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MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISSVAANVVPGLNLGAGDPMSGLRQAVAA RHGFAQDVANVGFAGDAGAGVASVITTDVGAGLASGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGF TAVIEAEVGAQVGAGLGIGTGLGAQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRLGGNGQIGV AGQGAVGAGVGAGVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGAALNG AAMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAAAGVVGGVGGATAAGVG GAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGGTGGYGGMNPPVTDAPAPQVPARAQPMTT AAEHTPAVTQPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0348 | iniB | - | 100% (479) | isoniazid inductible gene protein INIB |
M. bovis AF2122 / 97 | Mb3538 | PE_PGRS54 | 6e-36 | 34.36% (358) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb3543 | PE_PGRS57 | 1e-33 | 36.04% (333) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5091 | - | 9e-31 | 33.86% (378) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv0341 | iniB | 0.0 | 100.00% (479) | isoniazid inductible gene protein INIB |
M. leprae Br4923 | MLBr_01214 | - | 3e-05 | 26.92% (156) | putative secreted p60-family protein |
M. abscessus ATCC 19977 | MAB_4284c | - | 3e-30 | 31.20% (391) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_0614 | iniB | 9e-78 | 43.86% (456) | membrane protein, IniB |
M. avium 104 | MAV_4827 | - | 2e-09 | 35.37% (147) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-22 | 29.63% (378) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3889 | - | 8e-19 | 31.16% (292) | PUTATIVE putative conserved hypothetical protein |
M. ulcerans Agy99 | MUL_0579 | iniB | 7e-76 | 43.14% (452) | membrane protein, IniB |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 4e-30 | 36.10% (349) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES Mb0348|M.bovis_AF2122/97 -------------------------------------------------- Rv0341|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0614|M.marinum_M -------------------------------------------------- MUL_0579|M.ulcerans_Agy99 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT Mb0348|M.bovis_AF2122/97 -------------------------------------------------- Rv0341|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0614|M.marinum_M -------------------------------------------------- MUL_0579|M.ulcerans_Agy99 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA Mb0348|M.bovis_AF2122/97 -----------------------------------MTSLIDYILSLFRSE Rv0341|M.tuberculosis_H37Rv -----------------------------------MTSLIDYILSLFRSE MMAR_0614|M.marinum_M ---------------------------------MKMTSLVDYILSLFRSE MUL_0579|M.ulcerans_Agy99 -----------------------------------MTSLVDYILSLFRSE MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP TH_3889|M.thermoresistible__bu -----------------------------------MLTLIDFILDLFRSP MAV_4827|M.avium_104 -------------------------------------MNIVLGVSMAPSS MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP Mb0348|M.bovis_AF2122/97 -----------------------------------------DAARSFVAA Rv0341|M.tuberculosis_H37Rv -----------------------------------------DAARSFVAA MMAR_0614|M.marinum_M -----------------------------------------DAARSFVAS MUL_0579|M.ulcerans_Agy99 -----------------------------------------DAARSFVAS MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------VEAASYVAD TH_3889|M.thermoresistible__bu -----------------------------------------ALAARFIAD MAV_4827|M.avium_104 -------------------------------------IQMVVLEGEYADG MLBr_01214|M.leprae_Br4923 ------------------------------------------MNRIYTFV Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA Mb0348|M.bovis_AF2122/97 P---------------------GRAMTSAG----------LIDIAPHQIS Rv0341|M.tuberculosis_H37Rv P---------------------GRAMTSAG----------LIDIAPHQIS MMAR_0614|M.marinum_M P---------------------GQAMTNAG----------LVNVSPVEIS MUL_0579|M.ulcerans_Agy99 S---------------------GQAMTNAG----------LVNVSPVEIS MAB_4284c|M.abscessus_ATCC_199 P---------------------EAALANAG--------LSAVSAAQVGAV TH_3889|M.thermoresistible__bu P---------------------ENTMRDAG---------LQNVTAAQLQS MAV_4827|M.avium_104 AT------------------VEEDAIDVTG----------ADDAATASAP MLBr_01214|M.leprae_Br4923 T----------------------------G--------------LAMLVT . * Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG Mb0348|M.bovis_AF2122/97 SVAANVVPGLNLGAGDPMSGLRQAVAARHGFAQD---------------- Rv0341|M.tuberculosis_H37Rv SVAANVVPGLNLGAGDPMSGLRQAVAARHGFAQD---------------- MMAR_0614|M.marinum_M SAAANALPFLNLGAGDPIGGLQQAVADQYGLAPASEVGAASSYVAQDAGA MUL_0579|M.ulcerans_Agy99 SAAANALPFLNLGAGDPIGGLQQAVADQYGLAPASEVGTASSYVAQDAGA MAB_4284c|M.abscessus_ATCC_199 MPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSL TH_3889|M.thermoresistible__bu VAASAAPAGVLLGGGDPVVGLQRAVADHHNIASP---------------- MAV_4827|M.avium_104 DRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR-------DALAA MLBr_01214|M.leprae_Br4923 SILTCSLAYADSGTRTADYQQTIDTVVQRALAQR---------------- * Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG Mb0348|M.bovis_AF2122/97 ----------------VANVGFAG-DAGAGVASVITTDVGAGLAS----G Rv0341|M.tuberculosis_H37Rv ----------------VANVGFAG-DAGAGVASVITTDVGAGLAS----G MMAR_0614|M.marinum_M VVAQDAAAVVSDAGVAAADAGFAGADIGASVANVVAADIGAGLASGLTSG MUL_0579|M.ulcerans_Agy99 VVAQDAAAVVSDAGVAAADAGFAGADIGASVANVVAADIGAGLASGLTSG MAB_4284c|M.abscessus_ATCC_199 LSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGD TH_3889|M.thermoresistible__bu ----------------FSPQTSVGWQPTFAPETEVASRNHIQPEVFS--- MAV_4827|M.avium_104 RRIDNVMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSD MLBr_01214|M.leprae_Br4923 --------------------------------GVPFSWAGGGVSG----- Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT Mb0348|M.bovis_AF2122/97 LGAGFLGQG-------------GLALAASSGGFGG--------------Q Rv0341|M.tuberculosis_H37Rv LGAGFLGQG-------------GLALAASSGGFGG--------------Q MMAR_0614|M.marinum_M LGAGLWSQSGLGWQTGVGGVVPGLAYTQATGDFGG--------------Q MUL_0579|M.ulcerans_Agy99 LGAGLWSQSGLGWQTGVGGVVPGLAYTQATGDFGG--------------Q MAB_4284c|M.abscessus_ATCC_199 LQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNG------------D TH_3889|M.thermoresistible__bu ----------------------PDQSAGANAQTGG--------------- MAV_4827|M.avium_104 GSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPG-------GLLLV MLBr_01214|M.leprae_Br4923 -------------------------PTRGTGTGSN--------------- . . Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------ Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------ MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH Mb0348|M.bovis_AF2122/97 VGLAAQVGLG--------FTAVIEAEVGAQVGAG---------------- Rv0341|M.tuberculosis_H37Rv VGLAAQVGLG--------FTAVIEAEVGAQVGAG---------------- MMAR_0614|M.marinum_M VGLASQVGLG--------FGAGIQAGFGAQASAG---------------- MUL_0579|M.ulcerans_Agy99 VGLASQVGLG--------FGAGIQAGFGAQASAG---------------- MAB_4284c|M.abscessus_ATCC_199 VRDSNIINADHG------SNVGVDQSQTRVGGDY---------------- TH_3889|M.thermoresistible__bu ----FNLGFG---------DITLGDKTTNTATNG---------------- MAV_4827|M.avium_104 GSGVDVAPLKQVLQTTTFLDVSVAEEPETALARG-------------AAL MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG Mvan_1264|M.vanbaalenii_PYR-1 -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS Mb0348|M.bovis_AF2122/97 --LGIG----TGLGAQAGMGFG---------------------------- Rv0341|M.tuberculosis_H37Rv --LGIG----TGLGAQAGMGFG---------------------------- MMAR_0614|M.marinum_M --LGLGFGAQTGLGAQTGLGIGAGFEGGFAGQAGAGLGLGIGAQTGLGVG MUL_0579|M.ulcerans_Agy99 --LGLGFGAQTGLGAQTGLGIGAGFEGGFAGQAGAGLGLGIGAQTGLGVG MAB_4284c|M.abscessus_ATCC_199 --TNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTN TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 AAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVPVDPEPGDDELAY MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG Mvan_1264|M.vanbaalenii_PYR-1 ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY Mb0348|M.bovis_AF2122/97 --------GGVGLGLGG--------------------------------- Rv0341|M.tuberculosis_H37Rv --------GGVGLGLGG--------------------------------- MMAR_0614|M.marinum_M LGGQTAVGGGLGLGLGGGLGGQAGLGLGGGFGGAGEFGLGGGFVSQAGFD MUL_0579|M.ulcerans_Agy99 LGGQTAVGGGLGLGLGGGLGGQAGLGLGGGFGGAGEFGLGGGFVSQAGFD MAB_4284c|M.abscessus_ATCC_199 TEIGSHNQANIG-------------------------------------- TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 SAVGEEDAESPTVVIEKLFLP----------------------------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------STGAVGG-------VGGKG----IQGGQG----------- Mvan_1264|M.vanbaalenii_PYR-1 ----------ATGGAGG-------VGGKG----IQGGQG----------- MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA Mb0348|M.bovis_AF2122/97 -------------------------------------------------- Rv0341|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0614|M.marinum_M AQLGAQAGATVGAGIGGNAGLDVGGALGGQAGLGLGGGFVSQAGFDGQLG MUL_0579|M.ulcerans_Agy99 AQLGAQAGATVGAGIGGNAGLDVGGALGGQAGLGLGGGFVSQAGFDGQLG MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV Mb0348|M.bovis_AF2122/97 ---------QAGGVIGGSAAGAIG-------------------------- Rv0341|M.tuberculosis_H37Rv ---------QAGGVIGGSAAGAIG-------------------------- MMAR_0614|M.marinum_M GQAGVGVGGQAGGAVGGSAGGAIGGGFGGGAGVGGAVGGSAGGAIGGGFG MUL_0579|M.ulcerans_Agy99 GQAGAGVGGQAGGAVGGSAGGAIGGGFGGGAGVG---------------- MAB_4284c|M.abscessus_ATCC_199 -----TSTSAGGSAAVGGNAGLAGN------------------------- TH_3889|M.thermoresistible__bu -----------GVVVGGDNDGDIVS------------------------- MAV_4827|M.avium_104 ---EDSEPRRRPVLLVGSGLAVVGIS------------------------ MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD----------- Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN----------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP Mb0348|M.bovis_AF2122/97 -------------------------------------------------- Rv0341|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0614|M.marinum_M GGAGVGGQAGGSAGGAIGGGFGGGAGVGGQAGLGLGGGFVSQAGFEGQLG MUL_0579|M.ulcerans_Agy99 ----------------------------GQAGLGLGGGFVSQAGFDAQLG MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG--------------- MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ Mb0348|M.bovis_AF2122/97 --------AGVGGRLGG------NGQIG---------------------- Rv0341|M.tuberculosis_H37Rv --------AGVGGRLGG------NGQIG---------------------- MMAR_0614|M.marinum_M GQAGVGVGAGVGGQAGGAVGGSAGGAIGGGFGGGAGVG--------GQAG MUL_0579|M.ulcerans_Agy99 AQAGVGVGAGVGGQAGGAVGGSAGGAIGGGFGGGAGVG--------GQAG MAB_4284c|M.abscessus_ATCC_199 --------AGLAGNAGLAGNAGLAGNAGLAGNAG---------------- TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 --------AVLALEIALAIGIRTTGTVALQPTPNQHLIVP---------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG Mb0348|M.bovis_AF2122/97 --------------------VAGQGAVGAG--VGAGVGGQAG-------- Rv0341|M.tuberculosis_H37Rv --------------------VAGQGAVGAG--VGAGVGGQAG-------- MMAR_0614|M.marinum_M AAVGGSAGGAVGAGAGFGSRVVGNGQVGAGGQVGGGIAGQAGGGIAGQAG MUL_0579|M.ulcerans_Agy99 AAVGGSAGGAVGAGAGFGSRVVANGQVGAGGQVGGGIAGQAGGGIAGQAG MAB_4284c|M.abscessus_ATCC_199 --LAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG TH_3889|M.thermoresistible__bu ----------------GDGAVLGDGNTTNNGDIWAGPGSNVAVGKGNDIE MAV_4827|M.avium_104 --TEQAPAPPPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAP MLBr_01214|M.leprae_Br4923 --------------------TVGFDASGLIQYAYAGAGLKLPRS------ . Mflv_5091|M.gilvum_PYR-GCK ---------------GTGGTGGAGGTG----GDGGTGGTGGTGGTG---- Mvan_1264|M.vanbaalenii_PYR-1 ---------------GTGGTGGDGGTG----GTGGTGGTGGTGGTG---- MSMEG_0868|M.smegmatis_MC2_155 ---------------GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYV Mb0348|M.bovis_AF2122/97 -------------------------------------------------- Rv0341|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0614|M.marinum_M --------------IASQAGLAGQAGLAGQAGIASQAGLAGQAGLAGQAG MUL_0579|M.ulcerans_Agy99 GGIAGQAGLAGQAGIASQAGLAGQAGLAGQAGIASQAGLAGQAGIASQAG MAB_4284c|M.abscessus_ATCC_199 --------------------------------LAGNAGLAGNAGLAGNAG TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -----GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQ Mvan_1264|M.vanbaalenii_PYR-1 -----GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQ MSMEG_0868|M.smegmatis_MC2_155 DPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGK Mb0348|M.bovis_AF2122/97 ------IASQIGVSAG----------------------------GGLGGV Rv0341|M.tuberculosis_H37Rv ------IASQIGVSAG----------------------------GGLGGV MMAR_0614|M.marinum_M IASQAGIASQSGLAAGGSAGIASQAGLGIGGQAALGGQAGAAVGGGLAGV MUL_0579|M.ulcerans_Agy99 IASQAGIASQAGLAAGGSAGIASQAGLGIGGQAALGGQAGAAVGGGLAGV MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAG------------LAGNAGLAGNAAVAGNAAVA TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -----PLPEAPPIPAAP---------------------------PVVPVP MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGQGG-----------------TGGTGGQGG-LGGGGGTG---------- Mvan_1264|M.vanbaalenii_PYR-1 GGQGG-----------------TGGTGGQGG-LGGVGGTG---------- MSMEG_0868|M.smegmatis_MC2_155 GGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNV Mb0348|M.bovis_AF2122/97 GNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGAAMPHLSG------- Rv0341|M.tuberculosis_H37Rv GNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGAAMPHLSG------- MMAR_0614|M.marinum_M GNVSGLTGIGGNASLG--ATGQAGLIASEGAALNGAATPHVSG------- MUL_0579|M.ulcerans_Agy99 GNVSGLTGIGGNASLG--ATGQAGLIASEGAALNGAATPHVSG------- MAB_4284c|M.abscessus_ATCC_199 GNAAVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGSVG------ TH_3889|M.thermoresistible__bu -----------------------DNSKSAGGDLISDNDAPVLN------- MAV_4827|M.avium_104 VVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVP------ MLBr_01214|M.leprae_Br4923 ----------------------SGEMYKVGQKVLPR-------------- : Mflv_5091|M.gilvum_PYR-GCK -------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGA Mvan_1264|M.vanbaalenii_PYR-1 -------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGA MSMEG_0868|M.smegmatis_MC2_155 VQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGN Mb0348|M.bovis_AF2122/97 -------------PLAGVGVGGQAGAAGGAGLGFGA-------------- Rv0341|M.tuberculosis_H37Rv -------------PLAGVGVGGQAGAAGGAGLGFGA-------------- MMAR_0614|M.marinum_M -------------PLGGVGVGGQAGAAGGAGLGLGAGSRGGILSGDSTTL MUL_0579|M.ulcerans_Agy99 -------------PLGGVGVGGQAGAAGGAGLGLGAGSRGSILSGDSTTL MAB_4284c|M.abscessus_ATCC_199 -------------GSTAVGGGAHTGVGGGVSTGVGVG-----------SH TH_3889|M.thermoresistible__bu -------------DVDTSGGNGGGAVGGGSLIGIGGG----------NAS MAV_4827|M.avium_104 ---------QPPSPPQVGGTVPQSPPQHQTPPGEGTP---------PKPD MLBr_01214|M.leprae_Br4923 --------------HARRGDLIFYGPEGTESVTLYLG------------- * Mflv_5091|M.gilvum_PYR-GCK GGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGG Mvan_1264|M.vanbaalenii_PYR-1 GGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGG MSMEG_0868|M.smegmatis_MC2_155 GGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGG Mb0348|M.bovis_AF2122/97 VGHPTPQ----PAALGAAG---VVAKTEAAAGVVGGVG------------ Rv0341|M.tuberculosis_H37Rv VGHPTPQ----PAALGAAG---VVAKTEAAAGVVGGVG------------ MMAR_0614|M.marinum_M GGHPNPQ----PAALGAAGGTGIGAHSGAGGGMAAGLGGSAAGGAGVGLG MUL_0579|M.ulcerans_Agy99 GGHPNPQ----PAALGAAGGTGIGAHSGAGGGMAAGLGGSVAG------- MAB_4284c|M.abscessus_ATCC_199 VGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVG------------ TH_3889|M.thermoresistible__bu GGDGGSGG------------------------------------------ MAV_4827|M.avium_104 GPGNYGGGHVPTPGAGGSGGSGGGHVPTPGAGGSGGSGG----------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK LFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGA Mvan_1264|M.vanbaalenii_PYR-1 LFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGA MSMEG_0868|M.smegmatis_MC2_155 NGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGT Mb0348|M.bovis_AF2122/97 -------GATAAG------------------------------------- Rv0341|M.tuberculosis_H37Rv -------GATAAG------------------------------------- MMAR_0614|M.marinum_M GSAAGGAGAEAAGGFGGGTHIGGQAGLGGSAAGGAGTELGGTAGSPGAGM MUL_0579|M.ulcerans_Agy99 -----GAGAEAAGGFGGGTQIGGQAGLGGSAAGGAGTELGGTAGSPGAGM MAB_4284c|M.abscessus_ATCC_199 ------VGSHVGGGISES-----------------------------LGG TH_3889|M.thermoresistible__bu -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01214|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK TG-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNG Mvan_1264|M.vanbaalenii_PYR-1 TG-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNG MSMEG_0868|M.smegmatis_MC2_155 TGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGG Mb0348|M.bovis_AF2122/97 ---VGG----------------------------------AHGDILGHEG Rv0341|M.tuberculosis_H37Rv ---VGG----------------------------------AHGDILGHEG MMAR_0614|M.marinum_M GAGVGGGTHAGGQVGLGGGSTAGGQAGLGGGSSA--GGSVGHGDILGQEG MUL_0579|M.ulcerans_Agy99 GAGVGGCTHAGGQVGLGGGSTAGGQAGLGGGSTA--GGSVGHGDILGQEG MAB_4284c|M.abscessus_ATCC_199 SGSVGGSTAVGGGAHTGVGGGVNTGVG-------------VGSHVGGGIS