For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TNHIDLDGIYFSKRQLLARGGIALVVVLLVTSWLLAKSMGYLDRGVQVVADLRNIGDGLPAGSDVKYRGI QVGTVESLDPSIGNQPNQVRIRLKPEYAASIPVTVTARVVPSNVFAVSSIQLVEHGPGTPISDGERISED TDLPTVLFQTALTKLRDILAAAGRNRDDHTLGVLAAVGAATNNRNGALQLSTHQLIRIIDELNGVVATDE GPSTVAALVDAARGLSQSAPELLDALHDAVAPMRTLVDKQQALHDFLGAGQYTTGLAANSLQNHSDQLVQ ITTDLTPVVGVFADNAQHFVPITERITRFSDKFFEEVWDPASTVAHGRVNVSFTPSYTYTRADCPRYGEL RAPSCFTAPLVQARPDLPEVLLPQNYQPPPNLAPPPGTVVGPDGNLVAVGPPLINPTPNLEDPNPPLPAG VTPAPPVPGTANPDLLPAAPSSFGGNVGPVGSVQERAALSLITGEQATVATQLLLGPVARGAIASRTQQT PTESK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4919 | mce6A | - | 100% (496) | MCE-family protein Mce6A |
| M. ulcerans Agy99 | MUL_3796 | mce5A | e-166 | 60.16% (502) | Mce protein, Mce5A |
| M. ulcerans Agy99 | MUL_4059 | mce4D | 4e-12 | 23.00% (487) | MCE-family protein Mce4D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 2e-11 | 22.64% (424) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_0010 | - | 1e-152 | 53.23% (541) | hypothetical protein Mflv_0010 |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 2e-11 | 22.64% (424) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02589 | mce1A | 1e-05 | 22.18% (275) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_1695 | - | 0.0 | 68.45% (485) | putative Mce family protein |
| M. marinum M | MMAR_0177 | mce6A | 0.0 | 99.19% (496) | MCE-family protein Mce6A |
| M. avium 104 | MAV_0102 | - | 1e-166 | 57.99% (507) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1143 | - | 1e-164 | 57.82% (531) | mce related protein |
| M. thermoresistible (build 8) | TH_2386 | - | 1e-155 | 59.21% (456) | mce related protein |
| M. vanbaalenii PYR-1 | Mvan_0959 | - | 1e-163 | 56.57% (525) | hypothetical protein Mvan_0959 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3526c|M.bovis_AF2122/97 MMG--------RVAMLTGSRGLRYATVIALVAALVGGVYVLSSTG----N
Rv3496c|M.tuberculosis_H37Rv MMG--------RVAMLTGSRGLRYATVIALVAALVGGVYVLSSTG----N
MUL_4919|M.ulcerans_Agy99 MTN----HIDLDGIYFSKRQLLARGGIALVVVLLVTSWLLAKSMGYLDRG
MMAR_0177|M.marinum_M MTN----HIDLDGIYFSKRQLLARGGIALVVVLLVTSWLLAKSMGYLDRG
MAB_1695|M.abscessus_ATCC_1997 MLNRRDSHHDLDGAVFSRRQLLVRGGAALALVAVLTAGLLIKSTGVLDRY
MSMEG_1143|M.smegmatis_MC2_155 MGN----SIELDGRGPSERQLLACGLAVLVVAGLISTVLLVKATGRLDPY
TH_2386|M.thermoresistible__bu MAN----SFDLDGRGPTDRQLLAGGVVVIVVLSVISTYLLVKATGRLDPF
Mflv_0010|M.gilvum_PYR-GCK MAN----SFEFDGRGPSDRQLLVCGVAVLAIVSIVTAVLLVKSTGRLDPR
Mvan_0959|M.vanbaalenii_PYR-1 MAN----SLEMDGRGPTDRQLLACGVALLVIALVVSGALLVKSTGRMDAH
