For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MANLSEPALFDMPSDSSASSDALLDGLNPQQRAAVAHQGAPLLIVAGAGSGKTAVLTRRIAYLLAARDVS PGQILAITFTNKAAAEMRERVGRIVANRVQSMWVSTFHSSCVRILRNQASLLPGLNSNFSIYDSDDSRRL LQMIGRDMGLDIKRYSPRLLATAISNLKNELISPEQAVANLTAGGQDGELRGDLPQIVADVYGEYQRRLR AANALDFDDLIGETVAVLQQFPQIAQFYRRKFRHILVDEYQDTNHAQYVLVRELVGAHVDRTVDPDGPEP AELCVVGDADQSIYAFRGATIRNIEEFERDYPNAKTILLEQNYRSTQNILSAANSVIAKNANRREKRLWT DSGEGELIVGYVADNEHDEASFIAREIDGLFDRSDANYGDIAVFYRTNNNSRSLEEIFIRTGIPYKVVGG VRFYERKEIRDIVAYLRVLTNPGDAVSLRRILNTPRRGIGDRAEACVAVHAETNGIGFGEALADAAAGKV AMLNSRSEKAIAAFMDMLDQIRVTLRTDDPGALPDIGDVVEAVLNHTGYRYELENSSDPQELARLDNLNE LVSVAHEFSADAANAQAAGEDVPGDDEDVGAPPGSLEAFLERVSLVADADELPESSAGVVTMMTLHTAKG LEFPVVFVTGWEDGMFPHMRALGDPVELAEERRLAYVGITRARQRLYLSRAKVRSSWGQPMMNPESRFLQ EIPQELIDWRRTDPLPGRIATGAGGYGGGGYGSGGSRAGGGSLGAPSKKRTKPLMVLEAGDRVSHDKYGL GRVVEVTGVGESATSLIDFGSEGRVKLMHNFAPVQKL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_1054 | - | - | 100% (807) | putative ATP-dependent DNA helicase PcrA |
M. abscessus ATCC 19977 | MAB_3511c | - | 4e-54 | 34.88% (430) | DNA helicase II |
M. abscessus ATCC 19977 | MAB_3515c | - | 2e-43 | 24.66% (819) | ATP-dependent DNA helicase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0974 | uvrD1 | 0.0 | 74.91% (797) | ATP dependent DNA helicase UVRD1 |
M. gilvum PYR-GCK | Mflv_1861 | - | 0.0 | 74.69% (798) | ATP-dependent DNA helicase PcrA |
M. tuberculosis H37Rv | Rv0949 | uvrD1 | 0.0 | 74.91% (797) | ATP-dependent DNA helicase II UVRD1 |
M. leprae Br4923 | MLBr_00153 | uvrD | 0.0 | 71.23% (789) | putative ATP-dependent DNA helicase |
M. marinum M | MMAR_4553 | uvrD1 | 0.0 | 74.15% (793) | ATP-dependent DNA helicase II UvrD1 |
M. avium 104 | MAV_1071 | pcrA | 0.0 | 74.72% (791) | ATP-dependent DNA helicase PcrA |
M. smegmatis MC2 155 | MSMEG_5534 | pcrA | 0.0 | 75.57% (794) | ATP-dependent DNA helicase PcrA |
M. thermoresistible (build 8) | TH_1135 | uvrD2 | 4e-54 | 33.85% (514) | PROBABLE ATP-DEPENDENT DNA HELICASE II UVRD2 |
M. ulcerans Agy99 | MUL_4723 | uvrD1 | 0.0 | 73.90% (793) | ATP-dependent DNA helicase II UvrD1 |
M. vanbaalenii PYR-1 | Mvan_4873 | - | 0.0 | 74.75% (796) | ATP-dependent DNA helicase PcrA |
