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SRFTDAIATTASNSPRGLHFGAAGGLRFASWRDIHQTAVRVAGRLSAEGVTRGSRVTVLAAGPEDVAPVV QGIWRLGAAMTMLQQPTSQADLAGWHAGTLRAPALLDTRWVVIGEPFLAAAETLRAAGYRVIEIGESWPE LAATEEPTGEDDVALYQLTSGSTGDPKAVAITHGNLFADVAAMTAEVHLDPEVDITASWVPLSHDMALIA YLISPMFAGNGAVYITPTEFVVSPLKWMQILTERRATITAAPNFAYSIISRRLSAIEDGTYDLGALRCVV TGAEPIDPATMAEFARQAGRFGLRHTALGAAYGLAEATVAVSFSPVDNPLTTESVCVEELENRGLALPAC SCGGPTKQFVTLGPPMSGVEVRIVAADGSNLPPRRMGEIAIAGDAVARHYLTTDGEVAAVDPDGWLFTGD LGYLTEGGEIVVCGRRKNVIIVAGRNIFPADIERLAASVHGIRRGGVVAFGVTLADRREEIRIVAETVAD PSIEDGRELRRQIAQNVRGATGLRPTVLLVGKGNVPKTASGKIRHVMARELFGEVSPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4044 | - | - | 100% (549) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4648 | pks16 | e-115 | 41.34% (537) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4922 | pks16_1 | e-109 | 42.27% (511) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1041 | pks16 | 1e-110 | 39.85% (537) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_5217 | - | 1e-117 | 42.46% (544) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1013 | pks16 | 1e-110 | 39.85% (537) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_00243 | - | 1e-113 | 40.60% (537) | long-chain-fatty-acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_1140 | - | 1e-113 | 41.14% (542) | acyl-CoA synthetase |
| M. marinum M | MMAR_4970 | - | 0.0 | 98.36% (549) | acyl-coenzyme A synthetase |
| M. avium 104 | MAV_1150 | - | 1e-113 | 40.22% (537) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5435 | - | 1e-114 | 40.97% (537) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3958 | - | 1e-111 | 42.01% (507) | PUTATIVE AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_1051 | - | 1e-118 | 42.10% (544) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1041|M.bovis_AF2122/97 MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGGLAAAG
Rv1013|M.tuberculosis_H37Rv MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGGLAAAG
MAV_1150|M.avium_104 MSRFTEKMYRNARTAKTGMVTGEPHNPVRHTWGEVHERARRIAGGLAAAG
MSMEG_5435|M.smegmatis_MC2_155 MSRFTEKMYRNARTVTTGMVTGEPHEPVRHTWGEVHERARRIAGGLAAAG
TH_3958|M.thermoresistible__bu -------MFHNARTATTGMVTGEPHAPVRHTWGEVHERARRIAGGLAAAG
MLBr_00243|M.leprae_Br4923 MSKFTEKMFRNARESSKGIVTGEPHNPVRHTWGQVHERASRIAGGLAGVG
