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MSYMIAVPDMLSSAAGDLASIGSSINASTRAAAAATTRLLPAAADEVSAHIAALFSGHGEGYQAIARQMA AFHDQFTLALTSSAGAYASAEATNVEQQVLGLINAPTQALWGRPLIGNGADGTAANPNGGAGGLLYGNGG NGFSQTTAGLTGGTGGSAGLIGNGGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPAGAIGAPGVAG GAGGAGGSAGLFGNGGAGGAGGAGGQGGAGIGGADGTKGGDAGAGGAGGAGGWIHGHGGVGGDGGTGGQG GDGVQGEPGDTGAAGGAGGAGGRGGDGGSAGWLSGNGGDAGTGGGGGNAGAGGEGGIFGGNGGNGGTGGT AGGGGNGGRGAALFGHGGNAGHGGAGGNGAAGGNGADTQLGISGKGGTGGGGGGAGAGGTGGDGGLLYGN GGAGGNGGNGGAAGKGGIGAPGLSTAQGGDGGNGGSGGNAGNGGNGGRGSVLFGHGGNAGHGGAGGNGAV SGNGGSSITAVGGKGGTGGGGGGGAGGTGGDAGLLYGNGGAGGTGGSGGAGARGGDGGAGSGTAQGGDGG AGGVGGNAGNGGNGGSAGWLSGNGGTGGGGGTAGAGGQGGNGNSGIDPGNGGQGADTGNAGNGGHGGSAA KLFGDGGAGGAGGMGSTGGTGGGGGFGGGTGGNGGNGHAGGAGGSGGTAGLLGSGGTGGDGGNGGLGAGS GAKGNGGNGGDGGKGGDAQLIGNGGNGGNGGKGGTGLMPGINGTGGAGGSRGQISGNPGTPGQ
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1097c | PE_PGRS20 | - | 100% (763) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb1096c | PE_PGRS19 | 0.0 | 66.67% (699) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb1121 | PE_PGRS22 | 0.0 | 52.67% (860) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-162 | 48.23% (734) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1067c | PE_PGRS19 | 0.0 | 65.90% (698) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 1e-13 | 42.39% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 5e-55 | 34.55% (440) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_3316 | - | 0.0 | 50.88% (849) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 2e-23 | 41.71% (187) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-139 | 44.01% (784) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 6e-46 | 40.92% (303) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 47.99% (896) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-164 | 46.65% (761) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mb1097c|M.bovis_AF2122/97 -------------------------------------------------- Rv1067c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3316|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb1097c|M.bovis_AF2122/97 ------------------MSYMIAVPDMLSSAAGDLASIGSSINASTRAA Rv1067c|M.tuberculosis_H37Rv ------------------MSFVLVSPSQLMAAAADVAGIGSAISAANAAA MMAR_3316|M.marinum_M ------------------MAFVLVAPEMVTAAASDLANIGSAINTANTAV MUL_4367|M.ulcerans_Agy99 ------------------MSFVSVGPGLLEAAARDLAGLGAGLREANLAA Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------MSIIDFILNLFRDPVEAASYVADPEAALANAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEED Mb1097c|M.bovis_AF2122/97 AAATTRLLPAAADEVSAHIAALFSGHGEGYQAIARQMAAFHDQFTLALTS Rv1067c|M.tuberculosis_H37Rv LAPTSVLAAAGADEVSAAVAALFSAHAGQYQQLGARAALFHEQFVQALTG MMAR_3316|M.marinum_M AAPTAELLAAGTDEVSEAIASLFSGHALDYQNLGARMTAFHDQFVAALTA MUL_4367|M.ulcerans_Agy99 