------
Rv1067c|M.tuberculosis_H37Rv        --------------QGGNGAGAGASGTK--GGDAGAGGAGGAG-------
MMAR_3316|M.marinum_M               --------------AAGGGPAGIAYGQT--GGVGGNGGNGGNG-------
MUL_4367|M.ulcerans_Agy99           --------------AGGNGVGGGVNGAGGAGGAGGVGGGGGAG-------
Mflv_5091|M.gilvum_PYR-GCK          --------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG-------
Mvan_1264|M.vanbaalenii_PYR-1       --------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG-------
MSMEG_0868|M.smegmatis_MC2_155      VLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIG
TH_3810|M.thermoresistible__bu      ---------------SGVDGVDVVGGNPDGGTPGAHGESHTPG-------
MAB_4284c|M.abscessus_ATCC_199      --------------GNTTNTEIGSHNQANIGTSTSAGGSAAVG-------
MLBr_01183|M.leprae_Br4923          ---------------TETANHDSL--------------------------
MAV_4827|M.avium_104                --------------DPGTGAVDQYSLPDYLYVPVDPEPGDDE--------
                                                                                      

Mb1097c|M.bovis_AF2122/97           -----------GWIHGHG------GVGGDGGTGGQG--------------
Rv1067c|M.tuberculosis_H37Rv        -----------GWIHGHG------GAGGDGGAGGAG--------------
MMAR_3316|M.marinum_M               -----------GWFAGNA------GAGGNGGVGGDG--------------
MUL_4367|M.ulcerans_Agy99           -----------ASGVGAG------VAGGDGGTGGAG--------------
Mflv_5091|M.gilvum_PYR-GCK          ---------AVGAAGAAG------TVGTAGATGGTG--------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------AIGTAGVAG------AAGTAGATGGTG--------------
MSMEG_0868|M.smegmatis_MC2_155      ANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGT
TH_3810|M.thermoresistible__bu      -----------VYTDRQG----------EDGEDGTG--------------
MAB_4284c|M.abscessus_ATCC_199      -----------GNAGLAG------NAGLAGNAGLAG--------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------------------LAYSAVGEEDAES--------------
                                                                                      

Mb1097c|M.bovis_AF2122/97           ---GDGVQGEPG---DTGAAG--------------------GAGGAGGRG
Rv1067c|M.tuberculosis_H37Rv        ---GQASPGAPGPPSQPGGAG--------------------GAGGAGGRG
MMAR_3316|M.marinum_M               ---NAADNGLVGGTGGVGGAGG--------------SAGLFGDGGAGGQG
MUL_4367|M.ulcerans_Agy99           ---GAAGVGGAAGTGGTGGAAG--------------VAGTGGDGGDGGAG
Mflv_5091|M.gilvum_PYR-GCK          -TGANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTG
Mvan_1264|M.vanbaalenii_PYR-1       -VGGNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTG
MSMEG_0868|M.smegmatis_MC2_155      ATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTG
TH_3810|M.thermoresistible__bu      -------------------------------------------TGIGGRG
MAB_4284c|M.abscessus_ATCC_199      ---NAGLAGNAGLAGNAGLAGN------------------AGLAGNAGLA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---PTVVIEKLFLPEDSEPRRR-------------------PVLLVGSGL
                                                                                      