MAB_1140|M.abscessus_ATCC_1997 MSRFTDELYANALSSSKGMVTGEPDTPVRHTWKQVHERAKQVAGGLAGAG
Mflv_5217|M.gilvum_PYR-GCK MSQFTETMYANAHRSSKGLNTGEPHSPVRHTWEEVHQRARRIAGGLAAAG
Mvan_1051|M.vanbaalenii_PYR-1 MSRFTETMFANAHLSTKGFNTGEPHSPVRHSWEEVHQRARRVAGGLAAAG
MUL_4044|M.ulcerans_Agy99 MSRFTDAIATTASNSPRGLHFGAAGGLRFASWRDIHQTAVRVAGRLSAEG
MMAR_4970|M.marinum_M MSRFTDAIATTASNSPRGLHFGAAGGLRFASWRDIHQTAVRVAGRLSAEG
: .* *: * . :* ::*: * :** *:. *
Mb1041|M.bovis_AF2122/97 VGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAEDT
Rv1013|M.tuberculosis_H37Rv VGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAEDT
MAV_1150|M.avium_104 IGPGDAVGVLAGFPVEIAPTAQGLWMRGASLTMLHQPTPRTDLAVWADDT
MSMEG_5435|M.smegmatis_MC2_155 IGHGDAVGVLAGFPVEIAPTAQGVWMRGASLTMLHQPTPRTDLAVWAEDT
TH_3958|M.thermoresistible__bu VGHGDAVGVLAGWPVEIAPTAQALWIRGASLTMLHQPTPRTDLMMWAEDT
MLBr_00243|M.leprae_Br4923 VGHGDAVGVLVGVPVEIAPTAQGLWMRGASLTMLHQPTPRTDLAVWEEDT
MAB_1140|M.abscessus_ATCC_1997 LGPDDAIGMLVGMPVEIAPAIQAVWMRGASLTMLHQPTPRTDLAVWAEDT
Mflv_5217|M.gilvum_PYR-GCK VGHGDAVAMLAGAPVEIAPAAQGVWMRGASVTMVHQPTPRTDLIRWADET
Mvan_1051|M.vanbaalenii_PYR-1 VGPGDAVAMLAGAPVEIAPAAQGVWMRGASVTMVHQPTPRTDLVRWAEET
MUL_4044|M.ulcerans_Agy99 VTRGSRVTVLAAGPEDVAPVVQGIWRLGAAMTMLQQPTSQADLAGWHAGT
MMAR_4970|M.marinum_M VTRGSRVTVLAAGPEDVAPVVQGIWRLGAAMTMLQQPTSQADLAGWHAGT
: .. : :*.. * ::**. *.:* **::**::***.::** * *
Mb1041|M.bovis_AF2122/97 MTVIGMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEVG
Rv1013|M.tuberculosis_H37Rv MTVIGMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEVG
MAV_1150|M.avium_104 MNVIGMIEAKAVVVSEPFLVAIPVLQEKDIKVLTVADLLASDPIDPVEVG
MSMEG_5435|M.smegmatis_MC2_155 MNVIGMIELKAVIISEPFLVATPVLEEKGILVLKVADLLAADPIDPVETG
TH_3958|M.thermoresistible__bu MNVIGMIAAKVVVVSDPFTAAIPVLEERGIKVLTVEQLLAADPIDPVDTS
MLBr_00243|M.leprae_Br4923 TTVIDMIEAKAVIISDPFMAVAPILEARGVKVVTVEQLLAADPVDPIETD
MAB_1140|M.abscessus_ATCC_1997 LKVVDMIGAKAVIVSAPFDAAAPVLEEKGVIVVHIKDLWDADPIEPLEAD
Mflv_5217|M.gilvum_PYR-GCK TSVIDMISASAVVISDPFMAAAPLLSGMGMTVLSIADLLTAEPIDPVDTC
Mvan_1051|M.vanbaalenii_PYR-1 TAVITMIDAKAVVISDPFMAAAPVLEGLGMTVLTIADLLAADRVDPVETS
MUL_4044|M.ulcerans_Agy99 LRAPALLDTRWVVIGEPFLAAAETLRAAGYRVIEIGESWPELAATEEPTG
MMAR_4970|M.marinum_M LRALALLDTRWVVIGEPFLAAAETLRAAGYRIIEIGESWPELAATEEPTG
. :: *::. ** .. * . :: : : .
