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NSMTPSQWLDIAVLAVAFIAAVSGWRSGALGSMLSFAGVLLGAIAGVLLAPHIVSHINAPRAKLFAALFL ILGLVVVGEVAGVVLGRAVRGAIRNRPIRVIDSVIGVGVQLVVVLTAAWLLATPLTQSKDQPELAAAVRG SRVLAQVNAVAPTWLKTVPKRLSGLLNTSGLPAVLEPFSRTPVIPVASPDPALARNPVVEATAPSVLKIR SLAPSCQKVLEGSGFVIAPDRVMTNAHVVAGANSVQVFASGKPLDATVVSYDPSVDIAILAVPGLPPPPL IFAEREAPTGTNVVVLGYPGGGNFTATPARIREATRLSGPDIYRNLQPVTRDVYTIRANVEQGDSGGPLI DLNGQVLGVVFGAAVDDPDTGFVLTSGEVASQLARIGATERVATGSCVS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4245 | - | - | 100% (400) | membrane-associated serine protease |
| M. ulcerans Agy99 | MUL_4798 | pepA | 1e-15 | 27.35% (234) | serine protease PepA |
| M. ulcerans Agy99 | MUL_4699 | pepD | 9e-13 | 25.44% (283) | serine protease PepD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3695c | - | 0.0 | 86.15% (397) | putative membrane-associated serine protease |
| M. gilvum PYR-GCK | Mflv_1376 | - | 1e-143 | 64.48% (397) | colicin V production protein |
| M. tuberculosis H37Rv | Rv3671c | - | 0.0 | 85.89% (397) | membrane-associated serine protease |
| M. leprae Br4923 | MLBr_02298 | - | 1e-180 | 80.05% (401) | putative membrane-associated serine protease |
| M. abscessus ATCC 19977 | MAB_0421 | - | 1e-142 | 63.07% (398) | membrane-associated serine protease |
| M. marinum M | MMAR_5159 | - | 0.0 | 99.25% (400) | membrane-associated serine protease |
| M. avium 104 | MAV_0459 | - | 0.0 | 87.75% (400) | serine protease |
| M. smegmatis MC2 155 | MSMEG_6183 | - | 1e-152 | 68.26% (397) | serine protease |
| M. thermoresistible (build 8) | TH_0962 | - | 1e-147 | 64.39% (396) | serine protease |
| M. vanbaalenii PYR-1 | Mvan_5430 | - | 1e-146 | 65.24% (397) | colicin V production protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6183|M.smegmatis_MC2_155 -----MTPSLWLDLAVVAIAFVAAISGWRSGALGSLMSFIGVVLGAVAGV
TH_0962|M.thermoresistible__bu -----MTAAQWLDFAILAVALIAAISGWRSGAVGSLMSFLGVVLGAVAGV
Mflv_1376|M.gilvum_PYR-GCK -----MNSSQWLDIAILAVAMLAAVSGWRSGAPGSLMALVGVVLGAGAGI
Mvan_5430|M.vanbaalenii_PYR-1 -----MNSSQWLDISILALALIAAISGWRSGAPGSLLALVGVALGAAAGI
MAB_0421|M.abscessus_ATCC_1997 ---MNLNPSQWLDIGVIAVAFIAAVSGWRSGALGSLMSFVGVILGAVAGI
MUL_4245|M.ulcerans_Agy99 --MNSMTPSQWLDIAVLAVAFIAAVSGWRSGALGSMLSFAGVLLGAIAGV
MMAR_5159|M.marinum_M --MNSMTPSQWLDIAVLAVAFIAAVSGWRSGALGSMLSFAGVLLGAIAGV
Mb3695c|M.bovis_AF2122/97 -----MTPSQWLDIAVLAVAFIAAISGWRAGALGSMLSFGGVLLGATAGV
Rv3671c|M.tuberculosis_H37Rv -----MTPSQWLDIAVLAVAFIAAISGWRAGALGSMLSFGGVLLGATAGV
MAV_0459|M.avium_104 MNLNSMTPSQWLDVAVLAVAFIAAISGWRSGALGSLLSFVGVLLGAIAGV
MLBr_02298|M.leprae_Br4923 --MSSMTLSEWLDIAVLAVAFIAAISGWRSGALGSLLSLIGVLFGAMAGV
:. : ***..::*:*::**:****:** **:::: ** :** **:
