For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. bovis AF2122 / 97 Mb0348 (iniB)

annotation: isoniazid inductible gene protein INIB
coordinates: 410392 - 411831
length: 479

MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISSVAANVVPGLNLGAGDPMSGLRQAVAA
RHGFAQDVANVGFAGDAGAGVASVITTDVGAGLASGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGF
TAVIEAEVGAQVGAGLGIGTGLGAQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRLGGNGQIGV
AGQGAVGAGVGAGVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGAALNG
AAMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAAAGVVGGVGGATAAGVG
GAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGGTGGYGGMNPPVTDAPAPQVPARAQPMTT
AAEHTPAVTQPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0348iniB-100% (479)isoniazid inductible gene protein INIB
M. bovis AF2122 / 97Mb3538PE_PGRS546e-3634.36% (358) PE-PGRS family protein
M. bovis AF2122 / 97Mb3543PE_PGRS571e-3336.04% (333) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_5091-9e-3133.86% (378) triple helix repeat-containing collagen
M. tuberculosis H37RvRv0341iniB0.0100.00% (479) isoniazid inductible gene protein INIB
M. leprae Br4923MLBr_01214-3e-0526.92% (156) putative secreted p60-family protein
M. abscessus ATCC 19977MAB_4284c-3e-3031.20% (391) hypothetical protein MAB_4284c
M. marinum MMMAR_0614iniB9e-7843.86% (456) membrane protein, IniB
M. avium 104MAV_4827-2e-0935.37% (147) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-2229.63% (378) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3889-8e-1931.16% (292) PUTATIVE putative conserved hypothetical protein
M. ulcerans Agy99MUL_0579iniB7e-7643.14% (452) membrane protein, IniB
M. vanbaalenii PYR-1Mvan_1264-4e-3036.10% (349) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
Mb0348|M.bovis_AF2122/97            --------------------------------------------------
Rv0341|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0614|M.marinum_M               --------------------------------------------------
MUL_0579|M.ulcerans_Agy99           --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
Mb0348|M.bovis_AF2122/97            --------------------------------------------------
Rv0341|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0614|M.marinum_M               --------------------------------------------------
MUL_0579|M.ulcerans_Agy99           --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
Mb0348|M.bovis_AF2122/97            -----------------------------------MTSLIDYILSLFRSE
Rv0341|M.tuberculosis_H37Rv         -----------------------------------MTSLIDYILSLFRSE
MMAR_0614|M.marinum_M               ---------------------------------MKMTSLVDYILSLFRSE
MUL_0579|M.ulcerans_Agy99           -----------------------------------MTSLVDYILSLFRSE
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------MSIIDFILNLFRDP
TH_3889|M.thermoresistible__bu      -----------------------------------MLTLIDFILDLFRSP
MAV_4827|M.avium_104                -------------------------------------MNIVLGVSMAPSS
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
Mb0348|M.bovis_AF2122/97            -----------------------------------------DAARSFVAA
Rv0341|M.tuberculosis_H37Rv         -----------------------------------------DAARSFVAA
MMAR_0614|M.marinum_M               -----------------------------------------DAARSFVAS
MUL_0579|M.ulcerans_Agy99           -----------------------------------------DAARSFVAS
MAB_4284c|M.abscessus_ATCC_199      -----------------------------------------VEAASYVAD
TH_3889|M.thermoresistible__bu      -----------------------------------------ALAARFIAD
MAV_4827|M.avium_104                -------------------------------------IQMVVLEGEYADG
