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AAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIRTA RCATVSVPVDYDQPGGTQAKLAVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLV GFDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVA RDMDMVRQALGDDQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFND YAADCARSPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGL LGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAWVAADQRIRQVAPFLSYGQ FTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPLITFDGTQHTAV FDGNQCVDSAVMHYFLDGTLPPTSLRCAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2223c | - | - | 100% (520) | Probable exported protease |
| M. tuberculosis H37Rv | Rv2224c | - | e-142 | 49.61% (508) | exported protease |
| M. tuberculosis H37Rv | Rv2672 | - | 5e-20 | 24.90% (518) | secreted protease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2247c | - | 0.0 | 100.00% (520) | exported protease |
| M. gilvum PYR-GCK | Mflv_2906 | - | 0.0 | 63.15% (502) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_01632 | - | 0.0 | 75.77% (520) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1919 | - | 0.0 | 60.00% (520) | hypothetical protein MAB_1919 |
| M. marinum M | MMAR_3295 | - | 0.0 | 78.85% (520) | exported protease |
| M. avium 104 | MAV_2243 | - | 0.0 | 77.95% (517) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_4295 | - | 0.0 | 64.77% (511) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0213 | - | 0.0 | 62.33% (515) | Probable exported protease |
| M. ulcerans Agy99 | MUL_1334 | - | 0.0 | 78.46% (520) | exported protease |
| M. vanbaalenii PYR-1 | Mvan_3599 | - | 0.0 | 63.51% (496) | TAP domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2906|M.gilvum_PYR-GCK -------MTAMLRAGPMIAALALISAALSPTASAAP-GTSAEP-------
Mvan_3599|M.vanbaalenii_PYR-1 -------MAAMLRAARLIAALAVTAAAQCPTAAAAP-VAVEEP-------
MSMEG_4295|M.smegmatis_MC2_155 -------------MLPALMTALVTFG--IPVASATPEGDAATP-------
TH_0213|M.thermoresistible__bu -------MWRVGRLMAAALAALLLVGVFVPPASATPGETPVSN-------
Rv2223c|M.tuberculosis_H37Rv ----MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQT--P
Mb2247c|M.bovis_AF2122/97 ----MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQT--P
MMAR_3295|M.marinum_M MGETMSAMLRLRTLSSALLSFGLVLCGALPTTLAVAGAIPEPDVGQTQSP
MUL_1334|M.ulcerans_Agy99 ----MSAMLRLRTLSSALLSFGLVLCGALPTTLAVAGAISEPDVGQTQSP
MLBr_01632|M.leprae_Br4923 ----MVAMPSLRSLSSALLSLGLLL--QPAMTPPVVGASPE----QTPSP
MAV_2243|M.avium_104 -------MSRLRSLSSALLSFGLVLGGTSGVGLPVAGATPEPGAGQTPAP
MAB_1919|M.abscessus_ATCC_1997 ----------MMRMRRALPVIFLMLTAAVPAIPAAAAPLPAPSP-----S
: .
