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M. bovis AF2122 / 97 Mb0485 (hbhA)

annotation: heparin binding hemagglutinin HBHA (adhesin)
coordinates: 566816 - 567415
length: 199

MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKLQEDLPEQLTE
LREKFTAEELRKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTV
ASQTRAVGERAAKLVGIELPKKAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0485hbhA-100% (199)heparin binding hemagglutinin HBHA (adhesin)
M. bovis AF2122 / 97Mb0726rplV3e-0640.21% (97) 50S ribosomal protein L22
M. bovis AF2122 / 97Mb3010chupB6e-0655.88% (68) DNA-binding protein HU

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0100-8e-6965.61% (221) hypothetical protein Mflv_0100
M. tuberculosis H37RvRv0475hbhA1e-104100.00% (199) iron-regulated heparin binding hemagglutinin hbhA (adhesin)
M. leprae Br4923MLBr_02454-2e-8381.91% (199) putative hemagglutinin
M. abscessus ATCC 19977MAB_4083c-2e-6059.15% (213) Heparin-binding hemagglutinin (adhesin)
M. marinum MMMAR_0800hbhA9e-9086.14% (202) iron-regulated heparin binding hemagglutinin HbhA
M. avium 104MAV_4675-6e-8784.47% (206) heparin binding hemagglutinin hbha
M. smegmatis MC2 155MSMEG_0919-9e-6764.44% (225) heparin-binding hemagglutinin
M. thermoresistible (build 8)TH_0869-9e-6558.87% (231) heparin-binding hemagglutinin
M. ulcerans Agy99MUL_4543hbhA7e-8985.64% (202) iron-regulated heparin binding hemagglutinin HbhA
M. vanbaalenii PYR-1Mvan_0808-1e-7472.95% (207) hypothetical protein Mvan_0808

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0100|M.gilvum_PYR-GCK          -----MAEA-KNQLDVDDLKAPLLAAVGAADLALERVNEIVATLRERAGD
Mvan_0808|M.vanbaalenii_PYR-1       -----MAETNKNQLDIDDLKAPLLAAVGAADLALERVNEIVATLRERAGE
TH_0869|M.thermoresistible__bu      -----MAEK--NQPTVDDLRAPLLAAVGAADLALERVNEIVAALRERADE
MSMEG_0919|M.smegmatis_MC2_155      -----MADK--TQPTVEELKAPLLAAVGAADLALATVNEIIATLLERAGE
Mb0485|M.bovis_AF2122/97            -----MAEN----SNIDDIKAPLLAALGAADLALATVNELITNLRERAEE
Rv0475|M.tuberculosis_H37Rv         -----MAEN----SNIDDIKAPLLAALGAADLALATVNELITNLRERAEE
MMAR_0800|M.marinum_M               -----MAEN----TNIEDLRAPLLAALGAADLALATVNDLIANLRDRAEE
MUL_4543|M.ulcerans_Agy99           MKGNNMAEN----TNIEDLWAPLLAALGAADLALATVNDLIANLRDRAEE
MLBr_02454|M.leprae_Br4923          -----MAEN----PNVDDLRAPLLAALGAADLALTTVNELVGNMRERAEE
MAV_4675|M.avium_104                -----MAEN----PNIDDLRAPLLAALGAADLALATVNDLIANLRERAEE
MAB_4083c|M.abscessus_ATCC_199      -----MTKKN---TSFDDLKTPFYVAVGAGDLALAAVADVVVKLRERAEE
                                         *:.       .::: :*: .*:**.****  * :::  : :** :

Mflv_0100|M.gilvum_PYR-GCK          ARTDAETRVEESRARVAKLQEDLPNQFGDLRDRLTSDELR---------K
Mvan_0808|M.vanbaalenii_PYR-1       ARTDSKSRVEESRARITKLQEDLPAQFGDIREKLTAEELR---------K
TH_0869|M.thermoresistible__bu      VRSDANARAEERRARISKVRDELPAQFEEIRGKLSADELR---------R
MSMEG_0919|M.smegmatis_MC2_155      ARSDAEARVEESRARLTKLQEELPSQFGELREKLNSDELRKKLNSEELRK
Mb0485|M.bovis_AF2122/97            TRTDTRSRVEESRARLTKLQEDLPEQLTELREKFTAEELR---------K
Rv0475|M.tuberculosis_H37Rv         TRTDTRSRVEESRARLTKLQEDLPEQLTELREKFTAEELR---------K
MMAR_0800|M.marinum_M               TRTDTRSRVEESRARLTKLQEDLPEQFTELRERFTSDELR---------K
MUL_4543|M.ulcerans_Agy99           TRTDTRSRVEESRARLTKLQEDLPEQFTELRERFTSDELR---------K
MLBr_02454|M.leprae_Br4923          TRIDTRSRVEESRARVAKLQEVLPEHLSELREKFTADELR---------K
MAV_4675|M.avium_104                TRAETRTRVGERRARLTKFQEDLPEQFTELRDKFTTEELR---------K
MAB_4083c|M.abscessus_ATCC_199      AASEAGARVDETRDRLRELSAELPTDVNELRDRFTPEELR---------K
                                    .  :: :*. * * *: :.   ** .. ::* ::..:***         :

