For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LIERLDESPIVGEDGRVLSGLRLLNYVESAAYEPETSVPVLREVLAEASRGNWAPVIDAVHGPALLVNPA DLPYLSVACHDLSTPTQVGDVAALARAWTREAPLTGASRAWSVLPCTVWPTRAAAPPHRMTAAGSGPTLV IGVAGDPATPPHWGRELAATSYTAISAMGWRGTSLRRAEPLGTIVNDFFVSGRLPPAGLELPAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3101 | - | - | 100% (204) | hypothetical protein MUL_3101 |
| M. ulcerans Agy99 | MUL_1334 | - | 2e-07 | 29.07% (86) | exported protease |
| M. ulcerans Agy99 | MUL_1332 | - | 1e-05 | 27.06% (85) | exported protease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2247c | - | 5e-08 | 28.68% (129) | exported protease |
| M. gilvum PYR-GCK | Mflv_3914 | - | 2e-06 | 28.24% (170) | TAP domain-containing protein |
| M. tuberculosis H37Rv | Rv2223c | - | 5e-08 | 28.68% (129) | exported protease |
| M. leprae Br4923 | MLBr_01633 | - | 7e-07 | 25.32% (154) | putative secreted hydrolase |
| M. abscessus ATCC 19977 | MAB_1919 | - | 7e-08 | 29.37% (126) | hypothetical protein MAB_1919 |
| M. marinum M | MMAR_2626 | - | 1e-104 | 90.38% (208) | hypothetical protein MMAR_2626 |
| M. avium 104 | MAV_2241 | - | 8e-07 | 30.59% (85) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_4295 | - | 6e-05 | 28.24% (131) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0213 | - | 5e-07 | 29.01% (131) | Probable exported protease |
| M. vanbaalenii PYR-1 | Mvan_3600 | - | 3e-05 | 27.56% (127) | TAP domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3101|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2626|M.marinum_M MSSEARCGDRDQGVAGGCGSTVQSTAGTYAIAATGGGNNNDGGRGAGGAS
MSMEG_4295|M.smegmatis_MC2_155 --------------------------------------------------
TH_0213|M.thermoresistible__bu --------------------------------------------------
Mb2247c|M.bovis_AF2122/97 --------------------------------------------------
Rv2223c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1919|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01633|M.leprae_Br4923 --------------------------------------------------
MAV_2241|M.avium_104 --------------------------------------------------
Mvan_3600|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3914|M.gilvum_PYR-GCK --------------------------------------------------
MUL_3101|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2626|M.marinum_M IAMSGGIEGAGIDWAREQGTGQPQAAGTAVPGSSRPRWVFRRRLRAGPRR
MSMEG_4295|M.smegmatis_MC2_155 --------------------------------------MLPALMTALVTF
TH_0213|M.thermoresistible__bu --------------------------------MWRVGRLMAAALAALLLV
Mb2247c|M.bovis_AF2122/97 -----------------------------MAAMWRRRPLSSALLSFGLLL
Rv2223c|M.tuberculosis_H37Rv -----------------------------MAAMWRRRPLSSALLSFGLLL
MAB_1919|M.abscessus_ATCC_1997 -------------------------------MMRMRRALPVIFLMLTAAV
