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DLFAKLVADQDPLFQLSRAIHGIATFPKLGGAAGTRMTWRDDEYIIWNLNNYLGLADHPEVRAADAEFAG RYGLATPMGSRMMSGETDDLELLESELADYAQKPAALVLNYGYQGMISLIDSLTTEVDWIVSDAENHACI IDGIRLHRKRGERTRMFAHNDIDQLETHLAEINRVRGPDSGVLVVTEGVFGMSGDQGALREIAAFKQQYD FRLLVDDAHGIGVLGPNGGGTGEQQGVQDDIDLYFGTFTKAAAGAGAFVASQADVIWKLRYTMRSQIFSR GLPWPIVAGNRVRLGLLRRSDDLRRRAHAVAGKLQASLTEEGLNIGKANSLITPVYLPMDPLSALAFLTE LRHKHGIFCSAVTYPVVPPGIVQLRLISTAGHDIADVEPTVKAIAAVYNELTGNRTIPQLDNAPT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1966 | bioF2_2 | - | 100% (416) | 8-amino-7-oxononanoate synthase BioF2_2 |
| M. ulcerans Agy99 | MUL_0241 | bioF2_1 | e-160 | 67.81% (407) | 8-amino-7-oxononanoate synthase BioF2_1 |
| M. ulcerans Agy99 | MUL_4045 | bioF2 | 2e-35 | 29.17% (384) | 8-amino-7-oxononanoate synthase BioF2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0033 | bioF2 | 3e-46 | 33.06% (360) | 8-amino-7-oxononanoate synthase BioF2 |
| M. gilvum PYR-GCK | Mflv_3628 | - | 5e-24 | 29.34% (334) | 8-amino-7-oxononanoate synthase |
| M. tuberculosis H37Rv | Rv0032 | bioF2 | 3e-46 | 33.06% (360) | 8-amino-7-oxononanoate synthase BioF2 |
| M. leprae Br4923 | MLBr_01217 | bioF | 6e-25 | 29.95% (374) | 8-amino-7-oxononanoate synthase |
| M. abscessus ATCC 19977 | MAB_2687c | - | 9e-28 | 32.95% (349) | 8-amino-7-oxononanoate synthase |
| M. marinum M | MMAR_1724 | bioF2_2 | 0.0 | 99.04% (416) | 8-amino-7-oxononanoate synthase BioF2_2 |
| M. avium 104 | MAV_3205 | bioF | 1e-28 | 30.73% (371) | 8-amino-7-oxononanoate synthase |
| M. smegmatis MC2 155 | MSMEG_3189 | bioF | 2e-29 | 31.63% (332) | 8-amino-7-oxononanoate synthase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2789 | - | 2e-25 | 30.90% (356) | 8-amino-7-oxononanoate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLAT
Rv0032|M.tuberculosis_H37Rv MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLAT
MUL_1966|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1724|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 TDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVL
Rv0032|M.tuberculosis_H37Rv TDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVL
MUL_1966|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1724|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 PVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRV
Rv0032|M.tuberculosis_H37Rv PVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRV
MUL_1966|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1724|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 DTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPV
Rv0032|M.tuberculosis_H37Rv DTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPV
