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VVDFQEYRAQDATGLARLVAEKQVTADELLALAQARAAQVNPRINAIVRDVPAAPAGIADGPFAGVPFLI KDLAQDYAGLPSSRGSRALMSLPAAEHSTIVQRWIDAGVVIFGKTNTPEFGAKGITEPVAWGPTRNPWDV TRTPGGSSGGSAAAVAAGIVPCAGANDGGGSIRIPAACCGLVGLKPGRGLTPMGPELGESMHGSAVQGVV SRTVRDTAAMLDVISGGEPWGPFTPGMPNAPFASCVGQDPGRLRIGVRVPTAITPVPHREAFAAVEATVQ TLTDLGHHVDELPQAPFDDAALAREFLLTWFVYTAWELADAKRLTGAGDDAFERDTLILAAIGRATSSVD YLDAVQRRHDHTRRLTRFFDSYDLLLTPSLATPPPAIGEFDLPVALQKASDVLLKTRTAHLLRFTKIVDD IVDKNLGWVPYTQLANITGRPAISLPLHWTEEGLPLGVQFVAPLGGESLLVRLAAQLEQAMPWRDRVAPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5822 | - | - | 100% (490) | amidase |
| M. vanbaalenii PYR-1 | Mvan_2213 | - | 3e-64 | 35.57% (492) | amidase |
| M. vanbaalenii PYR-1 | Mvan_3824 | - | 7e-51 | 35.71% (434) | amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2912c | amiC | 1e-65 | 36.86% (491) | amidase |
| M. gilvum PYR-GCK | Mflv_1016 | - | 0.0 | 79.88% (487) | amidase |
| M. tuberculosis H37Rv | Rv2888c | amiC | 1e-65 | 36.86% (491) | amidase |
| M. leprae Br4923 | MLBr_01596 | - | 3e-68 | 36.98% (484) | amidase |
| M. abscessus ATCC 19977 | MAB_2181c | - | 0.0 | 68.44% (488) | putative amidase |
| M. marinum M | MMAR_4954 | amiC_2 | 1e-150 | 56.58% (486) | amidase, AmiC_2 |
| M. avium 104 | MAV_0676 | - | 1e-153 | 57.06% (489) | 6-aminohexanoate-cyclic-dimer hydrolase |
| M. smegmatis MC2 155 | MSMEG_6673 | - | 0.0 | 82.41% (489) | 6-aminohexanoate-cyclic-dimer hydrolase |
| M. thermoresistible (build 8) | TH_1357 | - | 1e-117 | 82.04% (245) | 6-aminohexanoate-cyclic-dimer hydrolase |
| M. ulcerans Agy99 | MUL_0540 | amiC_2 | 1e-149 | 56.17% (486) | amidase, AmiC_2 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6673|M.smegmatis_MC2_155 ------MNFDEYRTFDATGLAELVADKQVTAAELLEVAQARAEAVNPRIN
TH_1357|M.thermoresistible__bu --------------------------------------------------
Mvan_5822|M.vanbaalenii_PYR-1 -----MVDFQEYRAQDATGLARLVAEKQVTADELLALAQARAAQVNPRIN
Mflv_1016|M.gilvum_PYR-GCK ------MDFLEYRSHDATGLAKLVADGDVTADELLTLARERAAAVNPKIN
MAB_2181c|M.abscessus_ATCC_199 ------MDFSDYSQHDATGLAELVATKQVTPAELLAAARARAADVNNKIG
MMAR_4954|M.marinum_M ------MHLDEYMSLDATGLAELVATKQVRATELLALARQRADAVNPRLN
