For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AVLAVLGLGLATVPAPAHAASSNLALDRFADFPTLPLDPSAMVAQVGPQVVNVNTKLGYNNAVGAGTGII IDPAGVVLTNNHVISGATDISVFSVGDGRTYGVDVVGYDRTRDVAVLQMRGAGGLPAAAIGGGVSVGEPI VAMGNTGGQGGTPRAVPGRVVALDQTVEASDALTGAEETLNGLIQVDAAIAPGDSGGPIVNNMGQVVGMN TAASDNFQMSGGGTGFAIPIGQAMGIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNDTGAKVARVVGSAPA AVVGISTGDIITALGGAPINSATAMSDALNGHHPGDIVSISWTSSSGGQRTENVTLAEGPPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4798 | pepA | - | 100% (343) | serine protease PepA |
| M. ulcerans Agy99 | MUL_4699 | pepD | 1e-41 | 33.52% (364) | serine protease PepD |
| M. ulcerans Agy99 | MUL_4517 | htrA | 6e-26 | 33.94% (274) | serine protease HtrA (DegP protein) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0130 | pepA | 1e-165 | 83.09% (343) | serine protease PepA |
| M. gilvum PYR-GCK | Mflv_1278 | - | 5e-71 | 47.12% (295) | PDZ/DHR/GLGF domain-containing protein |
| M. tuberculosis H37Rv | Rv0125 | pepA | 1e-165 | 83.09% (343) | serine protease PepA |
| M. leprae Br4923 | MLBr_02659 | - | 1e-135 | 69.77% (344) | putative secreted serine protease |
| M. abscessus ATCC 19977 | MAB_1078 | - | 3e-40 | 35.37% (311) | putative serine protease |
| M. marinum M | MMAR_0324 | pepA | 0.0 | 98.83% (343) | serine protease PepA |
| M. avium 104 | MAV_5187 | - | 1e-135 | 68.30% (347) | trypsin |
| M. smegmatis MC2 155 | MSMEG_6289 | - | 1e-71 | 43.15% (343) | trypsin |
| M. thermoresistible (build 8) | TH_1677 | - | 5e-67 | 43.14% (306) | Trypsin |
| M. vanbaalenii PYR-1 | Mvan_5537 | - | 5e-72 | 43.40% (341) | PDZ/DHR/GLGF domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1278|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5537|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1677|M.thermoresistible__bu --------------------------------------------------
MSMEG_6289|M.smegmatis_MC2_155 --------------------------------------------------
MUL_4798|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0324|M.marinum_M --------------------------------------------------
Mb0130|M.bovis_AF2122/97 --------------------------------------------------
Rv0125|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02659|M.leprae_Br4923 --------------------------------------------------
MAV_5187|M.avium_104 -------------------------------------------------M
MAB_1078|M.abscessus_ATCC_1997 MTNDPHGSWAYRPSGSYSGQHGHHQAPNHHAQSSHHYQGQSYGYPSQQPQ
Mflv_1278|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5537|M.vanbaalenii_PYR-1 ---------------MIRRHRILPIALAAVLAL-----------VAPLTP
