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MPNSIESDGCGPSDRQLIGIGLVVVLLAAVLTIALLVKSTGRLNDYVRVTADLRNVGDGLPKRSDVKYHG VLVGMVDGVAPAANGRPNYVHINLKPEYAASIPAAVTARVVPSSVFAVSSVQLIDAPAPRGRQPAIRAGT HIPEDSRLPTVLFQTTVSKLRDLLAAAGRGREDNSLGILAAIAAATDHRRASLLSGGAQLNRLLDQLNSI VATDSEPSTVAALIDATRGLQASAPELVEALHQAVEPMKTFAETRAQLAALLAGADHTIGTAQQSLGNHI DQLIQITTDFTPVLGVLAQQSDNFLPAVIKLDNLATKFMDEVWMPENNTGNMRVNLSFTPSHSYTRADCP RYGELKGPSCFTAPLVPVRPDLPDVLLPQNYQPPKDLAPPPGTAVGPDGNLVALGPPLINPSPNLTDPNP PLPAWLTPSPRVPGTGDPDDAPPAPPAPPGAAAPSAFGGNVGPVGSRQEGDALALITGRPATVATELLLG PLARGTVVSLRNSGAGGEPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3796 | mce5A | - | 100% (510) | Mce protein, Mce5A |
| M. ulcerans Agy99 | MUL_4919 | mce6A | e-166 | 60.16% (502) | MCE-family protein Mce6A |
| M. ulcerans Agy99 | MUL_4057 | mce4F | 1e-10 | 24.05% (524) | MCE-family protein Mce4F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3524c | mce4F | 1e-09 | 23.06% (516) | MCE-family protein MCE4F |
| M. gilvum PYR-GCK | Mflv_0010 | - | 0.0 | 59.64% (555) | hypothetical protein Mflv_0010 |
| M. tuberculosis H37Rv | Rv3494c | mce4F | 8e-10 | 23.26% (516) | MCE-family protein MCE4F |
| M. leprae Br4923 | MLBr_02589 | mce1A | 2e-06 | 23.31% (296) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4568c | - | 0.0 | 63.35% (513) | putative Mce family protein |
| M. marinum M | MMAR_3864 | mce5A | 0.0 | 99.22% (510) | Mce protein, Mce5A |
| M. avium 104 | MAV_2388 | - | 0.0 | 71.08% (529) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1143 | - | 0.0 | 63.81% (536) | mce related protein |
| M. thermoresistible (build 8) | TH_2386 | - | 1e-173 | 63.33% (480) | mce related protein |
| M. vanbaalenii PYR-1 | Mvan_0959 | - | 0.0 | 64.14% (527) | hypothetical protein Mvan_0959 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3524c|M.bovis_AF2122/97 --------MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGV
Rv3494c|M.tuberculosis_H37Rv --------MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGV
MUL_3796|M.ulcerans_Agy99 MPNSIESDGCGPSDRQLIGIGLVVVLLAAVLTIALLVKSTGRLNDYVRVT
MMAR_3864|M.marinum_M MPNSIESDGRGPSDRQLIGIGLVVVLLAAVLTIALLVKSTGRLNDYVRVT
MAV_2388|M.avium_104 MPNSFELDGRGPSDRQLFGIGIAVLVVSALLTTVMLVKSTGRLDDYVRVV
MAB_4568c|M.abscessus_ATCC_199 MANSFETDGRGPSDRQLLLCGLVMAVVAALVGTALVIKSTGRFNDYVRVV
Mflv_0010|M.gilvum_PYR-GCK MANSFEFDGRGPSDRQLLVCGVAVLAIVSIVTAVLLVKSTGRLDPRVRVV
Mvan_0959|M.vanbaalenii_PYR-1 MANSLEMDGRGPTDRQLLACGVALLVIALVVSGALLVKSTGRMDAHVRVV
MSMEG_1143|M.smegmatis_MC2_155 MGNSIELDGRGPSERQLLACGLAVLVVAGLISTVLLVKATGRLDPYVRVV
TH_2386|M.thermoresistible__bu MANSFDLDGRGPTDRQLLAGGVVVIVVLSVISTYLLVKATGRLDPFVRVV
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVG--LLVVAVVIFGLVYGQFRGNFTPKSKLT
: : : . : . : .