MSMEG_6183|M.smegmatis_MC2_155 LLAPHVIPHVDGARTKLFVTLFLILALVVVGEIAGVVLGRAVRGTIRSGL
TH_0962|M.thermoresistible__bu LLAPHVVTYIDGARTRLFATLFLILALVVIGEIAGVVLGRAARSALRSGP
Mflv_1376|M.gilvum_PYR-GCK LLAPHVVDHISGPRTKLFATLFLILVLVVIGEIAGVVLGRAVRGAIRNPG
Mvan_5430|M.vanbaalenii_PYR-1 LLAPHVVSHISGPRTKLFVTLFLILALVVIGEIAGVVLGRAVRGAIRSPG
MAB_0421|M.abscessus_ATCC_1997 MLAPHVVANIEGSRTKLFASLLLILVLVVIGEVAGVVLGRAMRGAIRNRV
MUL_4245|M.ulcerans_Agy99 LLAPHIVSHINAPRAKLFAALFLILGLVVVGEVAGVVLGRAVRGAIRNRP
MMAR_5159|M.marinum_M LLAPHIVSHINAPRAKLFAALFLILGLVVVGEVAGVVLGRAVRGAIRNRP
Mb3695c|M.bovis_AF2122/97 LLAPHIVSQISAPRAKLFAALFLILALVVVGEVAGVVLGRAVRGAIRNRP
Rv3671c|M.tuberculosis_H37Rv LLAPHIVSQISAPRAKLFAALFLILALVVVGEVAGVVLGRAVRGAIRNRP
MAV_0459|M.avium_104 LLAPHLVSHIAAPRAKLFAALFLILALVVIGEVAGVVLGRAVRGAIRSRS
MLBr_02298|M.leprae_Br4923 LLVPHVVSHISAPRAKLFAALFLILALVVIGEVVGVVLGRAVRSANRSRT
:*.**:: : ..*::**.:*:*** ***:**:.******* *.: *.
MSMEG_6183|M.smegmatis_MC2_155 FRAFDSVVGVSLMLVAVLVAAWLLGS-LLTSSDQPNLAAAVKGSRVLSEV
TH_0962|M.thermoresistible__bu VRALDSVTGVAMQLVAVLLAAWLLATPLASTSGQPAVAAAVSDSRLLSEV
Mflv_1376|M.gilvum_PYR-GCK LRIVDSVVGVALQLVLVLTAAWLLGTALVSSP-QPNLAAAVSGSRVIAEV
Mvan_5430|M.vanbaalenii_PYR-1 LRVADSVVGVALQLVLVLTAAWLLGTALVSSP-QPNLAAAVQGSKVIAEV
MAB_0421|M.abscessus_ATCC_1997 LRTGDSVVGVVLQVAAVLVAAWLLSIPMQSSN-QPNISAAARESKVLSQV
MUL_4245|M.ulcerans_Agy99 IRVIDSVIGVGVQLVVVLTAAWLLATPLTQSKDQPELAAAVRGSRVLAQV
MMAR_5159|M.marinum_M IRVIDSVIGVGVQLVVVLTAAWLLATPLTQSKDQPELAAAVRGSRVLAQV
Mb3695c|M.bovis_AF2122/97 IRLIDSVIGVGVQLVVVLTAAWLLAMPLTQSKEQPELAAAVKGSRVLARV
Rv3671c|M.tuberculosis_H37Rv IRLIDSVIGVGVQLVVVLTAAWLLAMPLTQSKEQPELAAAVKGSRVLARV
MAV_0459|M.avium_104 IRTVDSVIGVGVQLVVVLTAAWLLATPLTQSKDQPELAAAVRGSRVLAKV
MLBr_02298|M.leprae_Br4923 VRLVDSVIGVGVQLIVVLTAAWLLATPLTQSKEQPELASAVRGSRALASV
.* *** ** : : ** *****. : : ** :::*. *: :: *
MSMEG_6183|M.smegmatis_MC2_155 DRVAPTWLRQVPTRLSGLLDTSGLPDVLEPFGRTPIVNVDAPDAALADDA
TH_0962|M.thermoresistible__bu DKVAPEWLRSVPQRISALLDDSGLPDVLEPFGRTPIAAVDEPDPALAQDT
Mflv_1376|M.gilvum_PYR-GCK DAVAPDWLRSVPDRMSSVWENAGLHDVLKPFGPTPVAAVDAPDPALATSP
Mvan_5430|M.vanbaalenii_PYR-1 DSVAPSWLRSVPNRLSALWETAGLHDVLKPFGPTPVAEIDPPDPSLATSP
MAB_0421|M.abscessus_ATCC_1997 DKYAPDQLRKVPNDLSKLLDTSGLPSVLQPFGKTPIAAVDAPDATLADGP
MUL_4245|M.ulcerans_Agy99 NAVAPTWLKTVPKRLSGLLNTSGLPAVLEPFSRTPVIPVASPDPALARNP
MMAR_5159|M.marinum_M NEVAPTWLKTVPKRLSGLLNTSGLPAVLEPFSRTPVIPVASPDPALARNP
Mb3695c|M.bovis_AF2122/97 NEAAPTWLKTVPKRLSALLNTSGLPAVLEPFSRTPVIPVASPDPALVNNP
Rv3671c|M.tuberculosis_H37Rv NEAAPTWLKTVPKRLSALLNTSGLPAVLEPFSRTPVIPVASPDPALVNNP
MAV_0459|M.avium_104 NEVAPPWLKTVPKRLSALLNTSGLPAVLEPFSRTPVIPVASPDPELASNP
MLBr_02298|M.leprae_Br4923 NEVAPPWLKTVPKRLSALLNTSGLPAVLEPFSRTPVLPVASPDPALVDNP
: ** *: ** :* : : :** **:**. **: : **. *. ..