AGATVGVLPAAGDEVSAAIAELFGGFGREYQAMGARVALLHDDFVRALTA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA Mb1097c|M.bovis_AF2122/97 SAG-------------------------------------AYASAEATNV Rv1067c|M.tuberculosis_H37Rv AAS-------------------------------------AYASAEATNV MMAR_3316|M.marinum_M GGG-------------------------------------LYSSAEAAAA MUL_4367|M.ulcerans_Agy99 GGS-------------------------------------AYGQAEALNM Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 QPDGP-----------------------------------SILSPSLLSP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AALR---------------------------------------------- Mb1097c|M.bovis_AF2122/97 E---------------------QQVLGLINAPTQALWGRPLIGNGADGTA Rv1067c|M.tuberculosis_H37Rv E---------------------QQVLGLINAPTQALLGRPLIGNGADGTA MMAR_3316|M.marinum_M TPL-------------------QDLLNVVNAPTQALLGRPLIGDGADGTA MUL_4367|M.ulcerans_Agy99 WPLQE---------------LEQQALGVVNAPSMALFGRPSIGNGVDGVA Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 RDNDFLSHN-------------DTDFASHNPIASGNQVMSPSGNVDSFNR MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------DALAARRIDNVMLVSAFLAAAALAQNV Mb1097c|M.bovis_AF2122/97 AN-PNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIG-NGGNGGAGGA Rv1067c|M.tuberculosis_H37Rv AN-PNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIG-NGGNGGAGGA MMAR_3316|M.marinum_M PG-QAGGAGGLLYGNGGNGAAGTNPGVAGGAGGAAGLIG-NGGAGGIGGA MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGGLG-AAGANGGAGGSAGLIG-TGGVGGAGGV Mflv_5091|M.gilvum_PYR-GCK QN------GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG Mvan_1264|M.vanbaalenii_PYR-1 QN------GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG MSMEG_0868|M.smegmatis_MC2_155 DNPNGG-TGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA TH_3810|M.thermoresistible__bu -----------VDGDGG----------SGGRTGLFSKLS-RGGDGGDGGL MAB_4284c|M.abscessus_ATCC_199 GPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASG-QGSTAVNGDV MLBr_01183|M.leprae_Br4923 ---------MPLFLNAEPQALTAAANTLEGLSAATVASN-AAAAQLTTEI MAV_4827|M.avium_104 GGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQ : . . Mb1097c|M.bovis_AF2122/97 GAN------GGAGGNGG--WLYGSGGNGGAGGAGPAG-----AIGAPGVA Rv1067c|M.tuberculosis_H37Rv GAN------GGAGGNGG--WLYGSGGNGGAGGAGPAG-----AIGAPGVA MMAR_3316|M.marinum_M GGS------GGAGGTGG--WLYGNGGAGGAGGAGAPG-----LVSFNGSN MUL_4367|M.ulcerans_Agy99 GAAGMTGGSGGAGGGGG--WLWGAGGSGGAAGAGGSGGSGGWLWGNAGQT Mflv_5091|M.gilvum_PYR-GCK GGN------GGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVA Mvan_1264|M.vanbaalenii_PYR-1 SGD------GGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVA MSMEG_0868|M.smegmatis_MC2_155 GLD------GGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTG TH_3810|M.thermoresistible__bu GGN------GGHGGGTGIISLLSLAGNGGNGGNGYRTT------DNNALD MAB_4284c|M.abscessus_ATCC_199 RDS------NIINADHG--SNVGVDQSQTRVGGDYTNVSGHGSADIDKSV MLBr_01183|M.leprae_Br4923 