Mb3524c|M.bovis_AF2122/97 SADFVAGGGLYKNANVTYRGVAVGRVESVGLNPNG------VTAHMRLNS
Rv3494c|M.tuberculosis_H37Rv SADFVAGGGLYKNANVTYRGVAVGRVESVGLNPNG------VTAHMRLNS
MUL_3796|M.ulcerans_Agy99 ADLRNVGDGLPKRSDVKYHGVLVGMVDGVAPAANGRP--NYVHINLKPEY
MMAR_3864|M.marinum_M ADLRNVGDGLPKRSDVKYHGVLVGMVDGVAPAANGRP--NYVHINLKPEY
MAV_2388|M.avium_104 ADLVNVGDGLPQKSDVKYHGVLVGMVDDVVPAAHGKP--NYVHINLKEDY
MAB_4568c|M.abscessus_ATCC_199 AELTNVGDGLPAKSDVKYQGVLVGAVDDLTPSQRGRP--NVVHINLKPAL
Mflv_0010|M.gilvum_PYR-GCK AAMVNVGDGLPQRSDVKYHGVLVGAVDDVTPAENGEP--NFVHIDLKPEY
Mvan_0959|M.vanbaalenii_PYR-1 AALVNVGDGLPQRSDVKYHGVLVGAVDDVTPAQYGDP--NFVHIDLKPEY
MSMEG_1143|M.smegmatis_MC2_155 AALINVGDGLPQRSDVKYHGVLVGMVEDVTPAAHGEP--NYVHINLNPEY
TH_2386|M.thermoresistible__bu ADLVNVGDGLPQRSDVKYHGVLVGHVDSVTPAAHGHP--NYVHINLDRHH
MLBr_02589|M.leprae_Br4923 MLADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRY
.* : :.:.*.** :* * .: . . .:
Mb3524c|M.bovis_AF2122/97 GTAIPSNVTATVRSVSAIGEQYIDLVPP--ENPSSTKLRNGFRIQRQNTR
Rv3494c|M.tuberculosis_H37Rv GTAIPSNVTATVRSVSAIGEQYIDLVPP--ENPSSTKLRNGFRIQRQNTR
MUL_3796|M.ulcerans_Agy99 AASIPAAVTARVVPSSVFAVSSVQLIDAPAPRGRQPAIRAGTHIPEDSRL
MMAR_3864|M.marinum_M AASIPAAVTARVVPSSVFAVSSVQLIDAPAPRGRQPAIRAGTHIPEDSRL
MAV_2388|M.avium_104 AKSIPASVTARVVPSNVFAVSSVQLVGN----GPGSKIRDGAHIPEDKRL
MAB_4568c|M.abscessus_ATCC_199 AHTVPRSVTARVVPSNVFAVSSVELVDH----GPGPAITDGAVIPEDTEL
Mflv_0010|M.gilvum_PYR-GCK AKSIPANVTARVVPSNVFAVSSVQLVG---SGGP--PIQPGAEIPEDTEL
Mvan_0959|M.vanbaalenii_PYR-1 AASIPAGVTARVVPSNVFAVSSVQLVDR--SGGP--PIQSGARIPEDTEL
MSMEG_1143|M.smegmatis_MC2_155 ASSIPSTVTARVVPSNVFAVSSVQLVDR--DGGAGPAISAGAQIPEDTEL
TH_2386|M.thermoresistible__bu ARSIPATVTARVVPSNVFAVSSVQLVDR--DGGPGTPIQAGAHIPEDTEL
MLBr_02589|M.leprae_Br4923 LSLIPANVNADIKATTVFGGKYVSLTTP----EHPSQKRLTPQTVIDARS
:* *.* : . ..:. . :.* :
Mb3524c|M.bovis_AF2122/97 IGQDVADLLRQAETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESAR
Rv3494c|M.tuberculosis_H37Rv IGQDVADLLRQAETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESAR
MUL_3796|M.ulcerans_Agy99 PTVLFQTTVSKLRDLLAAAGRGREDNSLGILAAIAAATDHRRASLLSGG-
MMAR_3864|M.marinum_M PTVLFQTTLSKLRDLLAAAGRGREDNSLGILAAIAAATDHRRASLLSGG-
MAV_2388|M.avium_104 PTVLFQTTVSKLRDLLAAAGRGRDDRSVGILAALGAATDHRRVSLLNAG-
MAB_4568c|M.abscessus_ATCC_199 PTVLFQTTISKLRDILLANGRGRDDDSVGIFAVIAAATEGRRATLLNAA-
Mflv_0010|M.gilvum_PYR-GCK PTVLFQTTISKLRDILAATGRGREDDTVGILAAVHAATEDRRTELLTSG-
Mvan_0959|M.vanbaalenii_PYR-1 PTVLFQTTISKLRDILAATGRGREDDTVGILAAVNAATEDRRTELLTSG-
MSMEG_1143|M.smegmatis_MC2_155 PTVLFQTTISKLRDILAATGRGREDRTVGVLAAVNAATEGRRTELLTSG-
TH_2386|M.thermoresistible__bu PTVLFQTTISKLRDILAATGRGREDRTVGILAAVNAATENRRTELLSAG-
MLBr_02589|M.leprae_Br4923 VTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNG-
. . : . : : . . : .
