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M. ulcerans Agy99 MUL_4723 (uvrD1)

annotation: ATP-dependent DNA helicase II UvrD1
coordinates: 5231960 - 5234269
length: 769

TVQATDADQLVEGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRIAYLIAARGVGVGQILAITFTNKA
AAEVRERVVSLVGGRAKYMWVSTFHSTCVRILRNQAALIKGLNSNFSIYDADDSRRLLQMIGRDMGLDIK
RYSPRLLTNAISNLKNELIDPDRAVSDLSEDSDDLARTVASVYAEYQRRLRAANALDFDDLIGETVGILQ
AFPDIAGHYRRRFRHVLVDEYQDTNHAQYVLVRELVGRGSEDEPGDVPPAQLCVVGDADQSIYAFRGATI
RNIEDFERDYPDATTILLEQNYRSTQNILSAANSVISRNSGRREKRLWTDAGAGELIVGYVADNEHDEAR
FVAEEIDALAERDEITYSDVAVFYRTNNSSRSLEEVFIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDN
PGDAVSMRRILNTPRRGIGDRAEACVAVYAENTGAGFSDALVAAAEGKVPMLNSRAEKAIAGFVELLDEL
RGRLDSSEGDVGELVEAVLERTGYRRELESSTDPQELARLDNLNELVSVAHEFSTDLANAAEPEPDAEDV
PDTGMLAAFLERVSLVADTDDIPEHGAGVVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRALDDPTELSE
ERRLAYVGITRARQRLYLSRAIVRSSWGQPMLNPESRFLREIPQELLNWRRLAPKPSFSAPVSGAGRFGT
ARSAPVRTSTSKRPLLVLQPGDRVTHDKYGLGRVEEVSGVGESAMSLIDFGSSGRVKLMHNHAPVAKL*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_4723uvrD1-100% (769)ATP-dependent DNA helicase II UvrD1
M. ulcerans Agy99MUL_2512uvrD21e-5233.59% (512) ATP-dependent DNA helicase II UvrD2
M. ulcerans Agy99MUL_2520-8e-4425.13% (788) ATP-dependent DNA helicase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0974uvrD10.088.42% (777) ATP dependent DNA helicase UVRD1
M. gilvum PYR-GCKMflv_1861-0.082.94% (768) ATP-dependent DNA helicase PcrA
M. tuberculosis H37RvRv0949uvrD10.088.42% (777) ATP-dependent DNA helicase II UVRD1
M. leprae Br4923MLBr_00153uvrD0.080.41% (781) putative ATP-dependent DNA helicase
M. abscessus ATCC 19977MAB_1054-0.073.90% (793) putative ATP-dependent DNA helicase PcrA
M. marinum MMMAR_4553uvrD10.099.22% (769) ATP-dependent DNA helicase II UvrD1
M. avium 104MAV_1071pcrA0.087.69% (780) ATP-dependent DNA helicase PcrA
M. smegmatis MC2 155MSMEG_5534pcrA0.080.33% (778) ATP-dependent DNA helicase PcrA
M. thermoresistible (build 8)TH_1135uvrD22e-5334.00% (500) PROBABLE ATP-DEPENDENT DNA HELICASE II UVRD2
M. vanbaalenii PYR-1Mvan_4873-0.082.62% (771) ATP-dependent DNA helicase PcrA