MUL_1966|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1724|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 LARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAF
Rv0032|M.tuberculosis_H37Rv LARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAF
MUL_1966|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1724|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 FLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRM
Rv0032|M.tuberculosis_H37Rv FLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRM
MUL_1966|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1724|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK ----------------------------MTRAGLSPLAWLDEVETQR---
Mvan_2789|M.vanbaalenii_PYR-1 ----------------------------MTRVSLSPLAWLDEVETQR---
MSMEG_3189|M.smegmatis_MC2_155 ----------------------------MTRAGLSPLAWLADIEQRR---
MLBr_01217|M.leprae_Br4923 ---------------------------MKVPIETSPLAWLEAVEQQR---
MAV_3205|M.avium_104 ---------------------------MKAPIEVSPLAWLDAVEQQR---
MAB_2687c|M.abscessus_ATCC_199 ---------------------------MPVVEASSPLAWLGEVERQR---
Mb0033|M.bovis_AF2122/97 EMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTL
Rv0032|M.tuberculosis_H37Rv EMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTL
MUL_1966|M.ulcerans_Agy99 -----------------------MDLFAKLVADQDPLFQLSRAIHGIAT-
MMAR_1724|M.marinum_M -----------------------MDLFAKLVADQDPLFQLSRAIHGIAT-
.* :
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 PDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYP
Rv0032|M.tuberculosis_H37Rv PDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYP
MUL_1966|M.ulcerans_Agy99 -------------------------------------------------F
MMAR_1724|M.marinum_M -------------------------------------------------F
Mflv_3628|M.gilvum_PYR-GCK RAAGLRRSLRARPPVGTVLDLASNDYLGLSQHPRVIDGGVAALRTWGAG-
Mvan_2789|M.vanbaalenii_PYR-1 RAAGLRRTVRTRPPVGAELDLASNDYLGLSQHPRVIDGGVSALRTWGAG-
MSMEG_3189|M.smegmatis_MC2_155 RAEGLRRELRVRPPVAAELDLASNDYLGLSQHPDVLDGGVEALRTWGGG-
MLBr_01217|M.leprae_Br4923 RGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGVAALRVWGAG-
MAV_3205|M.avium_104 RAAGLRRSLRPRPPVATELDLASNDYLGLSQHPDVIDGGVAALRLWGAG-
MAB_2687c|M.abscessus_ATCC_199 EAAGLRRRLRTRSAAEPEIDLASNDYLGLSRHPQVIEAGVEALRIWGAG-
Mb0033|M.bovis_AF2122/97 RFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTG-
Rv0032|M.tuberculosis_H37Rv RFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTG-
MUL_1966|M.ulcerans_Agy99 PKLGGAAGTRMTWRDDEYIIWNLNNYLGLADHPEVRAADAEFAGRYGLAT
MMAR_1724|M.marinum_M PKLGGAAGTRMTWRDDEYIIWNLNNYLGLADHPEVRAADAEFAGRYGLAT
* : *.****: ** * ... :* .
Mflv_3628|M.gilvum_PYR-GCK ATGSRLVTGNTELHEQFEDALASFVGADSALVFSSGYTANLGAVVALSGP
Mvan_2789|M.vanbaalenii_PYR-1 STGSRLVTGNTELHEAFEDVLAAFVGAESALVFSSGYTANLGAVVALSGP
