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KPASFDYHRPDTAEEAVDLLAELGEDAKILPGGQSLVPMLSMRLAFFDHLIDISRLGELQGIRLRDDQLW IGAGTPDSKVGTNSQVHQSIPLLARATPYIGHFQIRNRGTLGGSIAHADAAGEYPTVALTLDAVMEVLSP RGHRKIPAAEFFTGLWETAMEPDEVLTGVRFPTWTGKSGFAMREFSRRHGDFAIAGAAVAVQLDDEHRVS RCAIGLLGLGPTPRRATAAEAAVLGKPIDELVPEQIGQSAMSGLDDIASDLQGPASYRAQVGAVMTTRAW SRAVQEANAETAHA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0587 | coxM_2 | - | 100% (295) | aerobic-type carbon monoxide dehydrogenase, CoxM_2 |
| M. ulcerans Agy99 | MUL_4579 | coxM_1 | 1e-11 | 23.43% (286) | carbon monoxyde dehydrogenase (medium chain), CoxM_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0382c | - | 9e-33 | 32.96% (270) | carbon monoxyde dehydrogenase medium subunit |
| M. gilvum PYR-GCK | Mflv_1571 | - | 1e-102 | 61.67% (300) | carbon-monoxide dehydrogenase (acceptor) |
| M. tuberculosis H37Rv | Rv0375c | - | 1e-32 | 32.96% (270) | carbon monoxyde dehydrogenase medium subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2926c | - | 1e-07 | 25.27% (281) | putative oxidoreductase (molybdopterin dehydrogenase) |
| M. marinum M | MMAR_0622 | coxM_3 | 1e-158 | 94.58% (295) | aerobic-type carbon monoxide dehydrogenase, CoxM_3 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_5882 | - | 1e-100 | 62.85% (288) | carbon monoxide dehydrogenase medium chain |
| M. thermoresistible (build 8) | TH_1271 | - | 1e-110 | 65.97% (288) | carbon monoxide dehydrogenase medium chain |
| M. vanbaalenii PYR-1 | Mvan_5185 | - | 1e-102 | 61.81% (288) | carbon-monoxide dehydrogenase (acceptor) |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0382c|M.bovis_AF2122/97 -------------MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEY
Rv0375c|M.tuberculosis_H37Rv -------------MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEY
MUL_0587|M.ulcerans_Agy99 MKPASFDYHRPDTAEEAVDLLAELGEDAKILPGGQSLVPMLSMRLAFFDH
MMAR_0622|M.marinum_M MKPASFDYHRPDTAEEAVGLLAELGEDAKILAGGQSLVPMLSMRLAFFDH
Mflv_1571|M.gilvum_PYR-GCK MKAAPFAYHRPDTVADAVSLLGEYGDDAKILAGGQSLVPMLAMRLTHFEN
Mvan_5185|M.vanbaalenii_PYR-1 MKAAPFAYHRPDTVADAVSMLGEFGDDAKILAGGQSLVPMLAMRLTHFEN
MSMEG_5882|M.smegmatis_MC2_155 MKAAPFAYHRPASVTDAVALLGEYGDDAKILAGGQSLVPMLAMRLTHFDN
TH_1271|M.thermoresistible__bu MKPAPFAYHRPADLTEATQLLAEFGDEAKVLAGGQSLVPMLNLRLAFFDH
MAB_2926c|M.abscessus_ATCC_199 ---MDLYSIDSVLIPRDRADLSGLGTQDGVLAGG---TWLMSQPQPGLRR
* * ::.** :: .
