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MSTLAEQTRWMDATDQAALVVAGEASPSELLEAAIERIERINPALNAVVIRWFDHARETASADLPGGPFR GVPFLIKDLYALYAGQPISNGNLAFKQAHVIADADTTLVGRYRAAGLVIAGRTNSPELGSLPTTEPVAWG PTRNPWDTSRTPGGSSGGSAAAVASGMVPFAHASDGGGSIRIPASCCGLVGLKPSQGRITLGPLREESGM SVEHCLSRTVRDTAALLDATRGPGVGDTVIAPPPIRPYTEELGADPGRLRIGILDHHPRGGPVDAEVTHA TQAVCRLLESLGHHVEVAWPAALEDASFDSTFGALWSTNMGLAQRRFEEQLGRPLGEDEFELVNRAQADF AKHFTSVDYALALSAIAAFRRAIQSWWHDGWDLLLTPTVASLPVKLGTIVSTPEHPMAAMQRAGEFVPFT PPFNTSGQPAISLPLEWTPEGLPLGVQLVAAYGREDVLLRIASQLEQAKPWAQRTPDI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2798 | amiC_1 | - | 100% (478) | amidase AmiC_1 |
| M. ulcerans Agy99 | MUL_0540 | amiC_2 | 1e-83 | 40.20% (490) | amidase, AmiC_2 |
| M. ulcerans Agy99 | MUL_4478 | amiB2 | 5e-61 | 36.67% (480) | amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2912c | amiC | 1e-64 | 39.03% (474) | amidase |
| M. gilvum PYR-GCK | Mflv_1016 | - | 4e-89 | 41.68% (499) | amidase |
| M. tuberculosis H37Rv | Rv2888c | amiC | 1e-64 | 39.03% (474) | amidase |
| M. leprae Br4923 | MLBr_01596 | - | 1e-65 | 37.39% (468) | amidase |
| M. abscessus ATCC 19977 | MAB_2181c | - | 2e-86 | 41.87% (492) | putative amidase |
| M. marinum M | MMAR_3565 | amiC_1 | 0.0 | 99.37% (478) | amidase AmiC_1 |
| M. avium 104 | MAV_0676 | - | 4e-89 | 41.45% (497) | 6-aminohexanoate-cyclic-dimer hydrolase |
| M. smegmatis MC2 155 | MSMEG_6673 | - | 3e-91 | 41.16% (498) | 6-aminohexanoate-cyclic-dimer hydrolase |
| M. thermoresistible (build 8) | TH_2520 | - | 5e-62 | 36.23% (472) | PUTATIVE Amidase |
| M. vanbaalenii PYR-1 | Mvan_5822 | - | 5e-92 | 42.32% (501) | amidase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2798|M.ulcerans_Agy99 ----MSTLAEQTRWMDATDQAALVVAGEASPSELLEAAIERIERINPALN
MMAR_3565|M.marinum_M ----MSTLAEQTRWMDATDQAALVAAGEASPSELLEAAIERIERINPALN
MSMEG_6673|M.smegmatis_MC2_155 ------MNFDEYRTFDATGLAELVADKQVTAAELLEVAQARAEAVNPRIN
Mvan_5822|M.vanbaalenii_PYR-1 -----MVDFQEYRAQDATGLARLVAEKQVTADELLALAQARAAQVNPRIN
Mflv_1016|M.gilvum_PYR-GCK ------MDFLEYRSHDATGLAKLVADGDVTADELLTLARERAAAVNPKIN
MAB_2181c|M.abscessus_ATCC_199 ------MDFSDYSQHDATGLAELVATKQVTPAELLAAARARAADVNNKIG
MAV_0676|M.avium_104 ------------MALDATALAGLVADKQVTPAELLALARQRADAVNPRLN
Mb2912c|M.bovis_AF2122/97 MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAVNPALN
Rv2888c|M.tuberculosis_H37Rv MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAVNPALN
MLBr_01596|M.leprae_Br4923 MQRVHAFGDDALGDLDAVGLADAIRAGWVSRADVIEAAIVRTEAVNPALG
TH_2520|M.thermoresistible__bu MQRIHAFGDDALSDLDAVGLAAELRARRVSVPELIRAAIARTEAVNPALN