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1861|M.gilvum_PYR-GCK          -MTAHVTLPE-ATPMAG----DDLLEGLNPQQRQAVLHEGTPLLIVAGAG
Mvan_4873|M.vanbaalenii_PYR-1       -MTSLSVS---AGPTGT----DELLDGLNPQQRQAVLHQGTPLLIVAGAG
MSMEG_5534|M.smegmatis_MC2_155      -MTSPSAT---PFAAET----DQLLDGLNPQQRQAVLHEGSPLLIVAGAG
MUL_4723|M.ulcerans_Agy99           -MTVQATDA------------DQLVEGLNPQQRQAVVHEGSPLLIVAGAG
MMAR_4553|M.marinum_M               -MTVQATDA------------DQLLEGLNPQQRQAVVHEGSPLLIVAGAG
Mb0974|M.bovis_AF2122/97            -MSVHATDAKPPGPSPA----DQLLDGLNPQQRQAVVHEGSPLLIVAGAG
Rv0949|M.tuberculosis_H37Rv         -MSVHATDAKPPGPSPA----DQLLDGLNPQQRQAVVHEGSPLLIVAGAG
MAV_1071|M.avium_104                -MSVHVTDAKP--VSEA----EQLLEGLNPQQRQAVVHEGSPLLIVAGAG
MLBr_00153|M.leprae_Br4923          -MSVHTTDAKP--DSEV----DRLLDGLNPQQRQAVVHEGSPLLIVAGAG
MAB_1054|M.abscessus_ATCC_1997      -MANLSEPALFDMPSDSSASSDALLDGLNPQQRAAVAHQGAPLLIVAGAG
TH_1135|M.thermoresistible__bu      MMVAMPAEAS----SLR----ARLLDDLDDEQREAVTAPRGPVCVLAGAG
                                     *                     *::.*: :** **     *: ::****

Mflv_1861|M.gilvum_PYR-GCK          SGKTAVLTRRIAYLLAARDVGVGQVLAITFTNKAAAEMRERVVGLVGPRA
Mvan_4873|M.vanbaalenii_PYR-1       SGKTAVLTRRIAYLLAARDVGVGQVLAITFTNKAAAEMRERVVSLVGPRA
MSMEG_5534|M.smegmatis_MC2_155      SGKTAVLTRRIAYLLAEREVGVGQVLAITFTNKAAAEMRERVVQLVGPRA
MUL_4723|M.ulcerans_Agy99           SGKTAVLTRRIAYLIAARGVGVGQILAITFTNKAAAEVRERVVSLVGGRA
MMAR_4553|M.marinum_M               SGKTAVLTRRIAYLIAARGVGVGQILAITFTNKAAAEMRERVVSLVGGRA
Mb0974|M.bovis_AF2122/97            SGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAAEMRERVVGLVGEKA
Rv0949|M.tuberculosis_H37Rv         SGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAAEMRERVVGLVGEKA
MAV_1071|M.avium_104                SGKTAVLTRRVAYLIAARGVGVGQVLAITFTNKAAAEMRERVVRLVGNRA
MLBr_00153|M.leprae_Br4923          SGKTTVLARRIAYLIAARSVGVSQILAITFTNKAAAEMRERVARLVGDHT
MAB_1054|M.abscessus_ATCC_1997      SGKTAVLTRRIAYLLAARDVSPGQILAITFTNKAAAEMRERVGRIVANRV
TH_1135|M.thermoresistible__bu      TGKTRTITRRIAYLVAAGHVAPSQVLAVTFTQRAAGEMRGRLRALDDGVG
                                    :*** .::**:***:*   *. .*:**:***::**.*:* *:  :     

Mflv_1861|M.gilvum_PYR-GCK          R-NMWVSTFHSTCVRILRNQASLLPGLNSNFSIYDADDSRRLLLMIGKDM
Mvan_4873|M.vanbaalenii_PYR-1       R-NMWVSTFHSTCVRILRNQASLLPGLNSNFSIYDADDSRRLLLMIGKDM
MSMEG_5534|M.smegmatis_MC2_155      K-AMWVSTFHSTCVRILRNQASLLPGLNSNFSIYDSDDSRRLLMMIGKDL
MUL_4723|M.ulcerans_Agy99           K-YMWVSTFHSTCVRILRNQAALIKGLNSNFSIYDADDSRRLLQMIGRDM
MMAR_4553|M.marinum_M               K-YMWVSTFHSTCVRILRNQAALIKGLNSNFSIYDADDSRRLLQMIGRDM
Mb0974|M.bovis_AF2122/97            R-YMWVSTFHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDL
Rv0949|M.tuberculosis_H37Rv         R-YMWVSTFHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDL
MAV_1071|M.avium_104                R-AMWVSTFHSTCVRILRNQASLIEGLNSNFSIYDADDSRRLLQMIGRDM
MLBr_00153|M.leprae_Br4923          GPSMWVSTFHSTCVRILRNQASLIGGLNSNFSIYDVDDSRSLLQMIGQDM
MAB_1054|M.abscessus_ATCC_1997      Q-SMWVSTFHSSCVRILRNQASLLPGLNSNFSIYDSDDSRRLLQMIGRDM
TH_1135|M.thermoresistible__bu      TGAVQAMTFHAAARRQLR---YFWPQVVGDAPWQLLDSKFSVVASAANRC
                                       : . ***::. * **    :   : .: .    *..  ::   ..  