TH_1677|M.thermoresistible__bu ----------MGAHRLVRRPWLYLIALVATLGL-----------LSPAFP
MSMEG_6289|M.smegmatis_MC2_155 ----------MGKPRSRQFGSVILAALVAFATL-----------LLPAAP
MUL_4798|M.ulcerans_Agy99 ------------------------MAVLAVLGLGLATVP----APAHAAS
MMAR_0324|M.marinum_M ---------MSK-LRHHSPRWSWLVAVLAVLGLGLATVP----APALAAP
Mb0130|M.bovis_AF2122/97 ---------MSN-SRRRSLRWSWLLSVLAAVGLGLAT------APAQAAP
Rv0125|M.tuberculosis_H37Rv ---------MSN-SRRRSLRWSWLLSVLAAVGLGLAT------APAQAAP
MLBr_02659|M.leprae_Br4923 ---------MSR-QPHRSLWRSWLVSTLAALGLSLAVVPGS---ATPSGP
MAV_5187|M.avium_104 FTATQEGDGMSKSHHHRSVWWSWLVGVLTVVGLGLGLGSGVGLAPASAAP
MAB_1078|M.abscessus_ATCC_1997 QRPAQQPQRQAQPKGRSSGGLVVGAVVLALVSGGLGGTVGAVVADRQHKA
Mflv_1278|M.gilvum_PYR-GCK --------------------------------------MEPAVVRIDTAV
Mvan_5537|M.vanbaalenii_PYR-1 A----------VAAPGDP--------------VAASVQVEPAVVRIDTEV
TH_1677|M.thermoresistible__bu VTS--------VAQPPDV--------------LAAASRVEPAVARIDTRI
MSMEG_6289|M.smegmatis_MC2_155 A----------AAEPADP--------------LAAAAAVEPAVARIDTVV
MUL_4798|M.ulcerans_Agy99 SNLALDRFADFPTLPLDP--------------SAMVAQVGPQVVNVNTKL
MMAR_0324|M.marinum_M SNLALDRFADFPTLPLDP--------------SAMVAQVGPQVVNVNTKL
Mb0130|M.bovis_AF2122/97 PALSQDRFADFPALPLDP--------------SAMVAQVGPQVVNINTKL
Rv0125|M.tuberculosis_H37Rv PALSQDRFADFPALPLDP--------------SAMVAQVGPQVVNINTKL
MLBr_02659|M.leprae_Br4923 STLALDRFSNRPPLPLNP--------------AAMV---APQVVNISTRL
MAV_5187|M.avium_104 SGLALDRFADRPLAPIDP--------------SAMVGQVGPQVVNIDTKF
MAB_1078|M.abscessus_ATCC_1997 PVVTSSSTGLTPIAPGRPPAAQPVASLPAGSVEQVAAKVLPSVVKLETIM
* *..:.* .
Mflv_1278|M.gilvum_PYR-GCK DYQGVIGLGTGMVIDPGGLVLTNFHVVQGADR---ITATVG--GRPYPAQ
Mvan_5537|M.vanbaalenii_PYR-1 DYQGVVGLGTGIVLDPAGQVLTNFHVVQGADR---ITGTVA--GRAYPAQ
TH_1677|M.thermoresistible__bu DYQRAIGVGAGIVLHPNGEVLTNFHVVQGADT---ITATVN--GQPFPAE
MSMEG_6289|M.smegmatis_MC2_155 DYQQAYGVGTGFVLSPNGEVLTNYHVVQGANT---INATVN--GASFMAD
MUL_4798|M.ulcerans_Agy99 GYNNAVGAGTGIIIDPAGVVLTNNHVISGATD---ISVFSVGDGRTYGVD
MMAR_0324|M.marinum_M GYNNAVGAGTGIIIDPAGVVLTNNHVISGATD---ISVFSVGDGRTYGVD
Mb0130|M.bovis_AF2122/97 GYNNAVGAGTGIVIDPNGVVLTNNHVIAGATD---INAFSVGSGQTYGVD
Rv0125|M.tuberculosis_H37Rv GYNNAVGAGTGIVIDPNGVVLTNNHVIAGATD---INAFSVGSGQTYGVD
MLBr_02659|M.leprae_Br4923 GYNSAVGAGTGIVIDSSGVVLTNNHVISGATD---ISAFDVGNGKTYGVD
MAV_5187|M.avium_104 GYNNAVGAGTGIVIDPNGVVLTNNHVISGATE---ISAFDVGNGQTYAVD
MAB_1078|M.abscessus_ATCC_1997 GRSSEE--GSGVILSADGLVLTNAHVVQAAGDPGAKTTATIAGGKTSPFT
. . *:*.:: . * **** **: .* . * .