APP--------AADDVS--ILLAHFFSG--HGRQYQA---------HASQ MAV_4827|M.avium_104 LSAMVAG-LEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPE . . Mb1097c|M.bovis_AF2122/97 GGA--GGAGGSAGLFGNGG----------------AGGAGGAGG------ Rv1067c|M.tuberculosis_H37Rv GGA--GGAGGTAGLFGNGG----------------VGGVGGDGG------ MMAR_3316|M.marinum_M GGN--GGNGGAAGWWGTGG----------------AGGAGGEGG------ MUL_4367|M.ulcerans_Agy99 AGAGVGGAGGAGGAGDAGDQGVSGVAPGEAGAVGFAGGAGGAGG------ Mflv_5091|M.gilvum_PYR-GCK GAT--GATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------ Mvan_1264|M.vanbaalenii_PYR-1 GAT--GATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------ MSMEG_0868|M.smegmatis_MC2_155 GTG--GGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGY TH_3810|M.thermoresistible__bu GGH--GGNGGNVGFFSLFN----------------LGGAGGWGG------ MAB_4284c|M.abscessus_ATCC_199 TVVDDHSQRNTTNINDSFN----------------TDRSTNIGS------ MLBr_01183|M.leprae_Br4923 GAT--NHQDLIQSLLTSSS---------------------AYAG------ MAV_4827|M.avium_104 TALARGAALAAANAPLFAS----------------STAALAYAQ------ . . . Mb1097c|M.bovis_AF2122/97 --------------QGGAGIG-GADGTK--GGDAGAGGAGGAG------- Rv1067c|M.tuberculosis_H37Rv --------------QGGNGAGAGASGTK--GGDAGAGGAGGAG------- MMAR_3316|M.marinum_M --------------AAGGGPAGIAYGQT--GGVGGNGGNGGNG------- MUL_4367|M.ulcerans_Agy99 --------------AGGNGVGGGVNGAGGAGGAGGVGGGGGAG------- Mflv_5091|M.gilvum_PYR-GCK --------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG------- Mvan_1264|M.vanbaalenii_PYR-1 --------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG------- MSMEG_0868|M.smegmatis_MC2_155 VLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIG TH_3810|M.thermoresistible__bu ---------------SGVDGVDVVGGNPDGGTPGAHGESHTPG------- MAB_4284c|M.abscessus_ATCC_199 --------------GNTTNTEIGSHNQANIGTSTSAGGSAAVG------- MLBr_01183|M.leprae_Br4923 ---------------TETANHDSL-------------------------- MAV_4827|M.avium_104 --------------DPGTGAVDQYSLPDYLYVPVDPEPGDDE-------- Mb1097c|M.bovis_AF2122/97 -----------GWIHGHG------GVGGDGGTGGQG-------------- Rv1067c|M.tuberculosis_H37Rv -----------GWIHGHG------GAGGDGGAGGAG-------------- MMAR_3316|M.marinum_M -----------GWFAGNA------GAGGNGGVGGDG-------------- MUL_4367|M.ulcerans_Agy99 -----------ASGVGAG------VAGGDGGTGGAG-------------- Mflv_5091|M.gilvum_PYR-GCK ---------AVGAAGAAG------TVGTAGATGGTG-------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------AIGTAGVAG------AAGTAGATGGTG-------------- MSMEG_0868|M.smegmatis_MC2_155 ANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGT TH_3810|M.thermoresistible__bu -----------VYTDRQG----------EDGEDGTG-------------- MAB_4284c|M.abscessus_ATCC_199 -----------GNAGLAG------NAGLAGNAGLAG-------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------LAYSAVGEEDAES-------------- Mb1097c|M.bovis_AF2122/97 ---GDGVQGEPG---DTGAAG--------------------GAGGAGGRG