MUL_0540|M.ulcerans_Agy99 ------MHLDEYMSLDATGLAELVATKQVRATELLALARQRADAVNPRLN
MAV_0676|M.avium_104 ------------MALDATALAGLVADKQVTPAELLALARQRADAVNPRLN
Mb2912c|M.bovis_AF2122/97 MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAVNPALN
Rv2888c|M.tuberculosis_H37Rv MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAVNPALN
MLBr_01596|M.leprae_Br4923 MQRVHAFGDDALGDLDAVGLADAIRAGWVSRADVIEAAIVRTEAVNPALG
MSMEG_6673|M.smegmatis_MC2_155 AIVREVPAAPADAA------PGPFTGVPFLIKDIGQDYAGVPSSRGSRAL
TH_1357|M.thermoresistible__bu --------------------------------------------------
Mvan_5822|M.vanbaalenii_PYR-1 AIVRDVPAAPAGIA------DGPFAGVPFLIKDLAQDYAGLPSSRGSRAL
Mflv_1016|M.gilvum_PYR-GCK AIVRDVPAPVGGNR------GGPFAGVPFLIKDLAQDYAGLPTASGSRSL
MAB_2181c|M.abscessus_ATCC_199 AIVRTLPEADQQVQGD---LTGPFAGVPFLIKDLGQDYKGHPTSGGCRAL
MMAR_4954|M.marinum_M AIIRRIDALAEGRAADPE-LRGPLAGVPFLIKDLDQEYRGFPSSCGSRSL
MUL_0540|M.ulcerans_Agy99 AIIRRIDALAEGRAADPE-LRGPLAGVPFLIKDLDQEYRGFSSSCGSRSL
MAV_0676|M.avium_104 AIVCRLDDVADRQAADPN-LSGPFAGVPFLLKDLGQEYRGFPTSCGSRSL
Mb2912c|M.bovis_AF2122/97 ALAYAAFDVARDAAAMGTGQEAFFSGVPTFIKDN-VDVAGQPSMHGTDAW
Rv2888c|M.tuberculosis_H37Rv ALAYAAFDVARDAAAMGTGQEAFFSGVPTFIKDN-VDVAGQPSMHGTDAW
MLBr_01596|M.leprae_Br4923 GLAYEAFQWARQTASKAG--SGFFSGVPTFIKDN-IDVAGQPTMRGSDAW
MSMEG_6673|M.smegmatis_MC2_155 RSIPVTEHATVVQRWIEAGLVIFGKTNTPEFGAKGITEPEAWGPTRNPWN
TH_1357|M.thermoresistible__bu --------------------------------------------------
Mvan_5822|M.vanbaalenii_PYR-1 MSLPAAEHSTIVQRWIDAGVVIFGKTNTPEFGAKGITEPVAWGPTRNPWD
Mflv_1016|M.gilvum_PYR-GCK MSRPAGEHATVVQRWLDAGLVIFGKTNTPEFGAKGITEPQAYGPARNPWD
MAB_2181c|M.abscessus_ATCC_199 STLPAPEHSTIVRRWLDAGLVIFGKTNTPEFGSKGITEPELFGASRNPWD
MMAR_4954|M.marinum_M ANDVAKQHALVTQRFLDAGLVVFGMTNTPEFGAKGITEPDYWGPARNPWN
MUL_0540|M.ulcerans_Agy99 ANDVAKQHALVTQRFLDAGLVVFGMTNTPEFGAKGITEPDYWGPARNPWN
MAV_0676|M.avium_104 ANDVADRHALVTQRFLDAGLVIFGKTNTPEFGAKGVTEPDYWGPARNPWD
Mb2912c|M.bovis_AF2122/97 EPYAAVADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRNPWN
Rv2888c|M.tuberculosis_H37Rv EPYAAVADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRNPWN
MLBr_01596|M.leprae_Br4923 VPRNAFDDGEFTRLYLATGPVSLGKTQLSEFGFSASAEHMRLGPVRNPWD