CLUSTAL 2.0.9 multiple sequence alignment Mb0974|M.bovis_AF2122/97 -MSVHATDAKPPGPSPA----DQLLDGLNPQQRQAVVHEGSPLLIVAGAG Rv0949|M.tuberculosis_H37Rv -MSVHATDAKPPGPSPA----DQLLDGLNPQQRQAVVHEGSPLLIVAGAG MMAR_4553|M.marinum_M -MTVQATDA------------DQLLEGLNPQQRQAVVHEGSPLLIVAGAG MUL_4723|M.ulcerans_Agy99 -MTVQATDA------------DQLVEGLNPQQRQAVVHEGSPLLIVAGAG MAV_1071|M.avium_104 -MSVHVTDAKP--VSEA----EQLLEGLNPQQRQAVVHEGSPLLIVAGAG MLBr_00153|M.leprae_Br4923 -MSVHTTDAKP--DSEV----DRLLDGLNPQQRQAVVHEGSPLLIVAGAG Mflv_1861|M.gilvum_PYR-GCK -MTAHVTLPE-ATPMAG----DDLLEGLNPQQRQAVLHEGTPLLIVAGAG Mvan_4873|M.vanbaalenii_PYR-1 -MTSLSVS---AGPTGT----DELLDGLNPQQRQAVLHQGTPLLIVAGAG MSMEG_5534|M.smegmatis_MC2_155 -MTSPSAT---PFAAET----DQLLDGLNPQQRQAVLHEGSPLLIVAGAG MAB_1054|M.abscessus_ATCC_1997 -MANLSEPALFDMPSDSSASSDALLDGLNPQQRAAVAHQGAPLLIVAGAG TH_1135|M.thermoresistible__bu MMVAMPAEAS----SLR----ARLLDDLDDEQREAVTAPRGPVCVLAGAG * *::.*: :** ** *: ::**** Mb0974|M.bovis_AF2122/97 SGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAAEMRERVVGLVGEKA Rv0949|M.tuberculosis_H37Rv SGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAAEMRERVVGLVGEKA MMAR_4553|M.marinum_M SGKTAVLTRRIAYLIAARGVGVGQILAITFTNKAAAEMRERVVSLVGGRA MUL_4723|M.ulcerans_Agy99 SGKTAVLTRRIAYLIAARGVGVGQILAITFTNKAAAEVRERVVSLVGGRA MAV_1071|M.avium_104 SGKTAVLTRRVAYLIAARGVGVGQVLAITFTNKAAAEMRERVVRLVGNRA MLBr_00153|M.leprae_Br4923 SGKTTVLARRIAYLIAARSVGVSQILAITFTNKAAAEMRERVARLVGDHT Mflv_1861|M.gilvum_PYR-GCK SGKTAVLTRRIAYLLAARDVGVGQVLAITFTNKAAAEMRERVVGLVGPRA Mvan_4873|M.vanbaalenii_PYR-1 SGKTAVLTRRIAYLLAARDVGVGQVLAITFTNKAAAEMRERVVSLVGPRA MSMEG_5534|M.smegmatis_MC2_155 SGKTAVLTRRIAYLLAEREVGVGQVLAITFTNKAAAEMRERVVQLVGPRA MAB_1054|M.abscessus_ATCC_1997 SGKTAVLTRRIAYLLAARDVSPGQILAITFTNKAAAEMRERVGRIVANRV TH_1135|M.thermoresistible__bu TGKTRTITRRIAYLVAAGHVAPSQVLAVTFTQRAAGEMRGRLRALDDGVG :*** .::**:***:* *. .*:**:***::**.*:* *: : Mb0974|M.bovis_AF2122/97 R-YMWVSTFHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDL Rv0949|M.tuberculosis_H37Rv R-YMWVSTFHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDL MMAR_4553|M.marinum_M K-YMWVSTFHSTCVRILRNQAALIKGLNSNFSIYDADDSRRLLQMIGRDM MUL_4723|M.ulcerans_Agy99 K-YMWVSTFHSTCVRILRNQAALIKGLNSNFSIYDADDSRRLLQMIGRDM MAV_1071|M.avium_104 