Mb1097c|M.bovis_AF2122/97           GDGG------------------SAGWLSGNGGDAGTGGGGGNAGAGGEG-
Rv1067c|M.tuberculosis_H37Rv        GDGG------------------SAGWLSGNGGDAGNGGGGGTAGGAGNG-
MMAR_3316|M.marinum_M               GDGGGVTGLVGAGHGGAGGDGGRAGWLSGNAGAGGGGGAGGAVDNHGSG-
MUL_4367|M.ulcerans_Agy99           GAGSDASLAG------------QAGFAGGSGGAGGVGGSAGAGGVNGSG-
Mflv_5091|M.gilvum_PYR-GCK          GAGGVGGQ-------------GTAGGTGGVGGIGGAGSTGAVGGVGGKG-
Mvan_1264|M.vanbaalenii_PYR-1       GVGGIGGQ-------------GTEGGTGGVGGVGGVGATGGAGGVGGKG-
MSMEG_0868|M.smegmatis_MC2_155      GAGGMGEIYS-----------GADGEATGISAGGDGGSATGADSLGGRGG
TH_3810|M.thermoresistible__bu      GNGG---------------------SSSGTHPMAEDGE--HVKALDGRP-
MAB_4284c|M.abscessus_ATCC_199      GNAGLAGN----------------AGLAGNAGLAGNAGLAGNAGLAGNAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                AVVG------------------ISAVLALEIALAIGIRTTGTVALQPTPN
                                                                                      

Mb1097c|M.bovis_AF2122/97           ------------------------GIFGGNGGNGGTGGTA----------
Rv1067c|M.tuberculosis_H37Rv        ------------------------GQFGGDGGTGGTGGTA----------
MMAR_3316|M.marinum_M               ------------------------GDYAGGGGAGGSGGAAGLFGN-----
MUL_4367|M.ulcerans_Agy99           ------------------------GDGGAGAAGGAGGASATVAGS-----
Mflv_5091|M.gilvum_PYR-GCK          ---IQGGQG-------------LQGGKGGDGGAGGKGGDADSMGS-----
Mvan_1264|M.vanbaalenii_PYR-1       ---IQGGQG-------------LQGGQGGDGGTGGTGGDATSMGE-----
MSMEG_0868|M.smegmatis_MC2_155      TSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGV
TH_3810|M.thermoresistible__bu      ------------------------GLDGGNGSHGGN--------------
MAB_4284c|M.abscessus_ATCC_199      -----------------------LAGNAGLAGNAGLAGNAGLAGN-----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----------------------QHLIVPTEQAPAPPPVQASAPQP-----
                                                                                      

Mb1097c|M.bovis_AF2122/97           ------------------GGGGNGGRG------AALFG------------
Rv1067c|M.tuberculosis_H37Rv        ------------------GAGGNGGRG------AVLFG------------
MMAR_3316|M.marinum_M               --------------GAAGGAGGAGGAS------QTFTG------------
MUL_4367|M.ulcerans_Agy99           --------------GGVGGDGGAGGAAGGGVGAASLGG------------
Mflv_5091|M.gilvum_PYR-GCK          -------------AGATGGKGGNGGNGG----RGGLFG------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------AGATGGKGGNGGNGG----RGSLFG------------
MSMEG_0868|M.smegmatis_MC2_155      ATGNTAIGGNGGAASANGAVGGNGGFTN----IAAIHGSITDSSATSGHG
TH_3810|M.thermoresistible__bu      --------------------GGHGGRGG-------FLG------------
MAB_4284c|M.abscessus_ATCC_199      -----------------AGLAGNAGLAG----NAGLAG------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ------------------KISVPEPVAAPKPLSPPVAAP-----------
                                                                                      

Mb1097c|M.bovis_AF2122/97           ---HGGNAGHGGAG----------------------GNGAAGGNG--ADT
Rv1067c|M.tuberculosis_H37Rv        ---HGGNAGHGGAG----------------------GNGAAAGAG--GEH
MMAR_3316|M.marinum_M               ---AGGAGGTGGAGG------------------WLYGNGGAGGAG--GAS
MUL_4367|M.ulcerans_Agy99           ---DGGHAGAGGAGGEGLSGGFNTG--------AAGGIGGAGGAGGTGGD
Mflv_5091|M.gilvum_PYR-GCK          ---KGGNAGNGAD----------------------GGTGGAGGAGGTGG-
Mvan_1264|M.vanbaalenii_PYR-1       ---RGGNAGNGGN----------------------GGTGGNGGNGGTGG-
MSMEG_0868|M.smegmatis_MC2_155      GAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGA
TH_3810|M.thermoresistible__bu      ---IGGSGGWGGHG----------------------GNGGD---------
MAB_4284c|M.abscessus_ATCC_199      ---NAGLAGNAAVA----------------------GNAAVAGNAAVAG-
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---LPAAPPPAAPP---------------------LPEAPPIPAAPPVVP
                                                                                      