Mb1041|M.bovis_AF2122/97 EDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVSW
Rv1013|M.tuberculosis_H37Rv EDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVSW
MAV_1150|M.avium_104 EDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFIGAQYDVDKDVMVSW
MSMEG_5435|M.smegmatis_MC2_155 EDDLALMQLTSGSTGSPKAVQITHRNIHSNAEAMFVGAKYDVEKDVMVSW
TH_3958|M.thermoresistible__bu EDDVALMQLTSGSTGSPKAVVITHRNIYSNAEAMFVGAQYDVDNDVMVSW
MLBr_00243|M.leprae_Br4923 EDDLALMQLTSGSTGSPKAVQITHRNVYSNVEAMFIGVRYNVEKDVMISW
MAB_1140|M.abscessus_ATCC_1997 EDSVALMQLTSGSTGSPKAVKITHRNLYANAHGMYVASKYKPEIDVMVSW
Mflv_5217|M.gilvum_PYR-GCK DDDIALMQLTSGSTGSPKAVQITHANIVANADAMTAGCDFDIDTDVIVSW
Mvan_1051|M.vanbaalenii_PYR-1 DDDIALMQLTSGSTGSPKAVQITHANIVANADAMTAGCNFDIDTDVIVSW
MUL_4044|M.ulcerans_Agy99 EDDVALYQLTSGSTGDPKAVAITHGNLFADVAAMTAEVHLDPEVDITASW
MMAR_4970|M.marinum_M EDDVALYQLTSGSTGDPKAVAITHGNLFADVAAMTAEVHLDPEVDITASW
:*.:** ********.**** *** *: ::. .* . : *: **
Mb1041|M.bovis_AF2122/97 LPCFHDMGMVGFLTIPMFFGAELVKVTPMDFLRDTLLWAKLIDKYQGTMT
Rv1013|M.tuberculosis_H37Rv LPCFHDMGMVGFLTIPMFFGAELVKVTPMDFLRDTLLWAKLIDKYQGTMT
MAV_1150|M.avium_104 LPCFHDMGMVGFLTIPMYFGAELVKVTPMDFLRDTLLWAKLIDKYKGTMT
MSMEG_5435|M.smegmatis_MC2_155 LPCFHDMGMVGFLTIPMYFGAELVKVTPMDFLRDTLLWAKLIDKYKGTMT
TH_3958|M.thermoresistible__bu LPCFHDMGMIGFLTVPMYFGAELVKVTPMDFLRDTLLWARLIDKYKGTMT
MLBr_00243|M.leprae_Br4923 LPCFHDMGMIGFLTVPMYFGAELVKVTPIDFLRDTLLWAKLIDKYKGTVI
MAB_1140|M.abscessus_ATCC_1997 LPLFHDMGMVGFLTVPMFFGAELVKITPMDFMRDVLLWGRLIDKYKGTMT
Mflv_5217|M.gilvum_PYR-GCK LPCFHDMGMTGYLTVPMYFGAELVKITPMDFLGDILLWPRLIHKYRGTMT
Mvan_1051|M.vanbaalenii_PYR-1 LPCFHDMGMTGYLTVPMYFGAELVKVTPMDFLSDILLWPRLIDKYRGTMT
MUL_4044|M.ulcerans_Agy99 VPLSHDMALIAYLISPMFAGNGAVYITPTEFVVSPLKWMQILTERRATIT
MMAR_4970|M.marinum_M LPLSHDMGLIAYLISPMFAGNGAVYITPTEFVVSPLKWMQILTERRATIT
:* ***.: .:* **: * * :** :*: . * * ::: : :.*:
Mb1041|M.bovis_AF2122/97 AAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDAG
Rv1013|M.tuberculosis_H37Rv AAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDAG
MAV_1150|M.avium_104 AAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDAG
MSMEG_5435|M.smegmatis_MC2_155 AAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDFLDAG
TH_3958|M.thermoresistible__bu AAPNFAYALLAKRLRRQAKPGEFDLSTLRFALSGAEPVEPADVEDLIDAG
MLBr_00243|M.leprae_Br4923 CGPNFAYSLFTKRLRKQAKPGQFDLSTLRIAMSGAEPVDPADVEDLIDAG
MAB_1140|M.abscessus_ATCC_1997 AAPNFAYSLFAKRLRNQAKPGDFDLSTLRFVLSGAEPVDPAVVEDLCDAG
Mflv_5217|M.gilvum_PYR-GCK AAPNFAYNLLARRLRRQATPGEFDLSSLRWALSGAEQVDPDDVEDLCAAG
Mvan_1051|M.vanbaalenii_PYR-1 AAPNFAYNLLARRLRRQADPGEFDLSSLRWALSGAEQVDPLDVEDLCDAG
MUL_4044|M.ulcerans_Agy99 AAPNFAYSIISRRLS-AIEDGTYDLGALRCVVTGAEPIDPATMAEFARQA
MMAR_4970|M.marinum_M AAPNFAYSIISRRLS-AVEDGTYDLSALRCVVTGAEPIDPATMAEFARQA
..***** ::::** * :**.:** .::*** ::* : :: .