Rv1067c|M.tuberculosis_H37Rv ---GQASPGAPGPPSQPGGAG--------------------GAGGAGGRG MMAR_3316|M.marinum_M ---NAADNGLVGGTGGVGGAGG--------------SAGLFGDGGAGGQG MUL_4367|M.ulcerans_Agy99 ---GAAGVGGAAGTGGTGGAAG--------------VAGTGGDGGDGGAG Mflv_5091|M.gilvum_PYR-GCK -TGANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTG Mvan_1264|M.vanbaalenii_PYR-1 -VGGNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTG MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTG TH_3810|M.thermoresistible__bu -------------------------------------------TGIGGRG MAB_4284c|M.abscessus_ATCC_199 ---NAGLAGNAGLAGNAGLAGN------------------AGLAGNAGLA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---PTVVIEKLFLPEDSEPRRR-------------------PVLLVGSGL Mb1097c|M.bovis_AF2122/97 GDGG------------------SAGWLSGNGGDAGTGGGGGNAGAGGEG- Rv1067c|M.tuberculosis_H37Rv GDGG------------------SAGWLSGNGGDAGNGGGGGTAGGAGNG- MMAR_3316|M.marinum_M GDGGGVTGLVGAGHGGAGGDGGRAGWLSGNAGAGGGGGAGGAVDNHGSG- MUL_4367|M.ulcerans_Agy99 GAGSDASLAG------------QAGFAGGSGGAGGVGGSAGAGGVNGSG- Mflv_5091|M.gilvum_PYR-GCK GAGGVGGQ-------------GTAGGTGGVGGIGGAGSTGAVGGVGGKG- Mvan_1264|M.vanbaalenii_PYR-1 GVGGIGGQ-------------GTEGGTGGVGGVGGVGATGGAGGVGGKG- MSMEG_0868|M.smegmatis_MC2_155 GAGGMGEIYS-----------GADGEATGISAGGDGGSATGADSLGGRGG TH_3810|M.thermoresistible__bu GNGG---------------------SSSGTHPMAEDGE--HVKALDGRP- MAB_4284c|M.abscessus_ATCC_199 GNAGLAGN----------------AGLAGNAGLAGNAGLAGNAGLAGNAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AVVG------------------ISAVLALEIALAIGIRTTGTVALQPTPN Mb1097c|M.bovis_AF2122/97 ------------------------GIFGGNGGNGGTGGTA---------- Rv1067c|M.tuberculosis_H37Rv ------------------------GQFGGDGGTGGTGGTA---------- MMAR_3316|M.marinum_M ------------------------GDYAGGGGAGGSGGAAGLFGN----- MUL_4367|M.ulcerans_Agy99 ------------------------GDGGAGAAGGAGGASATVAGS----- Mflv_5091|M.gilvum_PYR-GCK ---IQGGQG-------------LQGGKGGDGGAGGKGGDADSMGS----- Mvan_1264|M.vanbaalenii_PYR-1 ---IQGGQG-------------LQGGQGGDGGTGGTGGDATSMGE----- MSMEG_0868|M.smegmatis_MC2_155 TSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGV TH_3810|M.thermoresistible__bu ------------------------GLDGGNGSHGGN-------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------LAGNAGLAGNAGLAGNAGLAGN----- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------QHLIVPTEQAPAPPPVQASAPQP----- Mb1097c|M.bovis_AF2122/97 ------------------GGGGNGGRG------AALFG------------ Rv1067c|M.tuberculosis_H37Rv ------------------GAGGNGGRG------AVLFG------------ MMAR_3316|M.marinum_M --------------GAAGGAGGAGGAS------QTFTG------------ MUL_4367|M.ulcerans_Agy99 --------------GGVGGDGGAGGAAGGGVGAASLGG------------ Mflv_5091|M.gilvum_PYR-GCK -------------AGATGGKGGNGGNGG----RGGLFG------------ Mvan_1264|M.vanbaalenii_PYR-1 -------------AGATGGKGGNGGNGG----RGSLFG------------ MSMEG_0868|M.smegmatis_MC2_155 