For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ANSFETDGRGPSDRQLLLCGLVMAVVAALVGTALVIKSTGRFNDYVRVVAELTNVGDGLPAKSDVKYQGV LVGAVDDLTPSQRGRPNVVHINLKPALAHTVPRSVTARVVPSNVFAVSSVELVDHGPGPAITDGAVIPED TELPTVLFQTTISKLRDILLANGRGRDDDSVGIFAVIAAATEGRRATLLNAAGQLTRIIDQLNDIVATDT GPSTLSALLDATKGLQTTAPELVDALHQAIKPMQTLAEKREQLQSLLNAGLHTTGTVRQSLDNQTDRMID ITTKLTPVVGVLAKNSVHFLPMATRLKVFSDKFFSEVWDPEKDVVNIRGILSFTPSTMYTRADCPRYGEL KGPSCFTAPELVVRPDLPETLLPQNFKPPPDLAPPPGTEVGPDGNLIVTGPPLLNPHPNLQDPNPPLPWW QPNPSPRVPGSADPDDLEPPPGSPGMPIPSTAPASFGGAVGPVGSKTERDQLGLITGGEASSSTQLLLGP VARGTKPVVVEQASAGGRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4568c | - | - | 100% (510) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4516c | - | 0.0 | 62.31% (520) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1010c | - | 0.0 | 65.06% (498) | putative MCE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 5e-14 | 24.12% (456) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_0010 | - | 1e-175 | 58.81% (539) | hypothetical protein Mflv_0010 |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 5e-14 | 24.12% (456) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_00048 | - | 7e-05 | 28.91% (128) | hypothetical protein MLBr_00048 |
| M. marinum M | MMAR_3864 | mce5A | 0.0 | 63.94% (513) | Mce protein, Mce5A |
| M. avium 104 | MAV_0102 | - | 0.0 | 64.92% (516) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1143 | - | 0.0 | 61.55% (528) | mce related protein |
| M. thermoresistible (build 8) | TH_2386 | - | 1e-163 | 60.25% (478) | mce related protein |
| M. ulcerans Agy99 | MUL_3796 | mce5A | 0.0 | 63.35% (513) | Mce protein, Mce5A |
| M. vanbaalenii PYR-1 | Mvan_0959 | - | 0.0 | 61.76% (523) | hypothetical protein Mvan_0959 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3526c|M.bovis_AF2122/97 MMGRVAMLTGS-----RGLRYATVIALVAALVGGVYVLSSTG----NKRT
Rv3496c|M.tuberculosis_H37Rv MMGRVAMLTGS-----RGLRYATVIALVAALVGGVYVLSSTG----NKRT
Mflv_0010|M.gilvum_PYR-GCK -MANSFEFDGRGPSDRQLLVCGVAVLAIVSIVTAVLLVKSTGRLDPRVRV
Mvan_0959|M.vanbaalenii_PYR-1 -MANSLEMDGRGPTDRQLLACGVALLVIALVVSGALLVKSTGRMDAHVRV
MSMEG_1143|M.smegmatis_MC2_155 -MGNSIELDGRGPSERQLLACGLAVLVVAGLISTVLLVKATGRLDPYVRV
TH_2386|M.thermoresistible__bu -MANSFDLDGRGPTDRQLLAGGVVVIVVLSVISTYLLVKATGRLDPFVRV
MMAR_3864|M.marinum_M -MPNSIESDGRGPSDRQLIGIGLVVVLLAAVLTIALLVKSTGRLNDYVRV
MUL_3796|M.ulcerans_Agy99 -MPNSIESDGCGPSDRQLIGIGLVVVLLAAVLTIALLVKSTGRLNDYVRV
MAV_0102|M.avium_104 -MANSLDFDGRGPTDHQLLALGATVLLIAGLITGGLLLKSTGRLNDYIRV
MAB_4568c|M.abscessus_ATCC_199 -MANSFETDGRGPSDRQLLLCGLVMAVVAALVGTALVIKSTGRFNDYVRV
MLBr_00048|M.leprae_Br4923 -MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTPNGEV
* . . : .* ..