Mb1041|M.bovis_AF2122/97 KPFGLRPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRAV
Rv1013|M.tuberculosis_H37Rv KPFGLRPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRAV
MAV_1150|M.avium_104 KPFGLKPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRAV
MSMEG_5435|M.smegmatis_MC2_155 KPFGLRPEAILPAYGMAETTLAVSFSPCGEG-LVVDEVDADLLAALRRAV
TH_3958|M.thermoresistible__bu KPFGLRPEAILPAYGMAETTLAVSFSECGAG-LIVDEVDADLLAALRRAV
MLBr_00243|M.leprae_Br4923 RPFGFRPEAILPAYGMAETTLAVSFSPVGEG-LLVDEVDADLLAALRRAV
MAB_1140|M.abscessus_ATCC_1997 KPFGFKPSAMVPAYGMAETALAVSFSEVEASGLVVDEVDADLLAALRRAV
Mflv_5217|M.gilvum_PYR-GCK APFGLRPEAVIPAYGMAETTVAVSFSECGGG-MVVDEVDADLLAVLHRAV
Mvan_1051|M.vanbaalenii_PYR-1 APFGLKPEAIVPAYGMAETTVAVSFSECGGG-MVVDEVDADLLAVLHRAV
MUL_4044|M.ulcerans_Agy99 GRFGLRHTALGAAYGLAEATVAVSFSPVDNP-LTTESVCVEELENRGLAL
MMAR_4970|M.marinum_M GRFGLRHTALGAAYGLAEATVAVSFSPVDNP-LTTESVCVEELENRGLAL
**:: *: .***:**:::***** : .:.* .: * *:
Mb1041|M.bovis_AF2122/97 PAT--KGNTRRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESLT
Rv1013|M.tuberculosis_H37Rv PAT--KGNTRRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESLT
MAV_1150|M.avium_104 PAT--KGNTRRLATLGPLLQDLEARIVDENGDVMPPRGVGVIELRGESVT
MSMEG_5435|M.smegmatis_MC2_155 PAT--KGNTKRLASLGPLLNDLEARVVDENGEVMPARGVGVIELRGEPVT
TH_3958|M.thermoresistible__bu PAS--KGNTRRLASLGPLLPDLEARVVDEDGNILPPRGVGIIELRGEPVT
MLBr_00243|M.leprae_Br4923 PAT--KGNIRRLVSLGPLLDGLEVRIVDEDGNVLPSRGVGVIELRGESLT
MAB_1140|M.abscessus_ATCC_1997 PAT--RGNLRHLATLGPLLPGIEARVVDEDLNVLPARGVGVIELRGESVT
Mflv_5217|M.gilvum_PYR-GCK PAA--KGHTRRLVALGRPLAGLEMRIVDEDGAALQPRGVGVIEVRGQSVT
Mvan_1051|M.vanbaalenii_PYR-1 PAT--KGHTRRLVTLGRPLQGLELRVVDEDGAELPARGVGVIEVRGEPVT
MUL_4044|M.ulcerans_Agy99 PACSCGGPTKQFVTLGPPMSGVEVRIVAADGSNLPPRRMGEIAIAGDAVA
MMAR_4970|M.marinum_M PACSCGGPTKQFVTLGPPMSGVEVRIVAADGSNLPPRRMGEIAIAGDAVA
** * :::.:** : .:* *:: : : .* :* * : *:.::
Mb1041|M.bovis_AF2122/97 PGYLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNI
Rv1013|M.tuberculosis_H37Rv PGYLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNI
MAV_1150|M.avium_104 PGYLTMGGFIPAQDENGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNI
MSMEG_5435|M.smegmatis_MC2_155 PGYITMGGFVPAQDEYGWYDTGDLGYITEEGNIVVCGRVKDVIIMAGRNI
TH_3958|M.thermoresistible__bu PGYVTMGGFVPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNI
MLBr_00243|M.leprae_Br4923 PGYITMGGFISAQDEHGWYDTGDLGYQMENGHIVVCGRVKDVIIMAGRNV
MAB_1140|M.abscessus_ATCC_1997 PGYVTMGGFLAAQDENGWYNTGDLGYLTEKGHVVVCGRVKDVIIMAGRNI
Mflv_5217|M.gilvum_PYR-GCK RGYTTAAGFIAAQDDRGWYDTGDIGYLTEDGDVVVCGRLKDVIIMAGRNI