Mb1097c|M.bovis_AF2122/97           QLGISGKGG-----------------TGGGGGGAGAGGTGGDGGLLYGNG
Rv1067c|M.tuberculosis_H37Rv        VVATAGKGG-----------------TGGVGGDGGGGGAGGGGGLLYGNG
MMAR_3316|M.marinum_M               GAGIGGDS------------------LGGSGGNGGNGGISG----LIGNG
MUL_4367|M.ulcerans_Agy99           SGGVGGVNG-----------------DGGAGGGGGRGGDGGSSTSTSGVG
Mflv_5091|M.gilvum_PYR-GCK          TGGAGGTGG-----------------TGGTGGIGGAGSTGGTGG-TGGTG
Mvan_1264|M.vanbaalenii_PYR-1       TGGNGGTGG-----------------TGGTGGIGGAGSTGGTGG-TGGTG
MSMEG_0868|M.smegmatis_MC2_155      TGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAG-ANGNG
TH_3810|M.thermoresistible__bu      --------------------------TDADGGNGGDG----------GNG
MAB_4284c|M.abscessus_ATCC_199      NAAVGGVLN-----------------TGVSGAIGGSSHVGGAIN--ESLG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                VPVVVPPVP-----------------VPVPVRIPVPDPVSPPQLLAPPRL
                                                                                      

Mb1097c|M.bovis_AF2122/97           GAGGNGGNG-GAAGKGGIGA-PGLSTAQGGDG-GNG------GSGGNAGN
Rv1067c|M.tuberculosis_H37Rv        GAGGAGNSG-GDGGTG-------LNAALGGNG-GGG------GVGGNAG-
MMAR_3316|M.marinum_M               GAGGAGGNG-SAAGYNG-------YSGNGGNG-GNGGAAQLIGAGGGGGV
MUL_4367|M.ulcerans_Agy99           GAGGAGGNG-GNAGFGVSAGGTGGSAGDGGAGGGAGGVDGVGGASGNGGA
Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGTG-GTGGTGGTGG-TGGKGGTGGTGGAGGTG----GDGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGTG-GTGGTGGTGG-TGGKGGTGGTGGDGGTG----GTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      GAGGAGGVSEGEGGTGGHGG-DGGRGGDGALGGNGGTGGVGLGNGGKGGN
TH_3810|M.thermoresistible__bu      GSAGRGGTG-GLRGVFG------INGGNGRAG------------------
MAB_4284c|M.abscessus_ATCC_199      GSGSVGGSTAVGGGAHTGVG----GGVSTGVG------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                SVPQPVQPPVRVPQPPSPPQ----VGGTVPQS------------------
                                                                                      

Mb1097c|M.bovis_AF2122/97           GGNGGRGSVLFGHGGNAGHGGAGGNGAVS--GNGGSSITAVGGKGGTGGG
Rv1067c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_3316|M.marinum_M               AGIGGAGGTGAAAGVTGSAGASGVGGRLY--SGNGIPDIFGRPLIGDGAD
MUL_4367|M.ulcerans_Agy99           AGAGGAGGSGIGAGIDGGAGGAGGTGGAAGFPGGGGTTGAWGTGGAGGAG
Mflv_5091|M.gilvum_PYR-GCK          GGTGGTG---------GTGGTGGTGGAG-----------DGTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGTG---------GTGGTGGTGGAG-----------DGLGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155      GGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mb1097c|M.bovis_AF2122/97           GGGGAGGTGGDAGLLY----------------GNGGAGGTGG-SGGAGAR
Rv1067c|M.tuberculosis_H37Rv        ----AGGTGGSAGWLS----------------GNGGAGGSGG-SAGAG--
MMAR_3316|M.marinum_M               GAPGTGQAGGDGGWLY----------------GNGGAGGSGA-AGQAGGA
MUL_4367|M.ulcerans_Agy99           GAGGAGDHGGVGVNPG----------------DSGTAGWAGG-AGGAGGA
Mflv_5091|M.gilvum_PYR-GCK          ----TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGGGT
Mvan_1264|M.vanbaalenii_PYR-1       ----TGGFGGQGGQGG-----------------TGGTGGQGG-LGGVGGT
MSMEG_0868|M.smegmatis_MC2_155      NGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGT
TH_3810|M.thermoresistible__bu      -------LGGRGXXXX-----------------GGGVGAAVR--------
MAB_4284c|M.abscessus_ATCC_199      ----VGSHVGGGISES-----------------LGGSGSVGG--------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -PPQHQTPPGEGTPPK-----------------PDGPGNYGG--------
                                                                                      