MLBr_01633|M.leprae_Br4923 -----------------MTAAHQEPKPSLAAYVSMALSYRDKIARMLLLG
MAV_2241|M.avium_104 --------------------------------MGMGLSRRGKSARTLLIW
Mvan_3600|M.vanbaalenii_PYR-1 ------------------------------MAACGAMKLKTGVARSGLL-
Mflv_3914|M.gilvum_PYR-GCK --------------------MRRVVRAVVLSLAVVLPLSACSPGLAANPR
MUL_3101|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2626|M.marinum_M ATWRRWFGVAATVLSVAAGTCWAAAWAGGSDQSAALSEWSPCAAANGAAG
MSMEG_4295|M.smegmatis_MC2_155 G------IPVASATP----EGDAATPFAAPP-VWGGCAQWVADPARIPT-
TH_0213|M.thermoresistible__bu GVF----VPPASATP----GETPVSNTGIAP-VWGDCSRFIPNAAALPT-
Mb2247c|M.bovis_AF2122/97 GGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIRT-
Rv2223c|M.tuberculosis_H37Rv GGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIRT-
MAB_1919|M.abscessus_ATCC_1997 PAIPAAAAPLPAPSP-------SLQAFYDQKVVWGGCDSFVTDTSRIPT-
MLBr_01633|M.leprae_Br4923 TAIAAVALVLAGCVRVVSGRALMAGPKLGEPVAWAPCRPS-NPAVKLPGG
MAV_2241|M.avium_104 MSIAAVALLLAGCVRVVVGRAVMSGPKLGQAVEWTPCRAA-NPKVKLPAG
Mvan_3600|M.vanbaalenii_PYR-1 --LSLAVLLVAGCSQVVAGRALISVPRPGTPIEWGPCEAGPSDQVRIPPG
Mflv_3914|M.gilvum_PYR-GCK YATDSGAGPQGAPETSDQPAGPPAVEAPKNELSWRDCTSRVFASASVPPL
MUL_3101|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2626|M.marinum_M MQCAILNVPLDWN-----LAESAMAQVAVARLPATGAHKLGVIVTNPGGP
MSMEG_4295|M.smegmatis_MC2_155 AQCGTLAVPVDW---NNPDPQGAQAQLAVIRVPAS-GDRIGALFVNPGGP
TH_0213|M.thermoresistible__bu ARCGYLPVPLNW---AEPD--GPQVQLAVIRVPAD-GPKVGALFVNPGGP
Mb2247c|M.bovis_AF2122/97 ARCATVSVPVDY---DQPG--GTQAKLAVIRVPAT-GQRFGALLVNPGGP
Rv2223c|M.tuberculosis_H37Rv ARCATVSVPVDY---DQPG--GTQAKLAVIRVPAT-GQRFGALLVNPGGP
MAB_1919|M.abscessus_ATCC_1997 ARCAKVKVPVNY---DKLM--GAVAELAVLRVPAT-GKRVGALLVNPGGP
MLBr_01633|M.leprae_Br4923 ALCGKLAVPVDY---DHHD--DDVAALAMIRFPAT-GDRMGSLVINPGGP
MAV_2241|M.avium_104 ALCGKLAVPVDY---DHLD--GDVATLAMIRFPAT-GDKIGSLVINPGGP
Mvan_3600|M.vanbaalenii_PYR-1 AECGMLSVPVDWVRADAPD--GEVAQIAVLRIKAA-GEKIGSLIINPGGP
Mflv_3914|M.gilvum_PYR-GCK PGVKLDCASYDADLDSINGASGTVSIGVVRATSQQTPADAGPLVMTTGSD
MUL_3101|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2626|M.marinum_M GISGIDDMAYSGNFWD--RLRQDFDIVTFDPRGVGASRPAIALAGDELVA
MSMEG_4295|M.smegmatis_MC2_155 GASAVDTVAGMGAALAGTEIGQRFDLVGFDPRGVGHSTPELRCRTDAEFD
TH_0213|M.thermoresistible__bu GGSAVNTVAGMAAALAGTDVTSRFDLIGFDPRGVGHSLPELRCRTDAEFD
Mb2247c|M.bovis_AF2122/97 GASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEFD
Rv2223c|M.tuberculosis_H37Rv GASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEFD
MAB_1919|M.abscessus_ATCC_1997 GGSGVDLAAGMGAKLGDSAIGQSFDIVGFDPRGVGGSTPTLRCRTDAEFD
MLBr_01633|M.leprae_Br4923 GESGIEAALGVVQTLP-KRVRERFDLVGFDPRGVGASRPAVWCNSDADND
MAV_2241|M.avium_104 GESGIEAALGVVQSLP-KRVRERFDLVGFDPRGVGASRPAVWCNSDADND