R-AMWVSTFHSTCVRILRNQASLIEGLNSNFSIYDADDSRRLLQMIGRDM MLBr_00153|M.leprae_Br4923 GPSMWVSTFHSTCVRILRNQASLIGGLNSNFSIYDVDDSRSLLQMIGQDM Mflv_1861|M.gilvum_PYR-GCK R-NMWVSTFHSTCVRILRNQASLLPGLNSNFSIYDADDSRRLLLMIGKDM Mvan_4873|M.vanbaalenii_PYR-1 R-NMWVSTFHSTCVRILRNQASLLPGLNSNFSIYDADDSRRLLLMIGKDM MSMEG_5534|M.smegmatis_MC2_155 K-AMWVSTFHSTCVRILRNQASLLPGLNSNFSIYDSDDSRRLLMMIGKDL MAB_1054|M.abscessus_ATCC_1997 Q-SMWVSTFHSSCVRILRNQASLLPGLNSNFSIYDSDDSRRLLQMIGRDM TH_1135|M.thermoresistible__bu TGAVQAMTFHAAARRQLR---YFWPQVVGDAPWQLLDSKFSVVASAANRC : . ***::. * ** : : .: . *.. :: .. Mb0974|M.bovis_AF2122/97 GLDIKRYSPRLLANAISNLKNELIDPHQALAGLTEDSDD------LARAV Rv0949|M.tuberculosis_H37Rv GLDIKRYSPRLLANAISNLKNELIDPHQALAGLTEDSDD------LARAV MMAR_4553|M.marinum_M GLDIKRYSPRLLANAISNLKNELIDPDRAVSDLSEDSDD------LARTV MUL_4723|M.ulcerans_Agy99 GLDIKRYSPRLLTNAISNLKNELIDPDRAVSDLSEDSDD------LARTV MAV_1071|M.avium_104 GLDIKRYSPRLLANAISNLKNELIDPAAAVANLTDDSDE------LSRTV MLBr_00153|M.leprae_Br4923 GLDIKRYSPRLMANAISNLKNELIDAESAVANLSSDTDD------LARTV Mflv_1861|M.gilvum_PYR-GCK GLDTKRHSPRLLANSISNLKNELIGPEQAAAEASEAADD------LARIV Mvan_4873|M.vanbaalenii_PYR-1 GLDTKRHSPRLLANGISNLKNELIGPEQAAAEASEAEDD------LARII MSMEG_5534|M.smegmatis_MC2_155 GLDTKRYSPRLLANGISNLKNELIGPEQAAAEASEASDE------MATVI MAB_1054|M.abscessus_ATCC_1997 GLDIKRYSPRLLATAISNLKNELISPEQAVANLTAGGQDGELRGDLPQIV TH_1135|M.thermoresistible__bu GLPTGTDDVRDLAGEIEWAKASLITPEDYPKAVAEAGRDIP---FDAAKV ** . * :: *. * .** . : : . : Mb0974|M.bovis_AF2122/97 ASVYD--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVL Rv0949|M.tuberculosis_H37Rv ASVYD--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVL MMAR_4553|M.marinum_M ASVYA--EYQRRLRAANALDFDDLIGETVGILQAFPDIAGHYRRRFRHVL MUL_4723|M.ulcerans_Agy99 ASVYA--EYQRRLRAANALDFDDLIGETVGILQAFPDIAGHYRRRFRHVL MAV_1071|M.avium_104 ASVYG--EYQRRLRAANALDFDDLIGETVAVLRAFPQIAQHYRRRFRHVL MLBr_00153|M.leprae_Br4923 ATVYG--EYQRRLRTANALDFDDLIGETVGILQAFPQIAEHYRRRFRHVL Mflv_1861|M.gilvum_PYR-GCK ADVYG--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHIL Mvan_4873|M.vanbaalenii_PYR-1 ASVYA--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHIL MSMEG_5534|M.smegmatis_MC2_155 AQVYG--EYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHIL MAB_1054|M.abscessus_ATCC_1997 ADVYG--EYQRRLRAANALDFDDLIGETVAVLQQFPQIAQFYRRKFRHIL TH_1135|M.thermoresistible__bu AAAYAGYEALKARQETVLLDFDDLLLHTAAAIENEPAVAQEFRDRYRCFV * .