TH_3889|M.thermoresistible__bu -----------------------------------------SIIIHDDRT MAV_4827|M.avium_104 ----------------------------------------GHVPTPGTGG MLBr_01214|M.leprae_Br4923 ------------------------------------------DEKMVEVG Mflv_5091|M.gilvum_PYR-GCK A-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG--- Mvan_1264|M.vanbaalenii_PYR-1 A-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD--- MSMEG_0868|M.smegmatis_MC2_155 AGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGG-- Mb0348|M.bovis_AF2122/97 AALGSVDTVNAGVTPVEHGLVLPSG------PLIHGGTG----------- Rv0341|M.tuberculosis_H37Rv AALGSVDTVNAGVTPVEHGLVLPSG------PLIHGGTG----------- MMAR_0614|M.marinum_M TTLGGNGGVSGGIPPVEHGPTIPTGQ----GPVIQGGGGAGAGAGGQVSP MUL_0579|M.ulcerans_Agy99 TTLGGNGGVSGGIPPVEHGPTIPTGQ----GPVIQGGGGAGAGAGGQVSP MAB_4284c|M.abscessus_ATCC_199 ESLGGSGSVGGSTAVGGGAHTSAIN-------DALGGSG----------- TH_3889|M.thermoresistible__bu SLVGGNQYDVRGGGLGSGNVADSSTN------------------------ MAV_4827|M.avium_104 PGGTGGSGGGHVPTPGAGTPGGSGGG-----HLPFPGAG----------- MLBr_01214|M.leprae_Br4923 EVVQVSPVRSNGMAPYLVRVLG---------------------------- Mflv_5091|M.gilvum_PYR-GCK ---------INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE- Mvan_1264|M.vanbaalenii_PYR-1 ---------INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE- MSMEG_0868|M.smegmatis_MC2_155 ---------ASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEP Mb0348|M.bovis_AF2122/97 ---------------GYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVT Rv0341|M.tuberculosis_H37Rv ---------------GYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVT MMAR_0614|M.marinum_M PSGNGPVIQSPGAGAGHGGANPPVINAPAPHVATPTPAHTPPVEHAPVVT MUL_0579|M.ulcerans_Agy99 PSGNGPVIQSPGAGAGHGGANPPVINAPAPHVATPTPAHTPPVEHAPVVT MAB_4284c|M.abscessus_ATCC_199 ---------------SVGG----------STAVGGGAHTSAINESMNSSI TH_3889|M.thermoresistible__bu ------------------------------VSTQVETNTKTSYDIEDNSS MAV_4827|M.avium_104 ------------------------------STPGGSGGGHLPTPGAGTPG MLBr_01214|M.leprae_Br4923 --------------------------------TQPTSVPQAPLQQVPTLP Mflv_5091|M.gilvum_PYR-GCK -------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGD Mvan_1264|M.vanbaalenii_PYR-1 -------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGD MSMEG_0868|M.smegmatis_MC2_155 GPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGA Mb0348|M.bovis_AF2122/97 QPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF Rv0341|M.tuberculosis_H37Rv QPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF MMAR_0614|M.marinum_M PQPHVPAEQPAHHEPPSPSVF--GHEPPVTHTPPVHVDPPSHGPVDPHGF MUL_0579|M.ulcerans_Agy99 PQPHVPAEQPAHHEPPSPSVF--GHEPPVTHTPPVHVDPPSHGPVDPHGF MAB_4284c|M.abscessus_ATCC_199 NASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH TH_3889|M.thermoresistible__bu SFDTNIGSNNDTSLASGNGFASGNTLDALTDIAPSSSTNTGVGLDAF--- MAV_4827|M.avium_104 GGLGGFGGGHAPAPGGGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGG MLBr_01214|M.leprae_Br4923 APQQTPTHRAPLQHMP-----------LQVPVRPVPVSTAR--------- Mflv_5091|M.gilvum_PYR-GCK SDD Mvan_1264|M.vanbaalenii_PYR-1 SD- MSMEG_0868|M.smegmatis_MC2_155 NNP Mb0348|M.bovis_AF2122/97 --- Rv0341|M.tuberculosis_H37Rv --- MMAR_0614|M.marinum_M --- MUL_0579|M.ulcerans_Agy99 --- MAB_4284c|M.abscessus_ATCC_199 --- TH_3889|M.thermoresistible__bu --- MAV_4827|M.avium_104 HK- MLBr_01214|M.leprae_Br4923 ---