Mflv_1861|M.gilvum_PYR-GCK          GLDTKRHSPRLLANSISNLKNELIGPEQAAAEASEAADD------LARIV
Mvan_4873|M.vanbaalenii_PYR-1       GLDTKRHSPRLLANGISNLKNELIGPEQAAAEASEAEDD------LARII
MSMEG_5534|M.smegmatis_MC2_155      GLDTKRYSPRLLANGISNLKNELIGPEQAAAEASEASDE------MATVI
MUL_4723|M.ulcerans_Agy99           GLDIKRYSPRLLTNAISNLKNELIDPDRAVSDLSEDSDD------LARTV
MMAR_4553|M.marinum_M               GLDIKRYSPRLLANAISNLKNELIDPDRAVSDLSEDSDD------LARTV
Mb0974|M.bovis_AF2122/97            GLDIKRYSPRLLANAISNLKNELIDPHQALAGLTEDSDD------LARAV
Rv0949|M.tuberculosis_H37Rv         GLDIKRYSPRLLANAISNLKNELIDPHQALAGLTEDSDD------LARAV
MAV_1071|M.avium_104                GLDIKRYSPRLLANAISNLKNELIDPAAAVANLTDDSDE------LSRTV
MLBr_00153|M.leprae_Br4923          GLDIKRYSPRLMANAISNLKNELIDAESAVANLSSDTDD------LARTV
MAB_1054|M.abscessus_ATCC_1997      GLDIKRYSPRLLATAISNLKNELISPEQAVANLTAGGQDGELRGDLPQIV
TH_1135|M.thermoresistible__bu      GLPTGTDDVRDLAGEIEWAKASLITPEDYPKAVAEAGRDIP---FDAAKV
                                    **     . * ::  *.  * .** .       :    :       .  :

Mflv_1861|M.gilvum_PYR-GCK          ADVYG--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHIL
Mvan_4873|M.vanbaalenii_PYR-1       ASVYA--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHIL
MSMEG_5534|M.smegmatis_MC2_155      AQVYG--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHIL
MUL_4723|M.ulcerans_Agy99           ASVYA--EYQRRLRAANALDFDDLIGETVGILQAFPDIAGHYRRRFRHVL
MMAR_4553|M.marinum_M               ASVYA--EYQRRLRAANALDFDDLIGETVGILQAFPDIAGHYRRRFRHVL
Mb0974|M.bovis_AF2122/97            ASVYD--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVL
Rv0949|M.tuberculosis_H37Rv         ASVYD--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVL
MAV_1071|M.avium_104                ASVYG--EYQRRLRAANALDFDDLIGETVAVLRAFPQIAQHYRRRFRHVL
MLBr_00153|M.leprae_Br4923          ATVYG--EYQRRLRTANALDFDDLIGETVGILQAFPQIAEHYRRRFRHVL
MAB_1054|M.abscessus_ATCC_1997      ADVYG--EYQRRLRAANALDFDDLIGETVAVLQQFPQIAQFYRRKFRHIL
TH_1135|M.thermoresistible__bu      AAAYAGYEALKARQETVLLDFDDLLLHTAAAIENEPAVAQEFRDRYRCFV
                                    * .*   *  :  : :  ******: .*.. :.  * :*  :* ::* .:

Mflv_1861|M.gilvum_PYR-GCK          VDEYQDTNHAQYVLVRELTGSGATESDE--SVAPAELCVVGDADQSIYAF
Mvan_4873|M.vanbaalenii_PYR-1       VDEYQDTNHAQYVLVRELVG---TETVD--GVPPAELCVVGDADQSIYAF
MSMEG_5534|M.smegmatis_MC2_155      VDEYQDTNHAQYVLVRELVG-HHLEDHD--GVPPSELCVVGDADQSIYAF
MUL_4723|M.ulcerans_Agy99           VDEYQDTNHAQYVLVRELVGRGSEDEPG--DVPPAQLCVVGDADQSIYAF
MMAR_4553|M.marinum_M               VDEYQDTNHAQYVLVRELVGRGSEDEPG--DVPPAQLCVVGDADQSIYAF
Mb0974|M.bovis_AF2122/97            VDEYQDTNHAQYVLVRELVGRDSND-----GIPPGELCVVGDADQSIYAF
Rv0949|M.tuberculosis_H37Rv         VDEYQDTNHAQYVLVRELVGRDSND-----GIPPGELCVVGDADQSIYAF
MAV_1071|M.avium_104                VDEYQDTNHAQYVLVRELVGTDTED-----GVPPGELCVVGDADQSIYAF
MLBr_00153|M.leprae_Br4923          VDEYQDTNHAQYVLVRELVGHGARNSPD--DMPPGELCVVGDADQSIYAF
MAB_1054|M.abscessus_ATCC_1997      VDEYQDTNHAQYVLVRELVGAHVDRTVDPDGPEPAELCVVGDADQSIYAF
TH_1135|M.thermoresistible__bu      VDEYQDVTPLQQRVLNAWLG------------ERDDLTVVGDANQTIYSF
                                    ******..  *  ::.   *               :* *****:*:**:*

Mflv_1861|M.gilvum_PYR-GCK          RGATIRNIEDFERDFPSATTILLEQNYRSTQTILNAANSVIARNAGRREK
Mvan_4873|M.vanbaalenii_PYR-1       RGATIRNIEDFERDFPNATTILLEQNYRSTQTILNAANSVIARNVGRRDK
MSMEG_5534|M.smegmatis_MC2_155      RGATIRNIEDFERDFPDATTILLEQNYRSTQTILNAANAVIARNTGRREK
MUL_4723|M.ulcerans_Agy99           RGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVISRNSGRREK
MMAR_4553|M.marinum_M               RGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVISRNSGRREK
Mb0974|M.bovis_AF2122/97            RGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSVIARNAGRREK
Rv0949|M.tuberculosis_H37Rv         RGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSVIARNAGRREK
MAV_1071|M.avium_104                RGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVIARNSGRRDK
MLBr_00153|M.leprae_Br4923          RGSTISNIEDFERDYPDTTTILLEQNYRSTQNILSAANSVIARNFGRRDK
MAB_1054|M.abscessus_ATCC_1997      RGATIRNIEEFERDYPNAKTILLEQNYRSTQNILSAANSVIAKNANRREK
TH_1135|M.thermoresistible__bu      TGATPQYLLDFSRRFPDATVVRLERDYRSTPQVVSLANRVIATARGRMAG
                                     *:*   : :*.* :*.: .: **::****  ::. ** **:   .*   

Mflv_1861|M.gilvum_PYR-GCK          RLWTDAGE---GELIVGYVADNEHDEARFIAQEIDALSDSIPDFSYNDVA
Mvan_4873|M.vanbaalenii_PYR-1       RLWTDAGE---GELIVGYVADNEHDEARFVAQEIDALSDAVADFSYNDVA
MSMEG_5534|M.smegmatis_MC2_155      RLWTDAGQ---GELIVGYVADNEHDEARFVADEIDALTDRHG-YNYNDIA
MUL_4723|M.ulcerans_Agy99           RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAERDE-ITYSDVA
MMAR_4553|M.marinum_M               RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAERDE-ITYNDVA
Mb0974|M.bovis_AF2122/97            RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAEGSE-ITYNDVA
Rv0949|M.tuberculosis_H37Rv         RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAEGSE-ITYNDVA
MAV_1071|M.avium_104                RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAQKGE-ITYNDVA
MLBr_00153|M.leprae_Br4923          RLWTDAGK---GELIVGYVSDNEHDEAKFIADEIDALVGGGE-ITYDDVA
MAB_1054|M.abscessus_ATCC_1997      RLWTDSGE---GELIVGYVADNEHDEASFIAREIDGLFDRSD-ANYGDIA
TH_1135|M.thermoresistible__bu      SKLHLVGQRPPGPQPTFSEYPDEVAEATAVAKNIARLIESGV--APAEIA
                                          *    *   .     :*  **  :* :*  *          ::*

