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SRFTEKMFRNARETTKGMVTGEPHTPVRHTWGEVHERARQIAGGLAAAGVGPGDAVGVLAGAPVEIAPTA QGLWIRGASLTMLHQPTPRTDLALWAEDTTTVVDMIEAKAVVISDPFMAAAPVLEERGIRVLTFEQLLAS EPIDPVEVGEDELALMQLTSGSTGSPKAVQITHRNLFANLEAMYISAEYDAETDVMVSWLPLFHDMGMIG FLTVPMYFAGELVKVTPMDFMRDTLLWAKLIDKYKGTMTAAPNFAYSLFAKRLRKQAKPGQFDLSSLRFA LSGAEPVEPSDVEDLCEAGAPFGLRPQAILPAYGMAEITLAVAFSECGAGLVVDEVDADLMAALRRAVPA AKGNTRRLASLGPLLQGIEARIVDADGNVLPSRGVGVIELRGESVTPGYLTMGGFIPAQDQLGWYDTGDL GYQMENGHVVVCGRVKDVIIMAGRNIYPTDIERAAGRVEGVRPGCAVAVRLDAGHSRETFAVAVESNAFE DPAEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRSNSLTLVT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4648 | pks16 | - | 100% (544) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4922 | pks16_1 | e-131 | 49.31% (505) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4044 | - | e-115 | 41.34% (537) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1041 | pks16 | 0.0 | 84.19% (544) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1935 | - | 0.0 | 82.54% (544) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1013 | pks16 | 0.0 | 84.19% (544) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_00243 | - | 0.0 | 82.90% (544) | long-chain-fatty-acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_1140 | - | 0.0 | 76.46% (548) | acyl-CoA synthetase |
| M. marinum M | MMAR_4476 | pks16 | 0.0 | 99.63% (544) | polyketide synthase Pks16 |
| M. avium 104 | MAV_1150 | - | 0.0 | 85.11% (544) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5435 | - | 0.0 | 82.90% (544) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3958 | - | 0.0 | 83.80% (537) | PUTATIVE AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_4798 | - | 0.0 | 82.35% (544) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4648|M.ulcerans_Agy99 MSRFTEKMFRNARETTKGMVTGEPHTPVRHTWGEVHERARQIAGGLAAAG
MMAR_4476|M.marinum_M MSRFTDKMFRNARETTKGMVTGEPHNPVRHTWGEVHERARQIAGGLAAAG
MLBr_00243|M.leprae_Br4923 MSKFTEKMFRNARESSKGIVTGEPHNPVRHTWGQVHERASRIAGGLAGVG
Mflv_1935|M.gilvum_PYR-GCK MSRFTEKMYRSAHTTGRGMVTGEPYEPVRHTWSEVHERAKRIAGGLAAAG
Mvan_4798|M.vanbaalenii_PYR-1 MSRFTEKMYRSAHTTGRGMVTGEPYEPVRHTWGEVHERAKRIAGGLAAAG
MSMEG_5435|M.smegmatis_MC2_155 MSRFTEKMYRNARTVTTGMVTGEPHEPVRHTWGEVHERARRIAGGLAAAG