MSMEG_6673|M.smegmatis_MC2_155 LTHTPGGSSGGSAAAVAAGIVPCAGANDGGGSIRIPAACCGLVGLKPGRG
TH_1357|M.thermoresistible__bu --------------------------------------------------
Mvan_5822|M.vanbaalenii_PYR-1 VTRTPGGSSGGSAAAVAAGIVPCAGANDGGGSIRIPAACCGLVGLKPGRG
Mflv_1016|M.gilvum_PYR-GCK LTRSPGGSSGGSAAAVAAGITPCAGASDGGGSIRIPAACCGLVGLKPGRG
MAB_2181c|M.abscessus_ATCC_199 LGRTPGGSSGGSAAAVAAGIVPVAGASDGGGSIRIPAGCCGLVGLKPGRG
MMAR_4954|M.marinum_M PQHTPGGSSGGSGAAVAAGIVPLAGANDGGGSIRIPAACNGLVGLKLSRG
MUL_0540|M.ulcerans_Agy99 PQHTPGGSSGGSGAAVAAGIVPLAGANDGGGSIRIPAACNGLVGLKLSRG
MAV_0676|M.avium_104 TERTPGGSSGGSGAAVAAGIVPAAGANDGGGSIRIPAACNGLVGLKPSRG
Mb2912c|M.bovis_AF2122/97 TDYTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPSRG
Rv2888c|M.tuberculosis_H37Rv TDYTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPSRG
MLBr_01596|M.leprae_Br4923 TDYTAGASSSGSGAFVAAGVVPMAHANDGGGSIRIPASCNGLVGLKPSRG
MSMEG_6673|M.smegmatis_MC2_155 LTPMGPALSESVHGATVQGVVSRTVRDTAAMLDVISGGEPSGPYAPKLPG
TH_1357|M.thermoresistible__bu --------------------------------------------------
Mvan_5822|M.vanbaalenii_PYR-1 LTPMGPELGESMHGSAVQGVVSRTVRDTAAMLDVISGGEPWGPFTPGMPN
Mflv_1016|M.gilvum_PYR-GCK LTPSGPASGEAMHGAAVQGVVTRTVRDSAAMLDVISGGEPYGPFVPALPE
MAB_2181c|M.abscessus_ATCC_199 ITPMGPTAGEPMHGAAVNGTVSRTVRDTASMLDIIAGPEPTSPYLSAMPQ
MMAR_4954|M.marinum_M LSPYGPQTGEPLFGMETQGVVSRTVRDSAASYDAIVGPNPRAAYQVALPD
MUL_0540|M.ulcerans_Agy99 LSPYGPQTGEPLFGMETQGVVSRTVRDSAAIYDAIVGPNPRAAYQVALPD
MAV_0676|M.avium_104 LAPYGPQTGELMLGMATQGVVTRTVRDSAALLDAIIGHHPDASYRVALPD
Mb2912c|M.bovis_AF2122/97 RLPLEPEYRRLPVGIVANGVLTRTVRDTAAFYREAERLWRN----HQLP-
Rv2888c|M.tuberculosis_H37Rv RLPLEPEYRRLPVGIVANGVLTRTVRDTAAFYREAERLWRN----HQLP-
MLBr_01596|M.leprae_Br4923 RLPLDSELRRLPVGIVVNGVLTRSVRDTAAFYREAERIWHN----PKLP-
MSMEG_6673|M.smegmatis_MC2_155 TPFASAVGADPGKLRIGVRVPSAINPNPHREAYAAVEATAQTLTELGHHV
TH_1357|M.thermoresistible__bu ------VGADPGRLRIGVRVPTAINPQPHPDAFAAVEATVRTLTELGHQV
Mvan_5822|M.vanbaalenii_PYR-1 APFASCVGQDPGRLRIGVRVPTAITPVPHREAFAAVEATVQTLTDLGHHV
Mflv_1016|M.gilvum_PYR-GCK ASFASCVGTDPGTLRIGVRVPSAITPQPHREAFAAVEATTRLLTDLGHEV
MAB_2181c|M.abscessus_ATCC_199 DSYASQVGRDPGRLRIGVRVPTVITPNPDPAAVAAVETAIRLLTHLGHEV
MMAR_4954|M.marinum_M TTFVEHIKKRPGALKIGYSASSAINAAPDREAVAAVEAAASLLEDLGHRV
