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MSSEARCGDRDQGVAGGCGSTVQSTAGTYAIAATGGGNNNDGGRGAGGASIAMSGGIEGAGIDWAREQGT GQPQAAGTAVPGSSRPRWVFRRRLRAGPRRATWRRWFGVAATVLSVAAGTCWAAAWAGGSDQSAALSEWS PCAAANGAAGMQCAILNVPLDWNLAESAMAQVAVARLPATGAHKLGVIVTNPGGPGISGIDDMAYSGNFW DRLRQDFDIVTFDPRGVGASRPAIALAGDELVAAVRNQPSIPRTEAQRRSRLEGTTRLVDAAQRGGVLGL VGTQEVARDLEALRVAMNVESIDYFGFSYGTYLGVVYADMFPGSTHRIVLDSAMNPANDYATLRHDQAVA FDRAIRAQFDAPEIQRIQALIERLDESPIVGEDGRVLSGLRLLNYVESAAYEPETSVPVLREVLAEASRG NWAPVIDAVHGPALLVNPADLPYLSVACHDLSTPTQVGDVAALARAWTREAPLTGASRAWSVLPCTVWPT RAAAPPHRMAAAGSGPTLVIGVAGDPATPPHWGRELAATLVHGQYLQWAGAGHVAYGRAGEPLGTIVNDF FVSGRLPPAGLELPAD
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2626 | - | - | 100% (576) | hypothetical protein MMAR_2626 |
M. marinum M | MMAR_3297 | - | 2e-42 | 29.22% (486) | exported protease |
M. marinum M | MMAR_3295 | - | 9e-38 | 28.12% (448) | exported protease |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2247c | - | 5e-42 | 29.81% (520) | exported protease |
M. gilvum PYR-GCK | Mflv_2904 | - | 2e-41 | 29.76% (467) | TAP domain-containing protein |
M. tuberculosis H37Rv | Rv2223c | - | 5e-42 | 29.81% (520) | exported protease |
M. leprae Br4923 | MLBr_01633 | - | 3e-41 | 28.07% (481) | putative secreted hydrolase |
M. abscessus ATCC 19977 | MAB_1919 | - | 1e-38 | 28.60% (465) | hypothetical protein MAB_1919 |
M. avium 104 | MAV_2241 | - | 4e-45 | 28.79% (528) | hydrolase, alpha/beta fold family protein, putative |
M. smegmatis MC2 155 | MSMEG_4296 | - | 1e-41 | 27.77% (479) | protease |
M. thermoresistible (build 8) | TH_0213 | - | 7e-38 | 28.63% (482) | Probable exported protease |
M. ulcerans Agy99 | MUL_3101 | - | 1e-104 | 90.38% (208) | hypothetical protein MUL_3101 |
M. vanbaalenii PYR-1 | Mvan_3599 | - | 6e-39 | 28.17% (504) | TAP domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment TH_0213|M.thermoresistible__bu -------------------------------------------------- Mvan_3599|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2247c|M.bovis_AF2122/97 -------------------------------------------------- Rv2223c|M.tuberculosis_H37Rv -------------------------------------------------- MAB_1919|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_2904|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_4296|M.smegmatis_MC2_155 -------------------------------------------------- MLBr_01633|M.leprae_Br4923 -------------------------------------------------- MAV_2241|M.avium_104 -------------------------------------------------- MMAR_2626|M.marinum_M MSSEARCGDRDQGVAGGCGSTVQSTAGTYAIAATGGGNNNDGGRGAGGAS