Mb3526c|M.bovis_AF2122/97 IVGYFTSAVGLYPGDQVRVLG----VPVGEIDMIEP----RSSDVKITMS
Rv3496c|M.tuberculosis_H37Rv IVGYFTSAVGLYPGDQVRVLG----VPVGEIDMIEP----RSSDVKITMS
Mflv_0010|M.gilvum_PYR-GCK VAAMVNVGDGLPQRSDVKYHG----VLVGAVDDVTPAENGEPNFVHIDLK
Mvan_0959|M.vanbaalenii_PYR-1 VAALVNVGDGLPQRSDVKYHG----VLVGAVDDVTPAQYGDPNFVHIDLK
MSMEG_1143|M.smegmatis_MC2_155 VAALINVGDGLPQRSDVKYHG----VLVGMVEDVTPAAHGEPNYVHINLN
TH_2386|M.thermoresistible__bu VADLVNVGDGLPQRSDVKYHG----VLVGHVDSVTPAAHGHPNYVHINLD
MMAR_3864|M.marinum_M TADLRNVGDGLPKRSDVKYHG----VLVGMVDGVAPAANGRPNYVHINLK
MUL_3796|M.ulcerans_Agy99 TADLRNVGDGLPKRSDVKYHG----VLVGMVDGVAPAANGRPNYVHINLK
MAV_0102|M.avium_104 VAELTNVGDGLPARSDVKYHG----LLVGAVDNVIPAAYGKPNYVHINLK
MAB_4568c|M.abscessus_ATCC_199 VAELTNVGDGLPAKSDVKYQG----VLVGAVDDLTPSQRGRPNVVHINLK
MLBr_00048|M.leprae_Br4923 ASPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSA
. * . . : :* * .
Mb3526c|M.bovis_AF2122/97 VSKD-------VKVPVDVQAVIMSPNLVAARFIQLTPVY---TGGAVLPD
Rv3496c|M.tuberculosis_H37Rv VSKD-------VKVPVDVQAVIMSPNLVAARFIQLTPVY---TGGAVLPD
Mflv_0010|M.gilvum_PYR-GCK PEYA-------KSIPANVTARVVPSNVFAVSSVQLVG---SGGP--PIQP
Mvan_0959|M.vanbaalenii_PYR-1 PEYA-------ASIPAGVTARVVPSNVFAVSSVQLVDR--SGGP--PIQS
MSMEG_1143|M.smegmatis_MC2_155 PEYA-------SSIPSTVTARVVPSNVFAVSSVQLVDR--DGGAGPAISA
TH_2386|M.thermoresistible__bu RHHA-------RSIPATVTARVVPSNVFAVSSVQLVDR--DGGPGTPIQA
MMAR_3864|M.marinum_M PEYA-------ASIPAAVTARVVPSSVFAVSSVQLIDAPAPRGRQPAIRA
MUL_3796|M.ulcerans_Agy99 PEYA-------ASIPAAVTARVVPSSVFAVSSVQLIDAPAPRGRQPAIRA
MAV_0102|M.avium_104 PEYA-------QDIPSAVTARVVPSNVFAVSSVQLVDG----APGPSIRN
MAB_4568c|M.abscessus_ATCC_199 PALA-------HTVPRSVTARVVPSNVFAVSSVELVDH----GPGPAITD
MLBr_00048|M.leprae_Br4923 PPRSPAASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPAT
* . . .*
Mb3526c|M.bovis_AF2122/97 NGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQGPLGAAINQAADT
Rv3496c|M.tuberculosis_H37Rv NGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQGPLGAAINQAADT
Mflv_0010|M.gilvum_PYR-GCK GAEIPEDTELPTVLFQTTISKLRDILAATGRGREDDTVGILAAVHAATED
Mvan_0959|M.vanbaalenii_PYR-1 GARIPEDTELPTVLFQTTISKLRDILAATGRGREDDTVGILAAVNAATED
MSMEG_1143|M.smegmatis_MC2_155 GAQIPEDTELPTVLFQTTISKLRDILAATGRGREDRTVGVLAAVNAATEG
TH_2386|M.thermoresistible__bu GAHIPEDTELPTVLFQTTISKLRDILAATGRGREDRTVGILAAVNAATEN
MMAR_3864|M.marinum_M GTHIPEDSRLPTVLFQTTLSKLRDLLAAAGRGREDNSLGILAAIAAATDH
MUL_3796|M.ulcerans_Agy99 GTHIPEDSRLPTVLFQTTVSKLRDLLAAAGRGREDNSLGILAAIAAATDH
MAV_0102|M.avium_104 GARIPEDLQLSTVIFQTTISKLRDILAATGRGREDHSVGILAAVAAATNN
MAB_4568c|M.abscessus_ATCC_199 GAVIPEDTELPTVLFQTTISKLRDILLANGRGRDDDSVGIFAVIAAATEG
MLBr_00048|M.leprae_Br4923 PMPMTPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPR
: . * : :