Mb1097c|M.bovis_AF2122/97           GGDG-----------------GAGSGTAQGGDGGAGGVGGNAGNGGNG--
Rv1067c|M.tuberculosis_H37Rv        ---------------------------------GAGGKGGDTPNG-----
MMAR_3316|M.marinum_M               GGAA-----------------GLIGNGGAGGTGGSGAAGGSGAAGGNG--
MUL_4367|M.ulcerans_Agy99           GGSA-----------------AFNGVNGAGGAGGNGGAGGGGGAGASG--
Mflv_5091|M.gilvum_PYR-GCK          G-----------------------GQGGTGGTGGQGGTGGTGGTGGTG--
Mvan_1264|M.vanbaalenii_PYR-1       G-----------------------GTGGTGGTGGQGGTGGTGGTGGTG--
MSMEG_0868|M.smegmatis_MC2_155      GGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPS
TH_3810|M.thermoresistible__bu      --------------------------------SGNGVFSGGGGTPSAG--
MAB_4284c|M.abscessus_ATCC_199      -----------------------------STAVGGGAHTGVGGGVSTG--
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------------------------GHVPTPGAGGSGGSGGGHVPT--
                                                                                      

Mb1097c|M.bovis_AF2122/97           --------GSAGWLSGNGGTGGGGGTAGAGGQGGNGNSGIDP--------
Rv1067c|M.tuberculosis_H37Rv        -------------------------------------LAINP--------
MMAR_3316|M.marinum_M               --------GAGGWLFGNGGTGGTGGDAVAGLPGLNGGNGGNGGAGGAAGW
MUL_4367|M.ulcerans_Agy99           --------IGAGVAGGDGGTGGTGGAAGTGGAAGTGGTGGAAGAAGSAGD
Mflv_5091|M.gilvum_PYR-GCK          ------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG
Mvan_1264|M.vanbaalenii_PYR-1       ------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155      AVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mb1097c|M.bovis_AF2122/97           ----GNGGQGAD-----------TGNAGNGGHGGSAAKLFGD--------
Rv1067c|M.tuberculosis_H37Rv        ----GIGGNGGD-----------TGNAGNGGNGGSAARLFGG--------
MMAR_3316|M.marinum_M               WGHGGIGGQGGTGGAAGGNPGIYAGNAGTGGDGGAGGWLFGD--------
MUL_4367|M.ulcerans_Agy99           GGAGGAGGAGDDGSAG--VVSGDPGTAGKAGGAGGAGGVGGNGVAGGVNG
Mflv_5091|M.gilvum_PYR-GCK          --QAGTAGKGGLFG--------GSGSAGKAGATGAAGASGGK--------
Mvan_1264|M.vanbaalenii_PYR-1       --QAGVAGKGGLFG--------GSGSAGTAGVTGASGASGGK--------
MSMEG_0868|M.smegmatis_MC2_155      GKATGTASQGGNGGPS----WVQSGYGSTLGGNATGTATAGK--------
TH_3810|M.thermoresistible__bu      -----------------------------FGVPTTIQFPAGS--------
MAB_4284c|M.abscessus_ATCC_199      ---VGVGSHVGGG---------ISESLGGSGSVGGSTAVGGG--------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------------------PGAGGSGGSGGGHVPTPGT--------
                                                                                      