MUL_0540|M.ulcerans_Agy99 TTFVEHIKNRPGALKIGYSASSAINAAPDREAVAAVEAAASLLEDLGHRV
MAV_0676|M.avium_104 KPFAQQITRPPGPLTIGYSARSALNPRPDREAVAAVENSAALLSALGHRV
Mb2912c|M.bovis_AF2122/97 -PVGDVTSPVKQRLRIAVVTRSVLR-EASPEVRQLTLKLAGLLEELGHRV
Rv2888c|M.tuberculosis_H37Rv -PVGDVTSPVKQRLRIAVVTRSVLR-EASPEVRQLTLKLAGLLEELGHRV
MLBr_01596|M.leprae_Br4923 -PVGDVTQPGRQRLRIAVVTRSVQR-ECSPELRELTLKSARLLEELGHRV
* *. . :. . * ***.*
MSMEG_6673|M.smegmatis_MC2_155 EELPQAPFDDAALAREFLLSWFVYTAWELEEAKRISGAGDEAFERDTLIL
TH_1357|M.thermoresistible__bu EELPQAPFDDAALARDFLLTWFVYTAWELADTKRRTGAGDDAFERDTLIL
Mvan_5822|M.vanbaalenii_PYR-1 DELPQAPFDDAALAREFLLTWFVYTAWELADAKRLTGAGDDAFERDTLIL
Mflv_1016|M.gilvum_PYR-GCK TELAEAPYDDAVLARDFLLTWFVTLAWEVAEAKRLTGAGDDQFETDTLVM
MAB_2181c|M.abscessus_ATCC_199 EEVS-APYDDGQLARDFLLTWFVHAAYEVDYTKRLTGAGDEGFERDTLLI
MMAR_4954|M.marinum_M EQVD-PPYDDAALARDFLTIWFAQLHSQVAEIRKRIGARDSDFEADTLAM
MUL_0540|M.ulcerans_Agy99 EQVD-PPYDDAALARDFLTIWFAQLHSQVAEIRKRIGARNSDFEADTLAM
MAV_0676|M.avium_104 REVA-PPYDDAALGRDFLTIWFAQLHQQVADIRRRTGARDNDFEADTLAI
Mb2912c|M.bovis_AF2122/97 EHVDHPPAP-ASFVDDFVLYWGFLALAQVRSGRRTFGRTFDPTRLDELTL
Rv2888c|M.tuberculosis_H37Rv EHVDHPPAP-ASFVDDFVLYWGFLALAQVRSGRRTFGRTFDPTRLDELTL
MLBr_01596|M.leprae_Br4923 ERVAEPPVP-PNFPDDFLLYWGLLAAMQVRTGRLAFGNTFDRTKLDSLTL
.: .* : :*: * :: : * . . * * :
MSMEG_6673|M.smegmatis_MC2_155 AAIGRATSSVA-YVDAVQRRHDHTRRLTTFFESYDLLMTPTLATPPPRIG
TH_1357|M.thermoresistible__bu AALGRATGSVD-YLDAVHRRHAHTRRLTEFFETHDLLLTPTLATPPPRIG
Mvan_5822|M.vanbaalenii_PYR-1 AAIGRATSSVD-YLDAVQRRHDHTRRLTRFFDSYDLLLTPSLATPPPAIG
Mflv_1016|M.gilvum_PYR-GCK AALGRATSSVD-YVDAVQRRHEHTRRLTRFFESYDLLLTPTLATPPPRIG
MAB_2181c|M.abscessus_ATCC_199 AALGRTTSGPE-YVAAVERRHDYVRELATFFGDYDLLLTPTLAKAPPRIG
MMAR_4954|M.marinum_M AELGRSTGVLA-PLLALDNRNNYIQSLASFHESYDYFLTPSLATPPLAVG
MUL_0540|M.ulcerans_Agy99 AELGRSTGVLA-PLLALDNRNNYIQSLASFHESYDYFLTPSLATPPLTVG
MAV_0676|M.avium_104 SELGRSGGVLP-VMSALENRNTYIQSLAAFHEGYDFFLTPTLATPPLVVG
Mb2912c|M.bovis_AF2122/97 GLARHTGRNLHRLPLAIMRLRMLRRRSVRFFGTYDVLLTPTVAEATPQVG
Rv2888c|M.tuberculosis_H37Rv GLARHTGRNLHRLPLAIMRLRMLRRRSVRFFGTYDVLLTPTVAEATPQVG
MLBr_01596|M.leprae_Br4923 GLDRHASRNMHRLPKAIMRLRRLRRRTADFFATYDVLLTPTVADETPRIG
. :: *: . . : . *. :* ::**::* . :*