* * : : : ******: .*.. :. * :* :* ::* .: Mb0974|M.bovis_AF2122/97 VDEYQDTNHAQYVLVRELVGRDSND-----GIPPGELCVVGDADQSIYAF Rv0949|M.tuberculosis_H37Rv VDEYQDTNHAQYVLVRELVGRDSND-----GIPPGELCVVGDADQSIYAF MMAR_4553|M.marinum_M VDEYQDTNHAQYVLVRELVGRGSEDEPG--DVPPAQLCVVGDADQSIYAF MUL_4723|M.ulcerans_Agy99 VDEYQDTNHAQYVLVRELVGRGSEDEPG--DVPPAQLCVVGDADQSIYAF MAV_1071|M.avium_104 VDEYQDTNHAQYVLVRELVGTDTED-----GVPPGELCVVGDADQSIYAF MLBr_00153|M.leprae_Br4923 VDEYQDTNHAQYVLVRELVGHGARNSPD--DMPPGELCVVGDADQSIYAF Mflv_1861|M.gilvum_PYR-GCK VDEYQDTNHAQYVLVRELTGSGATESDE--SVAPAELCVVGDADQSIYAF Mvan_4873|M.vanbaalenii_PYR-1 VDEYQDTNHAQYVLVRELVG---TETVD--GVPPAELCVVGDADQSIYAF MSMEG_5534|M.smegmatis_MC2_155 VDEYQDTNHAQYVLVRELVG-HHLEDHD--GVPPSELCVVGDADQSIYAF MAB_1054|M.abscessus_ATCC_1997 VDEYQDTNHAQYVLVRELVGAHVDRTVDPDGPEPAELCVVGDADQSIYAF TH_1135|M.thermoresistible__bu VDEYQDVTPLQQRVLNAWLG------------ERDDLTVVGDANQTIYSF ******.. * ::. * :* *****:*:**:* Mb0974|M.bovis_AF2122/97 RGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSVIARNAGRREK Rv0949|M.tuberculosis_H37Rv RGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSVIARNAGRREK MMAR_4553|M.marinum_M RGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVISRNSGRREK MUL_4723|M.ulcerans_Agy99 RGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVISRNSGRREK MAV_1071|M.avium_104 RGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVIARNSGRRDK MLBr_00153|M.leprae_Br4923 RGSTISNIEDFERDYPDTTTILLEQNYRSTQNILSAANSVIARNFGRRDK Mflv_1861|M.gilvum_PYR-GCK RGATIRNIEDFERDFPSATTILLEQNYRSTQTILNAANSVIARNAGRREK Mvan_4873|M.vanbaalenii_PYR-1 RGATIRNIEDFERDFPNATTILLEQNYRSTQTILNAANSVIARNVGRRDK MSMEG_5534|M.smegmatis_MC2_155 RGATIRNIEDFERDFPDATTILLEQNYRSTQTILNAANAVIARNTGRREK MAB_1054|M.abscessus_ATCC_1997 RGATIRNIEEFERDYPNAKTILLEQNYRSTQNILSAANSVIAKNANRREK TH_1135|M.thermoresistible__bu TGATPQYLLDFSRRFPDATVVRLERDYRSTPQVVSLANRVIATARGRMAG *:* : :*.* :*.: .: **::**** ::. ** **: .