Mb1097c|M.bovis_AF2122/97           ----GGAGGAGGMG----------STGGTGGGGGFG-----GGTGG-NGG
Rv1067c|M.tuberculosis_H37Rv        ----GGAGGAGGTG----------STAGSGGSGGTNPPTGLQAAGG-NGG
MMAR_3316|M.marinum_M               ----AGAGGQGGTGGAANDPLVTSSTGGSGGAGGNGGAAGLFGAGG-AGG
MUL_4367|M.ulcerans_Agy99           SGGAGGAGGAGGTGGAGASGVPASVDGGDGGAGGAGGAAGTGGSGGSAGN
Mflv_5091|M.gilvum_PYR-GCK          ----GAQGATGAQGATG-------AQGATG-ATGAAGKAGATGAAGAAGA
Mvan_1264|M.vanbaalenii_PYR-1       ----GAQGATGAQGATG-------AQGATG-ATGASGAQGSAGSAGSAGV
MSMEG_0868|M.smegmatis_MC2_155      ----GGEASNGGVAGNGGNALVM-AAGTTGVATGNTATGGDGGAATTAGA
TH_3810|M.thermoresistible__bu      --------CTSR------------AVSREGIMPSSRAASARAGAACASST
MAB_4284c|M.abscessus_ATCC_199      ----AHTGVGGGVN----------TGVGVGSHVGGGISESLGGSGSVGGS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----GGPGGTGGSG------------GGHVPTPGAGTPGGSGGGHLPFPG
                                                                                      

Mb1097c|M.bovis_AF2122/97           NG---------------------------------------------HAG
Rv1067c|M.tuberculosis_H37Rv        SG---------------------------------------------HAG
MMAR_3316|M.marinum_M               TGGTAGDGYLIGGDGGNGGQGGYGGWLAGSGGAGGTAGDGGAGIYPGGAG
MUL_4367|M.ulcerans_Agy99           TGAGGAGGAGGAGGSAASTGVNGDGGAGGAGGVGGLGGDSAATAGGGGAG
Mflv_5091|M.gilvum_PYR-GCK          AG-----------------------------SAG-----------TTGAQ
Mvan_1264|M.vanbaalenii_PYR-1       AG-----------------------------SAG-----------TTGAQ
MSMEG_0868|M.smegmatis_MC2_155      TG-----------------------------GAGGFSNIAAIHGAITDST
TH_3810|M.thermoresistible__bu      SR----------------------------------------------SR
MAB_4284c|M.abscessus_ATCC_199      TA----------------------------------------------VG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                AG-----------------------------------------------S
                                                                                      

Mb1097c|M.bovis_AF2122/97           GAGGSGGT---------AGLLGSGGTGGDGGNGGLG------------AG
Rv1067c|M.tuberculosis_H37Rv        GHGGNGGG---------AGLLGGGGTGGNGGGGGQGGL--------GAAA
MMAR_3316|M.marinum_M               GTGGSGGA---------ARFFGDGGAAGTGGVGGFGSK--------YVAG
MUL_4367|M.ulcerans_Agy99           GDGGKGGAGGAGVNGVGGGDGGKGGTGGAGGAGGAGSDG-IIPSNGGLGG
Mflv_5091|M.gilvum_PYR-GCK          GSAGTNGA--------NGANGSQGAAGKAGATGTTGATG--------AAG
Mvan_1264|M.vanbaalenii_PYR-1       GSAGTNGA--------NGANGSQGAAGKAGATGTTGATG--------AAG
MSMEG_0868|M.smegmatis_MC2_155      AISGHGGAG-------NGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAG
TH_3810|M.thermoresistible__bu      RSFCCSRA------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GGAHTSAIN--------DALGGSGSVGGSTAVGGGAHTS-----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                TPGGSGGG----------HLPTPGAGTPGGGLGGFGGG------------
                                                                                      