MSMEG_6183|M.smegmatis_MC2_155 VVAATRPSVVKIRGVAPSCQKVLEGSGFVVAPSRVMSNAHVVAGADSVTV
TH_0962|M.thermoresistible__bu VVGLTAPSVVKIRGVAEVCRKVLEGSGFVIAPNRVMSNAHVVAGADQVTI
Mflv_1376|M.gilvum_PYR-GCK VVNQTRSSVVKVKGVAQSCQKVLEGTGFVVAPNRVMSNAHVVAGSDTVTV
Mvan_5430|M.vanbaalenii_PYR-1 VVNTTRSSVVKVRGVAQSCQKVLEGTGFVVAPNRVMSNAHVVAGSDSVTV
MAB_0421|M.abscessus_ATCC_1997 VVRGSEPSVVKIKGIARSCQKSLEGTGFVIAPHRVMSNAHVVAGTNSVTV
MUL_4245|M.ulcerans_Agy99 VVEATAPSVLKIRSLAPSCQKVLEGSGFVIAPDRVMTNAHVVAGANSVQV
MMAR_5159|M.marinum_M VVEATAPSVLKIRSLAPSCQKVLEGSGFVIAPDRVMTNAHVVAGANSVQV
Mb3695c|M.bovis_AF2122/97 VVAATEPSVVKIRSLAPRCQKVLEGTGFVISPDRVMTNAHVVAGSNNVTV
Rv3671c|M.tuberculosis_H37Rv VVAATEPSVVKIRSLAPRCQKVLEGTGFVISPDRVMTNAHVVAGSNNVTV
MAV_0459|M.avium_104 VVQATAPSVVKVRSLAPSCQKVLEGSGFVIAPDRVMTNAHVVAGSNSVQI
MLBr_02298|M.leprae_Br4923 VVLATQPSVVKIRSVAPSCQKVLEGTGFVVSLDRVMTNAHVVAGSDGVQV
** : .**:*::.:* *:* ***:***:: ***:*******:: * :
MSMEG_6183|M.smegmatis_MC2_155 EVDGETYDAHVVSYDPDADISILDVPNLPSAPLAFAADPAPQGTDAVVMG
TH_0962|M.thermoresistible__bu DADGQEYPATVVSYDPDIDISILDVPDLPLRPLQFVDHEAPPGTDAVAMG
Mflv_1376|M.gilvum_PYR-GCK EVDGQEYTAGVVSYDPNADISILDVPDLPSVPLQFVDALAQTGTDGIVLG
Mvan_5430|M.vanbaalenii_PYR-1 EVDGQTYDAGVVSYDPNADISILDVPNLPSAPLQFVDAEAQPGTDGIVMG
MAB_0421|M.abscessus_ATCC_1997 ESAGQTYDASVVSYDPNADISILAVPDMPAAPLVFASKPAKTGDDAIVLG
MUL_4245|M.ulcerans_Agy99 FASGKPLDATVVSYDPSVDIAILAVPGLPPPPLIFAEREAPTGTNVVVLG
MMAR_5159|M.marinum_M FASGKPLDATVVSYDPSVDIAILAVPGLPPPPLIFAEREAPTGTNVVVLG
Mb3695c|M.bovis_AF2122/97 YAGDKPFEATVVSYDPSVDVAILAVPHLPPPPLVFAAEPAKTGADVVVLG
Rv3671c|M.tuberculosis_H37Rv YAGDKPFEATVVSYDPSVDVAILAVPHLPPPPLVFAAEPAKTGADVVVLG
MAV_0459|M.avium_104 YASGNPLDATVVSYDPSVDIAILAVPNLPPPPLPFAQTEAKTGASVVVLG
MLBr_02298|M.leprae_Br4923 YASGNPFDATVVSYDPSVDIAILAVPHLPPAPLRFDDTKAKPGTNVVMLG
.: * ******. *::** ** :* ** * * * . : :*
MSMEG_6183|M.smegmatis_MC2_155 YPGGGDFLATPARVREIIELNGPDIYRT-TTVTREVYTVRGTVRQGNSGG
TH_0962|M.thermoresistible__bu YPGGGDFVATPVRVRETITLKGPDIYQS-KTVTRSVYTVRGSIKQGNSGG
Mflv_1376|M.gilvum_PYR-GCK YPGGGDFTATPARVREVIELNGPDIYRS-TTVTREVYTIRGTVRQGNSGG
Mvan_5430|M.vanbaalenii_PYR-1 YPGGGEFTATPARVREVIELNGPDIYRS-TTVTREVYTIRGTVKQGNSGG