* Mb0974|M.bovis_AF2122/97 RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAEGSE-ITYNDVA Rv0949|M.tuberculosis_H37Rv RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAEGSE-ITYNDVA MMAR_4553|M.marinum_M RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAERDE-ITYNDVA MUL_4723|M.ulcerans_Agy99 RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAERDE-ITYSDVA MAV_1071|M.avium_104 RLWTDAGA---GELIVGYVADNEHDEARFVAEEIDALAQKGE-ITYNDVA MLBr_00153|M.leprae_Br4923 RLWTDAGK---GELIVGYVSDNEHDEAKFIADEIDALVGGGE-ITYDDVA Mflv_1861|M.gilvum_PYR-GCK RLWTDAGE---GELIVGYVADNEHDEARFIAQEIDALSDSIPDFSYNDVA Mvan_4873|M.vanbaalenii_PYR-1 RLWTDAGE---GELIVGYVADNEHDEARFVAQEIDALSDAVADFSYNDVA MSMEG_5534|M.smegmatis_MC2_155 RLWTDAGQ---GELIVGYVADNEHDEARFVADEIDALTDRHG-YNYNDIA MAB_1054|M.abscessus_ATCC_1997 RLWTDSGE---GELIVGYVADNEHDEASFIAREIDGLFDRSD-ANYGDIA TH_1135|M.thermoresistible__bu SKLHLVGQRPPGPQPTFSEYPDEVAEATAVAKNIARLIESGV--APAEIA * * . :* ** :* :* * ::* Mb0974|M.bovis_AF2122/97 VFYRTNNSSRSLEEVLIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDNP Rv0949|M.tuberculosis_H37Rv VFYRTNNSSRSLEEVLIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDNP MMAR_4553|M.marinum_M VFYRTNNSSRSLEEVFIRAGIPYKVVGGVRFYERKEIRDIIAYLRVLDNP MUL_4723|M.ulcerans_Agy99 VFYRTNNSSRSLEEVFIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDNP MAV_1071|M.avium_104 VFYRTNNSSRSFEEVFIRAGIPYKVVGGVRFYERKEIRDIIAYLRVLDNP MLBr_00153|M.leprae_Br4923 VLYRANNLSRSLEEVFIPTGIPYKVVGGFCFYESKEIRDLIAYLRVLDNP Mflv_1861|M.gilvum_PYR-GCK VFYRTNNSSRAIEEVFIRAGIPYKVVGGVRFYERREIRDIVAYLRVLDNP Mvan_4873|M.vanbaalenii_PYR-1 VFYRTNNSSRAIEEVFIRAGIPYKVVGGVRFYERREIRDIVAYLRVLDNP MSMEG_5534|M.smegmatis_MC2_155 VFYRTNNSSRALEEVFIRAGIPYKVVGGVRFYERREIRDIVAYLRVLDNP MAB_1054|M.abscessus_ATCC_1997 VFYRTNNNSRSLEEIFIRTGIPYKVVGGVRFYERKEIRDIVAYLRVLTNP TH_1135|M.thermoresistible__bu VLYRINAQSEVYEEALTEAGIAFQVRGGEGFFSRQEIRQALLVLQRA--- *:** * *. ** : :**.::* ** *:. :***: : *: Mb0974|M.bovis_AF2122/97 GDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPM Rv0949|M.tuberculosis_H37Rv GDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPM MMAR_4553|M.marinum_M GDAVSMRRILNTPRRGIGDRAEACVAVYAENTGAGFSDALVAAAEGKVPM MUL_4723|M.ulcerans_Agy99 GDAVSMRRILNTPRRGIGDRAEACVAVYAENTGAGFSDALVAAAEGKVPM MAV_1071|M.avium_104 GDAVSMRRILNTPRRGIGDRAEACVAVYAENTGASFADALVAAAEGKVPM