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LLATPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSATVAGPLAADSRGGNWPSQTGHSPAVPNALQAS LGHAVPPAGNKRKVWAVVGAAAIVLVAIVAAAGYLVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDS AGNVYVTSEGMYGRVVKLATGSTGTTVLPFNGLYQPQGLAVDGAGTVYVTDFNNRVVTLAAGSNNQTVLP FDGLNYPEGLAVDTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYVTDTDNNRV VKLEAESNNQVVLPFTDITAPWGIAVDEAGTVYVTEHNTNQVVKLLAGSTTSTVLPFTGLNTPLAVAVDS DRTVYVADRGNDRVVKLTS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0954c | pknDb | - | 100% (369) | serine/threonine protein kinase D |
M. bovis AF2122 / 97 | Mb3554 | - | 5e-56 | 45.61% (296) | hypothetical protein Mb3554 |
M. bovis AF2122 / 97 | Mb1003c | PE_PGRS17 | 4e-12 | 33.17% (205) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_1786 | - | 6e-08 | 25.68% (183) | SMP-30/gluconolaconase/LRE domain-containing protein |
M. tuberculosis H37Rv | Rv0931c | pknD | 0.0 | 100.00% (369) | transmembrane serine/threonine-protein kinase D PKND |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_2106c | - | 1e-07 | 25.53% (380) | lipoprotein LppL |
M. marinum M | MMAR_4577 | pknD | 1e-117 | 57.39% (399) | transmembrane serine/threonine-protein kinase D PknD |
M. avium 104 | MAV_4238 | - | 1e-124 | 66.02% (362) | serine/threonine-protein kinase PknD |
M. smegmatis MC2 155 | MSMEG_5629 | - | 4e-10 | 26.52% (230) | hypothetical protein MSMEG_5629 |
M. thermoresistible (build 8) | TH_0100 | - | 5e-13 | 28.24% (255) | CONSERVED HYPOTHETICAL PROTEIN |
M. ulcerans Agy99 | MUL_4817 | - | 2e-13 | 28.19% (259) | hypothetical protein MUL_4817 |
M. vanbaalenii PYR-1 | Mvan_1720 | - | 3e-14 | 27.31% (249) | YVTN beta-propeller repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 MGSRSAAHGGRSWRSGRHRKQRRIEPYAWLGAGAVTLGIGAAALSGAGIA MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 AADDPSTDSTSTSSSTEDNTSSDPRTPSSTRSTDAEEPSNDKNIEPPGND MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -----------------------------------------VTVIGAQQV Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 SDDEADHEVDTTTETDAAARDGADGVDEEPRRNKGREDGIETYDPSPSVD MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu VDIALAEAARRGKADETMVLVTDRADASLRWAGNSMTTNGESVSRTTTVV Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 KQDNDTEANELTAVVDEDDAPRPRGAESQQRPAVGAVSPALTNTQSAPVP MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu SVVRRENSTHVASVRSSEVDPAAIPALVAASQDAALTAPEARDSAPPLPG Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 LAPHETTTTQLSPETPENATTTRLLDAPTEPFDSPLAWLLLASSRRQIGR MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu DTTPDDWDDPVPGTGVGEFTAIADGLVRGFRGADRLYGYARHIVETTFLA Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 