MLBr_01214|M.leprae_Br4923          ------------------------------------------MNRIYTFV
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
Mb0348|M.bovis_AF2122/97            P---------------------GRAMTSAG----------LIDIAPHQIS
Rv0341|M.tuberculosis_H37Rv         P---------------------GRAMTSAG----------LIDIAPHQIS
MMAR_0614|M.marinum_M               P---------------------GQAMTNAG----------LVNVSPVEIS
MUL_0579|M.ulcerans_Agy99           S---------------------GQAMTNAG----------LVNVSPVEIS
MAB_4284c|M.abscessus_ATCC_199      P---------------------EAALANAG--------LSAVSAAQVGAV
TH_3889|M.thermoresistible__bu      P---------------------ENTMRDAG---------LQNVTAAQLQS
MAV_4827|M.avium_104                AT------------------VEEDAIDVTG----------ADDAATASAP
MLBr_01214|M.leprae_Br4923          T----------------------------G--------------LAMLVT
                                    .                            *                    

Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
Mb0348|M.bovis_AF2122/97            SVAANVVPGLNLGAGDPMSGLRQAVAARHGFAQD----------------
Rv0341|M.tuberculosis_H37Rv         SVAANVVPGLNLGAGDPMSGLRQAVAARHGFAQD----------------
MMAR_0614|M.marinum_M               SAAANALPFLNLGAGDPIGGLQQAVADQYGLAPASEVGAASSYVAQDAGA
MUL_0579|M.ulcerans_Agy99           SAAANALPFLNLGAGDPIGGLQQAVADQYGLAPASEVGTASSYVAQDAGA
MAB_4284c|M.abscessus_ATCC_199      MPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSL
TH_3889|M.thermoresistible__bu      VAASAAPAGVLLGGGDPVVGLQRAVADHHNIASP----------------
MAV_4827|M.avium_104                DRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR-------DALAA
MLBr_01214|M.leprae_Br4923          SILTCSLAYADSGTRTADYQQTIDTVVQRALAQR----------------
                                                *                                     

Mflv_5091|M.gilvum_PYR-GCK          GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1       GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155      LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
Mb0348|M.bovis_AF2122/97            ----------------VANVGFAG-DAGAGVASVITTDVGAGLAS----G
Rv0341|M.tuberculosis_H37Rv         ----------------VANVGFAG-DAGAGVASVITTDVGAGLAS----G
MMAR_0614|M.marinum_M               VVAQDAAAVVSDAGVAAADAGFAGADIGASVANVVAADIGAGLASGLTSG
MUL_0579|M.ulcerans_Agy99           VVAQDAAAVVSDAGVAAADAGFAGADIGASVANVVAADIGAGLASGLTSG
MAB_4284c|M.abscessus_ATCC_199      LSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGD
TH_3889|M.thermoresistible__bu      ----------------FSPQTSVGWQPTFAPETEVASRNHIQPEVFS---
MAV_4827|M.avium_104                RRIDNVMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSD
MLBr_01214|M.leprae_Br4923          --------------------------------GVPFSWAGGGVSG-----
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1       VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155      GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
Mb0348|M.bovis_AF2122/97            LGAGFLGQG-------------GLALAASSGGFGG--------------Q
Rv0341|M.tuberculosis_H37Rv         LGAGFLGQG-------------GLALAASSGGFGG--------------Q
MMAR_0614|M.marinum_M               LGAGLWSQSGLGWQTGVGGVVPGLAYTQATGDFGG--------------Q
MUL_0579|M.ulcerans_Agy99           LGAGLWSQSGLGWQTGVGGVVPGLAYTQATGDFGG--------------Q
MAB_4284c|M.abscessus_ATCC_199      LQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNG------------D
TH_3889|M.thermoresistible__bu      ----------------------PDQSAGANAQTGG---------------
MAV_4827|M.avium_104                GSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPG-------GLLLV
MLBr_01214|M.leprae_Br4923          -------------------------PTRGTGTGSN---------------
                                                              . .                     