**. * : . ::: * * :* :.
MUL_2798|M.ulcerans_Agy99 AVVIRWFDHARETASADL-PGGPFRGVPFLIKDLYALYAGQPISNGNLAF
MMAR_3565|M.marinum_M AVVIRWFDHARETASADL-PGGPFRGVPFLIKDLYALYAGQPISNGNLAF
MSMEG_6673|M.smegmatis_MC2_155 AIVREVPAAPADAA------PGPFTGVPFLIKDIGQDYAGVPSSRGSRAL
Mvan_5822|M.vanbaalenii_PYR-1 AIVRDVPAAPAGIA------DGPFAGVPFLIKDLAQDYAGLPSSRGSRAL
Mflv_1016|M.gilvum_PYR-GCK AIVRDVPAPVGGNR------GGPFAGVPFLIKDLAQDYAGLPTASGSRSL
MAB_2181c|M.abscessus_ATCC_199 AIVRTLPEADQQVQGDL---TGPFAGVPFLIKDLGQDYKGHPTSGGCRAL
MAV_0676|M.avium_104 AIVCRLDDVADRQAADPN-LSGPFAGVPFLLKDLGQEYRGFPTSCGSRSL
Mb2912c|M.bovis_AF2122/97 ALAYAAFDVARDAAAMGTGQEAFFSGVPTFIKDN-VDVAGQPSMHGTDAW
Rv2888c|M.tuberculosis_H37Rv ALAYAAFDVARDAAAMGTGQEAFFSGVPTFIKDN-VDVAGQPSMHGTDAW
MLBr_01596|M.leprae_Br4923 GLAYEAFQWARQTASKAG--SGFFSGVPTFIKDN-IDVAGQPTMRGSDAW
TH_2520|M.thermoresistible__bu GLAYEAFDRALARAEAGP-VPGFFGGIPTYVKDN-AAVAGMPTMEGTDAW
.:. . * *:* :** * * * :
MUL_2798|M.ulcerans_Agy99 KQAHVIADADTTLVGRYRAAGLVIAGRTNSPELGSLPTTEPVAWGPTRNP
MMAR_3565|M.marinum_M KQAHVIADADTTLVGRYRAAGLVIAGRTNSPELGSLPTTEPVAWGPTRNP
MSMEG_6673|M.smegmatis_MC2_155 RS--IPVTEHATVVQRWIEAGLVIFGKTNTPEFGAKGITEPEAWGPTRNP
Mvan_5822|M.vanbaalenii_PYR-1 MS--LPAAEHSTIVQRWIDAGVVIFGKTNTPEFGAKGITEPVAWGPTRNP
Mflv_1016|M.gilvum_PYR-GCK MS--RPAGEHATVVQRWLDAGLVIFGKTNTPEFGAKGITEPQAYGPARNP
MAB_2181c|M.abscessus_ATCC_199 ST--LPAPEHSTIVRRWLDAGLVIFGKTNTPEFGSKGITEPELFGASRNP
MAV_0676|M.avium_104 AN--DVADRHALVTQRFLDAGLVIFGKTNTPEFGAKGVTEPDYWGPARNP
Mb2912c|M.bovis_AF2122/97 EP--YAAVADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRNP
Rv2888c|M.tuberculosis_H37Rv EP--YAAVADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRNP
MLBr_01596|M.leprae_Br4923 VP--RNAFDDGEFTRLYLATGPVSLGKTQLSEFGFSASAEHMRLGPVRNP
TH_2520|M.thermoresistible__bu DP--RPQPAHGDFARLYLGTGVIPLGKTQMSEFGFSASAEHPRLGPVRNP
. .. :* : *:*: .*:* :* *. ***
MUL_2798|M.ulcerans_Agy99 WDTSRTPGGSSGGSAAAVASGMVPFAHASDGGGSIRIPASCCGLVGLKPS
MMAR_3565|M.marinum_M WDTSRTPGGSSGGSAAAVASGMVPFAHASDGGGSIRIPASCCGLVGLKPS
MSMEG_6673|M.smegmatis_MC2_155 WNLTHTPGGSSGGSAAAVAAGIVPCAGANDGGGSIRIPAACCGLVGLKPG
Mvan_5822|M.vanbaalenii_PYR-1 WDVTRTPGGSSGGSAAAVAAGIVPCAGANDGGGSIRIPAACCGLVGLKPG
Mflv_1016|M.gilvum_PYR-GCK WDLTRSPGGSSGGSAAAVAAGITPCAGASDGGGSIRIPAACCGLVGLKPG
MAB_2181c|M.abscessus_ATCC_199 WDLGRTPGGSSGGSAAAVAAGIVPVAGASDGGGSIRIPAGCCGLVGLKPG
MAV_0676|M.avium_104 WDTERTPGGSSGGSGAAVAAGIVPAAGANDGGGSIRIPAACNGLVGLKPS
Mb2912c|M.bovis_AF2122/97 WNTDYTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPS
Rv2888c|M.tuberculosis_H37Rv WNTDYTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPS
MLBr_01596|M.leprae_Br4923 WDTDYTAGASSSGSGAFVAAGVVPMAHANDGGGSIRIPASCNGLVGLKPS
TH_2520|M.thermoresistible__bu WHPEHTAGASSSGSGAFVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPS
*. :.*.**.**.* **:*:.* * *.**********.* *******.