MUL_3101|M.ulcerans_Agy99 -------------------------------------------------- TH_0213|M.thermoresistible__bu --------------------------------MWRVGRLMAAALAALLLV Mvan_3599|M.vanbaalenii_PYR-1 -----------------------------MAAMLRAARLIAALAVT---A Mb2247c|M.bovis_AF2122/97 -----------------------------MAAMWRRRPLSSALLSFGLLL Rv2223c|M.tuberculosis_H37Rv -----------------------------MAAMWRRRPLSSALLSFGLLL MAB_1919|M.abscessus_ATCC_1997 -----------------------------MMRMRRALPVIFLMLTAA--V Mflv_2904|M.gilvum_PYR-GCK -------------------------------------------------M MSMEG_4296|M.smegmatis_MC2_155 -------------------------------MAACGAMKVRFGLGALLAV MLBr_01633|M.leprae_Br4923 ------------MTAAHQEPKPSLAAYVSMALSYRDKIARMLLLGTAIAA MAV_2241|M.avium_104 ---------------------------MGMGLSRRGKSARTLLIWMSIAA MMAR_2626|M.marinum_M IAMSGGIEGAGIDWAREQGTGQPQAAGTAVPGSSRPRWVFRRRLRAGPRR MUL_3101|M.ulcerans_Agy99 -------------------------------------------------- TH_0213|M.thermoresistible__bu GVFVPPASATPGETPVSNTG---------IAPVWGDCSRFIPNAAALP-T Mvan_3599|M.vanbaalenii_PYR-1 AAQCPTAAAAPVAVEEPYT----------AAAVWSSCTPWIADVSRIP-T Mb2247c|M.bovis_AF2122/97 GGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIR-T Rv2223c|M.tuberculosis_H37Rv GGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIR-T MAB_1919|M.abscessus_ATCC_1997 PAIPAAAAPLPAPSPSLQAFYD-------QKVVWGGCDSFVTDTSRIP-T Mflv_2904|M.gilvum_PYR-GCK SALLVAGCSKVVDGNALVSVPRPG-----TPIDWSPCETGPSDQKRIPPG MSMEG_4296|M.smegmatis_MC2_155 TVLAAGGCSQVIDGRAIVAVPRPG-----TPVQWLPCNGGAGNQTPIPDS MLBr_01633|M.leprae_Br4923 VALVLAGCVRVVSGRALMAGPKLG-----EPVAWAPCRP-SNPAVKLPGG MAV_2241|M.avium_104 VALLLAGCVRVVVGRAVMSGPKLG-----QAVEWTPCRA-ANPKVKLPAG MMAR_2626|M.marinum_M ATWRRWFGVAATVLSVAAGTCWAAAWAGGSDQSAALSEWSPCAAANGAAG MUL_3101|M.ulcerans_Agy99 -------------------------------------------------- TH_0213|M.thermoresistible__bu ARCGYLPVPLNWAEP---DGPQVQLAVIRVPAD-GPKVGALFVNPGGPGG Mvan_3599|M.vanbaalenii_PYR-1 AQCGTVAVPVDYAKP---EGAQAQLAIIKVPAS-GPRVGVLIVNPGGPGA Mb2247c|M.bovis_AF2122/97 ARCATVSVPVDYDQP---GGTQAKLAVIRVPAT-GQRFGALLVNPGGPGA Rv2223c|M.tuberculosis_H37Rv ARCATVSVPVDYDQP---GGTQAKLAVIRVPAT-GQRFGALLVNPGGPGA MAB_1919|M.abscessus_ATCC_1997 ARCAKVKVPVNYDKL---MGAVAELAVLRVPAT-GKRVGALLVNPGGPGG Mflv_2904|M.gilvum_PYR-GCK SECGMLSVPVDWDNPEDPDGDVAQLAVLRVPAT-GDRIGSLVVNPGGPGK MSMEG_4296|M.smegmatis_MC2_155 AECGMLSVPVDYSKP---DGDVARLAMIRFPAT-GDRIGSLVINPGGPGE MLBr_01633|M.leprae_Br4923 ALCGKLAVPVDYDHH---DDDVAALAMIRFPAT-GDRMGSLVINPGGPGE MAV_2241|M.avium_104 ALCGKLAVPVDYDHL---DGDVATLAMIRFPAT-GDKIGSLVINPGGPGE MMAR_2626|M.marinum_M MQCAILNVPLDWNLA---ESAMAQVAVARLPATGAHKLGVIVTNPGGPGI