Mflv_1278|M.gilvum_PYR-GCK LVGYDRGRDVAVIQLLGAAGLPAAPIGDANILAPGEPVVALGNAMGSDAP
Mvan_5537|M.vanbaalenii_PYR-1 LVGYDRKRDVAVLQLIGANGLAAAPIGDAYALVPGQPVVALGNAMGTEAP
TH_1677|M.thermoresistible__bu LIGYNRRQDIAVLQLHGAAGLPVAPIGDSDNLAPGEPVVALGNANGTHAP
MSMEG_6289|M.smegmatis_MC2_155 LVGYNRRADIAVLQLRGAGGLPTASIGDSRSLVEGEPVVALGNAYGSNAP
MUL_4798|M.ulcerans_Agy99 VVGYDRTRDVAVLQMRGAGGLPAAAIGG--GVSVGEPIVAMGNTGGQGGT
MMAR_0324|M.marinum_M VVGYDRTRDVAVLQMRGAGGLPAAAIGG--GVSVGEPIVAMGNTGGQGGT
Mb0130|M.bovis_AF2122/97 VVGYDRTQDVAVLQLRGAGGLPSAAIGG--GVAVGEPVVAMGNSGGQGGT
Rv0125|M.tuberculosis_H37Rv VVGYDRTQDVAVLQLRGAGGLPSAAIGG--GVAVGEPVVAMGNSGGQGGT
MLBr_02659|M.leprae_Br4923 VVGYDRTQDVAVLQLRGASNLPTAVIGG--DVAIGEPIVALGNTGGQGGL
MAV_5187|M.avium_104 VVGYDRTQDIAVLQLRGAAGLPTATIGG--EATVGEPIVALGNVGGQGGT
MAB_1078|M.abscessus_ATCC_1997 VVGIDPGTDIAVVRITGASGLTPIALGSSANLVVGQSVVAIGSPLGLDG-
::* : *:**::: ** .*. :*. *:.:**:*. * .
Mflv_1278|M.gilvum_PYR-GCK LTREVGTLTAFGRTVEAEDTLTGSTDELTGLFEFAAPVRAGDSGGPVVSS
Mvan_5537|M.vanbaalenii_PYR-1 LTREVGTLTGFGRTVQAEDTLTGTSDELTGLFEFAAPVRAGDSGGPVVND
TH_1677|M.thermoresistible__bu LTRETGTVTEFGRTVTAEDTLTGSSEELSGLFEFAAPVRAGDSGGPVVNT
MSMEG_6289|M.smegmatis_MC2_155 LTREVGTVTAFGRTVNAEDSLTGTKDELTGLIEFAAPVRAGDSGGPVVDG
MUL_4798|M.ulcerans_Agy99 PRAVPGRVVALDQTVEASDALTGAEETLNGLIQVDAAIAPGDSGGPIVNN
MMAR_0324|M.marinum_M PRAVPGRVVALDQTVEASDALTGAEETLNGLIQVDAAIAPGDSGGPIVNN
Mb0130|M.bovis_AF2122/97 PRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNG
Rv0125|M.tuberculosis_H37Rv PRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNG
MLBr_02659|M.leprae_Br4923 PSVLPGRVVALNQTVQASEPLTGAQETLSGLIQVDAPIKPGDSGGPVVNS
MAV_5187|M.avium_104 PNAVAGKVVALNQSVSATDTLTGAQENLGGLIQADAPIKPGDSGGPMVNG
MAB_1078|M.abscessus_ATCC_1997 -TVTTGIVSSLNRPVFTAG-QAGNQDTVLDAIQTDAAINPGNSGGALVNL
* : :.:.* : :* : : . :: *.: .*:***.:*.
Mflv_1278|M.gilvum_PYR-GCK TGQVVGVTTAASVNFRMGPGGKGFAIPINDAMGVVGQIRAGVPSDTVHIG
Mvan_5537|M.vanbaalenii_PYR-1 LGQVVGITTAASVNFRMGPGGKGFAIPINDAMGVAGQIRGGIRSDSVHIG
TH_1677|M.thermoresistible__bu AGEVVGITTAASVSFRMGPGGRGFAIPINDAMAIADQIRARVPSDSVHIG
MSMEG_6289|M.smegmatis_MC2_155 AGQVVGVTTAASVNFRMGPGGKGFAIPINDAMAVANQIRSRTPSPEVHIG
MUL_4798|M.ulcerans_Agy99 MGQVVGMNTAASDNFQMSGGGTGFAIPIGQAMGIAGQIRSGGGSPTVHIG