MUL_2798|M.ulcerans_Agy99 QGRITLGPLREE--SGMSVEHCLSRTVRDTAALLDATRGPGVGDTVIAPP
MMAR_3565|M.marinum_M QGRITLGPLREE--SGMSVEHCLSRTVRDTAALLDATRGPGVGDTVIAPP
MSMEG_6673|M.smegmatis_MC2_155 RGLTPMGPALSESVHGATVQGVVSRTVRDTAAMLDVISGGEPSGPYAPKL
Mvan_5822|M.vanbaalenii_PYR-1 RGLTPMGPELGESMHGSAVQGVVSRTVRDTAAMLDVISGGEPWGPFTPGM
Mflv_1016|M.gilvum_PYR-GCK RGLTPSGPASGEAMHGAAVQGVVTRTVRDSAAMLDVISGGEPYGPFVPAL
MAB_2181c|M.abscessus_ATCC_199 RGITPMGPTAGEPMHGAAVNGTVSRTVRDTASMLDIIAGPEPTSPYLSAM
MAV_0676|M.avium_104 RGLAPYGPQTGELMLGMATQGVVTRTVRDSAALLDAIIGHHPDASYRVAL
Mb2912c|M.bovis_AF2122/97 RGRLPLEPEYRRLPVGIVANGVLTRTVRDTAAFYREAERLWRN----HQL
Rv2888c|M.tuberculosis_H37Rv RGRLPLEPEYRRLPVGIVANGVLTRTVRDTAAFYREAERLWRN----HQL
MLBr_01596|M.leprae_Br4923 RGRLPLDSELRRLPVGIVVNGVLTRSVRDTAAFYREAERIWHN----PKL
TH_2520|M.thermoresistible__bu RGRLPLDRHMRQMPLRIVANGVLTRSVRDTAAFYREAELLTGR----TRL
:* . . .: ::*:***:*::
MUL_2798|M.ulcerans_Agy99 PIRPYTEELGADPGRLRIGILDHHPRGGPVDAEVTHATQAVCRLLESLGH
MMAR_3565|M.marinum_M PIRPYTEELGADPGRLRIGILDHHPRGGPVDAEVTHATQAVGRLLESLGH
MSMEG_6673|M.smegmatis_MC2_155 PGTPFASAVGADPGKLRIGVRVPSAINPNPHREAYAAVEATAQTLTELGH
Mvan_5822|M.vanbaalenii_PYR-1 PNAPFASCVGQDPGRLRIGVRVPTAITPVPHREAFAAVEATVQTLTDLGH
Mflv_1016|M.gilvum_PYR-GCK PEASFASCVGTDPGTLRIGVRVPSAITPQPHREAFAAVEATTRLLTDLGH
MAB_2181c|M.abscessus_ATCC_199 PQDSYASQVGRDPGRLRIGVRVPTVITPNPDPAAVAAVETAIRLLTHLGH
MAV_0676|M.avium_104 PDKPFAQQITRPPGPLTIGYSARSALNPRPDREAVAAVENSAALLSALGH
Mb2912c|M.bovis_AF2122/97 P--PVGDVTSPVKQRLRIAVVTRS-VLREASPEVRQLTLKLAGLLEELGH
Rv2888c|M.tuberculosis_H37Rv P--PVGDVTSPVKQRLRIAVVTRS-VLREASPEVRQLTLKLAGLLEELGH
MLBr_01596|M.leprae_Br4923 P--PVGDVTQPGRQRLRIAVVTRS-VQRECSPELRELTLKSARLLEELGH
TH_2520|M.thermoresistible__bu P--PIGDITRPGAERLRIAVCTRS-INRDASPEVRELTLKTAALLEELGH
* . . * *. . * ***