Mb1041|M.bovis_AF2122/97 MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGGLAAAG
Rv1013|M.tuberculosis_H37Rv MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGGLAAAG
MAV_1150|M.avium_104 MSRFTEKMYRNARTAKTGMVTGEPHNPVRHTWGEVHERARRIAGGLAAAG
TH_3958|M.thermoresistible__bu -------MFHNARTATTGMVTGEPHAPVRHTWGEVHERARRIAGGLAAAG
MAB_1140|M.abscessus_ATCC_1997 MSRFTDELYANALSSSKGMVTGEPDTPVRHTWKQVHERAKQVAGGLAGAG
:: .* *:***** ****** :***** :*****..*
MUL_4648|M.ulcerans_Agy99 VGPGDAVGVLAGAPVEIAPTAQGLWIRGASLTMLHQPTPRTDLALWAEDT
MMAR_4476|M.marinum_M VGPGDAVGVLAGAPVEIAPTAQGLWIRGASLTMLHQPTPRTDLALWAEDT
MLBr_00243|M.leprae_Br4923 VGHGDAVGVLVGVPVEIAPTAQGLWMRGASLTMLHQPTPRTDLAVWEEDT
Mflv_1935|M.gilvum_PYR-GCK VGLGDAVGVLAGFPVEIAPTAQGLWMRGASLTMLHQPTPRTDLVMWAEDT
Mvan_4798|M.vanbaalenii_PYR-1 VGLGDAVGVLAGFPVEIAPTAQGLWMRGASLTMLHQPTPRTDLVVWAEDT
MSMEG_5435|M.smegmatis_MC2_155 IGHGDAVGVLAGFPVEIAPTAQGVWMRGASLTMLHQPTPRTDLAVWAEDT
Mb1041|M.bovis_AF2122/97 VGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAEDT
Rv1013|M.tuberculosis_H37Rv VGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAEDT
MAV_1150|M.avium_104 IGPGDAVGVLAGFPVEIAPTAQGLWMRGASLTMLHQPTPRTDLAVWADDT
TH_3958|M.thermoresistible__bu VGHGDAVGVLAGWPVEIAPTAQALWIRGASLTMLHQPTPRTDLMMWAEDT
MAB_1140|M.abscessus_ATCC_1997 LGPDDAIGMLVGMPVEIAPAIQAVWMRGASLTMLHQPTPRTDLAVWAEDT
:* .*.:*:*.* ******: *.:*:***************** :* :**
MUL_4648|M.ulcerans_Agy99 TTVVDMIEAKAVVISDPFMAAAPVLEERGIRVLTFEQLLASEPIDPVEVG
MMAR_4476|M.marinum_M TTVVDMIEAKAVVISDPFMAAAPVLEERGIRVLTFEQLLASEPIDPVEVG
MLBr_00243|M.leprae_Br4923 TTVIDMIEAKAVIISDPFMAVAPILEARGVKVVTVEQLLAADPVDPIETD
Mflv_1935|M.gilvum_PYR-GCK MNVIGMIEAKAVIVSEPFLVAIPVLEEKGIKVLTITDLLASEPIEPIEVG
Mvan_4798|M.vanbaalenii_PYR-1 MNVIGMIEAKAVIVSEPFLVAIPVLEEKGIKVLTVTDLLAADPIEPIEVG
MSMEG_5435|M.smegmatis_MC2_155 MNVIGMIELKAVIISEPFLVATPVLEEKGILVLKVADLLAADPIDPVETG
Mb1041|M.bovis_AF2122/97 MTVIGMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEVG
Rv1013|M.tuberculosis_H37Rv MTVIGMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEVG
MAV_1150|M.avium_104 MNVIGMIEAKAVVVSEPFLVAIPVLQEKDIKVLTVADLLASDPIDPVEVG
TH_3958|M.thermoresistible__bu MNVIGMIAAKVVVVSDPFTAAIPVLEERGIKVLTVEQLLAADPIDPVDTS
MAB_1140|M.abscessus_ATCC_1997 LKVVDMIGAKAVIVSAPFDAAAPVLEEKGVIVVHIKDLWDADPIEPLEAD
.*:.** *.*::* ** .. *:*: :.: *: . :* ::*: *::..