Mvan_3600|M.vanbaalenii_PYR-1 GKSGKESAAVMAPTLP-EEVRQRFDLVGFDPRGVAESTPAVRCNSDADHD
Mflv_3914|M.gilvum_PYR-GCK VPSSVQLPAWLS--RAGADVLKTNPIVSVDRRGIGMSG-ALDCRDLFDRQ
MUL_3101|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2626|M.marinum_M AVRNQPSIPRTEAQRRSRLEGTTRLVDAAQRG---GVLGLVGTQEVARDL
MSMEG_4295|M.smegmatis_MC2_155 AYRREPMADYSPAGVAHIESLYQQLAQQCLDRMGAPFLANIGTASAVRDM
TH_0213|M.thermoresistible__bu AYRREPMADYSPAGVAHIEELHRRFAQSCLDRNGADFLAGLGTANAARDM
Mb2247c|M.bovis_AF2122/97 AYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDM
Rv2223c|M.tuberculosis_H37Rv AYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDM
MAB_1919|M.abscessus_ATCC_1997 AFRKEPLADYSQAGVAHIEDVYRQYVNECANRMGLDFLANAGTASAARDM
MLBr_01633|M.leprae_Br4923 RLRSESQVDYSPAGVAHIEDETKQFIGRCIAKMGKIFLENIGTVNVAKDL
MAV_2241|M.avium_104 RLRTEPNVDYSPAGVAHIEDETKQFVGRCVDKMGKKFLANVGTVNVARDL
Mvan_3600|M.vanbaalenii_PYR-1 RLRADNVVEYTPEGVAHLENLTKEFVQRCVDKMGTDFLSNVGTESVVKDL
Mflv_3914|M.gilvum_PYR-GCK EMFEQAQFQSGDDPVANLGAVTMTATTSCTDTIAPGDSAYDN-AHAAEDI
MUL_3101|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2626|M.marinum_M EALRVAMNV----ESIDYFGFSYGTYLGVVYADMFPGSTHRIVLDSAMNP
MSMEG_4295|M.smegmatis_MC2_155 DAVRAALGE----HQISYLGFSYGTELGSAYAEAYPDRVRAMVLDGAIDP
TH_0213|M.thermoresistible__bu DAVRAALGE----EQINYLGFSYGTRLGAAYAEQFPDRVRTMVLDGAVDP
Mb2247c|M.bovis_AF2122/97 DMVRQALGD----DQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDP
Rv2223c|M.tuberculosis_H37Rv DMVRQALGD----DQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDP
MAB_1919|M.abscessus_ATCC_1997 DIVRSIVGAGAADTRLNYLGYSYGTELGTQYAEYFPQNVRTMVLDGAIDP
MLBr_01633|M.leprae_Br4923 DAIRAALGD----DKLTYLGYSYGTRIGAAYAEAYPQNVRSMILDGAVDP
MAV_2241|M.avium_104 DAIRAALGD----DKLTYLGYSYGTRIGSAYAEAYPHNVRAMILDGAVDP
Mvan_3600|M.vanbaalenii_PYR-1 DALRAALGD----EKLTFLGYSYGTRIGAGYAEEYPQNVRAMILDGAIDP
Mflv_3914|M.gilvum_PYR-GCK ERLRTTWDVP----ALALFGVGNGAQVALAYAGAHPTKVARLVLDSPLPL
MUL_3101|M.ulcerans_Agy99 -----------------------------------------------MIE
MMAR_2626|M.marinum_M ANDYATLRHDQAVAFDRAIR--------------AQFDAPEIQRIQALIE
MSMEG_4295|M.smegmatis_MC2_155 ALNPIDKTIRQMASFQKAFDAYAADCGKLVGCPLGNDPAQYVNRFHQLVD
TH_0213|M.thermoresistible__bu SQDPLAGTTRQMAGFQAAFDEYAADCARSPDCPLGTDPAKWVARYHELVD
Mb2247c|M.bovis_AF2122/97 AVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQWVNRYHALVD
Rv2223c|M.tuberculosis_H37Rv AVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQWVNRYHALVD
MAB_1919|M.abscessus_ATCC_1997 TIDPVESNVRQMTGFQVAFNDYAADCAKDPKCPLGPDPSQAVKRFHQLID
MLBr_01633|M.leprae_Br4923 NADPIEADLRQAKGFQDAFNNYAADCARKLSCPLGADPAKAVDVYHNLVN
MAV_2241|M.avium_104 NADQIEADLRQAKGFQDAFNNFAAECAKQPNCPLGTDPAKAVDVYHSLVD
Mvan_3600|M.vanbaalenii_PYR-1 NADPVEADVRQAAAFQQAFDDYATDCAIDEDCPLGTDPAKAVDVYRSLVW