Mb3526c|M.bovis_AF2122/97 LDGNGDSLHNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQI
Rv3496c|M.tuberculosis_H37Rv LDGNGDSLHNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQI
Mflv_0010|M.gilvum_PYR-GCK RRTELLTSGAQLNRMVDELDRIVATEP-GPTTVSALVDATRGLQQTAPEL
Mvan_0959|M.vanbaalenii_PYR-1 RRTELLTSGAQLNSLVDELDRIVATDP-GPTTVSALVDATRGLQQTAPEL
MSMEG_1143|M.smegmatis_MC2_155 RRTELLTSGAQLNRLIDEVDSIVATDPSAPTTVSTLIEATRGLQQTAPEL
TH_2386|M.thermoresistible__bu RRTELLSAGAQLDLLIDEIDSIVATDP-GPTTVSALIGATRGLQQTAPEL
MMAR_3864|M.marinum_M RRASLLSGGAQLNRLLDQLNSIVATDS-EPSTVAALIDATRGLQASAPEL
MUL_3796|M.ulcerans_Agy99 RRASLLSGGAQLNRLLDQLNSIVATDS-EPSTVAALIDATRGLQASAPEL
MAV_0102|M.avium_104 RRGPLLTAGAQLTRVLDELNAIVATDP-GPSTVSALLDATRGLQSTAPDL
MAB_4568c|M.abscessus_ATCC_199 RRATLLNAAGQLTRIIDQLNDIVATDT-GPSTLSALLDATKGLQTTAPEL
MLBr_00048|M.leprae_Br4923 PSANQHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAA
. . : . . .
Mb3526c|M.bovis_AF2122/97 VQFAGHVASVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETV
Rv3496c|M.tuberculosis_H37Rv VQFAGHVASVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETV
Mflv_0010|M.gilvum_PYR-GCK VDALHQAVQPMQTLVEQSAQLTSLVNGGIRTSETTRTAFDNHADRLVRIT
Mvan_0959|M.vanbaalenii_PYR-1 VDALHQAVEPMQTLVEQSAQLTTFINGGINTVGTTHTALNNHTDRMVRIT
MSMEG_1143|M.smegmatis_MC2_155 VDALHTAVRPMQTLVEQRSQLDSLISAGMNTLDTTRTALNNHTDRLVKIT
TH_2386|M.thermoresistible__bu LDALHQAVQPMQTLVQQRAQLDALIGGALHTSATTHTALTNHTDRMVTIT
MMAR_3864|M.marinum_M VEALHQAVEPMKTFAETRAQLAALLAGADHTIGTAQQSLGNHIDQLIQIT
MUL_3796|M.ulcerans_Agy99 VEALHQAVEPMKTFAETRAQLAALLAGADHTIGTAQQSLGNHIDQLIQIT
MAV_0102|M.avium_104 VDVLHDAVRPMQTLVEKREQFRSLVTGSYHTFSVNRQAFDNHTDQLIEMT
MAB_4568c|M.abscessus_ATCC_199 VDALHQAIKPMQTLAEKREQLQSLLNAGLHTTGTVRQSLDNQTDRMIDIT
MLBr_00048|M.leprae_Br4923 EPAPTQHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTGAKKPSKVVAKR
. :.. : : :: . ::
Mb3526c|M.bovis_AF2122/97 ------NQLNDFAQTLSDQSENIEQVLHVAGPGITNFYNIYDP-AQGTLN
Rv3496c|M.tuberculosis_H37Rv ------NQLNDFAQTLSDQSENIEQVLHVAGPGITNFYNIYDP-AQGTLN
Mflv_0010|M.gilvum_PYR-GCK ------TELTPVVGSLADTSRHWVPAFVKLNELSRKFFDEVWI-HEHDIG
Mvan_0959|M.vanbaalenii_PYR-1 ------TELTPVIGNLAQTSHHWVPAFVKLNGLSRKFFDEVWM-HDRDVG
MSMEG_1143|M.smegmatis_MC2_155 ------SELTPVVGNLADTSHHWLPAFVKLNNLSDKFFDEVWR-PERNVG
TH_2386|M.thermoresistible__bu ------TEMTPVIGNLADTSHHWLPAFIKMNGLSDKFFEEVWR-PERDIG
MMAR_3864|M.marinum_M ------TDFTPVLGVLAQQSDNFLPAVIKLDNLATKFMDEVWM-PENNTG
MUL_3796|M.ulcerans_Agy99 ------TDFTPVLGVLAQQSDNFLPAVIKLDNLATKFMDEVWM-PENNTG
MAV_0102|M.avium_104 ------QNLTPVLGVFAMNSDKFVPIFTRLNRLSDKFFQEVWD-PELDTG
MAB_4568c|M.abscessus_ATCC_199 ------TKLTPVVGVLAKNSVHFLPMATRLKVFSDKFFSEVWD-PEKDVV
MLBr_00048|M.leprae_Br4923 GWRHWVHTVTRINLGLSPDERYELDLRTRVRRPPRGSYQIGILGLKGGAG
.. . :: . . .