MUL_3101|M.ulcerans_Agy99 -------------------------------------------------- TH_0213|M.thermoresistible__bu SAVNTVAGMAAALAGTDVTSRFDLIGFDPRGVGHSLPELRCRTDAEFDAY Mvan_3599|M.vanbaalenii_PYR-1 SAVNTVASMGGALAGSEIGRHFDLVGIDPRGVGHSTPELRCRTDAEFDAF Mb2247c|M.bovis_AF2122/97 SAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEFDAY Rv2223c|M.tuberculosis_H37Rv SAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEFDAY MAB_1919|M.abscessus_ATCC_1997 SGVDLAAGMGAKLGDSAIGQSFDIVGFDPRGVGGSTPTLRCRTDAEFDAF Mflv_2904|M.gilvum_PYR-GCK SGVEAAAAMVSTLP-EEVLERFDIVGFDPRGVANSNPAVWCNSDADNDRL MSMEG_4296|M.smegmatis_MC2_155 SGVESALSLLPSLP-QEVKERFDIVGFDPRGVASSSPAVWCNSDADNDRL MLBr_01633|M.leprae_Br4923 SGIEAALGVVQTLP-KRVRERFDLVGFDPRGVGASRPAVWCNSDADNDRL MAV_2241|M.avium_104 SGIEAALGVVQSLP-KRVRERFDLVGFDPRGVGASRPAVWCNSDADNDRL MMAR_2626|M.marinum_M SGIDDMAYSGNFWD--RLRQDFDIVTFDPRGVGASRPAIALAGDELVAAV MUL_3101|M.ulcerans_Agy99 -------------------------------------------------- TH_0213|M.thermoresistible__bu RREPMADYSPAGVAHIEELHRRFAQSCLDRNGADFLAGLGTANAARDMDA Mvan_3599|M.vanbaalenii_PYR-1 RAEPLADYSPGGVAHIEGVLRDFAAQCLDRMGAEFLASVGTATAARDMDV Mb2247c|M.bovis_AF2122/97 RRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDM Rv2223c|M.tuberculosis_H37Rv RRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDM MAB_1919|M.abscessus_ATCC_1997 RKEPLADYSQAGVAHIEDVYRQYVNECANRMGLDFLANAGTASAARDMDI Mflv_2904|M.gilvum_PYR-GCK RADNVVEYTAEGVAHLESLTKEFIQRCVDKMGTDFLANVGTASVVKDLDA MSMEG_4296|M.smegmatis_MC2_155 RADPTVEYTPEGVAHLEAETKAFVQRCVDKMGTEFLANVGTENVAKDLDA MLBr_01633|M.leprae_Br4923 RSESQVDYSPAGVAHIEDETKQFIGRCIAKMGKIFLENIGTVNVAKDLDA MAV_2241|M.avium_104 RTEPNVDYSPAGVAHIEDETKQFVGRCVDKMGKKFLANVGTVNVARDLDA MMAR_2626|M.marinum_M RNQPSIPRTEAQRRSRLEGTTRLVDAAQRG---GVLGLVGTQEVARDLEA MUL_3101|M.ulcerans_Agy99 -------------------------------------------------- TH_0213|M.thermoresistible__bu VRAALGE----EQINYLGFSYGTRLGAAYAEQFPDRVRTMVLDGAVDPSQ Mvan_3599|M.vanbaalenii_PYR-1 VRDALGE----DRVNYLGFSYGTQLGAVYAARYPDRVRAMVLDGAVDPSL Mb2247c|M.bovis_AF2122/97 VRQALGD----DQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDPAV Rv2223c|M.tuberculosis_H37Rv VRQALGD----DQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDPAV MAB_1919|M.abscessus_ATCC_1997 VRSIVGAGAADTRLNYLGYSYGTELGTQYAEYFPQNVRTMVLDGAIDPTI Mflv_2904|M.gilvum_PYR-GCK LRVALGD----EKLTYLGYSYGTRIGASYAEQFPQNVRAMVLDGAIDPNA MSMEG_4296|M.smegmatis_MC2_155 IRAALGD----DKLTYLGYSYGTRIGATYAEQFPDKVRAMILDGAIDPNA MLBr_01633|M.leprae_Br4923 IRAALGD----DKLTYLGYSYGTRIGAAYAEAYPQNVRSMILDGAVDPNA MAV_2241|M.avium_104 IRAALGD----DKLTYLGYSYGTRIGSAYAEAYPHNVRAMILDGAVDPNA