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GDRSKPPSGSPGADFGPGGAFHAAGRCTAEADAAFDQARRRFEEAWNRQNGEHPINDSAEVQRVAQSLGA QSLELPKIGVDLENIAAALAEVQRSSSGKIAGLEGQLRQLDDEIGQAVMLERNHQLTAEDKAALDAFMHA CEDDAIRDTQAALAELNSIRDGYSNFLRTAEKSLAVDGFDPARIWGADNHEPESAEQAEQDVHDALAGDQ GAAGRVNAVLGSITPDQLAGKVPLTAEQASVLSQLQAQEHGMSVEALAAAEQRLGAQRGMIADSWQLMSN PNMSFPKTPLTVGAKQGSDTVKGGVTQLPESVQQALNSPGALFTHQMNDIAGIVKDGDKGFQPNTELDRA MIHKASVMMDTPIWHADPASQGQDVERDPVLDPAVSNVLSAVSPDHQVVHDTITGADHDKFLENITHHYW KDNGQGVGSLFSWTGDPAVVQGPQEGIAADTAHAYSSYIGNNQQELLHLPGNHTLGQVNPNLVRDMAHGL GPYVNNIAETSGGLPGFGDPLDGKTLSGALPVAKGVFSVLSSDNEAAQYFNGQAYAQAVLHEGAFAADPT HSGYNQHLYDAATLRALVDVGAHNGFQANEDNGYHQDVSEYQSKKSAYETGLQGLTAAGGFVPGVGRIAG PTIGVLGQNLENGILGPAPTAPTENPIQPMSLGMADQEILNAMLGTGHTVTGLPPGYILYDDDHPNGRIA TLEELEPQGVTPGQYSNVIGPALSQSLEPRPPSESLSPDAALVSRYDDIVGVPHPDQGRK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2305 | - | - | 100% (761) | hypothetical protein MUL_2305 |
| M. ulcerans Agy99 | MUL_5057 | - | 2e-50 | 42.48% (266) | hypothetical protein MUL_5057 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2105 | - | 1e-54 | 57.92% (183) | hypothetical protein Mb2105 |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2079 | - | 2e-53 | 57.38% (183) | hypothetical protein Rv2079 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1285c | - | 2e-68 | 35.16% (566) | hypothetical protein MAB_1285c |
| M. marinum M | MMAR_3061 | - | 0.0 | 95.48% (753) | hypothetical protein MMAR_3061 |
| M. avium 104 | MAV_1467 | - | 2e-52 | 61.45% (166) | hypothetical protein MAV_1467 |
| M. smegmatis MC2 155 | MSMEG_5089 | - | 1e-91 | 37.46% (582) | hypothetical protein MSMEG_5089 |
| M. thermoresistible (build 8) | TH_3653 | - | 5e-15 | 45.35% (86) | PUTATIVE - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2305|M.ulcerans_Agy99 ---------------MGD----RSKPPSGSPGADFGPGGAFHAAGRCTAE
MMAR_3061|M.marinum_M MQLRYIGIPLLIAEAGGDPWAIDQSLQAGRPAQISDLGAAFHAAGRCTAE
TH_3653|M.thermoresistible__bu --------------------------------------------------
Mb2105|M.bovis_AF2122/97 MQLRHINIRALIAEAGGDPWAIEHSLHAGRPAQIAELAEAFHAAGRCTAE
Rv2079|M.tuberculosis_H37Rv MQLRHINIRALIAEAGGDPWAIEHSLHAGRPAQIAELAEAFHAAGRYTAE
MAV_1467|M.avium_104 -------------------------------MQISNLANAFHAAGRSTAE
MSMEG_5089|M.smegmatis_MC2_155 -----------MGALDGFYSTWNKARETFGQGAPTDGSQFDQSRSLTQMK
MAB_1285c|M.abscessus_ATCC_199 ------------------------------------MGMTLAELQEWPPH
MUL_2305|M.ulcerans_Agy99 ADAAFDQARRRFEEAWNRQNGEHPINDSAEVQRVAQSLGAQSLELPKIGV