MLBr_00153|M.leprae_Br4923 GDAVSMRRILNTPRRGIGDRAEACVSVYAENTGTSFADALQAVAEGKVPM Mflv_1861|M.gilvum_PYR-GCK GDAVSMRRILNTPRRGIGDRAEACVAVHAENTGLNFNDALVAAAEGNVPM Mvan_4873|M.vanbaalenii_PYR-1 GDSVSMRRILNTPRRGIGDRAEACVAVYAETTGANFNDALAAAAEGKVPM MSMEG_5534|M.smegmatis_MC2_155 GDSVSMRRILNTPRRGIGDRAEACVAVYAENTGVSFNEALQAAAEGRVPM MAB_1054|M.abscessus_ATCC_1997 GDAVSLRRILNTPRRGIGDRAEACVAVHAETNGIGFGEALADAAAGKVAM TH_1135|M.thermoresistible__bu ----------------------------AERAGTGAVETPAG-------- ** * . :: Mb0974|M.bovis_AF2122/97 LNTRAEKAIAGFVEMFDELRGRLDD-------DLGELVEAVLERTGYRRE Rv0949|M.tuberculosis_H37Rv LNTRAEKAIAGFVEMFDELRGRLDD-------DLGELVEAVLERTGYRRE MMAR_4553|M.marinum_M LNSRAEKAIAGFVELLDELRGRLDSSEG----DLGELVEAVLERTGYRRE MUL_4723|M.ulcerans_Agy99 LNSRAEKAIAGFVELLDELRGRLDSSEG----DVGELVEAVLERTGYRRE MAV_1071|M.avium_104 LNSRAEKAIAGFVELLDDLRGRLDD-------DLGDLVESVLERTGYRRE MLBr_00153|M.leprae_Br4923 LNTRSVKAIAGFVALLDDLRCRVDD-------DLGELVESVLERSGYLRE Mflv_1861|M.gilvum_PYR-GCK LNTRSEKAIAGFVALLDDLRGGLDG-------ELGDLVEAVLDRTGYRAE Mvan_4873|M.vanbaalenii_PYR-1 LNTRSEKAIKGFVELLDELRGGLDG-------ELGDLVETVLDRTGYRAE MSMEG_5534|M.smegmatis_MC2_155 LNTRSEKCIASFVQMLDDLRGKLDE-------ELGDLVEAVLERTGYRRE MAB_1054|M.abscessus_ATCC_1997 LNSRSEKAIAAFMDMLDQIRVTLRTDDPGALPDIGDVVEAVLNHTGYRYE TH_1135|M.thermoresistible__bu -------------------------------AELAAAVRGLLEPLGLTAE ::. *. :*: * * Mb0974|M.bovis_AF2122/97 LEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGP------DDEDVP Rv0949|M.tuberculosis_H37Rv LEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGP------DDEDVP MMAR_4553|M.marinum_M LESSTDPQELARLDNLNELVSVAHEFSTDLANAAEPEP------DAEDVP MUL_4723|M.ulcerans_Agy99 LESSTDPQELARLDNLNELVSVAHEFSTDLANAAEPEP------DAEDVP MAV_1071|M.avium_104 LESSTDPQELARLDNLNELVSVAHEFSTDRANAAALDESL-DAADDEDVP MLBr_00153|M.leprae_Br4923 LESSTDPQELARLDNLNELVSFAHEFSTEQANAAALAKSL-HTPEDEDVP Mflv_1861|M.gilvum_PYR-GCK LEASSDPQDLARLDNLNELVSVAHEFSTDLANARALAEGD-EDAQDEDVP Mvan_4873|M.vanbaalenii_PYR-1 LEASSDPQDLARLDNLNELVSVAHEFSIDLANAKALASEEGAEPQDEDVP MSMEG_5534|M.smegmatis_MC2_155 LEASSDPQDLARLDNLNELVSVAHEFSIDLANAQALAEES-DEPVDEDIP MAB_1054|M.abscessus_ATCC_1997 LENSSDPQELARLDNLNELVSVAHEFSADAANAQAAGEDV--PGDDEDVG TH_1135|M.thermoresistible__bu PPAGTRAR--ERWEALAALADLVDEEVATQPGLT---------------- .: .: * : * *.....