Mb3524c|M.bovis_AF2122/97 LLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRA
Rv3494c|M.tuberculosis_H37Rv LLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRA
MUL_3796|M.ulcerans_Agy99 ----------AQLNRLLDQLNSIVATDS-EPSTVAALID-----------
MMAR_3864|M.marinum_M ----------AQLNRLLDQLNSIVATDS-EPSTVAALID-----------
MAV_2388|M.avium_104 ----------AQLNRLLDQLNSIVSTDT-GPSTVSALLD-----------
MAB_4568c|M.abscessus_ATCC_199 ----------GQLTRIIDQLNDIVATDT-GPSTLSALLD-----------
Mflv_0010|M.gilvum_PYR-GCK ----------AQLNRMVDELDRIVATEP-GPTTVSALVD-----------
Mvan_0959|M.vanbaalenii_PYR-1 ----------AQLNSLVDELDRIVATDP-GPTTVSALVD-----------
MSMEG_1143|M.smegmatis_MC2_155 ----------AQLNRLIDEVDSIVATDPSAPTTVSTLIE-----------
TH_2386|M.thermoresistible__bu ----------AQLDLLIDEIDSIVATDP-GPTTVSALIG-----------
MLBr_02589|M.leprae_Br4923 -------------NSVLDDVNSQLPQARHDIQQLASLGD-----------
::*: . : : :*
Mb3524c|M.bovis_AF2122/97 ADPRLRDTLAGAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHKS
Rv3494c|M.tuberculosis_H37Rv ADPRLRDTLADAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHKS
MUL_3796|M.ulcerans_Agy99 ATRGLQASAPELVEALHQAVEPMKTFAETRAQLAALLAGADHTIGTAQQS
MMAR_3864|M.marinum_M ATRGLQASAPELVEALHQAVEPMKTFAETRAQLAALLAGADHTIGTAQQS
MAV_2388|M.avium_104 ATRGLAQTAPDLLDALHQAVEPMQTFAETRGQLASLLSGADYTVGTTRQS
MAB_4568c|M.abscessus_ATCC_199 ATKGLQTTAPELVDALHQAIKPMQTLAEKREQLQSLLNAGLHTTGTVRQS
Mflv_0010|M.gilvum_PYR-GCK ATRGLQQTAPELVDALHQAVQPMQTLVEQSAQLTSLVNGGIRTSETTRTA
Mvan_0959|M.vanbaalenii_PYR-1 ATRGLQQTAPELVDALHQAVEPMQTLVEQSAQLTTFINGGINTVGTTHTA
MSMEG_1143|M.smegmatis_MC2_155 ATRGLQQTAPELVDALHTAVRPMQTLVEQRSQLDSLISAGMNTLDTTRTA
TH_2386|M.thermoresistible__bu ATRGLQQTAPELLDALHQAVQPMQTLVQQRAQLDALIGGALHTSATTHTA
MLBr_02589|M.leprae_Br4923 ---TYANSASDFFDFLNNSIVTSRTINQQQKDLDQVLLAAVGFGNTGADI
: . : :. : . : * :
Mb3524c|M.bovis_AF2122/97 IEQLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPP-PCMTGFLPP
Rv3494c|M.tuberculosis_H37Rv IEQLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPP-PCMTGFLPP
MUL_3796|M.ulcerans_Agy99 LGNHIDQLIQITTDFTPVLGVLAQQSDNFLPAVIKLDNLATKFMDEVWMP
MMAR_3864|M.marinum_M LGNHIDQLIQITTDFTPVLGVLAQQSDNFLPAVIKLDNLATKFMDEVWMP
MAV_2388|M.avium_104 FDNHIDQLIRITADFTPVLGVLAQKSNNFVPAVTKLDNLANQFMEQVWNP
MAB_4568c|M.abscessus_ATCC_199 LDNQTDRMIDITTKLTPVVGVLAKNSVHFLPMATRLKVFSDKFFSEVWDP
Mflv_0010|M.gilvum_PYR-GCK FDNHADRLVRITTELTPVVGSLADTSRHWVPAFVKLNELSRKFFDEVWIH
Mvan_0959|M.vanbaalenii_PYR-1 LNNHTDRMVRITTELTPVIGNLAQTSHHWVPAFVKLNGLSRKFFDEVWMH
MSMEG_1143|M.smegmatis_MC2_155 LNNHTDRLVKITSELTPVVGNLADTSHHWLPAFVKLNNLSDKFFDEVWRP
TH_2386|M.thermoresistible__bu LTNHTDRMVTITTEMTPVIGNLADTSHHWLPAFIKMNGLSDKFFEEVWRP
MLBr_02589|M.leprae_Br4923 FSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLRNYHDIEPKVTSFLGGN
: . : : : . : . . . .