MMAR_3061|M.marinum_M ADAAFDQARRRFEEAWNRQNSERPINDSAEVQRVAQSLGAQSLELPKIGV
TH_3653|M.thermoresistible__bu --------------------------------------------------
Mb2105|M.bovis_AF2122/97 ANAAFEEARRRFEASWNRENGEHPINDSAEVQRVTAALGVQSLQLPKIGV
Rv2079|M.tuberculosis_H37Rv ANAAFEEARRRFEASWNRENGEHPINDSAEVQRVTAALGVQSLQLPKIGV
MAV_1467|M.avium_104 ADTTFAQARSRFDAAWNHQDGDHPINDSAEVERVTKSLGAQSVQLPKIGA
MSMEG_5089|M.smegmatis_MC2_155 ASVEAAAPDDRWQGSGANAYAAANKEHAQVYQKLADLDQKMAAEVKNAAN
MAB_1285c|M.abscessus_ATCC_199 IKALADAASKRGDASQQAADKVQAIVDMSTWQGDAGEAARDAMKRSAARF
MUL_2305|M.ulcerans_Agy99 DLENIAAALAEVQRSSSGKIAGLEGQLRQLDDEIGQAVMLER-NHQLTAE
MMAR_3061|M.marinum_M DLENIAAALAEVQRSSSGKIAGLEGQLRQLDDEIGQAVMLER-NHQLTAE
TH_3653|M.thermoresistible__bu --------------------------------------------------
Mb2105|M.bovis_AF2122/97 DLENIAADLAEAQRAAAGRIATLESQLQRIDDQLDQALELEH-DPRLAAA
Rv2079|M.tuberculosis_H37Rv DLENIAADLAEAQRAAAGRIATLESQLQRIDDQLDQALELEH-DPRLAAA
MAV_1467|M.avium_104 DLENIAASLAEAQKAAAGQIGTLEAQLKGLDEMIAEAVEIETTHPELSAA
MSMEG_5089|M.smegmatis_MC2_155 VVSAGRTNLDNAKSWVEGMANSLPATSQQDRERKLIPIAREGINRVDNIV
MAB_1285c|M.abscessus_ATCC_199 DNAGFEALYVAMHANKAYGESQTLADDIGAFLAYAAAPPKVDINPKTNAV
MUL_2305|M.ulcerans_Agy99 DKAALDAFMHACEDDAIR---DTQAALAELNSIRDGYSNFLRTAEKS-LA
MMAR_3061|M.marinum_M DKAALDAFMHACEDDAIR---DTQAALAELNSIRDGYSNFLRTAEKS-LA
TH_3653|M.thermoresistible__bu --------------------------------------------------
Mb2105|M.bovis_AF2122/97 ERSELDALITCLEQDAID---DTASALGQLQSIRAGYSDHLQQSLAM-LR
Rv2079|M.tuberculosis_H37Rv ERSELDALITCLEQDAID---DTASALGQLQSIRAGYSDHLQQSLAM-LR
MAV_1467|M.avium_104 DRDALNGYITSLEDDAIR---DTKAALAQLQATRDGYSNTLQKALGN-LK
MSMEG_5089|M.smegmatis_MC2_155 KSATADMMGIKGNVEKLRGEYDTIKTTMRFGPESEKKPGDKKDDAQM-LG
MAB_1285c|M.abscessus_ATCC_199 TPPDISGLNKEQLQKVIDKLKDLQQRVTGLVARGEMLDDSLARVLDEGTG
MUL_2305|M.ulcerans_Agy99 VDGFDPARIWGADNHEPESAEQAEQDVHDALAGDQGAAGRVNAVLGSITP
MMAR_3061|M.marinum_M VDGLDPARIWGADNHEPESAEQAEQDVHDALAGDQGAAGRVNAVLGSITP
TH_3653|M.thermoresistible__bu --------------------------------------------------
Mb2105|M.bovis_AF2122/97 ADGYDGAGLQGLDAPQSPVKLEEPIQIPPPGTGAPEVHRWWTSLTSEERQ
Rv2079|M.tuberculosis_H37Rv ADGYDGAGLQGLDAPQSPVKPEEPIQIPPPGTGAPEVHRWWTSLTSEERQ
MAV_1467|M.avium_104 SDGYDPAGIRAQEGPLSPA--------PPLPDDPTQFTQVWNSLTQEQKD
MSMEG_5089|M.smegmatis_MC2_155 NEEKDDDGIPEMHAPSTEDQARMDVEQVLSE-GDGGAAERVDEVLSSIKP
MAB_1285c|M.abscessus_ATCC_199 GHTMAQKQIAEGTPEQAERDVHDVLAGTATEEQKARVQAASILSPEQIAD