Mflv_2906|M.gilvum_PYR-GCK ----YTAAAVWDSCTTVLADASAVPTARCGTVAVPVDYADPG--GAQAHL
Mvan_3599|M.vanbaalenii_PYR-1 ----YTAAAVWSSCTPWIADVSRIPTAQCGTVAVPVDYAKPE--GAQAQL
MSMEG_4295|M.smegmatis_MC2_155 ----FAAPPVWGGCAQWVADPARIPTAQCGTLAVPVDWNNPDPQGAQAQL
TH_0213|M.thermoresistible__bu ----TGIAPVWGDCSRFIPNAAALPTARCGYLPVPLNWAEPD--GPQVQL
Rv2223c|M.tuberculosis_H37Rv GAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPVDYDQPG--GTQAKL
Mb2247c|M.bovis_AF2122/97 GAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPVDYDQPG--GTQAKL
MMAR_3295|M.marinum_M GIPIAAPQQNWGSCGPFIDNVSEIPTARCTTVGVPIDYDKPG--GAQAKL
MUL_1334|M.ulcerans_Agy99 GIPIAAPQQNWGSCGPFIDNVSEIPTARCTTVGVPIDYDKPG--GAQAKL
MLBr_01632|M.leprae_Br4923 VP-----EQNWGNCSVFLSDTSDIPSARCATVSVPVDYNNPD--GVHAEL
MAV_2243|M.avium_104 NPPAAAAPQGWGSCSQFVTDTSDIPTAQCTTVSVPIDYNNPG--AGQAKL
MAB_1919|M.abscessus_ATCC_1997 LQAFYDQKVVWGGCDSFVTDTSRIPTARCAKVKVPVNYDKLM--GAVAEL
*..* : : : : :*:* : **::: . . ..*
Mflv_2906|M.gilvum_PYR-GCK AVISVPATGPRIGVLVVNPGGPGASAVDTVAGMGAALAGTEIARRFDLVG
Mvan_3599|M.vanbaalenii_PYR-1 AIIKVPASGPRVGVLIVNPGGPGASAVNTVASMGGALAGSEIGRHFDLVG
MSMEG_4295|M.smegmatis_MC2_155 AVIRVPASGDRIGALFVNPGGPGASAVDTVAGMGAALAGTEIGQRFDLVG
TH_0213|M.thermoresistible__bu AVIRVPADGPKVGALFVNPGGPGGSAVNTVAGMAAALAGTDVTSRFDLIG
Rv2223c|M.tuberculosis_H37Rv AVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVG
Mb2247c|M.bovis_AF2122/97 AVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVG
MMAR_3295|M.marinum_M AVIRVPATGQRIGALLINPGGPGASAVDMVAGMAPELRGTEIARHFDLVG
MUL_1334|M.ulcerans_Agy99 AVIRVPATGQRIGALLINPGGPGASAVDMVAGMAPELRGTEIARHFDLVG
MLBr_01632|M.leprae_Br4923 AVIRAPATGQRIGSLLFNPGGPGASAVDMVAEMIPGLQRTDIGRHFDLVG
MAV_2243|M.avium_104 AVIRVPATGQRLGSLLVNPGGPGGSAVDMVAAMASDMDNSAIRRSFDLVG
MAB_1919|M.abscessus_ATCC_1997 AVLRVPATGKRVGALLVNPGGPGGSGVDLAAGMGAKLGDSAIGQSFDIVG
*:: .** * :.* *..******.*.*: .* * : : : **::*
Mflv_2906|M.gilvum_PYR-GCK IDPRGVGHSTPQLRCRTDAEFDAFRTEPMVDYSPAGVAHIEDVLRQFAAR
Mvan_3599|M.vanbaalenii_PYR-1 IDPRGVGHSTPELRCRTDAEFDAFRAEPLADYSPGGVAHIEGVLRDFAAQ
MSMEG_4295|M.smegmatis_MC2_155 FDPRGVGHSTPELRCRTDAEFDAYRREPMADYSPAGVAHIESLYQQLAQQ
TH_0213|M.thermoresistible__bu FDPRGVGHSLPELRCRTDAEFDAYRREPMADYSPAGVAHIEELHRRFAQS
Rv2223c|M.tuberculosis_H37Rv FDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVTHVEQVYRQLAQD
Mb2247c|M.bovis_AF2122/97 FDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVTHVEQVYRQLAQD
MMAR_3295|M.marinum_M FDPRGVGHSTPALRCRTDAEFDAFRRDPMVDYSQAGVAHIEQVYRELAQH
MUL_1334|M.ulcerans_Agy99 FDPRGVGHSTPALRCRTDAEFDVFRRDPMVDYSQAGVAHIEQVYRELAQH
MLBr_01632|M.leprae_Br4923 FDPRGVGHSTPALRCRTDVEFDAYRTEPMVDYSPAGVAHIEQVYKQLAQQ
MAV_2243|M.avium_104 FDPRGVGHSTPPLRCRTDAEFDAYRREPMVDYSPAGVAHIEQLYRQLAQQ
MAB_1919|M.abscessus_ATCC_1997 FDPRGVGGSTPTLRCRTDAEFDAFRKEPLADYSQAGVAHIEDVYRQYVNE
:****** * * ******.***.:* :*:.*** .**:*:* : : .