Mb3526c|M.bovis_AF2122/97 GLLSIPNFANPVQFICGGSFDTAAGPSAP--DYYRRAEICRERLGPVLRR
Rv3496c|M.tuberculosis_H37Rv GLLSIPNFANPVQFICGGSFDTAAGPSAP--DYYRRAEICRERLGPVLRR
Mflv_0010|M.gilvum_PYR-GCK NMRINLSFTPTYSYTRADCPQYAGLKGPS--CYTAPLVPTRAALPDVLLP
Mvan_0959|M.vanbaalenii_PYR-1 NMRVNLSFTPTYSYTRADCPQYGELKGPS--CFTAPLVPTRPELPDVLLP
MSMEG_1143|M.smegmatis_MC2_155 NMRMNLSFTPSYTYTRADCPQYGELKGPS--CFTAPLVVTRPALPDQMLP
TH_2386|M.thermoresistible__bu NMRMNLSLTPSYTYTRADCPRYGELKGPS--CYTAPLVVTRPSLPDVLLP
MMAR_3864|M.marinum_M NMRVNLSFTPSHSYTRADCPRYGELKGPS--CFTAPLVPVRPDLPEVLLP
MUL_3796|M.ulcerans_Agy99 NMRVNLSFTPSHSYTRADCPRYGELKGPS--CFTAPLVPVRPDLPDVLLP
MAV_0102|M.avium_104 NMRVNLALTPTYTYTRADCPRYGQLQGPS--CFTAPTIAVRPDLPEVLLP
MAB_4568c|M.abscessus_ATCC_199 NIRGILSFTPSTMYTRADCPRYGELKGPS--CFTAPELVVRPDLPETLLP
MLBr_00048|M.leprae_Br4923 KTTVTVTLGSMFARVRNDRILVVDADTSCGNLADRAGRFSEANIADLLAD
: . . . : :
Mb3526c|M.bovis_AF2122/97 LTVNYPPIMFHPLNT-----ITAYKGQIIYDTP---ATEAKSETPVPELT
Rv3496c|M.tuberculosis_H37Rv LTVNYPPIMFHPLNT-----ITAYKGQIIYDTP---ATEAKSETPVPELT
Mflv_0010|M.gilvum_PYR-GCK QNYQPPKDLQPPPGT-----EIGPSGNLIAVGPPLVNPNPSLADPNPPLP
Mvan_0959|M.vanbaalenii_PYR-1 QNYQPPADLKPPPGT-----EVGPNGNLVAVGPPLVNPNPDLRDPNPPLP
MSMEG_1143|M.smegmatis_MC2_155 RNYQPPKDLAPPPGT-----VVGENGNLVAVGPPLINPNPSLADPNPPLP
TH_2386|M.thermoresistible__bu QNYQPPKDLAPPPGT-----IVGENGNLVAVGPPLVNPNPNLADPNPPLP
MMAR_3864|M.marinum_M QNYQPPKDLAPPPGT-----AVGPDGNLVALGPPLINPSPNLTDPNPPLP
MUL_3796|M.ulcerans_Agy99 QNYQPPKDLAPPPGT-----AVGPDGNLVALGPPLINPSPNLTDPNPPLP
MAV_0102|M.avium_104 QNYHPPTDLAPPPGT-----QIGPDGNLVATGPPLYNPDPSLADPNPPLP
MAB_4568c|M.abscessus_ATCC_199 QNFKPPPDLAPPPGT-----EVGPDGNLIVTGPPLLNPHPNLQDPNPPLP
MLBr_00048|M.leprae_Br4923 KDVKSYNDIRTHTSVNAVNLEVLPAAEYSTAQHALSGEDWNFAAATVSKY
: : .. .: . .