Mflv_3914|M.gilvum_PYR-GCK GVSAEAATEQRVKGEQAALDAWATQCVATN-CPLGPDP-------KAAVD
:
MUL_3101|M.ulcerans_Agy99 RLDE-------SPIVGEDGRVLSGLRLLNYVESAAYEP---ETSVPVLRE
MMAR_2626|M.marinum_M RLDE-------SPIVGEDGRVLSGLRLLNYVESAAYEP---ETSVPVLRE
MSMEG_4295|M.smegmatis_MC2_155 PLVA-------RPGATSDPRGLSYQDAITGTGNALYSPRYWPFLTSGLLG
TH_0213|M.thermoresistible__bu PLVH-------RPAPTSDPRGLSYQDAITGTVQALYSRQYWKYLTSGLLG
Mb2247c|M.bovis_AF2122/97 PLVQ-------KPGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGLLG
Rv2223c|M.tuberculosis_H37Rv PLVQ-------KPGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGLLG
MAB_1919|M.abscessus_ATCC_1997 PLVT-------KPAKTNDPRGLSYQDAITGTIQAMYTPRYWKYLTSGLSG
MLBr_01633|M.leprae_Br4923 PLVDPNNPMVSRPAPTKDPRGLSYSDAIVGTIMTLYSPTLWHHLTDGLSE
MAV_2241|M.avium_104 PMVDPDNPMVGRPIPTNDPRGLSYSDAIVGTIMALYSPNLWHHLTDGLSE
Mvan_3600|M.vanbaalenii_PYR-1 PLVD-------APADTTDPRGLSYNDAVVGTILPLYSPGLWRHLTQALTE
Mflv_3914|M.gilvum_PYR-GCK ALMT-------DARAGRGPGGASVAALADAISTALGYPRGGRVDAGNELA
: . . * . .
MUL_3101|M.ulcerans_Agy99 VLAEASRGNWAPVIDAVHGPALLVNPADLP--YLSVACHDLSTPTQVGDV
MMAR_2626|M.marinum_M VLAEASRGNWAPVIDAVHGPALLVNPADLP--YLSVACHDLSTPTQVGDV
MSMEG_4295|M.smegmatis_MC2_155 LERGTDAEDLLLLADDYQHRDRNGHYQNMQDAFTAIRCVDDVYPTDPAVW
TH_0213|M.thermoresistible__bu LRRGTDPVDLLLLADEYLRRDVNGHYQNQQDAFTAIRCVDAPYPTDPAVW
Mb2247c|M.bovis_AF2122/97 LQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAW
Rv2223c|M.tuberculosis_H37Rv LQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAW
MAB_1919|M.abscessus_ATCC_1997 LADGSGPDDLLWLADQYQERDDHGRYDNLQDAFNSIRCVDGPTPKDSAPW
MLBr_01633|M.leprae_Br4923 LVDHRG-DTLLALADMYMRRDSQGHYTNATDARVAVNCVDQPPITDRAKV
MAV_2241|M.avium_104 LVDHHG-DTLLALADMYMRRDAHGHYTNATDARVAINCVDQPPITDRAKV
Mvan_3600|M.vanbaalenii_PYR-1 IKKGRG-DTMLALSDLYMGRDAQGHYSNDTDSRVAVNCVDKPAITDRATL
Mflv_3914|M.gilvum_PYR-GCK QAIADARGGNTNRLNNLINQAETLRQTDGQFVNTCSDALNRPTPDRVREL
: . : . . :
MUL_3101|M.ulcerans_Agy99 AALARAWTREAPLTGASRAWSVLP---CTVWPTRAAAPPHRMTAAGSGPT
MMAR_2626|M.marinum_M AALARAWTREAPLTGASRAWSVLP---CTVWPTRAAAPPHRMAAAGSGPT
MSMEG_4295|M.smegmatis_MC2_155 AEADRQIREVAPFFAYGGFTGFAPRDVCAFWPVPATSTARPVTGPGPGKV
TH_0213|M.thermoresistible__bu AETDRQVRAVAPFLSYGEFTGFAPRNVCAMWPVPPTSTPAPATSPGPGKV
Mb2247c|M.bovis_AF2122/97 VAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKV
Rv2223c|M.tuberculosis_H37Rv VAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKV
MAB_1919|M.abscessus_ATCC_1997 VAADKTLREQAPFSSYGSFTGYAPRDMCAFWPVPPTSTPHTPSTPGLAPV
MLBr_01633|M.leprae_Br4923 IDEDRRSREVAPFMSYGKFTGDAPLGTCAFWPVPPTSKPHIVSAPGLAPT
MAV_2241|M.avium_104 IDEDRRSREIAPFMSYGQFTGNAPLGTCAFWPVPPTSKPHTISAPGLAPT
Mvan_3600|M.vanbaalenii_PYR-1 VEQDRRVREAAPFMAYGEFTGLAPMTTCGFWPVPPTSVPHELDVSGLPPI
Mflv_3914|M.gilvum_PYR-GCK VVAWG------KMYPQFGTTGALDMVKCLNWPS---GSAPAEPSELEIPT
: . * ** . .