Mflv_2906|M.gilvum_PYR-GCK CLDRMGPEFLAGVGTATAARDMDVVREALGE----DQINYLGFSYGTQLG
Mvan_3599|M.vanbaalenii_PYR-1 CLDRMGAEFLASVGTATAARDMDVVRDALGE----DRVNYLGFSYGTQLG
MSMEG_4295|M.smegmatis_MC2_155 CLDRMGAPFLANIGTASAVRDMDAVRAALGE----HQISYLGFSYGTELG
TH_0213|M.thermoresistible__bu CLDRNGADFLAGLGTANAARDMDAVRAALGE----EQINYLGFSYGTRLG
Rv2223c|M.tuberculosis_H37Rv CVDRMGFSFLANIGTASVARDMDMVRQALGD----DQINYLGYSYGTELG
Mb2247c|M.bovis_AF2122/97 CVDRMGFSFLANIGTASVARDMDMVRQALGD----DQINYLGYSYGTELG
MMAR_3295|M.marinum_M CADRMGLGFLANVGTAATARDMDMIRRALGD----DQLNYLGYSYGTELG
MUL_1334|M.ulcerans_Agy99 CADRMGLGFLANVGTAATARDMDMIRRALGD----DQLNYLGYSYGTELG
MLBr_01632|M.leprae_Br4923 CVARVGTAFLANVGTASAARDMDIVRLALGD----EQINYLGYSYGTELG
MAV_2243|M.avium_104 CVNRMGTVFLANAGTASVARDMDAVRQALGD----EQINYLGYSYGTELG
MAB_1919|M.abscessus_ATCC_1997 CANRMGLDFLANAGTASAARDMDIVRSIVGAGAADTRLNYLGYSYGTELG
* * * ***. *** ..**** :* :* ::.***:****.**
Mflv_2906|M.gilvum_PYR-GCK AVYASRYPQRVRTMVLDGAVDPTLDPITESLTQNTGFQRAFERYAADCAK
Mvan_3599|M.vanbaalenii_PYR-1 AVYAARYPDRVRAMVLDGAVDPSLDPITESLNQQAGFQKAFEAYAADCAE
MSMEG_4295|M.smegmatis_MC2_155 SAYAEAYPDRVRAMVLDGAIDPALNPIDKTIRQMASFQKAFDAYAADCGK
TH_0213|M.thermoresistible__bu AAYAEQFPDRVRTMVLDGAVDPSQDPLAGTTRQMAGFQAAFDEYAADCAR
Rv2223c|M.tuberculosis_H37Rv TAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCAR
Mb2247c|M.bovis_AF2122/97 TAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCAR
MMAR_3295|M.marinum_M TAYLERFGAHVRAMVLDGAIDPMAGPIDENAKQLAGFQTAFNDYAADCAR
MUL_1334|M.ulcerans_Agy99 TAYLERFGSHVRAMVLDGAIDPMAGPIDENAKQLAGFQTAFNDYAADCAR
MLBr_01632|M.leprae_Br4923 TAYLERFSDHVRAMVLDGAIDPSVSSIQKDIQQMAGFQIAFTDYAADCAR
MAV_2243|M.avium_104 TAYLEKFSNHVRAMVLDGAIDPTVGPVDENINQMAGFQTAFNDYATDCAR
MAB_1919|M.abscessus_ATCC_1997 TQYAEYFPQNVRTMVLDGAIDPTIDPVESNVRQMTGFQVAFNDYAADCAK
: * : .**:******:** ..: * :.** ** **:**..