MAB_0421|M.abscessus_ATCC_1997 YPGGGDYKASPARVREIIELKGPDIYRS-ITVTREVYTVRGSVLQGNSGG
MUL_4245|M.ulcerans_Agy99 YPGGGNFTATPARIREATRLSGPDIYRNLQPVTRDVYTIRANVEQGDSGG
MMAR_5159|M.marinum_M YPGGGNFTATPARIREAIRLSGPDIYRNPQPVTRDVYTIRANVEQGDSGG
Mb3695c|M.bovis_AF2122/97 YPGGGNFTATPARIREAIRLSGPDIYGDPEPVTRDVYTIRADVEQGDSGG
Rv3671c|M.tuberculosis_H37Rv YPGGGNFTATPARIREAIRLSGPDIYGDPEPVTRDVYTIRADVEQGDSGG
MAV_0459|M.avium_104 YPGGGNFTATPARIRELIKLSGPDIYRDPAPVTRDVYTIRASVEQGNSGG
MLBr_02298|M.leprae_Br4923 YPGGGNFTATSARIRQAIKLTGPDIYRGLAPVTRDVYTIRATVEQGNSGG
*****:: *:..*:*: *.***** .***.***:*. : **:***
MSMEG_6183|M.smegmatis_MC2_155 PMINRAGKVLGVVFGAAVDDVDTGFVLTAKEVERQLAKIGNTER-VATGT
TH_0962|M.thermoresistible__bu PMIDRSGKVLGVVFGAAVDDDDTGFVLTAKQVEHQIARVGNTEP-VPTGQ
Mflv_1376|M.gilvum_PYR-GCK PMVNRQGKVLGVVFGAAVDDIDTGFVLTADEVAAQMARVGNVDL-VPTGT
Mvan_5430|M.vanbaalenii_PYR-1 PMINRQGRVLGVVFGAAVDDVDTGFVLTADEVARQMAKVGNVER-VATGT
MAB_0421|M.abscessus_ATCC_1997 PLIDTEGRVLGVVFGAAIDDDDTGFALTAKQVKDQLAKADLADP-VATGS
MUL_4245|M.ulcerans_Agy99 PLIDLNGQVLGVVFGAAVDDPDTGFVLTSGEVASQLARIGATER-VATGS
MMAR_5159|M.marinum_M PLIDLNGQVLGVVFGAAVDDPDTGFVLTSGEVASQLARIGATER-VATGS
Mb3695c|M.bovis_AF2122/97 PLIDLNGQVLGVVFGAAVDDAETGFVLTAGEVAGQLAKIGATQP-VGTGA
Rv3671c|M.tuberculosis_H37Rv PLIDLNGQVLGVVFGAAIDDAETGFVLTAGEVAGQLAKIGATQP-VGTGA
MAV_0459|M.avium_104 PLIDLNGQVLGVVFGAAVDDPDTGFVLTADEVAGQLAKIGETKT-VGTGS
MLBr_02298|M.leprae_Br4923 PLIDLNGRVLGVVFGAAVDDSETGFVLTAEEVSHRLTEIGETQEAVATGA
*::: *:*********:** :***.**: :* :::. . .. * **
MSMEG_6183|M.smegmatis_MC2_155 CINS-----------------------
TH_0962|M.thermoresistible__bu CVGAPAP--------------------
Mflv_1376|M.gilvum_PYR-GCK CISSG----------------------
Mvan_5430|M.vanbaalenii_PYR-1 CISAG----------------------
MAB_0421|M.abscessus_ATCC_1997 CVSAAEANRPTEQPVNGPQSPVPGKAP
MUL_4245|M.ulcerans_Agy99 CVS------------------------
MMAR_5159|M.marinum_M CVS------------------------
Mb3695c|M.bovis_AF2122/97 CVS------------------------
Rv3671c|M.tuberculosis_H37Rv CVS------------------------
MAV_0459|M.avium_104 CVS------------------------
MLBr_02298|M.leprae_Br4923 CVS------------------------
*:.