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LPALMTALVTFGIPVASATPEGDAATPFAAPPVWGGCAQWVADPARIPTAQCGTLAVPVDWNNPDPQGAQ AQLAVIRVPASGDRIGALFVNPGGPGASAVDTVAGMGAALAGTEIGQRFDLVGFDPRGVGHSTPELRCRT DAEFDAYRREPMADYSPAGVAHIESLYQQLAQQCLDRMGAPFLANIGTASAVRDMDAVRAALGEHQISYL GFSYGTELGSAYAEAYPDRVRAMVLDGAIDPALNPIDKTIRQMASFQKAFDAYAADCGKLVGCPLGNDPA QYVNRFHQLVDPLVARPGATSDPRGLSYQDAITGTGNALYSPRYWPFLTSGLLGLERGTDAEDLLLLADD YQHRDRNGHYQNMQDAFTAIRCVDDVYPTDPAVWAEADRQIREVAPFFAYGGFTGFAPRDVCAFWPVPAT STARPVTGPGPGKVVVVSTTGDPATPYQAGVDLARQMGAALISFDGAQHTVVFNGDACVDTAVLRFLTDL QSPPGNLAC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4295 | - | - | 100% (500) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_4296 | - | e-140 | 51.15% (477) | protease |
| M. smegmatis MC2 155 | MSMEG_2786 | - | 9e-20 | 24.59% (545) | hydrolase, alpha/beta fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2247c | - | 0.0 | 64.77% (511) | exported protease |
| M. gilvum PYR-GCK | Mflv_2906 | - | 0.0 | 70.42% (497) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2223c | - | 0.0 | 64.77% (511) | exported protease |
| M. leprae Br4923 | MLBr_01632 | - | 0.0 | 64.57% (508) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1919 | - | 1e-176 | 59.37% (507) | hypothetical protein MAB_1919 |
| M. marinum M | MMAR_3295 | - | 0.0 | 63.37% (516) | exported protease |
| M. avium 104 | MAV_2243 | - | 0.0 | 64.92% (516) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0213 | - | 0.0 | 70.52% (502) | Probable exported protease |
| M. ulcerans Agy99 | MUL_1334 | - | 0.0 | 62.60% (516) | exported protease |
| M. vanbaalenii PYR-1 | Mvan_3599 | - | 0.0 | 71.81% (486) | TAP domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4295|M.smegmatis_MC2_155 ---------MLPALMTALVTFG--IPVASATPEGDAATPFA---------
TH_0213|M.thermoresistible__bu ---MWRVGRLMAAALAALLLVGVFVPPASATPGETPVSNTG---------
Mflv_2906|M.gilvum_PYR-GCK ----MTAMLRAGPMIAALALISAALSPTASAAPGTSAEPYT---------
Mvan_3599|M.vanbaalenii_PYR-1 ----MAAMLRAARLIAALAVTAAAQCPTAAAAPVAVEEPYT---------
MMAR_3295|M.marinum_M MGETMSAMLRLRTLSSALLSFGLVLCGALPTTLAVAGAIPEPDVGQTQSP
MUL_1334|M.ulcerans_Agy99 ----MSAMLRLRTLSSALLSFGLVLCGALPTTLAVAGAISEPDVGQTQSP
Mb2247c|M.bovis_AF2122/97 ----MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQT--P
Rv2223c|M.tuberculosis_H37Rv ----MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQT--P
MLBr_01632|M.leprae_Br4923 ----MVAMPSLRSLSSALLSLGLLL--QPAMTPPVVGASPE----QTPSP
MAV_2243|M.avium_104 -------MSRLRSLSSALLSFGLVLGGTSGVGLPVAGATPEPGAGQTPAP
MAB_1919|M.abscessus_ATCC_1997 ------MMRMRRALPVIFLMLTAAVPAIPAAAAPLPAPSPS---------
:
MSMEG_4295|M.smegmatis_MC2_155 ------APPVWGGCAQWVADPARIPTAQCGTLAVPVDWNNPDPQGAQAQL