VADEDAHSPAADALAVDAENTAPTAALRGQSSPGWFTGRVTGRVAASDVD MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu TSNGLRRRYTQPTGSVEINAKRDGASAWVGLNAPDFTAVTVDSMLEELST Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 GDRLSFTGMTTAKGTVTVTPWGTFTYRPSKAARHAAAATTASDAEKFDTF MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu RLGWARRRVELPAGRYETIMPPSTVADMLIYLNWHMDGRGAQEGRTALSA Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 AITVSDGNGGWTEVPVTVAVRPVNSSPSWLRSTKTKPNPVSGEVNGRIIA MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu PGGGTRVGEKLTDLPLTMYSDPTADGLECLPFVAVPASSDRVSVFDNGLA Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 IDRDGDAFTYTASAPGKGAVVVNLDGTFSYTASDSARAAARNTWYTDTDR MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu IGRVDWIRDGVINALAYPRAAAEEFHAPVAVPADNLLMTGGTASVRDMVA Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv --------------------------------------------MSDAVP MMAR_4577|M.marinum_M --------------------------------------------MSETGP MAV_4238|M.avium_104 --------------------------------------------MSDNGP MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 FIVVVNDGHGGTRSVSVRVEVAPSNNAPTTGAPNLDAPDPGTGAVRGTVN MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu RTERGLLLTTFWYIRTVDPTTLLVTGLTRDGVYLVEDGEVTAAVNNFRFN Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv --QVGSQFGPYQLLRLLGRGGMGEVYEAEDTRKHRVVALKLISPQYSDNA MMAR_4577|M.marinum_M GSRVGSRFGPYELVRLIGRGGMGEVYEAEDTRKRRVVALKLISTQYSGNP MAV_4238|M.avium_104 AAQVGSWFGPYRLVRLLRQGGMGEVYEAEDTRKHRLVALKLISQQFSGNP MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 AVDPDGDRITYRRETIMTAKGVLTIGSTGAFNYTPTTAARHAAATSDPNL MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu ESPLDVLRRATEAG--------ASEYTLPREWGDWATRAKMPALXXXVRA Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv VFRARMQREADTAG--------RLTEPHIVPIHDYGEINGQFFVEMRMID MMAR_4577|M.marinum_M TFRARMQREADTAG--------RLTEPHIVPIHDYGEIDDQFFVEMRLID MAV_4238|M.avium_104 EFSARLQREADIAG--------RLTEPHVVPIHDYGEIDGRFFVEMRLVD MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 AADSVTITARDRFGGVGAIVLTIPIAPTNTSPVGSAAGAGVTDPVTGVVR MSMEG_5629|M.smegmatis_MC2_155 --------------------------------------MTSPISLGNAAP TH_0100|M.thermoresistible__bu AALVDILSGQEVSLFWSKNTIPQRLWPSQGCPAGQRGLLSGLQRLDNVQP Mflv_1786|M.gilvum_PYR-GCK --------------------------------------MN---------- MUL_4817|M.ulcerans_Agy99 ---------------------------------MVRAVIPVTRRLQHAG- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv GTSLRALLKQYGPLTPARAVAIVRQIAAALDAAHANGVTHRDVKPENILV MMAR_4577|M.marinum_M GVSLRAMLTQFGPLTPARAVAIVRQIAAALDAAHSNGVTHRDVKPENILV MAV_4238|M.avium_104 GIDLGSLLHREGPLAPPRAIAIIRQVAAALDAAHAAGVTHRDVTPGNILV MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 