MUL_4648|M.ulcerans_Agy99 EDELALMQLTSGSTGSPKAVQITHRNLFANLEAMYISAEYDAETDVMVSW
MMAR_4476|M.marinum_M EDELALMQLTSGSTGSPKAVQITHRNLFANLEAMYISAEYDAETDVMVSW
MLBr_00243|M.leprae_Br4923 EDDLALMQLTSGSTGSPKAVQITHRNVYSNVEAMFIGVRYNVEKDVMISW
Mflv_1935|M.gilvum_PYR-GCK EDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFIGAQYDVEKDVMVSW
Mvan_4798|M.vanbaalenii_PYR-1 EDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFIGAQYDVEKDVMVSW
MSMEG_5435|M.smegmatis_MC2_155 EDDLALMQLTSGSTGSPKAVQITHRNIHSNAEAMFVGAKYDVEKDVMVSW
Mb1041|M.bovis_AF2122/97 EDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVSW
Rv1013|M.tuberculosis_H37Rv EDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVSW
MAV_1150|M.avium_104 EDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFIGAQYDVDKDVMVSW
TH_3958|M.thermoresistible__bu EDDVALMQLTSGSTGSPKAVVITHRNIYSNAEAMFVGAQYDVDNDVMVSW
MAB_1140|M.abscessus_ATCC_1997 EDSVALMQLTSGSTGSPKAVKITHRNLYANAHGMYVASKYKPEIDVMVSW
**.:**************** *****:.:* ..*::. .*. : ***:**
MUL_4648|M.ulcerans_Agy99 LPLFHDMGMIGFLTVPMYFAGELVKVTPMDFMRDTLLWAKLIDKYKGTMT
MMAR_4476|M.marinum_M LPLFHDMGMIGFLTVPMYFAGELVKVTPMDFMRDTLLWAKLIDKYKGTMT
MLBr_00243|M.leprae_Br4923 LPCFHDMGMIGFLTVPMYFGAELVKVTPIDFLRDTLLWAKLIDKYKGTVI
Mflv_1935|M.gilvum_PYR-GCK LPCFHDMGMVGFLTIPMYFGAELVKVTPMDFLRDTLLWAKLIDKYKGTMT
Mvan_4798|M.vanbaalenii_PYR-1 LPCFHDMGMVGFLTIPMYFGAELVKVTPLDFLRDTLLWAKLIDKYKGTMT
MSMEG_5435|M.smegmatis_MC2_155 LPCFHDMGMVGFLTIPMYFGAELVKVTPMDFLRDTLLWAKLIDKYKGTMT
Mb1041|M.bovis_AF2122/97 LPCFHDMGMVGFLTIPMFFGAELVKVTPMDFLRDTLLWAKLIDKYQGTMT
Rv1013|M.tuberculosis_H37Rv LPCFHDMGMVGFLTIPMFFGAELVKVTPMDFLRDTLLWAKLIDKYQGTMT
MAV_1150|M.avium_104 LPCFHDMGMVGFLTIPMYFGAELVKVTPMDFLRDTLLWAKLIDKYKGTMT
TH_3958|M.thermoresistible__bu LPCFHDMGMIGFLTVPMYFGAELVKVTPMDFLRDTLLWARLIDKYKGTMT
MAB_1140|M.abscessus_ATCC_1997 LPLFHDMGMVGFLTVPMFFGAELVKITPMDFMRDVLLWGRLIDKYKGTMT
** ******:****:**:*..****:**:**:**.***.:*****:**:
MUL_4648|M.ulcerans_Agy99 AAPNFAYSLFAKRLRKQAKPGQFDLSSLRFALSGAEPVEPSDVEDLCEAG
MMAR_4476|M.marinum_M AAPNFAYSLFAKRLRKQAKPGQFDLSSLRFALSGAEPVEPSDVEDLCEAG
MLBr_00243|M.leprae_Br4923 CGPNFAYSLFTKRLRKQAKPGQFDLSTLRIAMSGAEPVDPADVEDLIDAG
Mflv_1935|M.gilvum_PYR-GCK AAPNFAYALFAKRLRRQAKPGEFDLSTLRFALSGAEPVEPADVEDLLDAG
Mvan_4798|M.vanbaalenii_PYR-1 AAPNFAYALFAKRLRRQAKPGEFDLSTLRFALSGAEPVEPADVEDLLDAG
MSMEG_5435|M.smegmatis_MC2_155 AAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDFLDAG
Mb1041|M.bovis_AF2122/97 AAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDAG
Rv1013|M.tuberculosis_H37Rv AAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDAG
MAV_1150|M.avium_104 AAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDAG
TH_3958|M.thermoresistible__bu AAPNFAYALLAKRLRRQAKPGEFDLSTLRFALSGAEPVEPADVEDLIDAG
MAB_1140|M.abscessus_ATCC_1997 AAPNFAYSLFAKRLRNQAKPGDFDLSTLRFVLSGAEPVDPAVVEDLCDAG
..*****:*::****.*****:****:**:.:******:*: ***: :**
MUL_4648|M.ulcerans_Agy99 APFGLRPQAILPAYGMAEITLAVAFSECGAG-LVVDEVDADLMAALRRAV
MMAR_4476|M.marinum_M APFGLRPQAILPAYGMAEITLAVAFSECGAG-LVVDEVDADLMAALRRAV
MLBr_00243|M.leprae_Br4923 RPFGFRPEAILPAYGMAETTLAVSFSPVGEG-LLVDEVDADLLAALRRAV
Mflv_1935|M.gilvum_PYR-GCK KPFGLDPGAILPAYGMAETTLAVSFSPCGAG-LTVDEVDADLLAALRRAV
Mvan_4798|M.vanbaalenii_PYR-1 KPFGLDPGAILPAYGMAETTLAVSFSPCGAG-LTVDEVDADLLAALRRAV
MSMEG_5435|M.smegmatis_MC2_155 KPFGLRPEAILPAYGMAETTLAVSFSPCGEG-LVVDEVDADLLAALRRAV
Mb1041|M.bovis_AF2122/97 KPFGLRPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRAV
Rv1013|M.tuberculosis_H37Rv KPFGLRPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRAV
MAV_1150|M.avium_104 KPFGLKPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRAV
TH_3958|M.thermoresistible__bu KPFGLRPEAILPAYGMAETTLAVSFSECGAG-LIVDEVDADLLAALRRAV
MAB_1140|M.abscessus_ATCC_1997 KPFGFKPSAMVPAYGMAETALAVSFSEVEASGLVVDEVDADLLAALRRAV
***: * *::******* :***:** . * ********:*******
MUL_4648|M.ulcerans_Agy99 PAAKGNTRRLASLGPLLQGIEARIVDADGNVLPSRGVGVIELRGESVTPG
MMAR_4476|M.marinum_M PAAKGNTRRLASLGPLLQGIEARIVDADGNVLPSRGVGVIELRGESVTPG
MLBr_00243|M.leprae_Br4923 PATKGNIRRLVSLGPLLDGLEVRIVDEDGNVLPSRGVGVIELRGESLTPG
Mflv_1935|M.gilvum_PYR-GCK PASKGHTKRLAELGPLLTDLEARVIDDHGNLMPPRGVGVIELRGECVTPG
Mvan_4798|M.vanbaalenii_PYR-1 PATKGHTKRLAELGPLLTDLEARVIDDHGNVMPPRGVGVIELRGECVTPG
MSMEG_5435|M.smegmatis_MC2_155 PATKGNTKRLASLGPLLNDLEARVVDENGEVMPARGVGVIELRGEPVTPG
Mb1041|M.bovis_AF2122/97 PATKGNTRRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESLTPG
Rv1013|M.tuberculosis_H37Rv PATKGNTRRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESLTPG
MAV_1150|M.avium_104 PATKGNTRRLATLGPLLQDLEARIVDENGDVMPPRGVGVIELRGESVTPG
TH_3958|M.thermoresistible__bu PASKGNTRRLASLGPLLPDLEARVVDEDGNILPPRGVGIIELRGEPVTPG
MAB_1140|M.abscessus_ATCC_1997 PATRGNLRHLATLGPLLPGIEARVVDEDLNVLPARGVGVIELRGESVTPG
**::*: ::*. ***** .:*.*::* . :::*.****:****** :***
MUL_4648|M.ulcerans_Agy99 YLTMGGFIPAQDQLGWYDTGDLGYQMENGHVVVCGRVKDVIIMAGRNIYP
MMAR_4476|M.marinum_M YLTMGGFIPAQDQLGWYDTGDLGYQMENGHVVVCGRVKDVIIMAGRNIYP
MLBr_00243|M.leprae_Br4923 YITMGGFISAQDEHGWYDTGDLGYQMENGHIVVCGRVKDVIIMAGRNVYP
Mflv_1935|M.gilvum_PYR-GCK YMTMGGFIPAQDEHGWYDTGDLGYITEEGNVVVCGRVKDVIIMAGRNIYP
Mvan_4798|M.vanbaalenii_PYR-1 YMTMGGFIPAQDEHGWYDTGDLGYITEEGNVVVCGRVKDVIIMAGRNIYP