TH_0213|M.thermoresistible__bu ------IAPVWGDCSRFIPNAAALPTARCGYLPVPLNWAEPD--GPQVQL
Mflv_2906|M.gilvum_PYR-GCK ------AAAVWDSCTTVLADASAVPTARCGTVAVPVDYADPG--GAQAHL
Mvan_3599|M.vanbaalenii_PYR-1 ------AAAVWSSCTPWIADVSRIPTAQCGTVAVPVDYAKPE--GAQAQL
MMAR_3295|M.marinum_M GIPIAAPQQNWGSCGPFIDNVSEIPTARCTTVGVPIDYDKPG--GAQAKL
MUL_1334|M.ulcerans_Agy99 GIPIAAPQQNWGSCGPFIDNVSEIPTARCTTVGVPIDYDKPG--GAQAKL
Mb2247c|M.bovis_AF2122/97 GAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPVDYDQPG--GTQAKL
Rv2223c|M.tuberculosis_H37Rv GAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPVDYDQPG--GTQAKL
MLBr_01632|M.leprae_Br4923 VP-----EQNWGNCSVFLSDTSDIPSARCATVSVPVDYNNPD--GVHAEL
MAV_2243|M.avium_104 NPPAAAAPQGWGSCSQFVTDTSDIPTAQCTTVSVPIDYNNPG--AGQAKL
MAB_1919|M.abscessus_ATCC_1997 LQAFYDQKVVWGGCDSFVTDTSRIPTARCAKVKVPVNYDKLM--GAVAEL
*..* : : : : :*:* : **::: . . ..*
MSMEG_4295|M.smegmatis_MC2_155 AVIRVPASGDRIGALFVNPGGPGASAVDTVAGMGAALAGTEIGQRFDLVG
TH_0213|M.thermoresistible__bu AVIRVPADGPKVGALFVNPGGPGGSAVNTVAGMAAALAGTDVTSRFDLIG
Mflv_2906|M.gilvum_PYR-GCK AVISVPATGPRIGVLVVNPGGPGASAVDTVAGMGAALAGTEIARRFDLVG
Mvan_3599|M.vanbaalenii_PYR-1 AIIKVPASGPRVGVLIVNPGGPGASAVNTVASMGGALAGSEIGRHFDLVG
MMAR_3295|M.marinum_M AVIRVPATGQRIGALLINPGGPGASAVDMVAGMAPELRGTEIARHFDLVG
MUL_1334|M.ulcerans_Agy99 AVIRVPATGQRIGALLINPGGPGASAVDMVAGMAPELRGTEIARHFDLVG
Mb2247c|M.bovis_AF2122/97 AVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVG
Rv2223c|M.tuberculosis_H37Rv AVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVG
MLBr_01632|M.leprae_Br4923 AVIRAPATGQRIGSLLFNPGGPGASAVDMVAEMIPGLQRTDIGRHFDLVG
MAV_2243|M.avium_104 AVIRVPATGQRLGSLLVNPGGPGGSAVDMVAAMASDMDNSAIRRSFDLVG
MAB_1919|M.abscessus_ATCC_1997 AVLRVPATGKRVGALLVNPGGPGGSGVDLAAGMGAKLGDSAIGQSFDIVG
*:: .** * :.* *..******.*.*: .* * : : : **::*
MSMEG_4295|M.smegmatis_MC2_155 FDPRGVGHSTPELRCRTDAEFDAYRREPMADYSPAGVAHIESLYQQLAQQ
TH_0213|M.thermoresistible__bu FDPRGVGHSLPELRCRTDAEFDAYRREPMADYSPAGVAHIEELHRRFAQS
Mflv_2906|M.gilvum_PYR-GCK IDPRGVGHSTPQLRCRTDAEFDAFRTEPMVDYSPAGVAHIEDVLRQFAAR
Mvan_3599|M.vanbaalenii_PYR-1 IDPRGVGHSTPELRCRTDAEFDAFRAEPLADYSPGGVAHIEGVLRDFAAQ
MMAR_3295|M.marinum_M FDPRGVGHSTPALRCRTDAEFDAFRRDPMVDYSQAGVAHIEQVYRELAQH
MUL_1334|M.ulcerans_Agy99 FDPRGVGHSTPALRCRTDAEFDVFRRDPMVDYSQAGVAHIEQVYRELAQH
Mb2247c|M.bovis_AF2122/97 FDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVTHVEQVYRQLAQD
Rv2223c|M.tuberculosis_H37Rv FDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVTHVEQVYRQLAQD
MLBr_01632|M.leprae_Br4923 FDPRGVGHSTPALRCRTDVEFDAYRTEPMVDYSPAGVAHIEQVYKQLAQQ
MAV_2243|M.avium_104 FDPRGVGHSTPPLRCRTDAEFDAYRREPMVDYSPAGVAHIEQLYRQLAQQ
MAB_1919|M.abscessus_ATCC_1997 FDPRGVGGSTPTLRCRTDAEFDAFRKEPLADYSQAGVAHIEDVYRQYVNE
:****** * * ******.***.:* :*:.*** .**:*:* : : .