Mflv_1861|M.gilvum_PYR-GCK          VFYRTNNSSRAIEEVFIRAGIPYKVVGGVRFYERREIRDIVAYLRVLDNP
Mvan_4873|M.vanbaalenii_PYR-1       VFYRTNNSSRAIEEVFIRAGIPYKVVGGVRFYERREIRDIVAYLRVLDNP
MSMEG_5534|M.smegmatis_MC2_155      VFYRTNNSSRALEEVFIRAGIPYKVVGGVRFYERREIRDIVAYLRVLDNP
MUL_4723|M.ulcerans_Agy99           VFYRTNNSSRSLEEVFIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDNP
MMAR_4553|M.marinum_M               VFYRTNNSSRSLEEVFIRAGIPYKVVGGVRFYERKEIRDIIAYLRVLDNP
Mb0974|M.bovis_AF2122/97            VFYRTNNSSRSLEEVLIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDNP
Rv0949|M.tuberculosis_H37Rv         VFYRTNNSSRSLEEVLIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDNP
MAV_1071|M.avium_104                VFYRTNNSSRSFEEVFIRAGIPYKVVGGVRFYERKEIRDIIAYLRVLDNP
MLBr_00153|M.leprae_Br4923          VLYRANNLSRSLEEVFIPTGIPYKVVGGFCFYESKEIRDLIAYLRVLDNP
MAB_1054|M.abscessus_ATCC_1997      VFYRTNNNSRSLEEIFIRTGIPYKVVGGVRFYERKEIRDIVAYLRVLTNP
TH_1135|M.thermoresistible__bu      VLYRINAQSEVYEEALTEAGIAFQVRGGEGFFSRQEIRQALLVLQRA---
                                    *:** *  *.  ** :  :**.::* **  *:. :***: :  *:     

Mflv_1861|M.gilvum_PYR-GCK          GDAVSMRRILNTPRRGIGDRAEACVAVHAENTGLNFNDALVAAAEGNVPM
Mvan_4873|M.vanbaalenii_PYR-1       GDSVSMRRILNTPRRGIGDRAEACVAVYAETTGANFNDALAAAAEGKVPM
MSMEG_5534|M.smegmatis_MC2_155      GDSVSMRRILNTPRRGIGDRAEACVAVYAENTGVSFNEALQAAAEGRVPM
MUL_4723|M.ulcerans_Agy99           GDAVSMRRILNTPRRGIGDRAEACVAVYAENTGAGFSDALVAAAEGKVPM
MMAR_4553|M.marinum_M               GDAVSMRRILNTPRRGIGDRAEACVAVYAENTGAGFSDALVAAAEGKVPM
Mb0974|M.bovis_AF2122/97            GDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPM
Rv0949|M.tuberculosis_H37Rv         GDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPM
MAV_1071|M.avium_104                GDAVSMRRILNTPRRGIGDRAEACVAVYAENTGASFADALVAAAEGKVPM
MLBr_00153|M.leprae_Br4923          GDAVSMRRILNTPRRGIGDRAEACVSVYAENTGTSFADALQAVAEGKVPM
MAB_1054|M.abscessus_ATCC_1997      GDAVSLRRILNTPRRGIGDRAEACVAVHAETNGIGFGEALADAAAGKVAM
TH_1135|M.thermoresistible__bu      ----------------------------AERAGTGAVETPAG--------
                                                                **  * .  ::           