Mvan_1051|M.vanbaalenii_PYR-1 KGYTTVAGFIGAQDDRGWYDTGDIGYLTEVGDVVVCGRLKDVIIMAGRNI
MUL_4044|M.ulcerans_Agy99 RHYLTTDGEVAAVDPDGWLFTGDLGYLTEGGEIVVCGRRKNVIIVAGRNI
MMAR_4970|M.marinum_M RHYLTMDGEVAAVDPDGWLFTGDLGYLTEGGEIVVCGRRKNVIIVAGRNI
* * * : * * ** ***:** * *.:***** *:***:****:
Mb1041|M.bovis_AF2122/97 YPTDIERAAGRVDGVRPGCAVAVRLDAGHS----RESFAVAVESNAFEDP
Rv1013|M.tuberculosis_H37Rv YPTDIERAAGRVDGVRPGCAVAVRLDAGHS----RESFAVAVESNAFEDP
MAV_1150|M.avium_104 YPTDIERAACRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAFQDP
MSMEG_5435|M.smegmatis_MC2_155 YPTDIERAAGRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAWQDP
TH_3958|M.thermoresistible__bu YPTDIERAAQRVEGVRPGGAVAVRLDAGHS----RETFAVAVESNAWQDP
MLBr_00243|M.leprae_Br4923 YPTDIERAAGRVDGVRPGCAVAVRLDAGHS----RETFAVAVESNAFEDT
MAB_1140|M.abscessus_ATCC_1997 YPTDIERAAGRVDGVRPGCAVAVRLEAGVDPKNQRETFAVVVESNAFENP
Mflv_5217|M.gilvum_PYR-GCK FPADIERAASRVEGVRPGCAVAVRLDAGRS----RESFAVAVESKHFDDE
Mvan_1051|M.vanbaalenii_PYR-1 YPTDIERAAGRVDGVRPGCAVAVRLEAGRS----RETFAVAVECKDFGDE
MUL_4044|M.ulcerans_Agy99 FPADIERLAASVHGIRRGGVVAFGVTLADR----REEIRIVAETVADPSI
MMAR_4970|M.marinum_M FPADIERLAASVHGIRRGGVVAFGVTLADR----REEIRIVAETVADPSI
:*:**** * *.*:* * .**. : . ** : :..* .
Mb1041|M.bovis_AF2122/97 AEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRANSVTLV
Rv1013|M.tuberculosis_H37Rv AEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRANSVTLV
MAV_1150|M.avium_104 AEVRRIEHQVAREVVAEVDMRPRNVVVLGPGTIPKTPSGKLRRSNSVTLV
MSMEG_5435|M.smegmatis_MC2_155 AEVRRIEHQVAHEVVSEVDVRPRNVVVLGPGSIPKTPSGKLRRANSVSLV
TH_3958|M.thermoresistible__bu EEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGSIPKTSSGKLRRSTSVSLV
MLBr_00243|M.leprae_Br4923 AEVRRIEHQVAHEVLKEVDVRPRNVVVLGPGTIPKTPSGKLRRASSVTLV
MAB_1140|M.abscessus_ATCC_1997 DEVRRIEQQVAHEVVAEVDVRPRNVVVLGPGSIPKTPSGKLRRSTSVALV
Mflv_5217|M.gilvum_PYR-GCK VEVRRVERQVAHEVFAEVDVRPRNVVVLEPGTIPKTPSGKLRRAHALSLV
Mvan_1051|M.vanbaalenii_PYR-1 TQVRRVERQVAHEVFAEVDVRPRNVVVLAPGTIPKTPSGKLRRAHALSLV
MUL_4044|M.ulcerans_Agy99 EDGRELRRQIAQNVRGATGLRP-TVLLVGKGNVPKTASGKIRHVMARELF
MMAR_4970|M.marinum_M EDGRELRRQIAQNVRGATGLSP-TVLLVGKGKVPKTASGKIRHVMARELF
: *.:.:*:*::* ..: * .*::: *.:***.***:*: : *.
Mb1041|M.bovis_AF2122/97 T-----
Rv1013|M.tuberculosis_H37Rv T-----
MAV_1150|M.avium_104 T-----
MSMEG_5435|M.smegmatis_MC2_155 TQ----
TH_3958|M.thermoresistible__bu T-----
MLBr_00243|M.leprae_Br4923 T-----
MAB_1140|M.abscessus_ATCC_1997 I-----
Mflv_5217|M.gilvum_PYR-GCK S-----
Mvan_1051|M.vanbaalenii_PYR-1 S-----
MUL_4044|M.ulcerans_Agy99 GEVSPA
MMAR_4970|M.marinum_M GEVSPA