MUL_2798|M.ulcerans_Agy99 HVEVAWPAALEDASFDSTFGALWSTNMGLAQRRFEEQLGRPLGEDEFELV
MMAR_3565|M.marinum_M HVDVAWPAALEDASFDSTFGALWSTNMGLAQRRFEEQLGRPLGEDEFELV
MSMEG_6673|M.smegmatis_MC2_155 HVEELPQAPFDDAALAREFLLSWFVYTAWELEEAKRISG--AGDEAFERD
Mvan_5822|M.vanbaalenii_PYR-1 HVDELPQAPFDDAALAREFLLTWFVYTAWELADAKRLTG--AGDDAFERD
Mflv_1016|M.gilvum_PYR-GCK EVTELAEAPYDDAVLARDFLLTWFVTLAWEVAEAKRLTG--AGDDQFETD
MAB_2181c|M.abscessus_ATCC_199 EVEEVS-APYDDGQLARDFLLTWFVHAAYEVDYTKRLTG--AGDEGFERD
MAV_0676|M.avium_104 RVREVA-PPYDDAALGRDFLTIWFAQLHQQVADIRRRTG--ARDNDFEAD
Mb2912c|M.bovis_AF2122/97 RVEHVDHPPAPAS-FVDDFVLYWGFLALAQVRSGRRTFG--RTFDPTRLD
Rv2888c|M.tuberculosis_H37Rv RVEHVDHPPAPAS-FVDDFVLYWGFLALAQVRSGRRTFG--RTFDPTRLD
MLBr_01596|M.leprae_Br4923 RVERVAEPPVPPN-FPDDFLLYWGLLAAMQVRTGRLAFG--NTFDRTKLD
TH_2520|M.thermoresistible__bu HVTPIDN-PVPRQ-FQDDFLLYWAFLAMAVVRSGRRTFG--PGFDRDRLD
.* . : * * . * : .
MUL_2798|M.ulcerans_Agy99 NRAQADFAKHFTSVDYALALSAIAAFRRAIQSWWHDGWDLLLTPTVASLP
MMAR_3565|M.marinum_M NRAQADFAKHFTSVDYALALSAIAAFRRAIQSWWHDGWDLLLTPTVASLP
MSMEG_6673|M.smegmatis_MC2_155 TLILAAIGRATSSVAYVDAVQRRHDHTRRLTTFFES-YDLLMTPTLATPP
Mvan_5822|M.vanbaalenii_PYR-1 TLILAAIGRATSSVDYLDAVQRRHDHTRRLTRFFDS-YDLLLTPSLATPP
Mflv_1016|M.gilvum_PYR-GCK TLVMAALGRATSSVDYVDAVQRRHEHTRRLTRFFES-YDLLLTPTLATPP
MAB_2181c|M.abscessus_ATCC_199 TLLIAALGRTTSGPEYVAAVERRHDYVRELATFFGD-YDLLLTPTLAKAP
MAV_0676|M.avium_104 TLAISELGRSGGVLPVMSALENRNTYIQSLAAFHEG-YDFFLTPTLATPP
Mb2912c|M.bovis_AF2122/97 ELTLGLARHTGRNLHRLPLAIMRLRMLRRRSVRFFGTYDVLLTPTVAEAT
Rv2888c|M.tuberculosis_H37Rv ELTLGLARHTGRNLHRLPLAIMRLRMLRRRSVRFFGTYDVLLTPTVAEAT
MLBr_01596|M.leprae_Br4923 SLTLGLDRHASRNMHRLPKAIMRLRRLRRRTADFFATYDVLLTPTVADET
TH_2520|M.thermoresistible__bu NLTLGLDSHAARNLHRLPAAMVRLSRLRRVTARLTRDFDVVLTPTLADVP
. : : :*..:**::* .