Mflv_2906|M.gilvum_PYR-GCK SAGCPLGTDPTQFVARFHQLVNPLAVRPAATSDPRGLGYQDAITGTVSAL
Mvan_3599|M.vanbaalenii_PYR-1 SVGCPLGTDPAQFVARFHQLVDPLVTRPAATSDPRGLGYQDAITGTASGL
MSMEG_4295|M.smegmatis_MC2_155 LVGCPLGNDPAQYVNRFHQLVDPLVARPGATSDPRGLSYQDAITGTGNAL
TH_0213|M.thermoresistible__bu SPDCPLGTDPAKWVARYHELVDPLVHRPAPTSDPRGLSYQDAITGTVQAL
Rv2223c|M.tuberculosis_H37Rv SPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINAL
Mb2247c|M.bovis_AF2122/97 SPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINAL
MMAR_3295|M.marinum_M SPACPLGTDPAQWVNRYHALVYPLVSQPAKTSDPRGLSYADATTGTINAL
MUL_1334|M.ulcerans_Agy99 SPVCPLGTDPAQWVNRYHALVYPLVSQPAKTSDPRGLSYADATTGTINAL
MLBr_01632|M.leprae_Br4923 SASCPLGTDPSQWVNRYHALIDPLVTKPGRTSDPRGLGYADATTGTINAL
MAV_2243|M.avium_104 SPGCPLGTDPAQFVNRYHALVDPLVTRPGRTADPRGLSYADATTGTINAL
MAB_1919|M.abscessus_ATCC_1997 DPKCPLGPDPSQAVKRFHQLIDPLVTKPAKTNDPRGLSYQDAITGTIQAM
**** *.:: * *:* *: **. :*. * *****.* ** *** ..:
Mflv_2906|M.gilvum_PYR-GCK YSQRFWPYLTSGLLGLQRGTDPGDLLLLADEYQRRDRDGHYSNQQDAFTA
Mvan_3599|M.vanbaalenii_PYR-1 YSQRYWPYLTSGLLGLQRGTDPGDLLLLADDYQQRDRNGHYKNRQDAFNA
MSMEG_4295|M.smegmatis_MC2_155 YSPRYWPFLTSGLLGLERGTDAEDLLLLADDYQHRDRNGHYQNMQDAFTA
TH_0213|M.thermoresistible__bu YSRQYWKYLTSGLLGLRRGTDPVDLLLLADEYLRRDVNGHYQNQQDAFTA
Rv2223c|M.tuberculosis_H37Rv YSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNA
Mb2247c|M.bovis_AF2122/97 YSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNA
MMAR_3295|M.marinum_M YAPQRWKYLTSGLLGLQRGTDAGDLLLLADDYDGRDRAGRYNNGQDAFNA
MUL_1334|M.ulcerans_Agy99 YAPQRWKYLTSGLLGLQRGTDAGDLLLLADDYDGRDRAGRYNNGQDAFNA
MLBr_01632|M.leprae_Br4923 YTPVHWKYLTSGLLGLQRGTDAGDLLLLADDYNGRDRNGHYTNDQDAFNA
MAV_2243|M.avium_104 YTPAHWKYLTSGLLGLARGTDAGDLLALADDYQGRDRNGHYSNDQDAFNA
MAB_1919|M.abscessus_ATCC_1997 YTPRYWKYLTSGLSGLADGSGPDDLLWLADQYQERDDHGRYDNLQDAFNS
*: * :***** ** *:.. *** ***:* ** *:* * ****.:
Mflv_2906|M.gilvum_PYR-GCK IRCVDAVFPTDPAVWADADRRSRAAVPFLAYGQFTGFAPRDVCAMWPVPP
Mvan_3599|M.vanbaalenii_PYR-1 IRCVDAVYPTDSAPWVEADRRSREVAPFLSYGPFTGFAPRDLCAMWPVPP
MSMEG_4295|M.smegmatis_MC2_155 IRCVDDVYPTDPAVWAEADRQIREVAPFFAYGGFTGFAPRDVCAFWPVPA
TH_0213|M.thermoresistible__bu IRCVDAPYPTDPAVWAETDRQVRAVAPFLSYGEFTGFAPRNVCAMWPVPP
Rv2223c|M.tuberculosis_H37Rv VRCVDAPTPADPAAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPA
Mb2247c|M.bovis_AF2122/97 VRCVDAPTPADPAAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPA
MMAR_3295|M.marinum_M IRCVDAPTPTDAASWVSADQQFRQAAPFLSYGQFTGLAPRDLCALWPVPA
MUL_1334|M.ulcerans_Agy99 IRCVDAPTPTDAASWVSADQQFRQAAPFLSYGQFTGLAPRDLCALWPVPA
MLBr_01632|M.leprae_Br4923 IRCVDAPVPTDSASWVSADQQIRQAAPFLNYGQFTGNAPRDICALWPVPA
MAV_2243|M.avium_104 VRCVDAPNPTDQASWVSADQKIRQAAPFLSYGPFTGNAPRDLCALWPVPA
MAB_1919|M.abscessus_ATCC_1997 IRCVDGPTPKDSAPWVAADKTLREQAPFSSYGSFTGYAPRDMCAFWPVPP
:**** * * * *. :*: * .** ** *** ***::**:****.