Mb0382c|M.bovis_AF2122/97 LVDINDLAPELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIFR
Rv0375c|M.tuberculosis_H37Rv LVDINDLAPELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIFR
MUL_0587|M.ulcerans_Agy99 LIDISRLGELQGIRLRD-----DQLWIGAGTPDSKVGTNSQVHQSIPLLA
MMAR_0622|M.marinum_M LIDISRLAELQGIQLRN-----DQLWIGAGTPDSKVGTDSQVRQSVPLLT
Mflv_1571|M.gilvum_PYR-GCK LIDISRIEELRNIELRNGAD--SSVRIGAGTPHALVGMDDEVAESVPLLT
Mvan_5185|M.vanbaalenii_PYR-1 LIDISRVDELRNIEPRG-----DAVRIGAGTPHALVGMDDEVAESVPLLT
MSMEG_5882|M.smegmatis_MC2_155 LIDISRVHELTDIDRIG-----DEVRIGAATPHAFVGLDDEVAESVPLLT
TH_1271|M.thermoresistible__bu LVDISRLDELKGIERSN-----GSLTIRAGTTDATVGADDQVRSAVPLLT
MAB_2926c|M.abscessus_ATCC_199 LVDLTGMRWPDLVVDAGG---LEVAATCSIERLINASYPPAWQATALFGQ
*:*:. : . : :
Mb0382c|M.bovis_AF2122/97 DAERVIADPVVRNRGTLGGSLCQADPAEDLSTVCTVLDAVCLAKGPSGER
Rv0375c|M.tuberculosis_H37Rv DAERVIADPVVRNRGTLGGSLCQADPAEDLSTVCTVLDAVCLAKGPSGER
MUL_0587|M.ulcerans_Agy99 RATPYIGHFQIRNRGTLGGSIAHADAAGEYPTVALTLDAVMEVLSPRGHR
MMAR_0622|M.marinum_M RATPYIGHFQIRNRGTLGGSIAHADAAGEYPTVALTLDAVMEVLSPRGYR
Mflv_1571|M.gilvum_PYR-GCK LATPHIGHFQIRTRGTLGGAIAHADPAAEYAAVALALDAEIEATSGRGTR
Mvan_5185|M.vanbaalenii_PYR-1 LSTPHIGHFQIRTRGTLGGAIAHADPAAEYAAVALALDAEMEATSARGTR
MSMEG_5882|M.smegmatis_MC2_155 LATPHIGHFQIRTRGTLGGAIAHADPAAEYAAVALALDATIEATSARGVR
TH_1271|M.thermoresistible__bu RATPHIGHFQIRNRGTFGGSIAHADPAGEYPAVALALDAQMEAVSPTGRR
MAB_2926c|M.abscessus_ATCC_199 CARALLASFKIWRTATVGGNICLGLPAGAMISLCAALDAELHIWRHDGTD
: :. : .*.** :. . .* ::. .*** *
Mb0382c|M.bovis_AF2122/97 E-IAIDDFLVGPYETALAHNEVLIEVRIPLRHN-TSSAYAKVERRVGDWA
Rv0375c|M.tuberculosis_H37Rv E-IAIDDFLVGPYETALAHNEVLIEVRIPLRHN-TSSAYAKVERRVGDWA
MUL_0587|M.ulcerans_Agy99 K-IPAAEFFTGLWETAMEPDEVLTGVRFPTWTGKSGFAMREFSRRHGDFA
MMAR_0622|M.marinum_M E-IPAAEFFTGLWETAMEPDEVLTGVRFPTWTGKSGFAVREFSRRHGDFA
Mflv_1571|M.gilvum_PYR-GCK R-IPAAEFFTGLWETALASDEILTAVSFPVWSGRCGFAVQEFARRHGDFA
Mvan_5185|M.vanbaalenii_PYR-1 R-IPAAEFFTGLWETALAADEILTAVSFPVWTGHCGFAVQEFARRHGDFA
MSMEG_5882|M.smegmatis_MC2_155 E-IPAAEFFTGLWETALASDEILTAVRFPVWSGRCGFAVQEFARRHGDFA
TH_1271|M.thermoresistible__bu E-IAAADFFQGLWETALEPDEILAAVRFPVWDGRCGFAVHEFARRHGDFA
MAB_2926c|M.abscessus_ATCC_199 ERCTITEFVTGINETVLHPGDVLRAITFPSSALSQPTALRKIAYSP--LG
. . :*. * **.: .::* : :* * :. .