MSMEG_5435|M.smegmatis_MC2_155 YITMGGFVPAQDEYGWYDTGDLGYITEEGNIVVCGRVKDVIIMAGRNIYP
Mb1041|M.bovis_AF2122/97 YLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNIYP
Rv1013|M.tuberculosis_H37Rv YLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNIYP
MAV_1150|M.avium_104 YLTMGGFIPAQDENGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNIYP
TH_3958|M.thermoresistible__bu YVTMGGFVPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNIYP
MAB_1140|M.abscessus_ATCC_1997 YVTMGGFLAAQDENGWYNTGDLGYLTEKGHVVVCGRVKDVIIMAGRNIYP
*:*****:.***: ***:****** *:*::****************:**
MUL_4648|M.ulcerans_Agy99 TDIERAAGRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAFEDPAE
MMAR_4476|M.marinum_M TDIERAAGRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAFEDPAE
MLBr_00243|M.leprae_Br4923 TDIERAAGRVDGVRPGCAVAVRLDAGHS----RETFAVAVESNAFEDTAE
Mflv_1935|M.gilvum_PYR-GCK TDIERAAGRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNNWQDPVE
Mvan_4798|M.vanbaalenii_PYR-1 TDIERAAGRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNNWQDPAE
MSMEG_5435|M.smegmatis_MC2_155 TDIERAAGRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAWQDPAE
Mb1041|M.bovis_AF2122/97 TDIERAAGRVDGVRPGCAVAVRLDAGHS----RESFAVAVESNAFEDPAE
Rv1013|M.tuberculosis_H37Rv TDIERAAGRVDGVRPGCAVAVRLDAGHS----RESFAVAVESNAFEDPAE
MAV_1150|M.avium_104 TDIERAACRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAFQDPAE
TH_3958|M.thermoresistible__bu TDIERAAQRVEGVRPGGAVAVRLDAGHS----RETFAVAVESNAWQDPEE
MAB_1140|M.abscessus_ATCC_1997 TDIERAAGRVDGVRPGCAVAVRLEAGVDPKNQRETFAVVVESNAFENPDE
******* **:***** ******:** . **:***.**** :::. *
MUL_4648|M.ulcerans_Agy99 VRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRSNSLTLVT-
MMAR_4476|M.marinum_M VRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRSNSLTLVT-
MLBr_00243|M.leprae_Br4923 VRRIEHQVAHEVLKEVDVRPRNVVVLGPGTIPKTPSGKLRRASSVTLVT-
Mflv_1935|M.gilvum_PYR-GCK VRRIEHQVAHEVVAEVDVRPRNVVVLGPGSIPKTSSGKLRRSNSVSLVT-
Mvan_4798|M.vanbaalenii_PYR-1 VRRIEHQVAHEVVAEVDMRPRNVVVLGPGSIPKTSSGKLRRSNSVSLVT-
MSMEG_5435|M.smegmatis_MC2_155 VRRIEHQVAHEVVSEVDVRPRNVVVLGPGSIPKTPSGKLRRANSVSLVTQ
Mb1041|M.bovis_AF2122/97 VRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRANSVTLVT-
Rv1013|M.tuberculosis_H37Rv VRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRANSVTLVT-
MAV_1150|M.avium_104 VRRIEHQVAREVVAEVDMRPRNVVVLGPGTIPKTPSGKLRRSNSVTLVT-
TH_3958|M.thermoresistible__bu VRRIEHQVAHEVVAEVDVRPRNVVVLGPGSIPKTSSGKLRRSTSVSLVT-
MAB_1140|M.abscessus_ATCC_1997 VRRIEQQVAHEVVAEVDVRPRNVVVLGPGSIPKTPSGKLRRSTSVALVI-
*****:***:**: ***:***********:****.******:.*::**