Mb3524c|M.bovis_AF2122/97 PLVRSPADESVREIPRDMYCKTAQNDPSTVRGARNYPCQEFPGKRAPTVQ
Rv3494c|M.tuberculosis_H37Rv PLVRSPADESVREIPRDMYCKTAQNDPSTVRGARNYPCQEFPGKRAPTVQ
MUL_3796|M.ulcerans_Agy99 ENNTGNMRVNLSFTPSHSYTRADCPRYGELKGPSCFTAPLVPVR--PDLP
MMAR_3864|M.marinum_M ENNTGNMRVNLSFTPSHSYTRADCPRYGELKGPSCFTAPLVPVR--PDLP
MAV_2388|M.avium_104 QTNLGNMRAMLTFTPSSTYTRADCPHYGELKGPSCFTAPLIPVR--PDLP
MAB_4568c|M.abscessus_ATCC_199 EKDVVNIRGILSFTPSTMYTRADCPRYGELKGPSCFTAPELVVR--PDLP
Mflv_0010|M.gilvum_PYR-GCK EHDIGNMRINLSFTPTYSYTRADCPQYAGLKGPSCYTAPLVPTR--AALP
Mvan_0959|M.vanbaalenii_PYR-1 DRDVGNMRVNLSFTPTYSYTRADCPQYGELKGPSCFTAPLVPTR--PELP
MSMEG_1143|M.smegmatis_MC2_155 ERNVGNMRMNLSFTPSYTYTRADCPQYGELKGPSCFTAPLVVTR--PALP
TH_2386|M.thermoresistible__bu ERDIGNMRMNLSLTPSYTYTRADCPRYGELKGPSCYTAPLVVTR--PSLP
MLBr_02589|M.leprae_Br4923 GYSINDHVELLSGLGFLLNPTSAISIIGAGVLSQGLLAPLGLAG---VVN
: : . . . :
Mb3524c|M.bovis_AF2122/97 LCRDPRGYVPVGTNPWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDP
Rv3494c|M.tuberculosis_H37Rv LCRDPRGYVPVGTNPWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDP
MUL_3796|M.ulcerans_Agy99 DVLLPQNYQPP-----KDLAPPPGTAVGPDGNLVALG-----PPLINPSP
MMAR_3864|M.marinum_M EVLLPQNYQPP-----KDLAPPPGTAVGPDGNLVALG-----PPLINPSP
MAV_2388|M.avium_104 DVLLPQNYQPP-----KDLAPPPGTVIGPDGNLVAVG-----PPLINPTP
MAB_4568c|M.abscessus_ATCC_199 ETLLPQNFKPP-----PDLAPPPGTEVGPDGNLIVTG-----PPLLNPHP
Mflv_0010|M.gilvum_PYR-GCK DVLLPQNYQPP-----KDLQPPPGTEIGPSGNLIAVG-----PPLVNPNP
Mvan_0959|M.vanbaalenii_PYR-1 DVLLPQNYQPP-----ADLKPPPGTEVGPNGNLVAVG-----PPLVNPNP
MSMEG_1143|M.smegmatis_MC2_155 DQMLPRNYQPP-----KDLAPPPGTVVGENGNLVAVG-----PPLINPNP
TH_2386|M.thermoresistible__bu DVLLPQNYQPP-----KDLAPPPGTIVGENGNLVAVG-----PPLVNPNP
MLBr_02589|M.leprae_Br4923 GAANPYIYPEN--------LPRVNARGGPGG---APG----------CWQ
* : .: . .