Mflv_5091|M.gilvum_PYR-GCK          VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------
Mvan_1264|M.vanbaalenii_PYR-1       VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------
MSMEG_0868|M.smegmatis_MC2_155      VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
Mb0348|M.bovis_AF2122/97            VGLAAQVGLG--------FTAVIEAEVGAQVGAG----------------
Rv0341|M.tuberculosis_H37Rv         VGLAAQVGLG--------FTAVIEAEVGAQVGAG----------------
MMAR_0614|M.marinum_M               VGLASQVGLG--------FGAGIQAGFGAQASAG----------------
MUL_0579|M.ulcerans_Agy99           VGLASQVGLG--------FGAGIQAGFGAQASAG----------------
MAB_4284c|M.abscessus_ATCC_199      VRDSNIINADHG------SNVGVDQSQTRVGGDY----------------
TH_3889|M.thermoresistible__bu      ----FNLGFG---------DITLGDKTTNTATNG----------------
MAV_4827|M.avium_104                GSGVDVAPLKQVLQTTTFLDVSVAEEPETALARG-------------AAL
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG
Mvan_1264|M.vanbaalenii_PYR-1       -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG
MSMEG_0868|M.smegmatis_MC2_155      AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
Mb0348|M.bovis_AF2122/97            --LGIG----TGLGAQAGMGFG----------------------------
Rv0341|M.tuberculosis_H37Rv         --LGIG----TGLGAQAGMGFG----------------------------
MMAR_0614|M.marinum_M               --LGLGFGAQTGLGAQTGLGIGAGFEGGFAGQAGAGLGLGIGAQTGLGVG
MUL_0579|M.ulcerans_Agy99           --LGLGFGAQTGLGAQTGLGIGAGFEGGFAGQAGAGLGLGIGAQTGLGVG
MAB_4284c|M.abscessus_ATCC_199      --TNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTN
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                AAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVPVDPEPGDDELAY
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG
Mvan_1264|M.vanbaalenii_PYR-1       ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG
MSMEG_0868|M.smegmatis_MC2_155      TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
Mb0348|M.bovis_AF2122/97            --------GGVGLGLGG---------------------------------
Rv0341|M.tuberculosis_H37Rv         --------GGVGLGLGG---------------------------------
MMAR_0614|M.marinum_M               LGGQTAVGGGLGLGLGGGLGGQAGLGLGGGFGGAGEFGLGGGFVSQAGFD
MUL_0579|M.ulcerans_Agy99           LGGQTAVGGGLGLGLGGGLGGQAGLGLGGGFGGAGEFGLGGGFVSQAGFD
MAB_4284c|M.abscessus_ATCC_199      TEIGSHNQANIG--------------------------------------
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                SAVGEEDAESPTVVIEKLFLP-----------------------------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ----------STGAVGG-------VGGKG----IQGGQG-----------
Mvan_1264|M.vanbaalenii_PYR-1       ----------ATGGAGG-------VGGKG----IQGGQG-----------
MSMEG_0868|M.smegmatis_MC2_155      SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
Mb0348|M.bovis_AF2122/97            --------------------------------------------------
Rv0341|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0614|M.marinum_M               AQLGAQAGATVGAGIGGNAGLDVGGALGGQAGLGLGGGFVSQAGFDGQLG
MUL_0579|M.ulcerans_Agy99           AQLGAQAGATVGAGIGGNAGLDVGGALGGQAGLGLGGGFVSQAGFDGQLG
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK
Mvan_1264|M.vanbaalenii_PYR-1       --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK
MSMEG_0868|M.smegmatis_MC2_155      KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV
Mb0348|M.bovis_AF2122/97            ---------QAGGVIGGSAAGAIG--------------------------
Rv0341|M.tuberculosis_H37Rv         ---------QAGGVIGGSAAGAIG--------------------------
MMAR_0614|M.marinum_M               GQAGVGVGGQAGGAVGGSAGGAIGGGFGGGAGVGGAVGGSAGGAIGGGFG
MUL_0579|M.ulcerans_Agy99           GQAGAGVGGQAGGAVGGSAGGAIGGGFGGGAGVG----------------
MAB_4284c|M.abscessus_ATCC_199      -----TSTSAGGSAAVGGNAGLAGN-------------------------
TH_3889|M.thermoresistible__bu      -----------GVVVGGDNDGDIVS-------------------------
MAV_4827|M.avium_104                ---EDSEPRRRPVLLVGSGLAVVGIS------------------------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GGNGGNGGRGGLFG---------------KGGNAGNGAD-----------