ATGNTAIGGNGGAASANGAVGGNGGFTN----IAAIHGSITDSSATSGHG TH_3810|M.thermoresistible__bu --------------------GGHGGRGG-------FLG------------ MAB_4284c|M.abscessus_ATCC_199 -----------------AGLAGNAGLAG----NAGLAG------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------KISVPEPVAAPKPLSPPVAAP----------- Mb1097c|M.bovis_AF2122/97 ---HGGNAGHGGAG----------------------GNGAAGGNG--ADT Rv1067c|M.tuberculosis_H37Rv ---HGGNAGHGGAG----------------------GNGAAAGAG--GEH MMAR_3316|M.marinum_M ---AGGAGGTGGAGG------------------WLYGNGGAGGAG--GAS MUL_4367|M.ulcerans_Agy99 ---DGGHAGAGGAGGEGLSGGFNTG--------AAGGIGGAGGAGGTGGD Mflv_5091|M.gilvum_PYR-GCK ---KGGNAGNGAD----------------------GGTGGAGGAGGTGG- Mvan_1264|M.vanbaalenii_PYR-1 ---RGGNAGNGGN----------------------GGTGGNGGNGGTGG- MSMEG_0868|M.smegmatis_MC2_155 GAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGA TH_3810|M.thermoresistible__bu ---IGGSGGWGGHG----------------------GNGGD--------- MAB_4284c|M.abscessus_ATCC_199 ---NAGLAGNAAVA----------------------GNAAVAGNAAVAG- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---LPAAPPPAAPP---------------------LPEAPPIPAAPPVVP Mb1097c|M.bovis_AF2122/97 QLGISGKGG-----------------TGGGGGGAGAGGTGGDGGLLYGNG Rv1067c|M.tuberculosis_H37Rv VVATAGKGG-----------------TGGVGGDGGGGGAGGGGGLLYGNG MMAR_3316|M.marinum_M GAGIGGDS------------------LGGSGGNGGNGGISG----LIGNG MUL_4367|M.ulcerans_Agy99 SGGVGGVNG-----------------DGGAGGGGGRGGDGGSSTSTSGVG Mflv_5091|M.gilvum_PYR-GCK TGGAGGTGG-----------------TGGTGGIGGAGSTGGTGG-TGGTG Mvan_1264|M.vanbaalenii_PYR-1 TGGNGGTGG-----------------TGGTGGIGGAGSTGGTGG-TGGTG MSMEG_0868|M.smegmatis_MC2_155 TGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAG-ANGNG TH_3810|M.thermoresistible__bu --------------------------TDADGGNGGDG----------GNG MAB_4284c|M.abscessus_ATCC_199 NAAVGGVLN-----------------TGVSGAIGGSSHVGGAIN--ESLG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VPVVVPPVP-----------------VPVPVRIPVPDPVSPPQLLAPPRL Mb1097c|M.bovis_AF2122/97 GAGGNGGNG-GAAGKGGIGA-PGLSTAQGGDG-GNG------GSGGNAGN Rv1067c|M.tuberculosis_H37Rv GAGGAGNSG-GDGGTG-------LNAALGGNG-GGG------GVGGNAG- MMAR_3316|M.marinum_M GAGGAGGNG-SAAGYNG-------YSGNGGNG-GNGGAAQLIGAGGGGGV MUL_4367|M.ulcerans_Agy99 GAGGAGGNG-GNAGFGVSAGGTGGSAGDGGAGGGAGGVDGVGGASGNGGA Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTG-GTGGTGGTGG-TGGKGGTGGTGGAGGTG----GDGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTG-GTGGTGGTGG-TGGKGGTGGTGGDGGTG----GTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GAGGAGGVSEGEGGTGGHGG-DGGRGGDGALGGNGGTGGVGLGNGGKGGN TH_3810|M.thermoresistible__bu GSAGRGGTG-GLRGVFG------INGGNGRAG------------------ MAB_4284c|M.abscessus_ATCC_199 GSGSVGGSTAVGGGAHTGVG----GGVSTGVG------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 SVPQPVQPPVRVPQPPSPPQ----VGGTVPQS------------------ Mb1097c|M.bovis_AF2122/97 GGNGGRGSVLFGHGGNAGHGGAGGNGAVS--GNGGSSITAVGGKGGTGGG