Mflv_1861|M.gilvum_PYR-GCK          LNTRSEKAIAGFVALLDDLRGGLDG-------ELGDLVEAVLDRTGYRAE
Mvan_4873|M.vanbaalenii_PYR-1       LNTRSEKAIKGFVELLDELRGGLDG-------ELGDLVETVLDRTGYRAE
MSMEG_5534|M.smegmatis_MC2_155      LNTRSEKCIASFVQMLDDLRGKLDE-------ELGDLVEAVLERTGYRRE
MUL_4723|M.ulcerans_Agy99           LNSRAEKAIAGFVELLDELRGRLDSSEG----DVGELVEAVLERTGYRRE
MMAR_4553|M.marinum_M               LNSRAEKAIAGFVELLDELRGRLDSSEG----DLGELVEAVLERTGYRRE
Mb0974|M.bovis_AF2122/97            LNTRAEKAIAGFVEMFDELRGRLDD-------DLGELVEAVLERTGYRRE
Rv0949|M.tuberculosis_H37Rv         LNTRAEKAIAGFVEMFDELRGRLDD-------DLGELVEAVLERTGYRRE
MAV_1071|M.avium_104                LNSRAEKAIAGFVELLDDLRGRLDD-------DLGDLVESVLERTGYRRE
MLBr_00153|M.leprae_Br4923          LNTRSVKAIAGFVALLDDLRCRVDD-------DLGELVESVLERSGYLRE
MAB_1054|M.abscessus_ATCC_1997      LNSRSEKAIAAFMDMLDQIRVTLRTDDPGALPDIGDVVEAVLNHTGYRYE
TH_1135|M.thermoresistible__bu      -------------------------------AELAAAVRGLLEPLGLTAE
                                                                    ::.  *. :*:  *   *

Mflv_1861|M.gilvum_PYR-GCK          LEASSDPQDLARLDNLNELVSVAHEFSTDLANARALAEGD-EDAQDEDVP
Mvan_4873|M.vanbaalenii_PYR-1       LEASSDPQDLARLDNLNELVSVAHEFSIDLANAKALASEEGAEPQDEDVP
MSMEG_5534|M.smegmatis_MC2_155      LEASSDPQDLARLDNLNELVSVAHEFSIDLANAQALAEES-DEPVDEDIP
MUL_4723|M.ulcerans_Agy99           LESSTDPQELARLDNLNELVSVAHEFSTDLANAAEPEP------DAEDVP
MMAR_4553|M.marinum_M               LESSTDPQELARLDNLNELVSVAHEFSTDLANAAEPEP------DAEDVP
Mb0974|M.bovis_AF2122/97            LEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGP------DDEDVP
Rv0949|M.tuberculosis_H37Rv         LEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGP------DDEDVP
MAV_1071|M.avium_104                LESSTDPQELARLDNLNELVSVAHEFSTDRANAAALDESL-DAADDEDVP
MLBr_00153|M.leprae_Br4923          LESSTDPQELARLDNLNELVSFAHEFSTEQANAAALAKSL-HTPEDEDVP
MAB_1054|M.abscessus_ATCC_1997      LENSSDPQELARLDNLNELVSVAHEFSADAANAQAAGEDV--PGDDEDVG
TH_1135|M.thermoresistible__bu      PPAGTRAR--ERWEALAALADLVDEEVATQPGLT----------------
                                       .: .:   * : *  *.....*      .                  