Mb3524c|M.bovis_AF2122/97 GVPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPE
Rv3494c|M.tuberculosis_H37Rv GVPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPE
MUL_3796|M.ulcerans_Agy99 NLTDPNPPLPAWLT-PSPRVPGTGDPD------------------DAPPA
MMAR_3864|M.marinum_M NLTDPNPPLPAWLT-PSPRVPGTGDPD------------------DAPPA
MAV_2388|M.avium_104 NLTDPNPPLAPGIT-PSPPVPGSANPD------------------NPSPG
MAB_4568c|M.abscessus_ATCC_199 NLQDPNPPLPWWQPNPSPRVPGSADPDDL----------------EPPPG
Mflv_0010|M.gilvum_PYR-GCK SLADPNPPLPPWMP-PSPPVPLTANPALVP---------PPQLPAPLSPP
Mvan_0959|M.vanbaalenii_PYR-1 DLRDPNPPLPPWLS-PSPPVPGTANPALVP---------VPQPPVPLSPP
MSMEG_1143|M.smegmatis_MC2_155 SLADPNPPLPPWMA-PAPPVPGTANSALPV---------TPPPGVNQSPL
TH_2386|M.thermoresistible__bu NLADPNPPLPPGMF-PAPPVPGTSNPDLVP---------IPPPPVNLSPL
MLBr_02589|M.leprae_Br4923 HITRDLWPTPELVMDTGNSIAPYNHLD------------------SGSPY
: * . .. . .*
Mb3524c|M.bovis_AF2122/97 PPQVPYPATIPPPPPPEGTGPP-------------------------PGP
Rv3494c|M.tuberculosis_H37Rv PPQVPYPATIPPPPPPEGTGPP-------------------------PGP
MUL_3796|M.ulcerans_Agy99 PPAPP-------GAAAPSA------------------------------F
MMAR_3864|M.marinum_M PPAPP-------GAAAPSA------------------------------F
MAV_2388|M.avium_104 APATPQPQQPWVAPVAPKAPWI-------------------PQSSFRPSF
MAB_4568c|M.abscessus_ATCC_199 SPGMP------IPSTAPAS------------------------------F
Mflv_0010|M.gilvum_PYR-GCK APVAPKPGDPPPRPAAPAPAAPAPAPAAPAPAPAAPGPGSAEAPFAPASF
Mvan_0959|M.vanbaalenii_PYR-1 APVAPKPGDPPPPPAAPPVSGPAPLPAEAAPA----------------GY
MSMEG_1143|M.smegmatis_MC2_155 APVAPKPGSPPPPPPAPG-----PLPAEAAPA----------------SF
TH_2386|M.thermoresistible__bu APVAPNPNKPRPPVPAPP-----PAP------------------------
MLBr_02589|M.leprae_Br4923 AIEYVWGRQVGDNTINP---------------------------------
.
Mb3524c|M.bovis_AF2122/97 APGPQPQASGPAYTIYDQLSGAFADPAGGTGIFAPGMTGASSAENWVDLM
Rv3494c|M.tuberculosis_H37Rv APGPQPQASGPAYTIYDQLSGAFADPAGGTGIFAPGMTGASSAENWVDLM
MUL_3796|M.ulcerans_Agy99 GGNVGPVGSRQEGDALALITGRPATVATELLLGPLARGTVVSLRNS-GAG
MMAR_3864|M.marinum_M GGNVGPVGSRQERDALALITGRPATVATELLLGPLARGTVVSLRNS-GAG
MAV_2388|M.avium_104 GGNVGPVGSQYERTMLGAITGGPASEATQLLLGPVARGTTVSLAHPPGPS
MAB_4568c|M.abscessus_ATCC_199 GGAVGPVGSKTERDQLGLITGGEASSSTQLLLGPVARGTKPVVVEQASAG
Mflv_0010|M.gilvum_PYR-GCK GGNVGPVGSQQEQRQLSLITGRHATPATQLLLGPLARGTTVS------ID
Mvan_0959|M.vanbaalenii_PYR-1 GGNVGPVGSRHELDQLGYITGQPATVATQLLLGPVARGTTVS------EG
MSMEG_1143|M.smegmatis_MC2_155 GGNVGPVGSEQERVTLSVITGQPASTATQLLLGPVARGTTVSLAEP-TAG
TH_2386|M.thermoresistible__bu GG-----------------------------------------------G
MLBr_02589|M.leprae_Br4923 --------------------------------------------------
Mb3524c|M.bovis_AF2122/97 RDPRQL---
Rv3494c|M.tuberculosis_H37Rv RDPRQL---
MUL_3796|M.ulcerans_Agy99 GEPR-----
MMAR_3864|M.marinum_M GEPR-----
MAV_2388|M.avium_104 PAPRPGEGK
MAB_4568c|M.abscessus_ATCC_199 GRR------
Mflv_0010|M.gilvum_PYR-GCK GEP------
Mvan_0959|M.vanbaalenii_PYR-1 VR-------
MSMEG_1143|M.smegmatis_MC2_155 EEPR-----
TH_2386|M.thermoresistible__bu EEPR-----
MLBr_02589|M.leprae_Br4923 ---------