MSMEG_4295|M.smegmatis_MC2_155 CLDRMGAPFLANIGTASAVRDMDAVRAALGE----HQISYLGFSYGTELG
TH_0213|M.thermoresistible__bu CLDRNGADFLAGLGTANAARDMDAVRAALGE----EQINYLGFSYGTRLG
Mflv_2906|M.gilvum_PYR-GCK CLDRMGPEFLAGVGTATAARDMDVVREALGE----DQINYLGFSYGTQLG
Mvan_3599|M.vanbaalenii_PYR-1 CLDRMGAEFLASVGTATAARDMDVVRDALGE----DRVNYLGFSYGTQLG
MMAR_3295|M.marinum_M CADRMGLGFLANVGTAATARDMDMIRRALGD----DQLNYLGYSYGTELG
MUL_1334|M.ulcerans_Agy99 CADRMGLGFLANVGTAATARDMDMIRRALGD----DQLNYLGYSYGTELG
Mb2247c|M.bovis_AF2122/97 CVDRMGFSFLANIGTASVARDMDMVRQALGD----DQINYLGYSYGTELG
Rv2223c|M.tuberculosis_H37Rv CVDRMGFSFLANIGTASVARDMDMVRQALGD----DQINYLGYSYGTELG
MLBr_01632|M.leprae_Br4923 CVARVGTAFLANVGTASAARDMDIVRLALGD----EQINYLGYSYGTELG
MAV_2243|M.avium_104 CVNRMGTVFLANAGTASVARDMDAVRQALGD----EQINYLGYSYGTELG
MAB_1919|M.abscessus_ATCC_1997 CANRMGLDFLANAGTASAARDMDIVRSIVGAGAADTRLNYLGYSYGTELG
* * * ***. *** ..**** :* :* ::.***:****.**
MSMEG_4295|M.smegmatis_MC2_155 SAYAEAYPDRVRAMVLDGAIDPALNPIDKTIRQMASFQKAFDAYAADCGK
TH_0213|M.thermoresistible__bu AAYAEQFPDRVRTMVLDGAVDPSQDPLAGTTRQMAGFQAAFDEYAADCAR
Mflv_2906|M.gilvum_PYR-GCK AVYASRYPQRVRTMVLDGAVDPTLDPITESLTQNTGFQRAFERYAADCAK
Mvan_3599|M.vanbaalenii_PYR-1 AVYAARYPDRVRAMVLDGAVDPSLDPITESLNQQAGFQKAFEAYAADCAE
MMAR_3295|M.marinum_M TAYLERFGAHVRAMVLDGAIDPMAGPIDENAKQLAGFQTAFNDYAADCAR
MUL_1334|M.ulcerans_Agy99 TAYLERFGSHVRAMVLDGAIDPMAGPIDENAKQLAGFQTAFNDYAADCAR
Mb2247c|M.bovis_AF2122/97 TAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCAR
Rv2223c|M.tuberculosis_H37Rv TAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCAR
MLBr_01632|M.leprae_Br4923 TAYLERFSDHVRAMVLDGAIDPSVSSIQKDIQQMAGFQIAFTDYAADCAR
MAV_2243|M.avium_104 TAYLEKFSNHVRAMVLDGAIDPTVGPVDENINQMAGFQTAFNDYATDCAR
MAB_1919|M.abscessus_ATCC_1997 TQYAEYFPQNVRTMVLDGAIDPTIDPVESNVRQMTGFQVAFNDYAADCAK
: * : .**:******:** ..: * :.** ** **:**..