MMAR_2626|M.marinum_M LRVAMNV----ESIDYFGFSYGTYLGVVYADMFPGSTHRIVLDSAMNPAN MUL_3101|M.ulcerans_Agy99 -------------------------------------------------- TH_0213|M.thermoresistible__bu DPLAGTTRQMAGFQAAFDEYAADCARSPDCPLGTDPAKWVARYHELVDPL Mvan_3599|M.vanbaalenii_PYR-1 DPITESLNQQAGFQKAFEAYAADCAESVGCPLGTDPAQFVARFHQLVDPL Mb2247c|M.bovis_AF2122/97 SPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQWVNRYHALVDPL Rv2223c|M.tuberculosis_H37Rv SPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQWVNRYHALVDPL MAB_1919|M.abscessus_ATCC_1997 DPVESNVRQMTGFQVAFNDYAADCAKDPKCPLGPDPSQAVKRFHQLIDPL Mflv_2904|M.gilvum_PYR-GCK DPLEADVRQAAAFQQAFDDYAADCAIDDDCPLGTDPAKAVEVYHSLVWPL MSMEG_4296|M.smegmatis_MC2_155 DPVEESIRQAAAFQKAFDDYAADCAKSPDCPLGTDPAKAVDVYKSIIDPL MLBr_01633|M.leprae_Br4923 DPIEADLRQAKGFQDAFNNYAADCARKLSCPLGADPAKAVDVYHNLVNPL MAV_2241|M.avium_104 DQIEADLRQAKGFQDAFNNFAAECAKQPNCPLGTDPAKAVDVYHSLVDPM MMAR_2626|M.marinum_M DYATLRHDQAVAFDRAIR--------------AQFDAPEIQRIQALIERL MUL_3101|M.ulcerans_Agy99 ---------------------------------------------MIERL :: : TH_0213|M.thermoresistible__bu VHR-------PAPTSDPRGLSYQDAITGTVQALYSRQYWKYLTSGLLGLR Mvan_3599|M.vanbaalenii_PYR-1 VTR-------PAATSDPRGLGYQDAITGTASGLYSQRYWPYLTSGLLGLQ Mb2247c|M.bovis_AF2122/97 VQK-------PGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGLLGLQ Rv2223c|M.tuberculosis_H37Rv VQK-------PGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGLLGLQ MAB_1919|M.abscessus_ATCC_1997 VTK-------PAKTNDPRGLSYQDAITGTIQAMYTPRYWKYLTSGLSGLA Mflv_2904|M.gilvum_PYR-GCK VDE-------PAETSDPRGLSYNDAVVGTILPLYSPALWRHLTQALGEVK MSMEG_4296|M.smegmatis_MC2_155 VEN-------PAKTRDGRGLSYSDATVGTILPLYSPNLWRHLTDALTALK MLBr_01633|M.leprae_Br4923 VDPNNPMVSRPAPTKDPRGLSYSDAIVGTIMTLYSPTLWHHLTDGLSELV MAV_2241|M.avium_104 VDPDNPMVGRPIPTNDPRGLSYSDAIVGTIMALYSPNLWHHLTDGLSELV MMAR_2626|M.marinum_M DES-------PIVGEDGRVLSGLRLLNYVESAAYEP---ETSVPVLREVL MUL_3101|M.ulcerans_Agy99 DES-------PIVGEDGRVLSGLRLLNYVESAAYEP---ETSVPVLREVL * * * *. . * . * : TH_0213|M.thermoresistible__bu RGTDPVDLLLLADEYLRRDVNGHYQNQQDAFTAIRCVDAPYPTDPAVWAE Mvan_3599|M.vanbaalenii_PYR-1 RGTDPGDLLLLADDYQQRDRNGHYKNRQDAFNAIRCVDAVYPTDSAPWVE Mb2247c|M.bovis_AF2122/97 RGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAWVA Rv2223c|M.tuberculosis_H37Rv RGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAWVA MAB_1919|M.abscessus_ATCC_1997 DGSGPDDLLWLADQYQERDDHGRYDNLQDAFNSIRCVDGPTPKDSAPWVA Mflv_2904|M.gilvum_PYR-GCK EGKG-DTMLALADLYMERNAQGRYTNSTDVRIAVNCVDKPAITDRATLVE MSMEG_4296|M.smegmatis_MC2_155 KGDG-NLMLALADLYMGRDAKGHYNNSTDVRVAVNCMDKPAIKDKATVVE MLBr_01633|M.leprae_Br4923 