Mvan_1264|M.vanbaalenii_PYR-1       GGNGGNGGRGSLFG---------------RGGNAGNGGN-----------
MSMEG_0868|M.smegmatis_MC2_155      GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP
Mb0348|M.bovis_AF2122/97            --------------------------------------------------
Rv0341|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0614|M.marinum_M               GGAGVGGQAGGSAGGAIGGGFGGGAGVGGQAGLGLGGGFVSQAGFEGQLG
MUL_0579|M.ulcerans_Agy99           ----------------------------GQAGLGLGGGFVSQAGFDAQLG
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----------GGTGGAGGAGGTGG-TGGAGGTGG---------------
Mvan_1264|M.vanbaalenii_PYR-1       -----------GGTGGNGGNGGTGG-TGGNGGTGG---------------
MSMEG_0868|M.smegmatis_MC2_155      AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ
Mb0348|M.bovis_AF2122/97            --------AGVGGRLGG------NGQIG----------------------
Rv0341|M.tuberculosis_H37Rv         --------AGVGGRLGG------NGQIG----------------------
MMAR_0614|M.marinum_M               GQAGVGVGAGVGGQAGGAVGGSAGGAIGGGFGGGAGVG--------GQAG
MUL_0579|M.ulcerans_Agy99           AQAGVGVGAGVGGQAGGAVGGSAGGAIGGGFGGGAGVG--------GQAG
MAB_4284c|M.abscessus_ATCC_199      --------AGLAGNAGLAGNAGLAGNAGLAGNAG----------------
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                --------AVLALEIALAIGIRTTGTVALQPTPNQHLIVP----------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
Mvan_1264|M.vanbaalenii_PYR-1       --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
MSMEG_0868|M.smegmatis_MC2_155      TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG
Mb0348|M.bovis_AF2122/97            --------------------VAGQGAVGAG--VGAGVGGQAG--------
Rv0341|M.tuberculosis_H37Rv         --------------------VAGQGAVGAG--VGAGVGGQAG--------
MMAR_0614|M.marinum_M               AAVGGSAGGAVGAGAGFGSRVVGNGQVGAGGQVGGGIAGQAGGGIAGQAG
MUL_0579|M.ulcerans_Agy99           AAVGGSAGGAVGAGAGFGSRVVANGQVGAGGQVGGGIAGQAGGGIAGQAG
MAB_4284c|M.abscessus_ATCC_199      --LAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG
TH_3889|M.thermoresistible__bu      ----------------GDGAVLGDGNTTNNGDIWAGPGSNVAVGKGNDIE
MAV_4827|M.avium_104                --TEQAPAPPPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAP
MLBr_01214|M.leprae_Br4923          --------------------TVGFDASGLIQYAYAGAGLKLPRS------
                                                                         .            

Mflv_5091|M.gilvum_PYR-GCK          ---------------GTGGTGGAGGTG----GDGGTGGTGGTGGTG----
Mvan_1264|M.vanbaalenii_PYR-1       ---------------GTGGTGGDGGTG----GTGGTGGTGGTGGTG----
MSMEG_0868|M.smegmatis_MC2_155      ---------------GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYV
Mb0348|M.bovis_AF2122/97            --------------------------------------------------
Rv0341|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0614|M.marinum_M               --------------IASQAGLAGQAGLAGQAGIASQAGLAGQAGLAGQAG
MUL_0579|M.ulcerans_Agy99           GGIAGQAGLAGQAGIASQAGLAGQAGLAGQAGIASQAGLAGQAGIASQAG
MAB_4284c|M.abscessus_ATCC_199      --------------------------------LAGNAGLAGNAGLAGNAG
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQ
Mvan_1264|M.vanbaalenii_PYR-1       -----GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQ
MSMEG_0868|M.smegmatis_MC2_155      DPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGK
Mb0348|M.bovis_AF2122/97            ------IASQIGVSAG----------------------------GGLGGV
Rv0341|M.tuberculosis_H37Rv         ------IASQIGVSAG----------------------------GGLGGV
MMAR_0614|M.marinum_M               IASQAGIASQSGLAAGGSAGIASQAGLGIGGQAALGGQAGAAVGGGLAGV
MUL_0579|M.ulcerans_Agy99           IASQAGIASQAGLAAGGSAGIASQAGLGIGGQAALGGQAGAAVGGGLAGV
MAB_4284c|M.abscessus_ATCC_199      LAGNAGLAGNAGLAGNAG------------LAGNAGLAGNAAVAGNAAVA
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                -----PLPEAPPIPAAP---------------------------PVVPVP
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GGQGG-----------------TGGTGGQGG-LGGGGGTG----------
Mvan_1264|M.vanbaalenii_PYR-1       GGQGG-----------------TGGTGGQGG-LGGVGGTG----------
MSMEG_0868|M.smegmatis_MC2_155      GGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNV
Mb0348|M.bovis_AF2122/97            GNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGAAMPHLSG-------
Rv0341|M.tuberculosis_H37Rv         GNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGAAMPHLSG-------
MMAR_0614|M.marinum_M               GNVSGLTGIGGNASLG--ATGQAGLIASEGAALNGAATPHVSG-------
MUL_0579|M.ulcerans_Agy99           GNVSGLTGIGGNASLG--ATGQAGLIASEGAALNGAATPHVSG-------
MAB_4284c|M.abscessus_ATCC_199      GNAAVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGSVG------
TH_3889|M.thermoresistible__bu      -----------------------DNSKSAGGDLISDNDAPVLN-------
MAV_4827|M.avium_104                VVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVP------
MLBr_01214|M.leprae_Br4923          ----------------------SGEMYKVGQKVLPR--------------
                                                                    :                 

Mflv_5091|M.gilvum_PYR-GCK          -------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGA
Mvan_1264|M.vanbaalenii_PYR-1       -------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGA
MSMEG_0868|M.smegmatis_MC2_155      VQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGN
Mb0348|M.bovis_AF2122/97            -------------PLAGVGVGGQAGAAGGAGLGFGA--------------
Rv0341|M.tuberculosis_H37Rv         -------------PLAGVGVGGQAGAAGGAGLGFGA--------------
MMAR_0614|M.marinum_M               -------------PLGGVGVGGQAGAAGGAGLGLGAGSRGGILSGDSTTL
MUL_0579|M.ulcerans_Agy99           -------------PLGGVGVGGQAGAAGGAGLGLGAGSRGSILSGDSTTL
MAB_4284c|M.abscessus_ATCC_199      -------------GSTAVGGGAHTGVGGGVSTGVGVG-----------SH
TH_3889|M.thermoresistible__bu      -------------DVDTSGGNGGGAVGGGSLIGIGGG----------NAS
MAV_4827|M.avium_104                ---------QPPSPPQVGGTVPQSPPQHQTPPGEGTP---------PKPD
MLBr_01214|M.leprae_Br4923          --------------HARRGDLIFYGPEGTESVTLYLG-------------
                                                      *                               

Mflv_5091|M.gilvum_PYR-GCK          GGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGG
Mvan_1264|M.vanbaalenii_PYR-1       GGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGG
MSMEG_0868|M.smegmatis_MC2_155      GGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGG
Mb0348|M.bovis_AF2122/97            VGHPTPQ----PAALGAAG---VVAKTEAAAGVVGGVG------------
Rv0341|M.tuberculosis_H37Rv         VGHPTPQ----PAALGAAG---VVAKTEAAAGVVGGVG------------
MMAR_0614|M.marinum_M               GGHPNPQ----PAALGAAGGTGIGAHSGAGGGMAAGLGGSAAGGAGVGLG
MUL_0579|M.ulcerans_Agy99           GGHPNPQ----PAALGAAGGTGIGAHSGAGGGMAAGLGGSVAG-------
MAB_4284c|M.abscessus_ATCC_199      VGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVG------------
TH_3889|M.thermoresistible__bu      GGDGGSGG------------------------------------------
MAV_4827|M.avium_104                GPGNYGGGHVPTPGAGGSGGSGGGHVPTPGAGGSGGSGG-----------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          LFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGA
Mvan_1264|M.vanbaalenii_PYR-1       LFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGA
MSMEG_0868|M.smegmatis_MC2_155      NGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGT
Mb0348|M.bovis_AF2122/97            -------GATAAG-------------------------------------
Rv0341|M.tuberculosis_H37Rv         -------GATAAG-------------------------------------
MMAR_0614|M.marinum_M               GSAAGGAGAEAAGGFGGGTHIGGQAGLGGSAAGGAGTELGGTAGSPGAGM
MUL_0579|M.ulcerans_Agy99           -----GAGAEAAGGFGGGTQIGGQAGLGGSAAGGAGTELGGTAGSPGAGM
MAB_4284c|M.abscessus_ATCC_199      ------VGSHVGGGISES-----------------------------LGG
TH_3889|M.thermoresistible__bu      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01214|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          TG-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNG
Mvan_1264|M.vanbaalenii_PYR-1       TG-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNG
MSMEG_0868|M.smegmatis_MC2_155      TGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGG
Mb0348|M.bovis_AF2122/97            ---VGG----------------------------------AHGDILGHEG