MUL_3101|M.ulcerans_Agy99 LVIGVAGDPATPPHWGRELAATSYTAI---SAMGWRGT----SLRRAEPL
MMAR_2626|M.marinum_M LVIGVAGDPATPPHWGRELAATLVHG----QYLQWAGAGHVAYGRAGEPL
MSMEG_4295|M.smegmatis_MC2_155 VVVSTTGDPATPYQAGVDLARQMGAA-----LISFDGAQHTVVFNGDACV
TH_0213|M.thermoresistible__bu VVVSTTRDPATPHEAGLALARQLDAA-----LITFDGAQHTVVFNGNPCV
Mb2247c|M.bovis_AF2122/97 VVVSTTHDPATPYQSGVDLARQLGAP-----LITFDGTQHTAVFDGNQCV
Rv2223c|M.tuberculosis_H37Rv VVVSTTHDPATPYQSGVDLARQLGAP-----LITFDGTQHTAVFDGNQCV
MAB_1919|M.abscessus_ATCC_1997 VVISTTHDPATPYEAGVALARQLGGS-----LISYEGTQHTVAFNGEACV
MLBr_01633|M.leprae_Br4923 VVVSTTHDPATPYKAGVDLANQLRGS-----LLTFDGTQHTVVFQGDSCV
MAV_2241|M.avium_104 VVVSTTHDPATPYKAGVDLANELRSS-----LLTYDGTQHTVVFQGDGCI
Mvan_3600|M.vanbaalenii_PYR-1 LVISTTNDPATPYQAGVDLARQLDGT-----LVTFEGTQHTVSLQGDSCI
Mflv_3914|M.gilvum_PYR-GCK LLLGVANDPIVGNEGVAAVAATAINAGSSNRRVIWQGIGHGAAIYS-PCA
:::..: ** . . :* : : *
MUL_3101|M.ulcerans_Agy99 GTIVNDFFVSGRLPPAGLELPAD
MMAR_2626|M.marinum_M GTIVNDFFVSGRLPPAGLELPAD
MSMEG_4295|M.smegmatis_MC2_155 DTAVLRFLTDLQSPPGNLAC---
TH_0213|M.thermoresistible__bu DTAVLNFLIDGVPPPNGLAC---
Mb2247c|M.bovis_AF2122/97 DSAVMHYFLDGTLPPTSLRCAP-
Rv2223c|M.tuberculosis_H37Rv DSAVMHYFLDGTLPPTSLRCAP-
MAB_1919|M.abscessus_ATCC_1997 DDVVTRYFVDGTVPPKDVRC---
MLBr_01633|M.leprae_Br4923 DDYVTEYLIGGTTPPSGAKC---
MAV_2241|M.avium_104 DNYVTAYLVGGTIPPSGAKC---
Mvan_3600|M.vanbaalenii_PYR-1 DDIAVRYLVDVTVPPPDTRC---
Mflv_3914|M.gilvum_PYR-GCK LPPVLDYLTSGELPSTDTYCPA-
. :: . *. .