Rv1067c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3316|M.marinum_M AGIGGAGGTGAAAGVTGSAGASGVGGRLY--SGNGIPDIFGRPLIGDGAD MUL_4367|M.ulcerans_Agy99 AGAGGAGGSGIGAGIDGGAGGAGGTGGAAGFPGGGGTTGAWGTGGAGGAG Mflv_5091|M.gilvum_PYR-GCK GGTGGTG---------GTGGTGGTGGAG-----------DGTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTG---------GTGGTGGTGGAG-----------DGLGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb1097c|M.bovis_AF2122/97 GGGGAGGTGGDAGLLY----------------GNGGAGGTGG-SGGAGAR Rv1067c|M.tuberculosis_H37Rv ----AGGTGGSAGWLS----------------GNGGAGGSGG-SAGAG-- MMAR_3316|M.marinum_M GAPGTGQAGGDGGWLY----------------GNGGAGGSGA-AGQAGGA MUL_4367|M.ulcerans_Agy99 GAGGAGDHGGVGVNPG----------------DSGTAGWAGG-AGGAGGA Mflv_5091|M.gilvum_PYR-GCK ----TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGGGT Mvan_1264|M.vanbaalenii_PYR-1 ----TGGFGGQGGQGG-----------------TGGTGGQGG-LGGVGGT MSMEG_0868|M.smegmatis_MC2_155 NGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGT TH_3810|M.thermoresistible__bu -------LGGRGXXXX-----------------GGGVGAAVR-------- MAB_4284c|M.abscessus_ATCC_199 ----VGSHVGGGISES-----------------LGGSGSVGG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -PPQHQTPPGEGTPPK-----------------PDGPGNYGG-------- Mb1097c|M.bovis_AF2122/97 GGDG-----------------GAGSGTAQGGDGGAGGVGGNAGNGGNG-- Rv1067c|M.tuberculosis_H37Rv ---------------------------------GAGGKGGDTPNG----- MMAR_3316|M.marinum_M GGAA-----------------GLIGNGGAGGTGGSGAAGGSGAAGGNG-- MUL_4367|M.ulcerans_Agy99 GGSA-----------------AFNGVNGAGGAGGNGGAGGGGGAGASG-- Mflv_5091|M.gilvum_PYR-GCK G-----------------------GQGGTGGTGGQGGTGGTGGTGGTG-- Mvan_1264|M.vanbaalenii_PYR-1 G-----------------------GTGGTGGTGGQGGTGGTGGTGGTG-- MSMEG_0868|M.smegmatis_MC2_155 GGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPS TH_3810|M.thermoresistible__bu --------------------------------SGNGVFSGGGGTPSAG-- MAB_4284c|M.abscessus_ATCC_199 -----------------------------STAVGGGAHTGVGGGVSTG-- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------------GHVPTPGAGGSGGSGGGHVPT-- Mb1097c|M.bovis_AF2122/97 --------GSAGWLSGNGGTGGGGGTAGAGGQGGNGNSGIDP-------- Rv1067c|M.tuberculosis_H37Rv -------------------------------------LAINP-------- MMAR_3316|M.marinum_M --------GAGGWLFGNGGTGGTGGDAVAGLPGLNGGNGGNGGAGGAAGW MUL_4367|M.ulcerans_Agy99 --------IGAGVAGGDGGTGGTGGAAGTGGAAGTGGTGGAAGAAGSAGD Mflv_5091|M.gilvum_PYR-GCK ------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG Mvan_1264|M.vanbaalenii_PYR-1 ------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG MSMEG_0868|M.smegmatis_MC2_155 AVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb1097c|M.bovis_AF2122/97 ----GNGGQGAD-----------TGNAGNGGHGGSAAKLFGD-------- Rv1067c|M.tuberculosis_H37Rv ----GIGGNGGD-----------TGNAGNGGNGGSAARLFGG-------- MMAR_3316|M.marinum_M WGHGGIGGQGGTGGAAGGNPGIYAGNAGTGGDGGAGGWLFGD-------- MUL_4367|M.ulcerans_Agy99 