Rv0341|M.tuberculosis_H37Rv         ---VGG----------------------------------AHGDILGHEG
MMAR_0614|M.marinum_M               GAGVGGGTHAGGQVGLGGGSTAGGQAGLGGGSSA--GGSVGHGDILGQEG
MUL_0579|M.ulcerans_Agy99           GAGVGGCTHAGGQVGLGGGSTAGGQAGLGGGSTA--GGSVGHGDILGQEG
MAB_4284c|M.abscessus_ATCC_199      SGSVGGSTAVGGGAHTGVGGGVNTGVG-------------VGSHVGGGIS
TH_3889|M.thermoresistible__bu      -----------------------------------------SIIIHDDRT
MAV_4827|M.avium_104                ----------------------------------------GHVPTPGTGG
MLBr_01214|M.leprae_Br4923          ------------------------------------------DEKMVEVG
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          A-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG---
Mvan_1264|M.vanbaalenii_PYR-1       A-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD---
MSMEG_0868|M.smegmatis_MC2_155      AGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGG--
Mb0348|M.bovis_AF2122/97            AALGSVDTVNAGVTPVEHGLVLPSG------PLIHGGTG-----------
Rv0341|M.tuberculosis_H37Rv         AALGSVDTVNAGVTPVEHGLVLPSG------PLIHGGTG-----------
MMAR_0614|M.marinum_M               TTLGGNGGVSGGIPPVEHGPTIPTGQ----GPVIQGGGGAGAGAGGQVSP
MUL_0579|M.ulcerans_Agy99           TTLGGNGGVSGGIPPVEHGPTIPTGQ----GPVIQGGGGAGAGAGGQVSP
MAB_4284c|M.abscessus_ATCC_199      ESLGGSGSVGGSTAVGGGAHTSAIN-------DALGGSG-----------
TH_3889|M.thermoresistible__bu      SLVGGNQYDVRGGGLGSGNVADSSTN------------------------
MAV_4827|M.avium_104                PGGTGGSGGGHVPTPGAGTPGGSGGG-----HLPFPGAG-----------
MLBr_01214|M.leprae_Br4923          EVVQVSPVRSNGMAPYLVRVLG----------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ---------INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE-
Mvan_1264|M.vanbaalenii_PYR-1       ---------INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE-
MSMEG_0868|M.smegmatis_MC2_155      ---------ASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEP
Mb0348|M.bovis_AF2122/97            ---------------GYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVT
Rv0341|M.tuberculosis_H37Rv         ---------------GYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVT
MMAR_0614|M.marinum_M               PSGNGPVIQSPGAGAGHGGANPPVINAPAPHVATPTPAHTPPVEHAPVVT
MUL_0579|M.ulcerans_Agy99           PSGNGPVIQSPGAGAGHGGANPPVINAPAPHVATPTPAHTPPVEHAPVVT
MAB_4284c|M.abscessus_ATCC_199      ---------------SVGG----------STAVGGGAHTSAINESMNSSI
TH_3889|M.thermoresistible__bu      ------------------------------VSTQVETNTKTSYDIEDNSS
MAV_4827|M.avium_104                ------------------------------STPGGSGGGHLPTPGAGTPG
MLBr_01214|M.leprae_Br4923          --------------------------------TQPTSVPQAPLQQVPTLP
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGD
Mvan_1264|M.vanbaalenii_PYR-1       -------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGD
MSMEG_0868|M.smegmatis_MC2_155      GPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGA
Mb0348|M.bovis_AF2122/97            QPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF
Rv0341|M.tuberculosis_H37Rv         QPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF
MMAR_0614|M.marinum_M               PQPHVPAEQPAHHEPPSPSVF--GHEPPVTHTPPVHVDPPSHGPVDPHGF
MUL_0579|M.ulcerans_Agy99           PQPHVPAEQPAHHEPPSPSVF--GHEPPVTHTPPVHVDPPSHGPVDPHGF
MAB_4284c|M.abscessus_ATCC_199      NASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH
TH_3889|M.thermoresistible__bu      SFDTNIGSNNDTSLASGNGFASGNTLDALTDIAPSSSTNTGVGLDAF---
MAV_4827|M.avium_104                GGLGGFGGGHAPAPGGGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGG
MLBr_01214|M.leprae_Br4923          APQQTPTHRAPLQHMP-----------LQVPVRPVPVSTAR---------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          SDD
Mvan_1264|M.vanbaalenii_PYR-1       SD-
MSMEG_0868|M.smegmatis_MC2_155      NNP
Mb0348|M.bovis_AF2122/97            ---
Rv0341|M.tuberculosis_H37Rv         ---
MMAR_0614|M.marinum_M               ---
MUL_0579|M.ulcerans_Agy99           ---
MAB_4284c|M.abscessus_ATCC_199      ---
TH_3889|M.thermoresistible__bu      ---
MAV_4827|M.avium_104                HK-
MLBr_01214|M.leprae_Br4923          ---