Mb0382c|M.bovis_AF2122/97 ITAAGAAVTLDG-QTILAARVGLTAVNPDPVALAELSAGLVGQPATEEVF
Rv0375c|M.tuberculosis_H37Rv ITAAGAAVTLDG-QTILAARVGLTAVNPDPVALAELSAGLVGQPATEEVF
MUL_0587|M.ulcerans_Agy99 IAGAAVAVQLDDEHRVSRCAIGLLGLGPTPRRATAAEAAVLGKPIDELVP
MMAR_0622|M.marinum_M IAGAAVAVQLDDEHRVSRCAIGLLGLGATPRRATAAEAAVLGKPIDELVP
Mflv_1571|M.gilvum_PYR-GCK IAGATVAVALDEDDTVTRCGIGMLGMGSTPERGTAAEAAVLGRPVADITA
Mvan_5185|M.vanbaalenii_PYR-1 IAGATLAVELDGRDRVARCGIGLLGMGSTPERGTPAEQAVVGRPVTDITA
MSMEG_5882|M.smegmatis_MC2_155 IAGAVVGLQLGDDDRVTRCGIGLLGLGSTPLRATAAEAEVLGGPVDAVTP
TH_1271|M.thermoresistible__bu IAGAVLAVRLDGDDRISRCGIGLLGLGSTPRRATAAEQAILGRPVSEVDA
MAB_2926c|M.abscessus_ATCC_199 RSGALVTGRLDGADIVL-------GITAATRRPIVLRVPAEARRAREAVA
:.* *. . : .: . . .
Mb0382c|M.bovis_AF2122/97 AEAGRRAAQACTPVT-DVRGTAEYKRHLAGELTVRTLRTAAGRVLGAPAA
Rv0375c|M.tuberculosis_H37Rv AEAGRRAAQACTPVT-DVRGTAEYKRHLAGELTVRTLRTAAGRVLGAPAA
MUL_0587|M.ulcerans_Agy99 EQIGQSAMSGLDDIASDLQGPASYRAQVGAVMTTRAWSRAVQEANAETAH
MMAR_0622|M.marinum_M EQIGQSAMSGLADIASDLQGSGSYRAQVGAVMTTRAWSRAVQEANAETAH
Mflv_1571|M.gilvum_PYR-GCK EELGRLAVSTLHDIPADLQGSAAYRSRVCATMVARAWSEATTAARHTTEA
Mvan_5185|M.vanbaalenii_PYR-1 EEVGRLAVSELHDVPADLQGRPAYRSKVGATMVARAWSQATTAALETREA
MSMEG_5882|M.smegmatis_MC2_155 EEIGRLALSDLTEIPADLQGTAEYRRRVGATMVARAFEQARTQATEG--A
TH_1271|M.thermoresistible__bu DELGVLAMEGLDDIPADLQGSADYRRRVGAAMVARAWTDASREAASA---
MAB_2926c|M.abscessus_ATCC_199 AIPG-------VEFHTDAHGTAEWRGAVTTQLAGEVAAELTGALS-----
* . * :* :: : :. ..
Mb0382c|M.bovis_AF2122/97 PEA
Rv0375c|M.tuberculosis_H37Rv PEA
MUL_0587|M.ulcerans_Agy99 A--
MMAR_0622|M.marinum_M A--
Mflv_1571|M.gilvum_PYR-GCK LHA
Mvan_5185|M.vanbaalenii_PYR-1 LNA
MSMEG_5882|M.smegmatis_MC2_155 VDA
TH_1271|M.thermoresistible__bu ---
MAB_2926c|M.abscessus_ATCC_199 ---