MSMEG_3189|M.smegmatis_MC2_155 AGGSRLVTGNTELHEAFEHQLASFLGAESALVFSSGYTANLGALVALSGP
MLBr_01217|M.leprae_Br4923 ATGSRLVTGDTILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGP
MAV_3205|M.avium_104 ATGSRLVTGDTELHQQFESELADYVGAASGLLFSSGYAANLGAVVGLSGR
MAB_2687c|M.abscessus_ATCC_199 STGSRLVTGNTELHEELEQELATFMGTESALVFSSGYTANLGAVVALSGP
Mb0033|M.bovis_AF2122/97 CSGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCES
Rv0032|M.tuberculosis_H37Rv CSGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCES
MUL_1966|M.ulcerans_Agy99 PMGSRMMSGETDDLELLESELADYAQKPAALVLNYGYQGMISLIDSLTTE
MMAR_1724|M.marinum_M PMGSRMMSGETDDLELLESELADYAQKPAALVLNYGYQGMISLIDSLTTE
** ::.* :* ** : .:: . ** . :. : .*
Mflv_3628|M.gilvum_PYR-GCK GSLLVSDAYTHASLVDACRLSR---ARVVVTPHNDVAAVARALATRDEER
Mvan_2789|M.vanbaalenii_PYR-1 GSLLVSDANTHASLVDACRLSR---ARVVVTPHNDTAAVEQALATRSEAR
MSMEG_3189|M.smegmatis_MC2_155 GSLIVSDALSHASLVDACRLSR---ARVVVSPHRDVDAVDAALAARTEER
MLBr_01217|M.leprae_Br4923 GSLIVSDAYSHASLVDACRLSR---ARVVVTPHCDVDAVDTALRSCHEER
MAV_3205|M.avium_104 GALVVSDAYSHASLVDACRLSR---ARVVVTPHRDVDAVLAALADRDEER
MAB_2687c|M.abscessus_ATCC_199 GTLIVSDARTHASLIDACRLSR---ARVVVTPYRDTQAVAAALAQRPEER
Mb0033|M.bovis_AF2122/97 GDMIIQDALNHRSLFDAARLSG---ADFTLYRHNDMDHLARVLRRTEGRR
Rv0032|M.tuberculosis_H37Rv GDMIIQDALNHRSLFDAARLSG---ADFTLYRHNDMDHLARVLRRTEGRR
MUL_1966|M.ulcerans_Agy99 VDWIVSDAENHACIIDGIRLHRKRGERTRMFAHNDIDQLETHLAEINRVR
MMAR_1724|M.marinum_M VDWIVSDAENHACIIDGIRLHRKRGERTRMFAHNDIDQLETHLAEINRVR
::.** .* .:.*. ** : : * : * *
Mflv_3628|M.gilvum_PYR-GCK A-----VVVTDSVFSADGDLAPLRELHDACRRHGALMIVDEAHGLGVRGD
Mvan_2789|M.vanbaalenii_PYR-1 A-----VVVTDSVFSADGDLAPLRALHTACRKHGALLIVDEAHGLGVRGD
MSMEG_3189|M.smegmatis_MC2_155 A-----VVVTESVFSADGDLAPLRDLHAVCRRHGALLLVDEAHGLGVRGT
MLBr_01217|M.leprae_Br4923 A-----VVVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRG-
MAV_3205|M.avium_104 A-----VVITESVFSTDGALAPLRELHEVCRRHRALLIVDEAHGLGVRG-
MAB_2687c|M.abscessus_ATCC_199 A-----LVLTDAVFSADGALAPLAELYGVCRRHGAVLLVDEAHGLGVRGS
Mb0033|M.bovis_AF2122/97 R-----IIVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGP
Rv0032|M.tuberculosis_H37Rv R-----IIVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGP
MUL_1966|M.ulcerans_Agy99 GPDSGVLVVTEGVFGMSGDQGALREIAAFKQQYDFRLLVDDAHGIGVLGP
MMAR_1724|M.marinum_M GPDSGVLVVTEGVFGMSGDQGALREIAALKQQYDFRLLVDDAHGFGVLGP
:::.:.**. .* . : : :: : **::*.:** *
Mflv_3628|M.gilvum_PYR-GCK RGRGLLDEVGLAGAPDVVMTTTLSKALGSQGGVVLGPAAVRDHLIDAARP
Mvan_2789|M.vanbaalenii_PYR-1 GGRGLLDEVGLAGAPDLVMTTTLSKALGSQGGVVLGPAAVRAHLIDTARP
MSMEG_3189|M.smegmatis_MC2_155 RGQGLLHEVGLAGAPDIVMTTTLSKALGSQGGAVLGPEAVRAHLIDTARS
MLBr_01217|M.leprae_Br4923 GGRGLVYEVGLAGAPDVVITTTMSKALGSQGGAVLGSSAVRAHLINTARP
MAV_3205|M.avium_104 GGRGLVFEAGLAGAPDVVMTTTLSKALGSQGGAVLGPAAVRAHLIDAART