MAV_0102|M.avium_104 MAN----SLDFDGRGPTDHQLLALGATVLLIAGLITGGLLLKSTGRLNDY
MLBr_02589|M.leprae_Br4923 MTS------STKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPK
* . . : :: . *
Mb3526c|M.bovis_AF2122/97 KRTIVGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSD------VKITM
Rv3496c|M.tuberculosis_H37Rv KRTIVGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSD------VKITM
MUL_4919|M.ulcerans_Agy99 VQVVADLRNIGDGLPAGSDVKYRGIQVGTVESLDPSIGNQP--NQVRIRL
MMAR_0177|M.marinum_M VQVVADLRNIGDGLPAGSDVKYRGIQVGTVESLDPSIGNQP--NQVRIRL
MAB_1695|M.abscessus_ATCC_1997 VNVIADLHNVGDGLPPRSDVKYRGVLVGAVDGVTPSAGTQP--NRVRVRL
MSMEG_1143|M.smegmatis_MC2_155 VRVVAALINVGDGLPQRSDVKYHGVLVGMVEDVTPAAHGEP--NYVHINL
TH_2386|M.thermoresistible__bu VRVVADLVNVGDGLPQRSDVKYHGVLVGHVDSVTPAAHGHP--NYVHINL
Mflv_0010|M.gilvum_PYR-GCK VRVVAAMVNVGDGLPQRSDVKYHGVLVGAVDDVTPAENGEP--NFVHIDL
Mvan_0959|M.vanbaalenii_PYR-1 VRVVAALVNVGDGLPQRSDVKYHGVLVGAVDDVTPAQYGDP--NFVHIDL
MAV_0102|M.avium_104 IRVVAELTNVGDGLPARSDVKYHGLLVGAVDNVIPAAYGKP--NYVHINL
MLBr_02589|M.leprae_Br4923 SKLTMLADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDV
. . : ..: *: :* : : . : :
Mb3526c|M.bovis_AF2122/97 SVSKDVKVPVDVQAVIMSPNLVAARFIQLTPVYTGG-AVLPDNGRIDLDR
Rv3496c|M.tuberculosis_H37Rv SVSKDVKVPVDVQAVIMSPNLVAARFIQLTPVYTGG-AVLPDNGRIDLDR
MUL_4919|M.ulcerans_Agy99 KPEYAASIPVTVTARVVPSNVFAVSSIQLVEHGPGT--PISDGERISEDT
MMAR_0177|M.marinum_M KPEYAASIPVTVTARVVPSNVFAVSSIQLVEHGPGA--PISDGERISEDT
MAB_1695|M.abscessus_ATCC_1997 KPMYARSIPATVTARVVPSNVFAVSALQLVDHGPGA--PIREGGHIAEDT
MSMEG_1143|M.smegmatis_MC2_155 NPEYASSIPSTVTARVVPSNVFAVSSVQLVDRDGGAGPAISAGAQIPEDT
TH_2386|M.thermoresistible__bu DRHHARSIPATVTARVVPSNVFAVSSVQLVDRDGGPGTPIQAGAHIPEDT
Mflv_0010|M.gilvum_PYR-GCK KPEYAKSIPANVTARVVPSNVFAVSSVQLVG-SGGP--PIQPGAEIPEDT
Mvan_0959|M.vanbaalenii_PYR-1 KPEYAASIPAGVTARVVPSNVFAVSSVQLVDRSGGP--PIQSGARIPEDT
MAV_0102|M.avium_104 KPEYAQDIPSAVTARVVPSNVFAVSSVQLVDGAPGP--SIRNGARIPEDL
MLBr_02589|M.leprae_Br4923 YPRYLSLIPANVNADIKATTVFGGKYVSLTTPEHPS------QKRLTPQT
:* * * : ...:.. :.*. .: :
Mb3526c|M.bovis_AF2122/97 TAVPVEWDEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSL
Rv3496c|M.tuberculosis_H37Rv TAVPVEWDEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSL
MUL_4919|M.ulcerans_Agy99 DLPTVLFQTALTKLRDILAAAGRNRDDHTLGVLAAVGAATNNRNGALQLS
MMAR_0177|M.marinum_M DLPTVLFQTALTKLRDILAAAGRNRDDHTLGVLAAVGAATNNRNGALQLS
MAB_1695|M.abscessus_ATCC_1997 RLPTVLFQTTVNKLRQILTAAGRGREDNTVGILAAVGAATNHRRAELLTS