GGAGGAGGAGDDGSAG--VVSGDPGTAGKAGGAGGAGGVGGNGVAGGVNG Mflv_5091|M.gilvum_PYR-GCK --QAGTAGKGGLFG--------GSGSAGKAGATGAAGASGGK-------- Mvan_1264|M.vanbaalenii_PYR-1 --QAGVAGKGGLFG--------GSGSAGTAGVTGASGASGGK-------- MSMEG_0868|M.smegmatis_MC2_155 GKATGTASQGGNGGPS----WVQSGYGSTLGGNATGTATAGK-------- TH_3810|M.thermoresistible__bu -----------------------------FGVPTTIQFPAGS-------- MAB_4284c|M.abscessus_ATCC_199 ---VGVGSHVGGG---------ISESLGGSGSVGGSTAVGGG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------PGAGGSGGSGGGHVPTPGT-------- Mb1097c|M.bovis_AF2122/97 ----GGAGGAGGMG----------STGGTGGGGGFG-----GGTGG-NGG Rv1067c|M.tuberculosis_H37Rv ----GGAGGAGGTG----------STAGSGGSGGTNPPTGLQAAGG-NGG MMAR_3316|M.marinum_M ----AGAGGQGGTGGAANDPLVTSSTGGSGGAGGNGGAAGLFGAGG-AGG MUL_4367|M.ulcerans_Agy99 SGGAGGAGGAGGTGGAGASGVPASVDGGDGGAGGAGGAAGTGGSGGSAGN Mflv_5091|M.gilvum_PYR-GCK ----GAQGATGAQGATG-------AQGATG-ATGAAGKAGATGAAGAAGA Mvan_1264|M.vanbaalenii_PYR-1 ----GAQGATGAQGATG-------AQGATG-ATGASGAQGSAGSAGSAGV MSMEG_0868|M.smegmatis_MC2_155 ----GGEASNGGVAGNGGNALVM-AAGTTGVATGNTATGGDGGAATTAGA TH_3810|M.thermoresistible__bu --------CTSR------------AVSREGIMPSSRAASARAGAACASST MAB_4284c|M.abscessus_ATCC_199 ----AHTGVGGGVN----------TGVGVGSHVGGGISESLGGSGSVGGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----GGPGGTGGSG------------GGHVPTPGAGTPGGSGGGHLPFPG Mb1097c|M.bovis_AF2122/97 NG---------------------------------------------HAG Rv1067c|M.tuberculosis_H37Rv SG---------------------------------------------HAG MMAR_3316|M.marinum_M TGGTAGDGYLIGGDGGNGGQGGYGGWLAGSGGAGGTAGDGGAGIYPGGAG MUL_4367|M.ulcerans_Agy99 TGAGGAGGAGGAGGSAASTGVNGDGGAGGAGGVGGLGGDSAATAGGGGAG Mflv_5091|M.gilvum_PYR-GCK AG-----------------------------SAG-----------TTGAQ Mvan_1264|M.vanbaalenii_PYR-1 AG-----------------------------SAG-----------TTGAQ MSMEG_0868|M.smegmatis_MC2_155 TG-----------------------------GAGGFSNIAAIHGAITDST TH_3810|M.thermoresistible__bu SR----------------------------------------------SR MAB_4284c|M.abscessus_ATCC_199 TA----------------------------------------------VG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AG-----------------------------------------------S Mb1097c|M.bovis_AF2122/97 GAGGSGGT---------AGLLGSGGTGGDGGNGGLG------------AG Rv1067c|M.tuberculosis_H37Rv GHGGNGGG---------AGLLGGGGTGGNGGGGGQGGL--------GAAA MMAR_3316|M.marinum_M GTGGSGGA---------ARFFGDGGAAGTGGVGGFGSK--------YVAG MUL_4367|M.ulcerans_Agy99 GDGGKGGAGGAGVNGVGGGDGGKGGTGGAGGAGGAGSDG-IIPSNGGLGG Mflv_5091|M.gilvum_PYR-GCK GSAGTNGA--------NGANGSQGAAGKAGATGTTGATG--------AAG Mvan_1264|M.vanbaalenii_PYR-1 GSAGTNGA--------NGANGSQGAAGKAGATGTTGATG--------AAG MSMEG_0868|M.smegmatis_MC2_155 AISGHGGAG-------NGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAG TH_3810|M.thermoresistible__bu RSFCCSRA------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 