MUL_2305|M.ulcerans_Agy99 DQLAGKVPLTAEQASVLSQLQAQEHGMSVEALAAAEQRLGAQRGMIADSW
MMAR_3061|M.marinum_M DQLAGKVPLTAEQASVLSQLQAQEHGMSVGALTATEQRLGAQRAMIADSW
TH_3653|M.thermoresistible__bu --------------------------------------------------
Mb2105|M.bovis_AF2122/97 RLIAEHPEQIGNLNGVPVSARSDAN---IAVMTRDLNRVRDIATRYRTSV
Rv2079|M.tuberculosis_H37Rv RLIAEHPEQIGNLNGVPVSARSDAN---IAVMTRDLNRVRDIATRYRTSV
MAV_1467|M.avium_104 AEYARD-HFIGNHPGMPFPDRDHYN---RMHLPELQNANQADLDRLRAAH
MSMEG_5089|M.smegmatis_MC2_155 -----GDELTPQQDAYLSEMQRQQKGMSVEDLRAAEQRLGDHKNVIADSW
MAB_1285c|M.abscessus_ATCC_199 RDAGRPVQLTRPQQQVLGQLQAQMNGMSVEDIHRAEQRLGNNKSIIGNAL
MUL_2305|M.ulcerans_Agy99 QLMSNPNMSFPKTPLTVG---AKQGSDTVKGGVTQLPESVQQALNSPGAL
MMAR_3061|M.marinum_M QLMSNPNISFPKTPLTVG---AKQGSDTVKGGVTQLPESVQQALNSPGVL
TH_3653|M.thermoresistible__bu --------------------------------------------------
Mb2105|M.bovis_AF2122/97 DDVLGDPAKYGLSAGDIT---RYRNADETKKGLD--HNARNDPRNPSPVY
Rv2079|M.tuberculosis_H37Rv DDVLGDPAKYGLSAGDIT---RYRNADETKKGLD--HNARNDPRNPSPVY
MAV_1467|M.avium_104 PDWANGKTPFLKTNEYLD---WRRQWDAANRARDGYSKVKNEMGPPPDKV
MSMEG_5089|M.smegmatis_MC2_155 QLMSNDDVEYSAGAGDDKKGAASQLPDSVQKALTNAGDTWPIGDGIGQLR
MAB_1285c|M.abscessus_ATCC_199 QMMGSNQYGYAKTELRPG--AQGSTTELTTGGYDKLPTSVQEALNDKSPG
MUL_2305|M.ulcerans_Agy99 F-------------------THQMNDIAGIVKDGDKGFQPNTELDRAMIH
MMAR_3061|M.marinum_M F-------------------THQMNDIAGVVKDGDRGFQTNTELDRAMIH
TH_3653|M.thermoresistible__bu -----------------------MKDISAIVRDGDPELQTGTQVDRHMID
Mb2105|M.bovis_AF2122/97 L-------------------FAYDPMAFG-----GKGRAAIAIGNPDTAK
Rv2079|M.tuberculosis_H37Rv L-------------------FAYDPMAFG-----GKGRAAIAIGNPDTAK
MAV_1467|M.avium_104 Q-------------------PGEIPKYLGII--DDKGHAAVSLNNPDTAK
MSMEG_5089|M.smegmatis_MC2_155 Y-------------------EGDLKAISEIVKDGNPGFQTGTELDRQLIV
MAB_1285c|M.abscessus_ATCC_199 FSYVSQGPGQGTAPITQGSTLGNLDRLSDVIKDGDPGFQNGTELDRRLMQ
. : :
MUL_2305|M.ulcerans_Agy99 KASVMMDTPIWHADPASQGQDVE-RDPVLDPAVSNVLSAVSPDHQVVHDT
MMAR_3061|M.marinum_M KASVMMDTPIWHADPASQGQDVE-RDPALDPAVSNVLSAVSPDHQVVHDT
TH_3653|M.thermoresistible__bu KADRMMDAPIWEKDPASNGGSLDQRDPYLDGVVSDIFTSAGRDHIAVGEH
Mb2105|M.bovis_AF2122/97 HTAVIVPGTSSSVKGGWLHDNHD-DALNLFNQAKAADPNNP---TAVIAW
Rv2079|M.tuberculosis_H37Rv HTAVIVPGTSSSVKGGWLHDNHD-DALNLFNQAKAADPNNP---TAVIAW
MAV_1467|M.avium_104 RNATFVPGTGQDLTR--FDASAD-KSRAMLQATMNADKSLQPGDVSVTTW
MSMEG_5089|M.smegmatis_MC2_155 AADKAMDAR-----DIPGGQILG-----RESTVQSLFEAVDDDHQIINDH