Mb1097c|M.bovis_AF2122/97           SGAKG---------------------------------------------
Rv1067c|M.tuberculosis_H37Rv        GGVDG---------------------------------------------
MMAR_3316|M.marinum_M               SGGSGGTGGAAGWLIGNGGAGGQGGVAGTPDGVNRVFGGTGGAGGTGGT-
MUL_4367|M.ulcerans_Agy99           NGGNGGNGGQAFGDGVGGAGGIGGKGGNAAIGTIVINGGVGGAGGSGGLG
Mflv_5091|M.gilvum_PYR-GCK          EDGDAGSGGSG------------------------INGGAGGAGG-----
Mvan_1264|M.vanbaalenii_PYR-1       DAGDPGSEAVD------------------------INGGAGGAGG-----
MSMEG_0868|M.smegmatis_MC2_155      NGGDGGVNGTGG-----------------------ASGGDGGNGGNTSV-
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mb1097c|M.bovis_AF2122/97           -------------------------------NGGNGGDGGKGGDAQL---
Rv1067c|M.tuberculosis_H37Rv        -------------------------------NGGNGGNGGKGGDAQL---
MMAR_3316|M.marinum_M               ------AGWLYGSGGSGGAGGAGTASIYPGSTGGNGGNGGNGGAAQV---
MUL_4367|M.ulcerans_Agy99           GATEDGVGGVGCAGGAGGNGGRGDMLFTVGGSGGTGGDGGGGGSASG---
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------AGGEGGEGGDGGKGGAGAE---
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------AGGEGGEGGAGGAGGDGSE---
MSMEG_0868|M.smegmatis_MC2_155      ---------------------WKSGGQTADGEHNTGGNGGNGGDGSEPGP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------------------AINESMNSSINASHSSSMN---
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------------------------HAPAPGGGLGGGGGHAPAP--
                                                                                      

Mb1097c|M.bovis_AF2122/97           --IGNGGNGGNGGKGGTG--------LMPG----------INGTGGAGGS
Rv1067c|M.tuberculosis_H37Rv        --VGDGGNGGNGGKGGAG--------LIAG----------LDGAGGAGGT
MMAR_3316|M.marinum_M               --IGTGGTGGTAGTGGAGGPDDPPNNIPAGNDG-------QDGVGGAGGS
MUL_4367|M.ulcerans_Agy99           --SGTGGSGGTGGVGGIGGDGKLGGFGGDGGDGGDGGFGVIGGQGGGGGF
Mflv_5091|M.gilvum_PYR-GCK          -----GGAGGGGGAGGSG-------AGGAG---------GAGGSGGSGGS
Mvan_1264|M.vanbaalenii_PYR-1       -----GGAGGSGGAGGSG-------TGGAG---------GAGGSGGSGGS
MSMEG_0868|M.smegmatis_MC2_155      GGNGAGGAGGNGGTGGTT-------AGGSGNG-------GNGGNGGNGGA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --ESFGSSMGSHGAAGTG----------------------FEAQGHAQGH
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----GGGLGGFGGGHSG-----------------------GGLGGLGGG
                                                                                      

Mb1097c|M.bovis_AF2122/97           RGQ-------------ISGNPGTPGQ---
Rv1067c|M.tuberculosis_H37Rv        RGL-------------IFGNAGTPGQ---
MMAR_3316|M.marinum_M               GGL-------------VFGNSGG------
MUL_4367|M.ulcerans_Agy99           GGLGGTGAGGAPSDKGINGEPGNPG----
Mflv_5091|M.gilvum_PYR-GCK          GGS--------------GGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1       GGA--------------GGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155      DGT--------------PGTAGTTGANNP
TH_3810|M.thermoresistible__bu      -----------------------------
MAB_4284c|M.abscessus_ATCC_199      ASET--------------AHTTLPGAEHH
MLBr_01183|M.leprae_Br4923          -----------------------------
MAV_4827|M.avium_104                HK---------------------------