MSMEG_1143|M.smegmatis_MC2_155 ELPTVLFQTTISKLRDILAATGRGREDRTVGVLAAVNAATEGRRTELLTS
TH_2386|M.thermoresistible__bu ELPTVLFQTTISKLRDILAATGRGREDRTVGILAAVNAATENRRTELLSA
Mflv_0010|M.gilvum_PYR-GCK ELPTVLFQTTISKLRDILAATGRGREDDTVGILAAVHAATEDRRTELLTS
Mvan_0959|M.vanbaalenii_PYR-1 ELPTVLFQTTISKLRDILAATGRGREDDTVGILAAVNAATEDRRTELLTS
MAV_0102|M.avium_104 QLSTVIFQTTISKLRDILAATGRGREDHSVGILAAVAAATNNRRGPLLTA
MLBr_02589|M.leprae_Br4923 VIDARSVTTEINTLFQTITLIAEKVDP--IKLNLTLSAAAQSLAGLGERF
. * : . : :: *::
Mb3526c|M.bovis_AF2122/97 HNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVA
Rv3496c|M.tuberculosis_H37Rv HNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVA
MUL_4919|M.ulcerans_Agy99 THQLIRIIDELNGVVATDE-GPSTVAALVDAARGLSQSAPELLDALHDAV
MMAR_0177|M.marinum_M THQLIRIIDELNGVVATDQ-GPSTVAALVDAARGLSQSAPELLDAFHDAV
MAB_1695|M.abscessus_ATCC_1997 AAQLDRMLDQLNAIVATDQ-GPSTVSALVQAAHGLSQTAPDLVDALHQAV
MSMEG_1143|M.smegmatis_MC2_155 GAQLNRLIDEVDSIVATDPSAPTTVSTLIEATRGLQQTAPELVDALHTAV
TH_2386|M.thermoresistible__bu GAQLDLLIDEIDSIVATDP-GPTTVSALIGATRGLQQTAPELLDALHQAV
Mflv_0010|M.gilvum_PYR-GCK GAQLNRMVDELDRIVATEP-GPTTVSALVDATRGLQQTAPELVDALHQAV
Mvan_0959|M.vanbaalenii_PYR-1 GAQLNSLVDELDRIVATDP-GPTTVSALVDATRGLQQTAPELVDALHQAV
MAV_0102|M.avium_104 GAQLTRVLDELNAIVATDP-GPSTVSALLDATRGLQSTAPDLVDVLHDAV
MLBr_02589|M.leprae_Br4923 GQSIVNGNSVLDDVNSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSI
: . . : : * .: ::.:
Mb3526c|M.bovis_AF2122/97 SVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ
Rv3496c|M.tuberculosis_H37Rv SVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ
MUL_4919|M.ulcerans_Agy99 APMRTLVDKQQALHDFLGAGQYTTGLAANSLQNHSDQLVQITTDLTPVVG
MMAR_0177|M.marinum_M APMRTLVDKQQALHDFLGAGQYTTGLAVNSLQNHSDQLVQITTDLTPVVG
MAB_1695|M.abscessus_ATCC_1997 RPMQTLAEKREQLRTFIGAGVQTTGTTVRSLHNHTDQLIQITTDLTPVLG
MSMEG_1143|M.smegmatis_MC2_155 RPMQTLVEQRSQLDSLISAGMNTLDTTRTALNNHTDRLVKITSELTPVVG
TH_2386|M.thermoresistible__bu QPMQTLVQQRAQLDALIGGALHTSATTHTALTNHTDRMVTITTEMTPVIG
Mflv_0010|M.gilvum_PYR-GCK QPMQTLVEQSAQLTSLVNGGIRTSETTRTAFDNHADRLVRITTELTPVVG
Mvan_0959|M.vanbaalenii_PYR-1 EPMQTLVEQSAQLTTFINGGINTVGTTHTALNNHTDRMVRITTELTPVIG
MAV_0102|M.avium_104 RPMQTLVEKREQFRSLVTGSYHTFSVNRQAFDNHTDQLIEMTQNLTPVLG
MLBr_02589|M.leprae_Br4923 VTSRTINQQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQ
:.: :. : : : . : . ::
Mb3526c|M.bovis_AF2122/97 TLSDQSE-NIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQF
Rv3496c|M.tuberculosis_H37Rv TLSDQSE-NIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQF
MUL_4919|M.ulcerans_Agy99 VFADNAQHFVPITERITRFSDKFFEEVWDPASTVAHGRVNVS-FTPSYTY
MMAR_0177|M.marinum_M VFADNAQHFVPITERITRFSDKFFEEVWDPASTVAHGRVNVS-FTPSYTY
MAB_1695|M.abscessus_ATCC_1997 VLADNAQHFVPITRRITRFSDTFFREVWDPELATAKGRVNLS-FTPSYTY
MSMEG_1143|M.smegmatis_MC2_155 NLADTSHHWLPAFVKLNNLSDKFFDEVWRPERNVGNMRMNLS-FTPSYTY
TH_2386|M.thermoresistible__bu NLADTSHHWLPAFIKMNGLSDKFFEEVWRPERDIGNMRMNLS-LTPSYTY
Mflv_0010|M.gilvum_PYR-GCK SLADTSRHWVPAFVKLNELSRKFFDEVWIHEHDIGNMRINLS-FTPTYSY
Mvan_0959|M.vanbaalenii_PYR-1 NLAQTSHHWVPAFVKLNGLSRKFFDEVWMHDRDVGNMRVNLS-FTPTYSY
MAV_0102|M.avium_104 VFAMNSDKFVPIFTRLNRLSDKFFQEVWDPELDTGNMRVNLA-LTPTYTY
MLBr_02589|M.leprae_Br4923 LLDTYSPAIFCTLRNYHDIEPKVTSFLGGNGYSINDHVELLSGLGFLLNP
: : . . . : . :. :
Mb3526c|M.bovis_AF2122/97 ICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTI
Rv3496c|M.tuberculosis_H37Rv ICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTI
MUL_4919|M.ulcerans_Agy99 TRADCPRYGELRAPSCFTAPLVQARPDLPEVLLPQNYQPPPNLAPPPGTV
MMAR_0177|M.marinum_M TRADCPRYGELRAPSCFTAPLVQARPDLPEVLLPQNYQPPPNLAPPPGTV
MAB_1695|M.abscessus_ATCC_1997 TRADCPRYGELKGPSCFTAPQIAVRPDLPEVLLPQNYQPPANLAPPPGTV
MSMEG_1143|M.smegmatis_MC2_155 TRADCPQYGELKGPSCFTAPLVVTRPALPDQMLPRNYQPPKDLAPPPGTV
TH_2386|M.thermoresistible__bu TRADCPRYGELKGPSCYTAPLVVTRPSLPDVLLPQNYQPPKDLAPPPGTI
Mflv_0010|M.gilvum_PYR-GCK TRADCPQYAGLKGPSCYTAPLVPTRAALPDVLLPQNYQPPKDLQPPPGTE
Mvan_0959|M.vanbaalenii_PYR-1 TRADCPQYGELKGPSCFTAPLVPTRPELPDVLLPQNYQPPADLKPPPGTE
MAV_0102|M.avium_104 TRADCPRYGQLQGPSCFTAPTIAVRPDLPEVLLPQNYHPPTDLAPPPGTQ
MLBr_02589|M.leprae_Br4923 TSAISIIGAGVLSQGLLAPLGLAG--VVNGAANPYIYPENLPRVNARGGP
. . . . : . .
Mb3526c|M.bovis_AF2122/97 TAYKGQIIYDTPATEAKSETPVPELTWVPAG-----GGAPVGNPADLQSL
Rv3496c|M.tuberculosis_H37Rv TAYKGQIIYDTPATEAKSETPVPELTWVPAG-----GGAPVGNPADLQSL
MUL_4919|M.ulcerans_Agy99 VGPDGNLVAVGPPLINPTPNLEDPNPPLPAG---VTPAPPVPGTANPDLL
MMAR_0177|M.marinum_M VGPDGNLVAVGPPLINPTPNLEDPNPPLPAG---VTPAPPVPGTANPDLL
MAB_1695|M.abscessus_ATCC_1997 LGDNGNLIAVGPPLVNPNPDLRDPNPPVPPW---LTPAPPVPGSADPGQI
MSMEG_1143|M.smegmatis_MC2_155 VGENGNLVAVGPPLINPNPSLADPNPPLPPW---MAPAPPVPGTANSALP
TH_2386|M.thermoresistible__bu VGENGNLVAVGPPLVNPNPNLADPNPPLPPG---MFPAPPVPGTSNPDLV
Mflv_0010|M.gilvum_PYR-GCK IGPSGNLIAVGPPLVNPNPSLADPNPPLPPW---MPPSPPVPLTANPALV
Mvan_0959|M.vanbaalenii_PYR-1 VGPNGNLVAVGPPLVNPNPDLRDPNPPLPPW---LSPSPPVPGTANPALV
MAV_0102|M.avium_104 IGPDGNLVATGPPLYNPDPSLADPNPPLPWWPWQIGPAPRVPGTADPDDA
MLBr_02589|M.leprae_Br4923 GGAPGCWQHITRDLWPTPELVMDTGNSIAPYN-HLDSGSPYAIEYVWGRQ
. * :. ..