* . Mb0974|M.bovis_AF2122/97 DT-GVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTG Rv0949|M.tuberculosis_H37Rv DT-GVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTG MMAR_4553|M.marinum_M DT-GMLAAFLERVSLVADTDDIPEHGAGVVTLMTLHTAKGLEFPVVFVTG MUL_4723|M.ulcerans_Agy99 DT-GMLAAFLERVSLVADTDDIPEHGAGVVTLMTLHTAKGLEFPVVFVTG MAV_1071|M.avium_104 DT-GVLAEFLERVSLVSDSDEIPEDGAGMVTLMTLHTAKGLEFPVVFVTG MLBr_00153|M.leprae_Br4923 DT-GALAAFLEKVSLMSDTDQIPENNSGVVTLMTLHAAKGLEFPVVFVTG Mflv_1861|M.gilvum_PYR-GCK DT-GVLAAFLERVSLVADADDIPEHGSGVVTMMTLHTAKGLEFPLVFVTG Mvan_4873|M.vanbaalenii_PYR-1 DT-GVLAAFLERVSLVADADDIPEHGAGVVTMMTLHTAKGLEFPVVFVTG MSMEG_5534|M.smegmatis_MC2_155 DT-GVLAQFLERVSLVADADDIPEEGSGVVTMMTLHTAKGLEFPAVFVTG MAB_1054|M.abscessus_ATCC_1997 APPGSLEAFLERVSLVADADELPESSAGVVTMMTLHTAKGLEFPVVFVTG TH_1135|M.thermoresistible__bu -----LPGLLNELRRRADARHPPVVQG--VTLASLHAAKGLEWDAVFLVG * :*:.: :*: . * . **: :**:*****: **:.* Mb0974|M.bovis_AF2122/97 WEDGMFPHMRALDNPTE---LSEERRLAYVGITRARQRLYVSRAIVRSSW Rv0949|M.tuberculosis_H37Rv WEDGMFPHMRALDNPTE---LSEERRLAYVGITRARQRLYVSRAIVRSSW MMAR_4553|M.marinum_M WEDGMFPHMRALDDPTE---LSEERRLAYVGITRARQRLYLSRAIVRSSW MUL_4723|M.ulcerans_Agy99 WEDGMFPHMRALDDPTE---LSEERRLAYVGITRARQRLYLSRAIVRSSW MAV_1071|M.avium_104 WEDGMFPHMRSLDDPVE---LSEERRLAYVGITRARQRLYLSRAIVRSSW MLBr_00153|M.leprae_Br4923 WEDGMLPHMRTLGDPTE---LSEERRLAYVGITRARQRLYLSRAITRSSW Mflv_1861|M.gilvum_PYR-GCK WEDGMFPHMRALGDPLE---LSEERRLAYVGITRARQRLYLSRAKVRSSW Mvan_4873|M.vanbaalenii_PYR-1 WEDGMFPHMRALGDPGE---LSEERRLAYVGITRARQRLYLSRAKVRSSW MSMEG_5534|M.smegmatis_MC2_155 WEDGMFPHMRALGDPNE---LSEERRLAYVGITRARQRLYLSRAKVRSSW MAB_1054|M.abscessus_ATCC_1997 WEDGMFPHMRALGDPVE---LAEERRLAYVGITRARQRLYLSRAKVRSSW TH_1135|M.thermoresistible__bu LADGTLPISHALAHGPESEPVEEERRLLYVGITRARVHLALSWALARAPG ** :* ::* . * : ***** ******** :* :* * .