GTVTATDSDGDDLLFSGTTTTEKGSVVVDSIGTYTYTPTTAARHHVNAED MSMEG_5629|M.smegmatis_MC2_155 ---------------------ARYTAN--PSVAEGWHLRQVTAPSRLFGA TH_0100|M.thermoresistible__bu KPADGRTPHPMAAPMAGAHQQARYTPQNPPGAAPGWRLDRITGPSRLFGA Mflv_1786|M.gilvum_PYR-GCK ---------------------ARYAAQN-PTAAEGWTLRSVTAPSPLFGA MUL_4817|M.ulcerans_Agy99 ----------------------HYPVTRAPNVAEGWTLTRLTAPSRLFGA Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv TASDFAYLVDFG--------IARAASDPGLTQTGTAVGTYNYMAPERFTG MMAR_4577|M.marinum_M ADNDFAYLVDFG--------IARAAADPGLTQGGMAVGTYNYMAPERFTG MAV_4238|M.avium_104 TPSDFAYLADFG--------IARAASDPGLTQVGTAIGTYYYMAPERFTD MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 ATDADRRDSFVVTVTDGHGGTAQVLVSVAIAPSSNQAPGGVSYSANPNTD MSMEG_5629|M.smegmatis_MC2_155 NGLRTGPDGRVYVAQVTGSQISALDIVTGELQTVAARGGDIIAPDDVAFD TH_0100|M.thermoresistible__bu NGLRTGPDGRVYIAQVTGSQISALDIATGALETISPKGGDIISPDDVAFD Mflv_1786|M.gilvum_PYR-GCK NGLRTGPDGRIYIAQVTGSQISALDPATGALETVSAKGGDIIAPDDVAFA MUL_4817|M.ulcerans_Agy99 NGLRTGPDGRVYIAQVTGSQISALDLSTGRLDTVCPKGGAIIAPDDLAFD Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv DEVTYRADIYALACVLGECLTGAPPYRADSVERLIAAHLMDPAPQPSQLR MMAR_4577|M.marinum_M NDVTYRADIYALACVLGECLTGAPPYRADSVERLIAAHLMEPPPRPSQLR MAV_4238|M.avium_104 DEVTNSVDIYSLACVLTECLTGVPPYRADTVERLVAAHLTKTAPPLSQLR MAB_2106c|M.abscessus_ATCC_199 ---------------------------MGNPSSIAMMDAMNRLPRRGMRG Mvan_1720|M.vanbaalenii_PYR-1 TGVVEGRVTATDPEGDSLTFSGSAETGKGTVAVAPDGSFVYTPTDDARLS MSMEG_5629|M.smegmatis_MC2_155 IRGNLYATEVMDGRVSVREPNGTTRVLRDDVPSANGITFHEGRLFIGECR TH_0100|M.thermoresistible__bu PHGNLVATEVMEGRVSLRDTAGRARVLRDDIPSANGITFHRGRLFIGECR Mflv_1786|M.gilvum_PYR-GCK DDGTLFATEVMDGRVSAREPSGRTRVLRDDLPCANGITVDRGRLFVGECR MUL_4817|M.ulcerans_Agy99 QDGNLYATEVMDGRVSVRAPDGHTRVLRDDIPSANGITFHQGRLFVGECR Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv PGRVPPALDQVIAKGMAKNPAERFMSAGDLAIAAHDALTTSEQHQATTIL MMAR_4577|M.marinum_M PGRVPAALDEVIAKGMAKNPDERYMSAGDLAIAAHEALTTPEQRQEATIL MAV_4238|M.avium_104 PGGFPPALDRVIAKGMAKRPEDRYRTAGEFAAAAHEALTTSEQRKAATIL MAB_2106c|M.abscessus_ATCC_199 IRGTVAALAVVITAAAAASSG---------------------------CS Mvan_1720|M.vanbaalenii_PYR-1 AGAPGAPVASKEDSFVVDVSDGHGGTTSISVSVEIVPLIDNESPVAGTPI MSMEG_5629|M.smegmatis_MC2_155 EGGRLLEFDLAGGPPRVLLENVPSPNAMEVGPDGLLYFP----------- TH_0100|M.thermoresistible__bu EGGRLLEFSLNGDAPRVLLDNVPSPNAMEVGPDGLLYFP----------- Mflv_1786|M.gilvum_PYR-GCK DGGRLMELPLDGGEPRILLENLPSPNAMEVGPDGLLYYP----------- MUL_4817|M.ulcerans_Agy99 DGGRLLELDLNGGAPRVLARNLPSPNAMEVGPDGLLYFP----------- Mb0954c|M.bovis_AF2122/97 -------MLATPADTGLSQSESGIAGAGTGPPTPGAAR---WS------- Rv0931c|M.tuberculosis_H37Rv RRGDNATLLATPADTGLSQSESGIAGAGTGPPTPGAAR---WS------- MMAR_4577|M.marinum_M