Mb3526c|M.bovis_AF2122/97 LVPPAPG-------------------------------------------
Rv3496c|M.tuberculosis_H37Rv LVPPAPG-------------------------------------------
MUL_4919|M.ulcerans_Agy99 PAAPSS--------------------------------------------
MMAR_0177|M.marinum_M PAAPSS--------------------------------------------
MAB_1695|M.abscessus_ATCC_1997 LTAPAS--------------------------------------------
MSMEG_1143|M.smegmatis_MC2_155 VTPPPGVNQSPLAPVAPKPGSPPPPPPAPG-----PLPAEAAPA------
TH_2386|M.thermoresistible__bu PIPPPPVNLSPLAPVAPNPNKPRPPVPAPP-----PAP------------
Mflv_0010|M.gilvum_PYR-GCK PPPQLPAPLSPPAPVAPKPGDPPPRPAAPAPAAPAPAPAAPAPAPAAPGP
Mvan_0959|M.vanbaalenii_PYR-1 PVPQPPVPLSPPAPVAPKPGDPPPPPAAPPVSGPAPLPAEAAPA------
MAV_0102|M.avium_104 PPPPPPSP--PPSPAPPGPVAPAA--------------------------
MLBr_02589|M.leprae_Br4923 VGDNTINP------------------------------------------
Mb3526c|M.bovis_AF2122/97 ------------------------------------PAPAPPAPGAGPGE
Rv3496c|M.tuberculosis_H37Rv ------------------------------------PAPAPPAPGAGPGE
MUL_4919|M.ulcerans_Agy99 -----------FGGNVGPVGSVQERAALSLITGE--QATVATQLLLGPVA
MMAR_0177|M.marinum_M -----------FGGNVGPVGSVQERAALSLITGE--QATVATQLLLGPVA
MAB_1695|M.abscessus_ATCC_1997 -----------FGGNVGPVGSTQERGQLGQILGQ--PATSADQLVLGPLA
MSMEG_1143|M.smegmatis_MC2_155 ----------SFGGNVGPVGSEQERVTLSVITGQ--PASTATQLLLGPVA
TH_2386|M.thermoresistible__bu ------------GG------------------------------------
Mflv_0010|M.gilvum_PYR-GCK GSAEAPFAPASFGGNVGPVGSQQEQRQLSLITGR--HATPATQLLLGPLA
Mvan_0959|M.vanbaalenii_PYR-1 ----------GYGGNVGPVGSRHELDQLGYITGQ--PATVATQLLLGPVA
MAV_0102|M.avium_104 -----------YGGNVGPVGSQRERDQLGLITGQGRPASVATQLLLGPVA
MLBr_02589|M.leprae_Br4923 --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 HGGGG-------------
Rv3496c|M.tuberculosis_H37Rv HGGGG-------------
MUL_4919|M.ulcerans_Agy99 RGAIASRTQQTPTESK--
MMAR_0177|M.marinum_M RGAIASRTQQTPTESK--
MAB_1695|M.abscessus_ATCC_1997 RGTVVTRAADPHEEGGAR
MSMEG_1143|M.smegmatis_MC2_155 RGTTVSLAEPTAGEEPR-
TH_2386|M.thermoresistible__bu ------------GEEPR-
Mflv_0010|M.gilvum_PYR-GCK RGTTVS-----IDGEP--
Mvan_0959|M.vanbaalenii_PYR-1 RGTTVS-----EGVR---
MAV_0102|M.avium_104 RGSAVSLQPRPAPGGPK-
MLBr_02589|M.leprae_Br4923 ------------------