*:. Mb0974|M.bovis_AF2122/97 GQPMLNPESRFLREIPQELIDWRRT-APKPSFSAP--VSGAG----RFGS Rv0949|M.tuberculosis_H37Rv GQPMLNPESRFLREIPQELIDWRRT-APKPSFSAP--VSGAG----RFGS MMAR_4553|M.marinum_M GQPMLNPESRFLREIPQELLNWRRL-APKPSFSAP--VSGAG----RFGT MUL_4723|M.ulcerans_Agy99 GQPMLNPESRFLREIPQELLNWRRL-APKPSFSAP--VSGAG----RFGT MAV_1071|M.avium_104 GQPMLNPESRFLREIPQELIEWRRT-APAPSFSAP--VSGAG----RFGT MLBr_00153|M.leprae_Br4923 GQPILNPESRFLREIPPELIDWRRS-ILTDSYSTP--ASGAS----RFGR Mflv_1861|M.gilvum_PYR-GCK GQPMLNPESRFLREIPQELIDWRRTEAPASSFSAP--VGNAG----RYGT Mvan_4873|M.vanbaalenii_PYR-1 GQPMLNPESRFLREIPQELIDWRRTEQPSS-FSAP--VGNAG----RYGA MSMEG_5534|M.smegmatis_MC2_155 GQPMLNPESRFLREIPQELIDWRRIEAPTPAYAAPGRMSSSGGGGIGFGS MAB_1054|M.abscessus_ATCC_1997 GQPMMNPESRFLQEIPQELIDWRRTDPLPGRIATG--AGGYGGGGYGSGG TH_1135|M.thermoresistible__bu GRQGRRP-SRFLNGIAPNVGSAGDRSGPTRPRRQRGATPRCRICNAVLTA *: .* ****. *. :: . Mb0974|M.bovis_AF2122/97 ARP---SPTRSGASR-RPLLVLQVGDRVTHDKYGLGRVEEVSGVGESAMS Rv0949|M.tuberculosis_H37Rv ARP---SPTRSGASR-RPLLVLQVGDRVTHDKYGLGRVEEVSGVGESAMS MMAR_4553|M.marinum_M ARS---APVRTSTSK-RPLLVLQPGDRVTHDKYGLGRVEEVSGVGESAMS MUL_4723|M.ulcerans_Agy99 ARS---APVRTSTSK-RPLLVLQPGDRVTHDKYGLGRVEEVSGVGESAMS MAV_1071|M.avium_104 PRA---APTRAAMSK-RPLLVLAPGDRVTHDKYGLGRVEEVSGAGESAMS MLBr_00153|M.leprae_Br4923 VRP---SSIRSGASK-RALLVLAPGDRVTHDKYGLGRVEEVSGVGESAIS Mflv_1861|M.gilvum_PYR-GCK PRP---SPTRPAAGK-RPLIVLEPGDRVTHDKYGLGRVEEVSGAGESAMS Mvan_4873|M.vanbaalenii_PYR-1 PRP---SPTRPAAGK-RPLIVLEPGDRVTHDKYGLGRVEEVSGAGESAMS MSMEG_5534|M.smegmatis_MC2_155 PRP---SPNRPGGGRNKPLMVLQPGDRVTHDKYGLGRVEEVAGTGESAMS MAB_1054|M.abscessus_ATCC_1997 SRAGGGSLGAPSKKRTKPLMVLEAGDRVSHDKYGLGRVVEVTGVGESATS TH_1135|M.thermoresistible__bu PPAIMLRRCESCPADIDEELLAELKEWRSRTAKEMSVPAYVVFTDNTLIA . . :: : :: :. * ..:: : Mb0974|M.bovis_AF2122/97 LIDFGSSGRVKLMHNHAPVTKL---------------- Rv0949|M.tuberculosis_H37Rv LIDFGSSGRVKLMHNHAPVTKL---------------- MMAR_4553|M.marinum_M LIDFGSSGRVKLMHNHAPVAKL---------------- MUL_4723|M.ulcerans_Agy99 LIDFGSSGRVKLMHNHAPVAKL---------------- MAV_1071|M.avium_104 LIDFGSSGRVKLMHNHAPISKL---------------- MLBr_00153|M.leprae_Br4923 LIDFGSSGRIKLMHNHAPVTKL---------------- Mflv_1861|M.gilvum_PYR-GCK LIDFGSAGRVKLMHNHAPISKL---------------- Mvan_4873|M.vanbaalenii_PYR-1 LIDFGSAGRVKLMHNHAPVSKL---------------- MSMEG_5534|M.smegmatis_MC2_155 LIDFGSAGRVKLMHNHAPLQKL---------------- MAB_1054|M.abscessus_ATCC_1997 LIDFGSEGRVKLMHNFAPVQKL---------------- TH_1135|M.thermoresistible__bu IAEMLPTDDAALVAIPGIGARKLEQFGPDVLAMVKNRR : :: . . *: . :