Mflv_1861|M.gilvum_PYR-GCK          DT-GVLAAFLERVSLVADADDIPEHGSGVVTMMTLHTAKGLEFPLVFVTG
Mvan_4873|M.vanbaalenii_PYR-1       DT-GVLAAFLERVSLVADADDIPEHGAGVVTMMTLHTAKGLEFPVVFVTG
MSMEG_5534|M.smegmatis_MC2_155      DT-GVLAQFLERVSLVADADDIPEEGSGVVTMMTLHTAKGLEFPAVFVTG
MUL_4723|M.ulcerans_Agy99           DT-GMLAAFLERVSLVADTDDIPEHGAGVVTLMTLHTAKGLEFPVVFVTG
MMAR_4553|M.marinum_M               DT-GMLAAFLERVSLVADTDDIPEHGAGVVTLMTLHTAKGLEFPVVFVTG
Mb0974|M.bovis_AF2122/97            DT-GVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTG
Rv0949|M.tuberculosis_H37Rv         DT-GVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTG
MAV_1071|M.avium_104                DT-GVLAEFLERVSLVSDSDEIPEDGAGMVTLMTLHTAKGLEFPVVFVTG
MLBr_00153|M.leprae_Br4923          DT-GALAAFLEKVSLMSDTDQIPENNSGVVTLMTLHAAKGLEFPVVFVTG
MAB_1054|M.abscessus_ATCC_1997      APPGSLEAFLERVSLVADADELPESSAGVVTMMTLHTAKGLEFPVVFVTG
TH_1135|M.thermoresistible__bu      -----LPGLLNELRRRADARHPPVVQG--VTLASLHAAKGLEWDAVFLVG
                                         *  :*:.:   :*: . *   .  **: :**:*****:  **:.*

Mflv_1861|M.gilvum_PYR-GCK          WEDGMFPHMRALGDPLE---LSEERRLAYVGITRARQRLYLSRAKVRSSW
Mvan_4873|M.vanbaalenii_PYR-1       WEDGMFPHMRALGDPGE---LSEERRLAYVGITRARQRLYLSRAKVRSSW
MSMEG_5534|M.smegmatis_MC2_155      WEDGMFPHMRALGDPNE---LSEERRLAYVGITRARQRLYLSRAKVRSSW
MUL_4723|M.ulcerans_Agy99           WEDGMFPHMRALDDPTE---LSEERRLAYVGITRARQRLYLSRAIVRSSW
MMAR_4553|M.marinum_M               WEDGMFPHMRALDDPTE---LSEERRLAYVGITRARQRLYLSRAIVRSSW
Mb0974|M.bovis_AF2122/97            WEDGMFPHMRALDNPTE---LSEERRLAYVGITRARQRLYVSRAIVRSSW
Rv0949|M.tuberculosis_H37Rv         WEDGMFPHMRALDNPTE---LSEERRLAYVGITRARQRLYVSRAIVRSSW
MAV_1071|M.avium_104                WEDGMFPHMRSLDDPVE---LSEERRLAYVGITRARQRLYLSRAIVRSSW
MLBr_00153|M.leprae_Br4923          WEDGMLPHMRTLGDPTE---LSEERRLAYVGITRARQRLYLSRAITRSSW
MAB_1054|M.abscessus_ATCC_1997      WEDGMFPHMRALGDPVE---LAEERRLAYVGITRARQRLYLSRAKVRSSW
TH_1135|M.thermoresistible__bu      LADGTLPISHALAHGPESEPVEEERRLLYVGITRARVHLALSWALARAPG
                                      ** :*  ::* .  *   : ***** ******** :* :* * .*:. 

Mflv_1861|M.gilvum_PYR-GCK          GQPMLNPESRFLREIPQELIDWRRTEAPASSFSAP--VGNAG----RYGT
Mvan_4873|M.vanbaalenii_PYR-1       GQPMLNPESRFLREIPQELIDWRRTEQPSS-FSAP--VGNAG----RYGA
MSMEG_5534|M.smegmatis_MC2_155      GQPMLNPESRFLREIPQELIDWRRIEAPTPAYAAPGRMSSSGGGGIGFGS
MUL_4723|M.ulcerans_Agy99           GQPMLNPESRFLREIPQELLNWRRL-APKPSFSAP--VSGAG----RFGT
MMAR_4553|M.marinum_M               GQPMLNPESRFLREIPQELLNWRRL-APKPSFSAP--VSGAG----RFGT
Mb0974|M.bovis_AF2122/97            GQPMLNPESRFLREIPQELIDWRRT-APKPSFSAP--VSGAG----RFGS
Rv0949|M.tuberculosis_H37Rv         GQPMLNPESRFLREIPQELIDWRRT-APKPSFSAP--VSGAG----RFGS
MAV_1071|M.avium_104                GQPMLNPESRFLREIPQELIEWRRT-APAPSFSAP--VSGAG----RFGT
MLBr_00153|M.leprae_Br4923          GQPILNPESRFLREIPPELIDWRRS-ILTDSYSTP--ASGAS----RFGR
MAB_1054|M.abscessus_ATCC_1997      GQPMMNPESRFLQEIPQELIDWRRTDPLPGRIATG--AGGYGGGGYGSGG
TH_1135|M.thermoresistible__bu      GRQGRRP-SRFLNGIAPNVGSAGDRSGPTRPRRQRGATPRCRICNAVLTA
                                    *:   .* ****. *. :: .                             