DHRG-DTLLALADMYMRRDSQGHYTNATDARVAVNCVDQPPITDRAKVID MAV_2241|M.avium_104 DHHG-DTLLALADMYMRRDAHGHYTNATDARVAINCVDQPPITDRAKVID MMAR_2626|M.marinum_M AEASRGNWAPVIDAVHGPALLVNPADLP--YLSVACHDLSTPTQVGDVAA MUL_3101|M.ulcerans_Agy99 AEASRGNWAPVIDAVHGPALLVNPADLP--YLSVACHDLSTPTQVGDVAA . : * . : :: * * : . TH_0213|M.thermoresistible__bu TDRQVRAVAPFLSYGEFTGFAPRNVCAMWPVPPTSTPAPATSPGPGKVVV Mvan_3599|M.vanbaalenii_PYR-1 ADRRSREVAPFLSYGPFTGFAPRDLCAMWPVPPTPVVGVASSPGPGKVVV Mb2247c|M.bovis_AF2122/97 ADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVV Rv2223c|M.tuberculosis_H37Rv ADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVV MAB_1919|M.abscessus_ATCC_1997 ADKTLREQAPFSSYGSFTGYAPRDMCAFWPVPPTSTPHTPSTPGLAPVVV Mflv_2904|M.gilvum_PYR-GCK QDRRVRDAAPFMAYGEFTGLAPMPTCGFWPVPPTSKPHEISVTGLPPILV MSMEG_4296|M.smegmatis_MC2_155 QDKRLREVAPFMSYGEFTGDAPLGTCAFWPVPPTSEPHELKVEGLPPILV MLBr_01633|M.leprae_Br4923 EDRRSREVAPFMSYGKFTGDAPLGTCAFWPVPPTSKPHIVSAPGLAPTVV MAV_2241|M.avium_104 EDRRSREIAPFMSYGQFTGNAPLGTCAFWPVPPTSKPHTISAPGLAPTVV MMAR_2626|M.marinum_M LARAWTREAPLTGASRAWSVLP---CTVWPTRAAAPPHRMAAAGSGPTLV MUL_3101|M.ulcerans_Agy99 LARAWTREAPLTGASRAWSVLP---CTVWPTRAAAPPHRMTAAGSGPTLV : **: . . . * * .**. .:. * :* TH_0213|M.thermoresistible__bu VSTTRDPATPHEAGLALARQLDAA--LITFDGAQHTVVFNGNPCVDTAVL Mvan_3599|M.vanbaalenii_PYR-1 VSTTGDPATPYQAGVNLAQQMDAR--LITFEGTQHTVVFNGDACVDTATV Mb2247c|M.bovis_AF2122/97 VSTTHDPATPYQSGVDLARQLGAP--LITFDGTQHTAVFDGNQCVDSAVM Rv2223c|M.tuberculosis_H37Rv VSTTHDPATPYQSGVDLARQLGAP--LITFDGTQHTAVFDGNQCVDSAVM MAB_1919|M.abscessus_ATCC_1997 ISTTHDPATPYEAGVALARQLGGS--LISYEGTQHTVAFNGEACVDDVVT Mflv_2904|M.gilvum_PYR-GCK VSTTNDPATPYQAGVNLARQLGGA--LVTFEGTQHTVALQGDSCVDDIVV MSMEG_4296|M.smegmatis_MC2_155 VSTTNDPATPYQAGVDLARQLGGT--LVTFEGTQHTVVFQGNKCVDDVAA MLBr_01633|M.leprae_Br4923 VSTTHDPATPYKAGVDLANQLRGS--LLTFDGTQHTVVFQGDSCVDDYVT MAV_2241|M.avium_104 VSTTHDPATPYKAGVDLANELRSS--LLTYDGTQHTVVFQGDGCIDNYVT MMAR_2626|M.marinum_M IGVAGDPATPPHWGRELAATLVHG-QYLQWAGAGHVAYGRAGEPLGTIVN MUL_3101|M.ulcerans_Agy99 IGVAGDPATPPHWGRELAATSYTAISAMGWRGT----SLRRAEPLGTIVN :..: ***** . * ** : : *: :. . TH_0213|M.thermoresistible__bu NFLIDGVPPPNGLAC--- Mvan_3599|M.vanbaalenii_PYR-1 EFLVNSTPPPAGLRC--- Mb2247c|M.bovis_AF2122/97 HYFLDGTLPPTSLRCAP- Rv2223c|M.tuberculosis_H37Rv HYFLDGTLPPTSLRCAP- MAB_1919|M.abscessus_ATCC_1997 RYFVDGTVPPKDVRC--- Mflv_2904|M.gilvum_PYR-GCK PYLIDGSVPPPDTRC--- MSMEG_4296|M.smegmatis_MC2_155 TYLIDVEVPPADTRC--- MLBr_01633|M.leprae_Br4923 EYLIGGTTPPSGAKC--- MAV_2241|M.avium_104 AYLVGGTIPPSGAKC--- MMAR_2626|M.marinum_M DFFVSGRLPPAGLELPAD MUL_3101|M.ulcerans_Agy99 DFFVSGRLPPAGLELPAD :::. ** .