GGAHTSAIN--------DALGGSGSVGGSTAVGGGAHTS----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TPGGSGGG----------HLPTPGAGTPGGGLGGFGGG------------ Mb1097c|M.bovis_AF2122/97 SGAKG--------------------------------------------- Rv1067c|M.tuberculosis_H37Rv GGVDG--------------------------------------------- MMAR_3316|M.marinum_M SGGSGGTGGAAGWLIGNGGAGGQGGVAGTPDGVNRVFGGTGGAGGTGGT- MUL_4367|M.ulcerans_Agy99 NGGNGGNGGQAFGDGVGGAGGIGGKGGNAAIGTIVINGGVGGAGGSGGLG Mflv_5091|M.gilvum_PYR-GCK EDGDAGSGGSG------------------------INGGAGGAGG----- Mvan_1264|M.vanbaalenii_PYR-1 DAGDPGSEAVD------------------------INGGAGGAGG----- MSMEG_0868|M.smegmatis_MC2_155 NGGDGGVNGTGG-----------------------ASGGDGGNGGNTSV- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb1097c|M.bovis_AF2122/97 -------------------------------NGGNGGDGGKGGDAQL--- Rv1067c|M.tuberculosis_H37Rv -------------------------------NGGNGGNGGKGGDAQL--- MMAR_3316|M.marinum_M ------AGWLYGSGGSGGAGGAGTASIYPGSTGGNGGNGGNGGAAQV--- MUL_4367|M.ulcerans_Agy99 GATEDGVGGVGCAGGAGGNGGRGDMLFTVGGSGGTGGDGGGGGSASG--- Mflv_5091|M.gilvum_PYR-GCK ----------------------------AGGEGGEGGDGGKGGAGAE--- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------AGGEGGEGGAGGAGGDGSE--- MSMEG_0868|M.smegmatis_MC2_155 ---------------------WKSGGQTADGEHNTGGNGGNGGDGSEPGP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------AINESMNSSINASHSSSMN--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------------HAPAPGGGLGGGGGHAPAP-- Mb1097c|M.bovis_AF2122/97 --IGNGGNGGNGGKGGTG--------LMPG----------INGTGGAGGS Rv1067c|M.tuberculosis_H37Rv --VGDGGNGGNGGKGGAG--------LIAG----------LDGAGGAGGT MMAR_3316|M.marinum_M --IGTGGTGGTAGTGGAGGPDDPPNNIPAGNDG-------QDGVGGAGGS MUL_4367|M.ulcerans_Agy99 --SGTGGSGGTGGVGGIGGDGKLGGFGGDGGDGGDGGFGVIGGQGGGGGF Mflv_5091|M.gilvum_PYR-GCK -----GGAGGGGGAGGSG-------AGGAG---------GAGGSGGSGGS Mvan_1264|M.vanbaalenii_PYR-1 -----GGAGGSGGAGGSG-------TGGAG---------GAGGSGGSGGS MSMEG_0868|M.smegmatis_MC2_155 GGNGAGGAGGNGGTGGTT-------AGGSGNG-------GNGGNGGNGGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --ESFGSSMGSHGAAGTG----------------------FEAQGHAQGH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----GGGLGGFGGGHSG-----------------------GGLGGLGGG Mb1097c|M.bovis_AF2122/97 RGQ-------------ISGNPGTPGQ--- Rv1067c|M.tuberculosis_H37Rv RGL-------------IFGNAGTPGQ--- MMAR_3316|M.marinum_M GGL-------------VFGNSGG------ MUL_4367|M.ulcerans_Agy99 GGLGGTGAGGAPSDKGINGEPGNPG---- Mflv_5091|M.gilvum_PYR-GCK GGS--------------GGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 GGA--------------GGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 DGT--------------PGTAGTTGANNP TH_3810|M.thermoresistible__bu ----------------------------- MAB_4284c|M.abscessus_ATCC_199 ASET--------------AHTTLPGAEHH MLBr_01183|M.leprae_Br4923 ----------------------------- MAV_4827|M.avium_104 HK---------------------------