Mflv_0100|M.gilvum_PYR-GCK          FAEGYAEAAQTTYTKLIERGEAALERLRSQPALEGAASRVEEYTDQAVEL
Mvan_0808|M.vanbaalenii_PYR-1       FAEGYAEAAQSTYNKLIERGEAAIERLRTQPALEEAASRVEEYTDQAVEL
TH_0869|M.thermoresistible__bu      AAEAYADAAQGTYTKLVERGAAALERLRSQPAFEDAAERVESYTDQAVEL
MSMEG_0919|M.smegmatis_MC2_155      AAESYADQATATYNKLVERGEAALERLRNQPALEEAATRVETYTDQAVEL
Mb0485|M.bovis_AF2122/97            AAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVEL
Rv0475|M.tuberculosis_H37Rv         AAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVEL
MMAR_0800|M.marinum_M               AAEGYLEAATGRYNDLVQRGEAALERLRSQPAFEDASARAEGYVDQAVEL
MUL_4543|M.ulcerans_Agy99           AAEGYLEAATGRYNDLVQRGEAALERLRSQPAFEDASARAEGYVDQAVEL
MLBr_02454|M.leprae_Br4923          AAEGYLEAATNRYNELVERGEAALERLRSRPVFEDASARAEGYVDQAVEL
MAV_4675|M.avium_104                AAEGYLEAATNRYNELVERGEAALQRLRSQTAFEDASARAEGYVDQAVEL
MAB_4083c|M.abscessus_ATCC_199      VAEAYLQVATDIYNNLAERGEEAIERLRSTPGIEENVTRAEGLVGNYAEL
                                     **.* : *   *..* :**  *::***.   :*    *.*  ..: .**

Mflv_0100|M.gilvum_PYR-GCK          TQEALGNVASQTRAVGERAAKLVGVELPKK-----AESAAEPVKKAAEKA
Mvan_0808|M.vanbaalenii_PYR-1       TQEALGNVASQTRAVGERAAKLVGVELPKK-----AESAAAPAKKA----
TH_0869|M.thermoresistible__bu      TQEALGTVAAQTRAVGERAAKLVGVDFPKKGDETQAETSAESSAESSAGA
MSMEG_0919|M.smegmatis_MC2_155      TQEALGTVASQTRAVGERAAKLVGVELPKR-AEAAAETASEAAAETAEPV
Mb0485|M.bovis_AF2122/97            TQEALGTVASQTRAVGERAAKLVGIELPKKAAP------AKKAAPAKKAA
Rv0475|M.tuberculosis_H37Rv         TQEALGTVASQTRAVGERAAKLVGIELPKKAAP------AKKAAPAKKAA
MMAR_0800|M.marinum_M               TQEALGTVATQTRAVGERAAKLVGIELPKKEELE----APAKKAPAKKAP
MUL_4543|M.ulcerans_Agy99           TQEALGTVATQTRAVGERAAKLVGIELPKKEELE----APAKKAPAKKTP
MLBr_02454|M.leprae_Br4923          TQEALGTVASQTRAVGGRAAKLVGIELPKK-----------------AAA
MAV_4675|M.avium_104                TQEALGTVASQTRAVGERAAKLVGIELPGKAEAAGKKAQKAIAKAPAKKA
MAB_4083c|M.abscessus_ATCC_199      TEQALGTVASQTRAVGERAAKLVGIDLSGKATP-AKKAAPAKKAPAKKAA
                                    *::***.**:****** *******:::. :                    

Mflv_0100|M.gilvum_PYR-GCK          PAKKAP-AKKATP-----AAAAKANPTVP-AKKAPAKKAPAKKVTQK
Mvan_0808|M.vanbaalenii_PYR-1       -AKKAP-AKKASP-----AAAAKTSAATP-AKKAPAKKAAAKKVTQK
TH_0869|M.thermoresistible__bu      PAKKAP-AKKAAPKDTAKDTAAKTTAAKAGAKKAPAKKTAAKKVTQK
MSMEG_0919|M.smegmatis_MC2_155      KKAAAPAAKKAAP-------AKKAAPAKKATPAKSAAKAPAKKVTQK
Mb0485|M.bovis_AF2122/97            PAKKAA------------------------AKKAPAKKAAAKKVTQK
Rv0475|M.tuberculosis_H37Rv         PAKKAA------------------------AKKAPAKKAAAKKVTQK
MMAR_0800|M.marinum_M               AAKKAP------------------------AKKAPAKKAPAKKVTQK
MUL_4543|M.ulcerans_Agy99           AAKKAP------------------------AKKAPAKKAPAKKVTQK
MLBr_02454|M.leprae_Br4923          PARKAP------------------------AKKAPAKKAPAKKVTQK
MAV_4675|M.avium_104                PAKKAP------------------------AKKAPAKKAAAKKVTQK
MAB_4083c|M.abscessus_ATCC_199      PAKKAAPAKAAAK-------------KAAPAKKAPAKKAAPRTVTQK
                                        *.                        :   .* *:..:.****