MMAR_0324|M.marinum_M MGQVVGMNTAASDNFQMSGGGTGFAIPIGQAMGIAGQIRSGGGSPTVHIG
Mb0130|M.bovis_AF2122/97 LGQVVGMNTAASDNFQLSQGGQGFAIPIGQAMAIAGQIRSGGGSPTVHIG
Rv0125|M.tuberculosis_H37Rv LGQVVGMNTAASDNFQLSQGGQGFAIPIGQAMAIAGQIRSGGGSPTVHIG
MLBr_02659|M.leprae_Br4923 RGQVVGMNTAATDNYKML-GGQGFAIPIGQAMEVVGAIRSGAGSNTVHIG
MAV_5187|M.avium_104 AGQVIGVDTAATDSYKMS-GGQGFAIPIGRAMAVANQIRSGAGSNTVHIG
MAB_1078|M.abscessus_ATCC_1997 NGELVGINSAIAT-MGGDSSGETQGGSIGLGFAIPVDQAKRVADQLITNG
*:::*: :* : .* . .*. .: : . : *
Mflv_1278|M.gilvum_PYR-GCK PPTLLGVGVRAAP-RDAPGVLIQEVMVGGPADRAGLLAGDIIVMLDGTPL
Mvan_5537|M.vanbaalenii_PYR-1 PPTLLGVGVRTAP-RDEPGVLIQEVMVGGPADLAGLRAGDILIELDGTPL
TH_1677|M.thermoresistible__bu PPTLLGVGVRTAPLRTRPGVLIQDVLRGGPAEAAGLRSGDILIELDGTRL
MSMEG_6289|M.smegmatis_MC2_155 PPTLLGVGVRTAQ-RSGGGVIIQDVLRGGPAEAAGLVPGDILMSIEGTLL
MUL_4798|M.ulcerans_Agy99 PTAFLGLGVVDNN---DTGAKVARVVGSAPAAVVGISTGDIITALGGAPI
MMAR_0324|M.marinum_M PTAFLGLGVVDNN---GTGAKVARVVGSAPAAVVGISTGDIITALGGAPI
Mb0130|M.bovis_AF2122/97 PTAFLGLGVVDNN---GNGARVQRVVGSAPAASLGISTGDVITAVDGAPI
Rv0125|M.tuberculosis_H37Rv PTAFLGLGVVDNN---GNGARVQRVVGSAPAASLGISTGDVITAVDGAPI
MLBr_02659|M.leprae_Br4923 PTAFFGLGVLDNN---GNGARVARVVATGPAAMAGISVGDIITSVDGVPI
MAV_5187|M.avium_104 PTAFLGLGVTDNN---GNGARVQRVVNTGPAAAAGIAPGDVITGVDTVPI
MAB_1078|M.abscessus_ATCC_1997 RATHASLGVRVGNDKEVQGARIVEVVAGGAAEKAGIPNGAVVTKVDNRPV
.: .:** *. : *: ..* *: * :: : :
Mflv_1278|M.gilvum_PYR-GCK DSTNTLTSVLDRHYPGDVLDLTWIDTLGQ-TRTGKAVLTPVV--
Mvan_5537|M.vanbaalenii_PYR-1 DSTNTLTSVLDRHYTGDVLDLTWVDSTGV-TRDGKAVLTPTV--
TH_1677|M.thermoresistible__bu DSATTLTYTLDRHYPGDVVDLVWIDASGQ-TRTGKATLTAHL--
MSMEG_6289|M.smegmatis_MC2_155 DTARTLTLVLDQHYPGDVVDLTWRDRGGF-DRNGKATLAAGP--
MUL_4798|M.ulcerans_Agy99 NSATAMSDALNGHHPGDIVSISWTSSSGG-QRTENVTLAEGPPA
MMAR_0324|M.marinum_M NSATAMSDALNGHHPGDIVSISWTSNSGG-QRTENVTLAEGPPA
Mb0130|M.bovis_AF2122/97 NSATAMADALNGHHPGDVISVTWQTKSGG-TRTGNVTLAEGPPA
Rv0125|M.tuberculosis_H37Rv NSATAMADALNGHHPGDVISVTWQTKSGG-TRTGNVTLAEGPPA
MLBr_02659|M.leprae_Br4923 SEATAMTNVLVPHHPGETVAVNYRSAGGG-DLTANVTLAEGPPA
MAV_5187|M.avium_104 NGATSMTEVLVPHHPGDTIAVHFRSVDGG-ERTANITLAEGPPA
MAB_1078|M.abscessus_ATCC_1997 NSADGLVAAVRSKAPGDKVTLTYTDGNGGQEKTADVTLGEVAR-
. : : .: : .*: : : : * . .*