MSMEG_4295|M.smegmatis_MC2_155 LVGCPLGNDPAQYVNRFHQLVDPLVARPGATSDPRGLSYQDAITGTGNAL
TH_0213|M.thermoresistible__bu SPDCPLGTDPAKWVARYHELVDPLVHRPAPTSDPRGLSYQDAITGTVQAL
Mflv_2906|M.gilvum_PYR-GCK SAGCPLGTDPTQFVARFHQLVNPLAVRPAATSDPRGLGYQDAITGTVSAL
Mvan_3599|M.vanbaalenii_PYR-1 SVGCPLGTDPAQFVARFHQLVDPLVTRPAATSDPRGLGYQDAITGTASGL
MMAR_3295|M.marinum_M SPACPLGTDPAQWVNRYHALVYPLVSQPAKTSDPRGLSYADATTGTINAL
MUL_1334|M.ulcerans_Agy99 SPVCPLGTDPAQWVNRYHALVYPLVSQPAKTSDPRGLSYADATTGTINAL
Mb2247c|M.bovis_AF2122/97 SPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINAL
Rv2223c|M.tuberculosis_H37Rv SPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINAL
MLBr_01632|M.leprae_Br4923 SASCPLGTDPSQWVNRYHALIDPLVTKPGRTSDPRGLGYADATTGTINAL
MAV_2243|M.avium_104 SPGCPLGTDPAQFVNRYHALVDPLVTRPGRTADPRGLSYADATTGTINAL
MAB_1919|M.abscessus_ATCC_1997 DPKCPLGPDPSQAVKRFHQLIDPLVTKPAKTNDPRGLSYQDAITGTIQAM
**** *.:: * *:* *: **. :*. * *****.* ** *** ..:
MSMEG_4295|M.smegmatis_MC2_155 YSPRYWPFLTSGLLGLERGTDAEDLLLLADDYQHRDRNGHYQNMQDAFTA
TH_0213|M.thermoresistible__bu YSRQYWKYLTSGLLGLRRGTDPVDLLLLADEYLRRDVNGHYQNQQDAFTA
Mflv_2906|M.gilvum_PYR-GCK YSQRFWPYLTSGLLGLQRGTDPGDLLLLADEYQRRDRDGHYSNQQDAFTA
Mvan_3599|M.vanbaalenii_PYR-1 YSQRYWPYLTSGLLGLQRGTDPGDLLLLADDYQQRDRNGHYKNRQDAFNA
MMAR_3295|M.marinum_M YAPQRWKYLTSGLLGLQRGTDAGDLLLLADDYDGRDRAGRYNNGQDAFNA
MUL_1334|M.ulcerans_Agy99 YAPQRWKYLTSGLLGLQRGTDAGDLLLLADDYDGRDRAGRYNNGQDAFNA
Mb2247c|M.bovis_AF2122/97 YSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNA
Rv2223c|M.tuberculosis_H37Rv YSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNA
MLBr_01632|M.leprae_Br4923 YTPVHWKYLTSGLLGLQRGTDAGDLLLLADDYNGRDRNGHYTNDQDAFNA
MAV_2243|M.avium_104 YTPAHWKYLTSGLLGLARGTDAGDLLALADDYQGRDRNGHYSNDQDAFNA
MAB_1919|M.abscessus_ATCC_1997 YTPRYWKYLTSGLSGLADGSGPDDLLWLADQYQERDDHGRYDNLQDAFNS
*: * :***** ** *:.. *** ***:* ** *:* * ****.:
MSMEG_4295|M.smegmatis_MC2_155 IRCVDDVYPTDPAVWAEADRQIREVAPFFAYGGFTGFAPRDVCAFWPVPA
TH_0213|M.thermoresistible__bu IRCVDAPYPTDPAVWAETDRQVRAVAPFLSYGEFTGFAPRNVCAMWPVPP
Mflv_2906|M.gilvum_PYR-GCK IRCVDAVFPTDPAVWADADRRSRAAVPFLAYGQFTGFAPRDVCAMWPVPP
Mvan_3599|M.vanbaalenii_PYR-1 IRCVDAVYPTDSAPWVEADRRSREVAPFLSYGPFTGFAPRDLCAMWPVPP
MMAR_3295|M.marinum_M IRCVDAPTPTDAASWVSADQQFRQAAPFLSYGQFTGLAPRDLCALWPVPA
MUL_1334|M.ulcerans_Agy99 IRCVDAPTPTDAASWVSADQQFRQAAPFLSYGQFTGLAPRDLCALWPVPA
Mb2247c|M.bovis_AF2122/97 VRCVDAPTPADPAAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPA
Rv2223c|M.tuberculosis_H37Rv VRCVDAPTPADPAAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPA
MLBr_01632|M.leprae_Br4923 IRCVDAPVPTDSASWVSADQQIRQAAPFLNYGQFTGNAPRDICALWPVPA
MAV_2243|M.avium_104 VRCVDAPNPTDQASWVSADQKIRQAAPFLSYGPFTGNAPRDLCALWPVPA
MAB_1919|M.abscessus_ATCC_1997 IRCVDGPTPKDSAPWVAADKTLREQAPFSSYGSFTGYAPRDMCAFWPVPP
:**** * * * *. :*: * .** ** *** ***::**:****.