Mflv_1861|M.gilvum_PYR-GCK          PRP---SPTRPAAGK-RPLIVLEPGDRVTHDKYGLGRVEEVSGAGESAMS
Mvan_4873|M.vanbaalenii_PYR-1       PRP---SPTRPAAGK-RPLIVLEPGDRVTHDKYGLGRVEEVSGAGESAMS
MSMEG_5534|M.smegmatis_MC2_155      PRP---SPNRPGGGRNKPLMVLQPGDRVTHDKYGLGRVEEVAGTGESAMS
MUL_4723|M.ulcerans_Agy99           ARS---APVRTSTSK-RPLLVLQPGDRVTHDKYGLGRVEEVSGVGESAMS
MMAR_4553|M.marinum_M               ARS---APVRTSTSK-RPLLVLQPGDRVTHDKYGLGRVEEVSGVGESAMS
Mb0974|M.bovis_AF2122/97            ARP---SPTRSGASR-RPLLVLQVGDRVTHDKYGLGRVEEVSGVGESAMS
Rv0949|M.tuberculosis_H37Rv         ARP---SPTRSGASR-RPLLVLQVGDRVTHDKYGLGRVEEVSGVGESAMS
MAV_1071|M.avium_104                PRA---APTRAAMSK-RPLLVLAPGDRVTHDKYGLGRVEEVSGAGESAMS
MLBr_00153|M.leprae_Br4923          VRP---SSIRSGASK-RALLVLAPGDRVTHDKYGLGRVEEVSGVGESAIS
MAB_1054|M.abscessus_ATCC_1997      SRAGGGSLGAPSKKRTKPLMVLEAGDRVSHDKYGLGRVVEVTGVGESATS
TH_1135|M.thermoresistible__bu      PPAIMLRRCESCPADIDEELLAELKEWRSRTAKEMSVPAYVVFTDNTLIA
                                      .       .        ::    :  ::    :.    *  ..::  :

Mflv_1861|M.gilvum_PYR-GCK          LIDFGSAGRVKLMHNHAPISKL----------------
Mvan_4873|M.vanbaalenii_PYR-1       LIDFGSAGRVKLMHNHAPVSKL----------------
MSMEG_5534|M.smegmatis_MC2_155      LIDFGSAGRVKLMHNHAPLQKL----------------
MUL_4723|M.ulcerans_Agy99           LIDFGSSGRVKLMHNHAPVAKL----------------
MMAR_4553|M.marinum_M               LIDFGSSGRVKLMHNHAPVAKL----------------
Mb0974|M.bovis_AF2122/97            LIDFGSSGRVKLMHNHAPVTKL----------------
Rv0949|M.tuberculosis_H37Rv         LIDFGSSGRVKLMHNHAPVTKL----------------
MAV_1071|M.avium_104                LIDFGSSGRVKLMHNHAPISKL----------------
MLBr_00153|M.leprae_Br4923          LIDFGSSGRIKLMHNHAPVTKL----------------
MAB_1054|M.abscessus_ATCC_1997      LIDFGSEGRVKLMHNFAPVQKL----------------
TH_1135|M.thermoresistible__bu      IAEMLPTDDAALVAIPGIGARKLEQFGPDVLAMVKNRR
                                    : :: . .   *:   .   :