MSMEG_6673|M.smegmatis_MC2_155 EFELPELLKRGSDVLLKTRTAGLLRFTKILDDSVDANLAWVPYTQLANIT
TH_1357|M.thermoresistible__bu QFDLPAALERASDVLIKTRTAGLLRFTKFVDDAVEQNLAWVPYTQLANLT
Mvan_5822|M.vanbaalenii_PYR-1 EFDLPVALQKASDVLLKTRTAHLLRFTKIVDDIVDKNLGWVPYTQLANIT
Mflv_1016|M.gilvum_PYR-GCK EFDMPAVMQRAADVLLKTRTARLLRHTGIVDDMVDQNLGWVPYTQLANIT
MAB_2181c|M.abscessus_ATCC_199 EFNLPAPLAAVSDLLLRTKTARVLKYANIVDSMINDNLGWVPYTQLANLT
MMAR_4954|M.marinum_M DTTTSPRLQTAARLLSKLRAGKVLSLSGIMDDLIQESLGWVPYTQLANLT
MUL_0540|M.ulcerans_Agy99 DTTTSPRLQTAARLLSKLRAGKVLSLSGIMDDLIQESLGWVPYTQLANLT
MAV_0676|M.avium_104 ATSTSAALQRAARLVSRVRGGKLMRLSGILDDLIRESLGWVPYTQLANLT
Mb2912c|M.bovis_AF2122/97 YLAPTDYQT-----------------------VLDRLSSWVVFTPVQNVT
Rv2888c|M.tuberculosis_H37Rv YLAPTDYQT-----------------------VLDRLSSWVVFTPVQNVT
MLBr_01596|M.leprae_Br4923 YLTPTDYQQ-----------------------VMDRLMGWVAFTPLQNVT
. : .** :* : *:*
MSMEG_6673|M.smegmatis_MC2_155 GRPAVTLPLHWTADGLPLGVQFVAPLEGESLLIRLGAQLEEAMPWKDRVA
TH_1357|M.thermoresistible__bu GRPAISLPLHWTADGLPLGVQFVAPLAGEQTLIRLAAQLEEAMPWADRVP
Mvan_5822|M.vanbaalenii_PYR-1 GRPAISLPLHWTEEGLPLGVQFVAPLGGESLLVRLAAQLEQAMPWRDRVA
Mflv_1016|M.gilvum_PYR-GCK GRPAISLPLHWTADGLPLGVQFVAPLAGEALLLRLAGQLEQAAPWAHRTA
MAB_2181c|M.abscessus_ATCC_199 GRPAISLPLYQTPKGLPLGVQFVAPLGGESLLIRLAAQLEATEPWAHRRP
MMAR_4954|M.marinum_M GRPAISVPLHWTPAGLPLGVQFVGGLGSDGDLLALAAQLEEARPWAQRHP
MUL_0540|M.ulcerans_Agy99 GRPAISLPLHWTPAGLPLGVQFVGGLGSDGDLLALAAQLEEARPWAHRHP
MAV_0676|M.avium_104 GRPAISVPLHWTDDGLPLGVQFVGKLGADGDLLQLAAQLEQARPWAQRHP
Mb2912c|M.bovis_AF2122/97 GVPAISLPLAQSADGMPVGMMLSADTGREALLLELAYELEEARPWARIHA
Rv2888c|M.tuberculosis_H37Rv GVPAISLPLAQSADGMPVGMMLSADTGREALLLELAYELEEARPWARIHA
MLBr_01596|M.leprae_Br4923 GEPAISLPLAQSADGMPVGMMFTADFGQEAQLLELAFELEEARPWARIQI
* **:::** : *:*:*: : . : *: *. :** : **
MSMEG_6673|M.smegmatis_MC2_155 PV------
TH_1357|M.thermoresistible__bu PL------
Mvan_5822|M.vanbaalenii_PYR-1 PV------
Mflv_1016|M.gilvum_PYR-GCK AL------
MAB_2181c|M.abscessus_ATCC_199 TL------
MMAR_4954|M.marinum_M A--TPPAG
MUL_0540|M.ulcerans_Agy99 A--TPPAG
MAV_0676|M.avium_104 APVTPPN-
Mb2912c|M.bovis_AF2122/97 PNIAE---
Rv2888c|M.tuberculosis_H37Rv PNIAE---
MLBr_01596|M.leprae_Br4923 GD------