MSMEG_4295|M.smegmatis_MC2_155 TSTARPVTGPGPGKVVVVSTTGDPATPYQAGVDLARQMGAALISFDGAQH
TH_0213|M.thermoresistible__bu TSTPAPATSPGPGKVVVVSTTRDPATPHEAGLALARQLDAALITFDGAQH
Mflv_2906|M.gilvum_PYR-GCK TSVVGAATSPGPGKVVVVSTTGDPATPYEAGIALADQLDAQLISFTGTQH
Mvan_3599|M.vanbaalenii_PYR-1 TPVVGVASSPGPGKVVVVSTTGDPATPYQAGVNLAQQMDARLITFEGTQH
MMAR_3295|M.marinum_M TSVPHAASPAAPGKAVVVSTTHDPATPYQAGVDLARQLGAPLITYDGTQH
MUL_1334|M.ulcerans_Agy99 TSVPHAASPAAPGKAVVVSTTHDPATPYQAGVDLARQLGAPLITYDGTQH
Mb2247c|M.bovis_AF2122/97 TSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPLITFDGTQH
Rv2223c|M.tuberculosis_H37Rv TSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPLITFDGTQH
MLBr_01632|M.leprae_Br4923 TSMPHPAPPVAPGKVVVVSTTHDPATPYQAGVDLARELSSPLITYDGTQH
MAV_2243|M.avium_104 TSAPHAAPPMPAGKVVVVSTTHDPATPYQAGVNLARQLGGPLITYDGTQH
MAB_1919|M.abscessus_ATCC_1997 TSTPHTPSTPGLAPVVVISTTHDPATPYEAGVALARQLGGSLISYEGTQH
*. . . .**:*** *****:::*: ** ::.. **:: *:**
MSMEG_4295|M.smegmatis_MC2_155 TVVFNGDACVDTAVLRFLTDLQSPPGNLAC--
TH_0213|M.thermoresistible__bu TVVFNGNPCVDTAVLNFLIDGVPPPNGLAC--
Mflv_2906|M.gilvum_PYR-GCK TVVFNGDACVDTAVVAFLTNSTPPPSGLRC--
Mvan_3599|M.vanbaalenii_PYR-1 TVVFNGDACVDTATVEFLVNSTPPPAGLRC--
MMAR_3295|M.marinum_M TAVFDGNDCVDGAVVRYLLNLTPPPANLRCGS
MUL_1334|M.ulcerans_Agy99 TAVFDGNDCVDGAVVRYLLNLTPPPANLRCGS
Mb2247c|M.bovis_AF2122/97 TAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP
Rv2223c|M.tuberculosis_H37Rv TAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP
MLBr_01632|M.leprae_Br4923 TAVFNGDQCVDSAVVHYFVDETLLPASLQCQP
MAV_2243|M.avium_104 TAVFNGDQCVDNAVVRYFVAGTPPPASYRCQS
MAB_1919|M.abscessus_ATCC_1997 TVAFNGEACVDDVVTRYFVDGTVPPKDVRC--
*..*:*: *** .. :: * . *