MAB_1285c|M.abscessus_ATCC_199 RGADILHFE---------NQNHDSHEGAADSTIQNIFSSAGRDHIVDHDM
:
MUL_2305|M.ulcerans_Agy99 ITGA---DHDKFLENITHHYWKDNGQGVGSLFSWTGDPAVVQGPQEGIAA
MMAR_3061|M.marinum_M ITGA---DHDKFLKNITHHYWKDNGQGVGSLFSWTGDPAVVQGPEEGIAA
TH_3653|M.thermoresistible__bu LLSE---KGDDFQG------------------------------------
Mb2105|M.bovis_AF2122/97 MGYD---APNDFTDPRIATPMLARIGGAALAEDVNGLWVTHLGVGQN---
Rv2079|M.tuberculosis_H37Rv MGYD---APNDFTDPRIATPMLARIGGAALAEDVNGLWVTHLGVGQN---
MAV_1467|M.avium_104 MGYD---RPMNVFEA--ASTSYAHNGAAALDDFQAGVRASHNDAVTGGRP
MSMEG_5089|M.smegmatis_MC2_155 LMGRNGVDVDDFLRDVNTTDWPDNGKAAGYLFSWTNEASS--GPEAHIAA
MAB_1285c|M.abscessus_ATCC_199 MVNPEGKRNDQFLGDLTHHQFTDGGKAAGSLMSWTHDSAHVGPGVSADQA
: ..
MUL_2305|M.ulcerans_Agy99 DTAHAYSSYIGNNQQELLHLPGN------------HTLGQVNPNLVRDMA
MMAR_3061|M.marinum_M DTAHAYSSYIGGYQQELLHLPGN------------HTLGQVNPNLVRDMA
TH_3653|M.thermoresistible__bu --------------VEVQAMP-----------------------------
Mb2105|M.bovis_AF2122/97 --VTVLGHSYGSTTVADAFALGG-------------MHANDAVLLGCPGT
Rv2079|M.tuberculosis_H37Rv --VTVLGHSYGSTTVADAFALGG-------------MHANDAVLLGCPGT
MAV_1467|M.avium_104 SLNTVIGHSYGSTEVGAAALNGH------------HLDADNVIAVASPG-
MSMEG_5089|M.smegmatis_MC2_155 EVADKYAGYIGEHRTDLMNFDG-------------QTLGQRNPELVQQYA
MAB_1285c|M.abscessus_ATCC_199 KLSGETAHAYASYVADHKELNALPANDNQGLGQGTKTLGQLSPELVKGMA
MUL_2305|M.ulcerans_Agy99 HGLGPYVNNIAETSGGLP------GFGDPLDGKTLSGALPVAKGVFSVLS
MMAR_3061|M.marinum_M HGLGPYVNNIAETSGGLP------GFGKPLDSETLSGALPVAKGVFSVLS
TH_3653|M.thermoresistible__bu ---PRWITHDPEGRVRIL------SYGEVHD-------LPCAT-------
Mb2105|M.bovis_AF2122/97 DLAHSAASFHLD-GGRVY------VGAASTDPISMLGQLDSLSQYVN---
Rv2079|M.tuberculosis_H37Rv DLAHSAASFHLD-GGRVY------VGAASTDPISMLGQLDSLSQYVN---
MAV_1467|M.avium_104 MLTGHASDLNLDPGSHVF------ATRAQNDIIGVVTGMT----------
MSMEG_5089|M.smegmatis_MC2_155 HGLVPFVDDMAGNNGSGG------EFEIDTEKDRRAGLMPNAKGVFSVLN
MAB_1285c|M.abscessus_ATCC_199 WGLAPYTAAIGGGDPAIFGSTPGFDNALDTDDAIGNGSMPQAKALFKVLS
: :
MUL_2305|M.ulcerans_Agy99 SDNEAAQYFNGQAYAQAVLHEGAFAADPTHSGYNQH--LYDAATLRALVD
MMAR_3061|M.marinum_M SDNEAAQYFNGQAYAQAVLHEGAFAADPTHSGYNQH--LYDAATLRALVD
TH_3653|M.thermoresistible__bu ---------------------------PSFSEYNRT--LAEAT-------
Mb2105|M.bovis_AF2122/97 ---------RGNLAGQLQGLAVGLGTDPAGDGFGSV--RFRAEVPNSDGI
Rv2079|M.tuberculosis_H37Rv ---------RGNLAGQLQGLAVGLGTDPAGDGFGSV--RFRAEVPNSDGI
MAV_1467|M.avium_104 -----------------------LGPDPTGASFGGT--PFEAAPGKAWPF
MSMEG_5089|M.smegmatis_MC2_155 TDPTAATTINSAAISQAMIAETAFAENPNDPLAHSY--LSSAATLRGLVD