Mb3526c|M.bovis_AF2122/97 WVP--AGGGAPVGNPADLQSLLVP----PAPGPAPAPPAPG---------
Rv3496c|M.tuberculosis_H37Rv WVP--AGGGAPVGNPADLQSLLVP----PAPGPAPAPPAPG---------
Mflv_0010|M.gilvum_PYR-GCK PW---MPPSPPVPLTANPALVPPPQLPAPLSPPAPVAPKPGDPPPRPAAP
Mvan_0959|M.vanbaalenii_PYR-1 PW---LSPSPPVPGTANPALVPVPQPPVPLSPPAPVAPKPGDPPPPPAAP
MSMEG_1143|M.smegmatis_MC2_155 PW---MAPAPPVPGTANSALPVTPPPGVNQSPLAPVAPKPGSPPP-----
TH_2386|M.thermoresistible__bu PG---MFPAPPVPGTSNPDLVPIPPPPVNLSPLAPVAPNPNKPRP-----
MMAR_3864|M.marinum_M AW---LTPSPRVPGTGDP----------DDAPPAPPAP-PG---------
MUL_3796|M.ulcerans_Agy99 AW---LTPSPRVPGTGDP----------DDAPPAPPAP-PG---------
MAV_0102|M.avium_104 WWPWQIGPAPRVPGTADPD---------DAPPPPPPSPPPSPAPP-----
MAB_4568c|M.abscessus_ATCC_199 WWQ--PNPSPRVPGSADPD-------DLEPPPGSPGMPIPS---------
MLBr_00048|M.leprae_Br4923 YNVMLADCGVGLFDPVTRGVLSTASGVVIVTSTSVDAARQAAIALDWLRH
. : . . . .
Mb3526c|M.bovis_AF2122/97 --AGPG-------------------------EHGGGG-------------
Rv3496c|M.tuberculosis_H37Rv --AGPG-------------------------EHGGGG-------------
Mflv_0010|M.gilvum_PYR-GCK APAAPAPAPAAPAPAPAAPGPGSAEAPFAPASFGGNVGPVGSQQEQRQLS
Mvan_0959|M.vanbaalenii_PYR-1 PVSGPAPLPAEAAPA----------------GYGGNVGPVGSRHELDQLG
MSMEG_1143|M.smegmatis_MC2_155 PPPAPGPLPAEAAPA----------------SFGGNVGPVGSEQERVTLS
TH_2386|M.thermoresistible__bu PVPAPPPAP------------------------GG---------------
MMAR_3864|M.marinum_M -AAAPS-------------------------AFGGNVGPVGSRQERDALA
MUL_3796|M.ulcerans_Agy99 -AAAPS-------------------------AFGGNVGPVGSRQEGDALA
MAV_0102|M.avium_104 GPVAPA-------------------------AYGGNVGPVGSQRERDQLG
MAB_4568c|M.abscessus_ATCC_199 --TAPA-------------------------SFGGAVGPVGSKTERDQLG
MLBr_00048|M.leprae_Br4923 NGYQDLLSRACVVINHVMPKEPNIASKDLVQQFEQQIQPGRVVVLPWDKH
Mb3526c|M.bovis_AF2122/97 --------------------------------------
Rv3496c|M.tuberculosis_H37Rv --------------------------------------
Mflv_0010|M.gilvum_PYR-GCK LITG--RHATPATQLLLGPLARGTTVS-----IDGEP-
Mvan_0959|M.vanbaalenii_PYR-1 YITG--QPATVATQLLLGPVARGTTVS-----EGVR--
MSMEG_1143|M.smegmatis_MC2_155 VITG--QPASTATQLLLGPVARGTTVSLAEPTAGEEPR
TH_2386|M.thermoresistible__bu ---------------------------------GEEPR
MMAR_3864|M.marinum_M LITG--RPATVATELLLGPLARGTVVSLRNSGAGGEPR
MUL_3796|M.ulcerans_Agy99 LITG--RPATVATELLLGPLARGTVVSLRNSGAGGEPR
MAV_0102|M.avium_104 LITGQGRPASVATQLLLGPVARGSAVSLQPRPAPGGPK
MAB_4568c|M.abscessus_ATCC_199 LITG--GEASSSTQLLLGPVARGTKPVVVEQASAGGRR
MLBr_00048|M.leprae_Br4923 IAAGTEIRLDRLDPLYRRRILELAAALSDDFERAGRH-