MUL_2798|M.ulcerans_Agy99 VKLGTIVSTPEHPMAA---------------------MQRAGEFVPFTPP
MMAR_3565|M.marinum_M VKLGTIVSTPEHPMAA---------------------MQRAGEFVPFTPP
MSMEG_6673|M.smegmatis_MC2_155 PRIGEFELPELLKRGSDVLLKTRTAGLLRFTKILDDSVDANLAWVPYTQL
Mvan_5822|M.vanbaalenii_PYR-1 PAIGEFDLPVALQKASDVLLKTRTAHLLRFTKIVDDIVDKNLGWVPYTQL
Mflv_1016|M.gilvum_PYR-GCK PRIGEFDMPAVMQRAADVLLKTRTARLLRHTGIVDDMVDQNLGWVPYTQL
MAB_2181c|M.abscessus_ATCC_199 PRIGEFNLPAPLAAVSDLLLRTKTARVLKYANIVDSMINDNLGWVPYTQL
MAV_0676|M.avium_104 LVVGATSTSAALQRAARLVSRVRGGKLMRLSGILDDLIRESLGWVPYTQL
Mb2912c|M.bovis_AF2122/97 PQVGYLAPT-DYQTVL----------------------DRLSSWVVFTPV
Rv2888c|M.tuberculosis_H37Rv PQVGYLAPT-DYQTVL----------------------DRLSSWVVFTPV
MLBr_01596|M.leprae_Br4923 PRIGYLTPT-DYQQVM----------------------DRLMGWVAFTPL
TH_2520|M.thermoresistible__bu PRIGHLDPTADYQQII----------------------DRLVDWVAFTPL
:* . :* :*
MUL_2798|M.ulcerans_Agy99 FNTSGQPAISLPLEWTPEGLPLGVQLVAAYGREDVLLRIASQLEQAKPWA
MMAR_3565|M.marinum_M FNTSGQPAISLPLEWTPEGLPLGVQLVAAYGREDVLLRIASQLEQAKPWA
MSMEG_6673|M.smegmatis_MC2_155 ANITGRPAVTLPLHWTADGLPLGVQFVAPLEGESLLIRLGAQLEEAMPWK
Mvan_5822|M.vanbaalenii_PYR-1 ANITGRPAISLPLHWTEEGLPLGVQFVAPLGGESLLVRLAAQLEQAMPWR
Mflv_1016|M.gilvum_PYR-GCK ANITGRPAISLPLHWTADGLPLGVQFVAPLAGEALLLRLAGQLEQAAPWA
MAB_2181c|M.abscessus_ATCC_199 ANLTGRPAISLPLYQTPKGLPLGVQFVAPLGGESLLIRLAAQLEATEPWA
MAV_0676|M.avium_104 ANLTGRPAISVPLHWTDDGLPLGVQFVGKLGADGDLLQLAAQLEQARPWA
Mb2912c|M.bovis_AF2122/97 QNVTGVPAISLPLAQSADGMPVGMMLSADTGREALLLELAYELEEARPWA
Rv2888c|M.tuberculosis_H37Rv QNVTGVPAISLPLAQSADGMPVGMMLSADTGREALLLELAYELEEARPWA
MLBr_01596|M.leprae_Br4923 QNVTGEPAISLPLAQSADGMPVGMMFTADFGQEAQLLELAFELEEARPWA
TH_2520|M.thermoresistible__bu HNVTGEPAVSLPLAQSRDGLPVGMMFAAALGEEARLLRLAYELEEARPWP
* :* **:::** : .*:*:*: : . : *:.:. :** : **
MUL_2798|M.ulcerans_Agy99 QRTPDI-----
MMAR_3565|M.marinum_M QRTPDI-----
MSMEG_6673|M.smegmatis_MC2_155 DRVAPV-----
Mvan_5822|M.vanbaalenii_PYR-1 DRVAPV-----
Mflv_1016|M.gilvum_PYR-GCK HRTAAL-----
MAB_2181c|M.abscessus_ATCC_199 HRRPTL-----
MAV_0676|M.avium_104 QRHPAPVTPPN
Mb2912c|M.bovis_AF2122/97 RIHAPNIAE--
Rv2888c|M.tuberculosis_H37Rv RIHAPNIAE--
MLBr_01596|M.leprae_Br4923 RIQIGD-----
TH_2520|M.thermoresistible__bu RIDQRS-----