MAB_2687c|M.abscessus_ATCC_199 GGRGLVAEMNLAGRDDLVVTVTLSKALGSQGGAVLGSAAVRAHLIDAARP
Mb0033|M.bovis_AF2122/97 DGRGASAALGVLARMDVVMG-TFSKSFASVGGFIAGDRPVVDYIRHNGSG
Rv0032|M.tuberculosis_H37Rv DGRGASAALGVLARMDVVMG-TFSKSFASVGGFIAGDRPVVDYIRHNGSG
MUL_1966|M.ulcerans_Agy99 NGGGTGEQQGVQDDIDLYFG-TFTKAAAGAGAFVASQADVIWKLRYTMRS
MMAR_1724|M.marinum_M NGGGTGEQQGVQDDIDLYFG-TFTKAAAGAGAFVASQADVIWKLRYTMRS
* * .: *: . *::*: .. *. : . * :
Mflv_3628|M.gilvum_PYR-GCK FIFDTGLAPAAVGAAHAALQVLVEEPWRAQRVLDHATTLAQICGVA----
Mvan_2789|M.vanbaalenii_PYR-1 FIFDTGLAPAAVGAAFAALQVLIDEPWRAQRVLDHAATLASICDVT----
MSMEG_3189|M.smegmatis_MC2_155 FIFDTGLAPAAVGAASAALRVLDAEPQRARAVLDRAAELATIAGVT----
MLBr_01217|M.leprae_Br4923 FIFDTGLAPAAVGAARAALQILKAETWRPEAVLQHARTLAKICDLS----
MAV_3205|M.avium_104 FIFDTGLAPAAVGAARAALGVLRAEPWRVGAVLRHAGVLAEVCRVR----
MAB_2687c|M.abscessus_ATCC_199 FIFDTGLAPAAVGSALAALRLMIDEPARIRAVLAHAAALGQWCGVP----
Mb0033|M.bovis_AF2122/97 HVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQA
Rv0032|M.tuberculosis_H37Rv HVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQA
MUL_1966|M.ulcerans_Agy99 QIFSRGLPWPIVAGNRVRLGLLRRSDDLRRRAHAVAGKLQASLTEEGLNI
MMAR_1724|M.marinum_M QIFSRGLPWPIVAGNRVRLGLLRRSDDLRRRAHAVAGKLQASLTEEGLNI
:*. .*. . ... . * : . . * :
Mflv_3628|M.gilvum_PYR-GCK DVPSSAVVSVILGEPEVALAAAMGCLER--GVRVGCFRPPTVPAGTSRLR
Mvan_2789|M.vanbaalenii_PYR-1 EVPSSAVVSVILGEPEVAFAAAAACLDR--GVRVGCFRPPTVPAGTSRLR
MSMEG_3189|M.smegmatis_MC2_155 EAPVSAVVSVILGDPEIAVGAAAACLDR--GVRVGCFRPPTVPAGTSRLR
MLBr_01217|M.leprae_Br4923 ELPQSAVVSVVLGDPEVALAAAIACLDA--GVRVGCFRPPTVPAGTSRLR
MAV_3205|M.avium_104 EVPQSAVVSVILGDPDVAVAAATACLDA--GVRVGCFRPPTVPAGTSRLR
MAB_2687c|M.abscessus_ATCC_199 DKPESAVVPVVLGDPTVAFNAARSCLEQ--GVRVGCFRPPSVPEGQSLLR
Mb0033|M.bovis_AF2122/97 EYHGTAIVPVILGNPTVAHAGYLRLMRS--GVYVNPVAPPAVPEERSGFR
Rv0032|M.tuberculosis_H37Rv EYHGTAIVPVILGNPTVAHAGYLRLMRS--GVYVNPVAPPAVPEERSGFR
MUL_1966|M.ulcerans_Agy99 GKANSLITPVYLPMDPLSALAFLTELRHKHGIFCSAVTYPVVPPGIVQLR
MMAR_1724|M.marinum_M GKANSLITPVYLPMDPLSALAFLTELRHKHGIFCSAVTYPVVPPGIVQLR
: :..* * :: . : *: . . * ** :*
Mflv_3628|M.gilvum_PYR-GCK LTARASLSDDEMALAREVLTDVLSRA--------------
Mvan_2789|M.vanbaalenii_PYR-1 LTARASLSEDEMTLARRVLTEVLSPR--------------
MSMEG_3189|M.smegmatis_MC2_155 LAARASLTDDEMALARQVLTDVLATARA------------
MLBr_01217|M.leprae_Br4923 LTAHASLDSAKLEVARRVLTDVLGGCCVARR---------
MAV_3205|M.avium_104 LTARASLDDAELEVARRVLTDVLAGLG-------------
MAB_2687c|M.abscessus_ATCC_199 LTARASLTEADMERVHEVLAGVLTLARR------------
Mb0033|M.bovis_AF2122/97 TSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL-------
Rv0032|M.tuberculosis_H37Rv TSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL-------
MUL_1966|M.ulcerans_Agy99 LISTAGHDIADVEPTVKAIAAVYNELTGNRTIPQLDNAPT
MMAR_1724|M.marinum_M LISTAGHDIADVEPTVKAIAAVYKELTGNQTIPQLDNAPT
*. .: . ..:: :