RQGDNMALMTPAVDPGAGGSWTNYSGSGAQPPAPQPVAPPPQY------- MAV_4238|M.avium_104 RDGQIAALGAGAAE----QRSTHWPDSFAPSPS----------------- MAB_2106c|M.abscessus_ATCC_199 SGGD----SENSADPRVITPASAAQSPPVTTAP----------------- Mvan_1720|M.vanbaalenii_PYR-1 VGDPTPGTGVVSGTLGFTDPEGSSLAYTVTGPPAKGLVSIDTTGGFTYTP . MSMEG_5629|M.smegmatis_MC2_155 ------------VMGANEIWRIHPD--GGTPE------------------ TH_0100|M.thermoresistible__bu ------------VMGANEIWRIDPDQPGAAPQ------------------ Mflv_1786|M.gilvum_PYR-GCK ------------LMTANEIWRIDPS--GGEPQ------------------ MUL_4817|M.ulcerans_Agy99 ------------VMGANEIWRIDPD--GGVPQ------------------ Mb0954c|M.bovis_AF2122/97 ------------PGDSATVAGPLAADSR--------------------GG Rv0931c|M.tuberculosis_H37Rv ------------PGDSATVAGPLAADSR--------------------GG MMAR_4577|M.marinum_M ------------PTGDETVARPVPASTTGWRSRPDVSDQRTQAAPVITGT MAV_4238|M.avium_104 ---------------AETVVGPSPARAG---------------------- MAB_2106c|M.abscessus_ATCC_199 ---------------AGTVHR----------------------------- Mvan_1720|M.vanbaalenii_PYR-1 NPEDRPEAGEAPGYDAFTVVATDPQGLAAQVTVDVVVAPLLPPSDGPVVG : MSMEG_5629|M.smegmatis_MC2_155 VVATGLGVPDAVKFGADGHLVSTQVASGQVLRIDPRS------------- TH_0100|M.thermoresistible__bu TVATGLGVPDAVKFDPAGHIVSTQVATGQVLRIDPRT------------- Mflv_1786|M.gilvum_PYR-GCK RVAADLGVPDAVKFDTDGFIVSTQVASGQVLRIDPRT------------- MUL_4817|M.ulcerans_Agy99 CVAGDLRVPDAVKFDPHGHLVSTQVHSGEVLRINPRT------------- Mb0954c|M.bovis_AF2122/97 NWPSQTGHSPAVPN------ALQASLGHAVPPAGNKR------------- Rv0931c|M.tuberculosis_H37Rv NWPSQTGHSPAVPN------ALQASLGHAVPPAGNKR------------- MMAR_4577|M.marinum_M SWPSQSGIRPAVGTGSSPSATPPASQPATAPPASPKKS------------ MAV_4238|M.avium_104 --APSSGLIRAAPTGSGRVYAPGPDFGRPVAPTDNKR------------- MAB_2106c|M.abscessus_ATCC_199 ----IAGQASAVLFDTSTKTVSILADEGQIVTTVTRD------------- Mvan_1720|M.vanbaalenii_PYR-1 TPPYDIDSVDEVTGVISGHVTAYTSNGTALTFAVAESPDVASGRVALDSA . . . MSMEG_5629|M.smegmatis_MC2_155 ------------GEQTVLAQLTPGLDNLTFADGRLFVSNFTGAITEIMGD TH_0100|M.thermoresistible__bu ------------GEQTVLATLTPGLDNLTFVGDRLFVSNFTGEITEILGD Mflv_1786|M.gilvum_PYR-GCK ------------GEKTVLAQLNPGLDNLTFVGDRLFASNFTGEITEIGRD MUL_4817|M.ulcerans_Agy99 ------------GDRTVLAALHPGLDNLTFVGERLFVSSFTGEITEILGT Mb0954c|M.bovis_AF2122/97 -----------KVWAVVGAAAIVLVA--IVAAAGYLVLRPSWSPTQASGQ Rv0931c|M.tuberculosis_H37Rv -----------KVWAVVGAAAIVLVA--IVAAAGYLVLRPSWSPTQASGQ MMAR_4577|M.marinum_M -----------RKNWIIGAAVVAVLL--VVAGATAFVLAKPKGSTEPRGQ MAV_4238|M.avium_104 -----------KQWIIVGAVALVALVAFVVAVVGYLSTASSGPAKQAGGQ MAB_2106c|M.abscessus_ATCC_199 -----------------------------DLDTVRRVTRLPSPATAAVGD Mvan_1720|M.vanbaalenii_PYR-1 TGRWTFTPTASTLVSAWSSDTPTPVTFTIRVSDGEKSTDITVSATVSPSE . . MSMEG_5629|M.smegmatis_MC2_155 GTTRDFLGGGLNWPLDLTVGADGAVYVADGTYFYRVG--PDGSLDTVGML TH_0100|M.thermoresistible__bu GSTRATLPGGLNWPLDLAVGADGALYVADGTYFYAVR--PDGSLQTVGML Mflv_1786|M.gilvum_PYR-GCK GQTSALLPGGLNWPLDLTV-SDGRLYVADGTYFYRVG--PDGALETVGML MUL_4817|M.ulcerans_Agy99 GETRTTLPGGLTWPLGLAVAADGDLYIADGTYFYVLL--ADGTLRVGGML Mb0954c|M.bovis_AF2122/97 TVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGMYGRVVKLATGSTGTTVLP Rv0931c|M.tuberculosis_H37Rv TVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGMYGRVVKLATGSTGTTVLP MMAR_4577|M.marinum_M VVLPFTGLNFRFAPGGVAVDANGTVYVTNQTMYGRVVALPAGSSTPTVKP MAV_4238|M.avium_104 SVLPFNGIDFRLSPGGVTLDGAGNVYVTSEGMYGRVVKLAAGSGATTVLP MAB_2106c|M.abscessus_ATCC_199 --------------------DRGTVYLSTAGGYFALD---IASGRADKVN Mvan_1720|M.vanbaalenii_PYR-1 QAVINSVEYLGSEPSGVTVGPDGRMYVIDSGANTLSIINPADASMITVTV * :*: : MSMEG_5629|M.smegmatis_MC2_155 ----------------------------------FSPGYPGFLRGVIAGG TH_0100|M.thermoresistible__bu ----------------------------------FSSGYPGFIRGVEPSG Mflv_1786|M.gilvum_PYR-GCK ----------------------------------FSPGYPGFLRGVVAVG MUL_4817|M.ulcerans_Agy99 ----------------------------------FSAGYPGFLRGVAALG Mb0954c|M.bovis_AF2122/97 ----------------------------------FNGLYQ--PQGLAVDG Rv0931c|M.tuberculosis_H37Rv ----------------------------------FNGLYQ--PQGLAVDG MMAR_4577|M.marinum_M ----------------------------------FNGLYE--PQGVAVDT MAV_4238|M.avium_104 ----------------------------------FNGLYQ--PQGLAVDG MAB_2106c|M.abscessus_ATCC_199 ----------------------------------ISGHENTEFSAITRRP Mvan_1720|M.vanbaalenii_PYR-1 GKNPTSVASDDLGRLWVTNSGDHTVTVLNAEAEILRTVQVGLVPASVVIR : . MSMEG_5629|M.smegmatis_MC2_155 AGEFIVTTAADTVARYRPGSD-ESEPLAAGVDQPYGVALAPDGTVVVVEQ TH_0100|M.thermoresistible__bu PGEFVVTTSGGQVTRYRPADS-ESEVLADGLDQLYGLALAGDGTVVCAEQ Mflv_1786|M.gilvum_PYR-GCK GDEFVVTTSGGQVARYRPGAG-ETDFLATDFDQLYGVDVAGDGSIVFAEL MUL_4817|M.ulcerans_Agy99 SGEFAVTTSNGEVARYRPWAS-ETEVLATGLDQLYGVAVAGSGALFVAER Mb0954c|M.bovis_AF2122/97 AGTVYVTDFNNRVVTLAAGSNNQTVLPFDGLNYPEGLAVDTQGAVYVADR Rv0931c|M.tuberculosis_H37Rv AGTVYVTDFNNRVVTLAAGSNNQTVLPFDGLNYPEGLAVDTQGAVYVADR MMAR_4577|M.marinum_M SGKIYVTDFNNRVVALAAGSNNQVELPFNGLNYPEGIAVDAQGNVYVADR MAV_4238|M.avium_104 AGTVYVADFNNRVLSMAAGSNSQKELPFSGLNYPEGVAVDSQGGVYVADR MAB_2106c|M.abscessus_ATCC_199 DGRIVLGSADGTVFTLD--LQNQVIAHAAGFAHIDSLAYQGN-TVAVLDR Mvan_1720|M.vanbaalenii_PYR-1 GDLAYIANFGGNSLSVIDAADDYSVRSVDVGTNPIDIAIGSDGRIYVANF . : . .: . : : MSMEG_5629|M.smegmatis_MC2_155 GAGRLLAVRPGS---VDVLADGLDTPVGVAIGPDGAPLVSVAGA--VVRV TH_0100|M.thermoresistible__bu GTGRLLAVRGGE---VEVLATGLTQPVGVALDPDGTPLVAESGAGRIVRV Mflv_1786|M.gilvum_PYR-GCK GTGRVLRLDDGR---VETLASGLRQPVGVAIDADGAPLVSESGAGRVVRV MUL_4817|M.ulcerans_Agy99 