Mflv_2906|M.gilvum_PYR-GCK TSVVGAATSPGPGKVVVVSTTGDPATPYEAGIALADQLDAQLISFTGTQH
Mvan_3599|M.vanbaalenii_PYR-1 TPVVGVASSPGPGKVVVVSTTGDPATPYQAGVNLAQQMDARLITFEGTQH
MSMEG_4295|M.smegmatis_MC2_155 TSTARPVTGPGPGKVVVVSTTGDPATPYQAGVDLARQMGAALISFDGAQH
TH_0213|M.thermoresistible__bu TSTPAPATSPGPGKVVVVSTTRDPATPHEAGLALARQLDAALITFDGAQH
Rv2223c|M.tuberculosis_H37Rv TSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPLITFDGTQH
Mb2247c|M.bovis_AF2122/97 TSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPLITFDGTQH
MMAR_3295|M.marinum_M TSVPHAASPAAPGKAVVVSTTHDPATPYQAGVDLARQLGAPLITYDGTQH
MUL_1334|M.ulcerans_Agy99 TSVPHAASPAAPGKAVVVSTTHDPATPYQAGVDLARQLGAPLITYDGTQH
MLBr_01632|M.leprae_Br4923 TSMPHPAPPVAPGKVVVVSTTHDPATPYQAGVDLARELSSPLITYDGTQH
MAV_2243|M.avium_104 TSAPHAAPPMPAGKVVVVSTTHDPATPYQAGVNLARQLGGPLITYDGTQH
MAB_1919|M.abscessus_ATCC_1997 TSTPHTPSTPGLAPVVVISTTHDPATPYEAGVALARQLGGSLISYEGTQH
*. . . .**:*** *****:::*: ** ::.. **:: *:**
Mflv_2906|M.gilvum_PYR-GCK TVVFNGDACVDTAVVAFLTNSTPPPSGLRC--
Mvan_3599|M.vanbaalenii_PYR-1 TVVFNGDACVDTATVEFLVNSTPPPAGLRC--
MSMEG_4295|M.smegmatis_MC2_155 TVVFNGDACVDTAVLRFLTDLQSPPGNLAC--
TH_0213|M.thermoresistible__bu TVVFNGNPCVDTAVLNFLIDGVPPPNGLAC--
Rv2223c|M.tuberculosis_H37Rv TAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP
Mb2247c|M.bovis_AF2122/97 TAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP
MMAR_3295|M.marinum_M TAVFDGNDCVDGAVVRYLLNLTPPPANLRCGS
MUL_1334|M.ulcerans_Agy99 TAVFDGNDCVDGAVVRYLLNLTPPPANLRCGS
MLBr_01632|M.leprae_Br4923 TAVFNGDQCVDSAVVHYFVDETLLPASLQCQP
MAV_2243|M.avium_104 TAVFNGDQCVDNAVVRYFVAGTPPPASYRCQS
MAB_1919|M.abscessus_ATCC_1997 TVAFNGEACVDDVVTRYFVDGTVPPKDVRC--
*..*:*: *** .. :: * . *