MAB_1285c|M.abscessus_ATCC_199 TNAEAATTLGGALYGDSVMATNHYAEAVKHSGVGEIGDLDQAGRFRGLAD
*
MUL_2305|M.ulcerans_Agy99 VGAHNGFQANEDNGYHQDVSEYQSKKSAYETGLQGLTAAGGFVPGVGRIA
MMAR_3061|M.marinum_M VGTHNAFQANEDNGYHQGVSEYQSKKSAYETGLQGLTAAGGFVPGVGRIA
TH_3653|M.thermoresistible__bu -----------EQTLGQGSSEHMKSAPTYRY-------------------
Mb2105|M.bovis_AF2122/97 NPHDHSYYYHRGSEALRSMADIASGHGDALASDGMLAQP-----------
Rv2079|M.tuberculosis_H37Rv NPHDHSYYYHRGSEALRSMADIASGHGDALASDGMLAQP-----------
MAV_1467|M.avium_104 G--------------LPSIGAHGS-YWDNMSNPALINMG-----------
MSMEG_5089|M.smegmatis_MC2_155 VGAHEAFQAFNENGYNAGVDETTWKKAGFDAAVTAFSTGSTFVPGVGVVA
MAB_1285c|M.abscessus_ATCC_199 AGLAAGNDAQHKADTVSKEQYAKDLQRLKETAYGAITKILPIPAEAATPF
MUL_2305|M.ulcerans_Agy99 GPTIGVLGQNLENGILGPAPTAPTENPIQPMSLGMADQEILNAMLGTGHT
MMAR_3061|M.marinum_M GPTIGVLGQNLENGILGPAPTAPTENPIQPMSLGMTDQEILNAMLGTGHT
TH_3653|M.thermoresistible__bu --------------------------------------------------
Mb2105|M.bovis_AF2122/97 --------------------------------------------------
Rv2079|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1467|M.avium_104 --------------------------------------------------
MSMEG_5089|M.smegmatis_MC2_155 SPVISQVGSIFSNEFFENPPGPVERPLPQLSEPVATTTLLNAMLAAN---
MAB_1285c|M.abscessus_ATCC_199 GIMSDALKDSIVG--KAPEPGQPANTTVPNLNPAYGQQQLLNAYAATGVL
MUL_2305|M.ulcerans_Agy99 VTGLPPGYILYDDDHPNGRIATLEELEPQGVTPGQYSNVIGPALSQS---
MMAR_3061|M.marinum_M VTGLPPGYIVYDDDHPNGRIATLEELEPQGVTPGQYSNVIGPALSQS---
TH_3653|M.thermoresistible__bu ---------------------------------NQVSEVMNPQTDQ----
Mb2105|M.bovis_AF2122/97 ------------------RHQPGVEIDIPGLGSVEIDIPGTPASIDP---
Rv2079|M.tuberculosis_H37Rv ------------------RHQPGVEIDIPGLGSVEIDIPGTPASIDP---
MAV_1467|M.avium_104 ------------------RIIAG-------------RTDVTPPTFTP---
MSMEG_5089|M.smegmatis_MC2_155 ----------QPLDLPPGYVVGNEVVQPPGVSDHEFAATLNAEIGRQTVT
MAB_1285c|M.abscessus_ATCC_199 RPEQFPPNMLVPDPKHPGVMRVGTLEELRQMKGPDDRPVYEHLTSDKYHT
MUL_2305|M.ulcerans_Agy99 LEPRPPSESLSPDAALVSRYDDIVGVPHPDQGRK-
MMAR_3061|M.marinum_M LEPRPPSESLSPDAALVSRYDDIVGVPHPDQGRK-
TH_3653|M.thermoresistible__bu --PEPP-----------------------------
Mb2105|M.bovis_AF2122/97 EWSRPPGSITDDHVFDAPLHR--------------
Rv2079|M.tuberculosis_H37Rv EWSRPPGSITDDHVFDAPLHR--------------
MAV_1467|M.avium_104 -----------------------------------
MSMEG_5089|M.smegmatis_MC2_155 VDGDGPDEIYADQYNLIIQDPDIQAPPTATRSENK
MAB_1285c|M.abscessus_ATCC_199 MVNEALRRIPGDAGSAQPLIDAYNNAVKTTE----