GAGRVLSVRPDG---VEVMASGLSDPVGVAVTADGRCVVTEADAGRVRTL Mb0954c|M.bovis_AF2122/97 GNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYVTDTDNNRVVKL Rv0931c|M.tuberculosis_H37Rv GNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYVTDTDNNRVVKL MMAR_4577|M.marinum_M GNNRVVKMPAGSTSQVVLPFNGLKNPDGVAVDSDGNVYVTDTDNNRVLQL MAV_4238|M.avium_104 GNSRVLKLAAGSQNQTVLPFTGLNNPDGVAVDPAGNVYVADTDNNRVVKL MAB_2106c|M.abscessus_ATCC_199 AQSSVTTLTAAGDGTAHALRAGEG-ATTMLADDKGRLLVADTRGGALLAF Mvan_1720|M.vanbaalenii_PYR-1 GNGTISVLRPDDMDDVLLVDSGGEHPHGILVDDDGTVYVTHPLDDTVTVL . . : : . * . : * *: . : . MSMEG_5629|M.smegmatis_MC2_155 TGTGVERLVD-------------------GLHTPQGLLVRD-GALYLVDA TH_0100|M.thermoresistible__bu AGGRTDTVVD-------------------QLSCPQGILVRG-NQLYIVDA Mflv_1786|M.gilvum_PYR-GCK SSGAVDTVID-------------------GLQRPQGLHVRD-NRLYIVDA MUL_4817|M.ulcerans_Agy99 G--DTGTLLD-------------------GLQCPQGVAICD-RQVYVIDS Mb0954c|M.bovis_AF2122/97 EAESNNQVVLP----------------FTDITAPWGIAVDEAGTVYVTEH Rv0931c|M.tuberculosis_H37Rv EAESNNQVVLP----------------FTDITAPWGIAVDEAGTVYVTEH MMAR_4577|M.marinum_M DAGTSNQSVLP----------------FSNLTAPWGITVDSAGNVYVTEH MAV_4238|M.avium_104 DAASNTQSELP----------------FHDLSVPWGIAVDNGGTVYVTEH MAB_2106c|M.abscessus_ATCC_199 GLADSLILRQR----------------YPVPGAPYGLAYSA-TLIWVSQT Mvan_1720|M.vanbaalenii_PYR-1 NPAPVNRFSLRSLFSADATSGQYTYRSVTVIGAPTKITKDTAGRIYVTNS * : ::: : MSMEG_5629|M.smegmatis_MC2_155 GSKDLISVDLTTGVRTTIASGLP----------------VGPPPGVVPKP TH_0100|M.thermoresistible__bu TAKELLAVDLATGQRQRIATGLP----------------VGSPPGVQPKP Mflv_1786|M.gilvum_PYR-GCK GAKELVEFDLGTKARSTIATGLP----------------VGPPPGVEPKP MUL_4817|M.ulcerans_Agy99 GAKQLVAVDLGSRTRHTIAWDLP----------------VGAPAGVTPNP Mb0954c|M.bovis_AF2122/97 NTNQVVKLLAGSTTST---------------------------------- Rv0931c|M.tuberculosis_H37Rv NTNQVVKLLAGSTTST---------------------------------- MMAR_4577|M.marinum_M DNNAVAKLAAGATTST---------------------------------- MAV_4238|M.avium_104 DKNDVVKYPPGATSGT---------------------------------- MAB_2106c|M.abscessus_ATCC_199 ATNTVIGYDLSTGIPEE--------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 SGATITVLDPLTLAANEIHTGANPSSVYVDRFGNLYVTNAGQKTVAVIHA : : MSMEG_5629|M.smegmatis_MC2_155 LKGMPPFSGPQGPFAGIAAGPDGTLYISADGDGSVLALQRR--------- TH_0100|M.thermoresistible__bu LKGMPPFSGPQGPFAGITAGPDGTLYLSADGDGSVLALRRTR-------- Mflv_1786|M.gilvum_PYR-GCK LKGMPPFSGPQGPFAGITSGPDGTLFVSADGDGSVLAVSRG--------- MUL_4817|M.ulcerans_Agy99 LRGMPPFSGPEGPFAAITPGPDATLYISADADGSVLALRRES-------- Mb0954c|M.bovis_AF2122/97 ---VLPFTGLNTPLA-VAVDSDRTVYVADRGNDRVVKLTS---------- Rv0931c|M.tuberculosis_H37Rv ---VLPFTGLNTPLA-VAVDSDRTVYVADRGNDRVVKLTS---------- MMAR_4577|M.marinum_M ---ELPFTGLNTPLS-VAVDKKGNVYVADRGNGRVLKLAQGS-------- MAV_4238|M.avium_104 ---VLPFTALNTPLA-VAVDRDQSVYVADRGDDRVVKLAQ---------- MAB_2106c|M.abscessus_ATCC_199 ---RARFATVRQPNSLVSDGS--TLFVASGAGDGIQATDIRSLG------ Mvan_1720|M.vanbaalenii_PYR-1 QTRNITTYRADVKTSQVTTDDDGNLVMVSTYDGHRSVLSTDTVSTGADAL : :: . .: : .. MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 QIANVWGSYGSLVASPDGKWLYAVRNRRVDTTGGLYPNRYDIVAIDTSNN MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 SVRTFAWDAHINGSMVLTMNRDGDRLYAAYYTLDPEVFDGVVAKVAIINV MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 DGSTLQLDGAPVELNLGSTTAFVSDIVVNPAGTKVFVIGDRLAVPGQWDA MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 PEGQWNMYGNLWMVDLENDRAVSRPPIPRPLQAEGGVPDLAISPDGRYAY MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 LVMTPLPGWEGNHYLGIFDTQSFALTTVLLGHFEAPNGVRRLVVSPDGTR MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 IYLSDGQIVGVTGTQHELLEDRIQGIDQERFVDIAINPEGTRLYTTTWDG MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 VLTTIDTSTGLPVGNPTDLGNRAWGMTFGPKGDTLYVRRGVDYVASHRAP MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 QSIADLWENVRDLPNGDNEGIFTQVVRHADGTNRMVVYLGGTNPRNWLVG MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 EQAIGENVVSELGILKDEHLGAITRALAHCRNDATCGDIADVMLVGFSQG MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 GIDGQNFASQWDRLGFGVQLSALVTFGSPITKNPNVPTLHIQDIDDEVVN MSMEG_5629|M.smegmatis_MC2_155 -------------------------------------------------- TH_0100|M.thermoresistible__bu -------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK -------------------------------------------------- MUL_4817|M.ulcerans_Agy99 -------------------------------------------------- Mb0954c|M.bovis_AF2122/97 -------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4577|M.marinum_M -------------------------------------------------- MAV_4238|M.avium_104 -------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 TELLARLAATVQYVPMPSWLRINFAAATVTAMARGQLYQGAADTDISVLD MSMEG_5629|M.smegmatis_MC2_155 ------------------------------------------------- TH_0100|M.thermoresistible__bu ------------------------------------------------- Mflv_1786|M.gilvum_PYR-GCK ------------------------------------------------- MUL_4817|M.ulcerans_Agy99 ------------------------------------------------- Mb0954c|M.bovis_AF2122/97 ------------------------------------------------- Rv0931c|M.tuberculosis_H37Rv ------------------------------------------------- MMAR_4577|M.marinum_M ------------------------------------------------- MAV_4238|M.avium_104 ------------------------------------------------- MAB_2106c|M.abscessus_ATCC_199 ------------------------------------------------- Mvan_1720|M.vanbaalenii_PYR-1 IFAVHGNRATYQQLASEMDARTGTDFAALGPVRTFFGGTALIPGDPTPL